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Protein

Basic leucine zipper transcriptional factor ATF-like

Gene

BATF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like
Alternative name(s):
B-cell-activating transcription factor
Short name:
B-ATF
SF-HT-activated gene 2 protein
Short name:
SFA-2
Gene namesi
Name:BATF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000156127.6
HGNCiHGNC:958 BATF
MIMi612476 gene
neXtProtiNX_Q16520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10538
OpenTargetsiENSG00000156127
PharmGKBiPA25268

Polymorphism and mutation databases

BioMutaiBATF
DMDMi32171340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765951 – 125Basic leucine zipper transcriptional factor ATF-likeAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei48PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).By similarity
Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16520
MaxQBiQ16520
PaxDbiQ16520
PeptideAtlasiQ16520
PRIDEiQ16520
ProteomicsDBi60892

PTM databases

iPTMnetiQ16520
PhosphoSitePlusiQ16520

Expressioni

Tissue specificityi

Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).3 Publications

Inductioni

Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.2 Publications

Gene expression databases

BgeeiENSG00000156127
CleanExiHS_BATF
ExpressionAtlasiQ16520 baseline and differential
GenevisibleiQ16520 HS

Organism-specific databases

HPAiHPA059588
HPA064962

Interactioni

Subunit structurei

Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115792, 19 interactors
DIPiDIP-52482N
IntActiQ16520, 17 interactors
MINTiQ16520
STRINGi9606.ENSP00000286639

Structurei

3D structure databases

ProteinModelPortaliQ16520
SMRiQ16520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 89bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 50Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni54 – 75Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000236325
HOVERGENiHBG039173
InParanoidiQ16520
KOiK09034
OMAiDSNDTSY
OrthoDBiEOG091G0YSM
PhylomeDBiQ16520
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029820 BATF
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF14 PTHR23351:SF14, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q16520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK
60 70 80 90 100
ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST
110 120
PSPPEVVYSA HAFHQPHVSS PRFQP
Length:125
Mass (Da):14,120
Last modified:November 1, 1996 - v1
Checksum:i7FD633C6F1963DF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15460 mRNA Translation: AAC50314.1
D42106 mRNA Translation: BAA07686.1
AF016898 Genomic DNA Translation: AAC78243.1
AC007182 Genomic DNA Translation: AAD51372.1
BC032294 mRNA Translation: AAH32294.1
CCDSiCCDS9843.1
PIRiJC4799
RefSeqiNP_006390.1, NM_006399.3
UniGeneiHs.509964

Genome annotation databases

EnsembliENST00000286639; ENSP00000286639; ENSG00000156127
GeneIDi10538
KEGGihsa:10538
UCSCiuc001xrr.4 human

Similar proteinsi

Entry informationi

Entry nameiBATF_HUMAN
AccessioniPrimary (citable) accession number: Q16520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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