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Protein

Neuronatin

Gene

NNAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

GO - Biological processi

  • brain development Source: GO_Central
  • neuron differentiation Source: Ensembl
  • positive regulation of insulin secretion Source: GO_Central
  • protein lipoylation Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:NNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000053438.8
HGNCiHGNC:7860 NNAT
MIMi603106 gene
neXtProtiNX_Q16517

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi4826
OpenTargetsiENSG00000053438
PharmGKBiPA31665

Polymorphism and mutation databases

BioMutaiNNAT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968821 – 81NeuronatinAdd BLAST81

Proteomic databases

PaxDbiQ16517
PeptideAtlasiQ16517
PRIDEiQ16517
ProteomicsDBi60889
60890 [Q16517-2]
TopDownProteomicsiQ16517-1 [Q16517-1]

PTM databases

iPTMnetiQ16517
PhosphoSitePlusiQ16517

Expressioni

Developmental stagei

Abundant in 18-24 week old fetal brain. Postnatally its expression decline and only minimal levels were present in adulthood.

Gene expression databases

BgeeiENSG00000053438 Expressed in 207 organ(s), highest expression level in adenohypophysis
CleanExiHS_NNAT
GenevisibleiQ16517 HS

Interactioni

Protein-protein interaction databases

BioGridi110890, 2 interactors
IntActiQ16517, 1 interactor
STRINGi9606.ENSP00000062104

Structurei

3D structure databases

ProteinModelPortaliQ16517
SMRiQ16517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOVERGENiHBG001605
InParanoidiQ16517
OMAiMGERRQR
OrthoDBiEOG091G1AP2
PhylomeDBiQ16517
TreeFamiTF338710

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: Q16517-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AYTVSRTGRQ VLGERRQRAP N
Length:81
Mass (Da):9,237
Last modified:November 1, 1996 - v1
Checksum:i067086C7663E3D20
GO
Isoform Beta (identifier: Q16517-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,153
Checksum:i184E7C9642006C87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64V → L in AAV38233 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00433125 – 51Missing in isoform Beta. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25033 mRNA Translation: AAA93224.1
U25034 mRNA Translation: AAA93225.1
U31767 Genomic DNA Translation: AAC50627.1
U31767 Genomic DNA Translation: AAC50626.1
AB002392 mRNA Translation: BAA25016.1
AK312069 mRNA Translation: BAG35005.1
BT019426 mRNA Translation: AAV38233.1
AL109614 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76059.1
CH471077 Genomic DNA Translation: EAW76060.1
BC001768 mRNA Translation: AAH01768.1
CCDSiCCDS13296.1 [Q16517-1]
CCDS13297.1 [Q16517-2]
PIRiG01783
RefSeqiNP_001309731.1, NM_001322802.1
NP_005377.1, NM_005386.3 [Q16517-1]
NP_859017.1, NM_181689.2 [Q16517-2]
UniGeneiHs.504703

Genome annotation databases

EnsembliENST00000062104; ENSP00000062104; ENSG00000053438 [Q16517-1]
ENST00000346199; ENSP00000335497; ENSG00000053438 [Q16517-2]
GeneIDi4826
KEGGihsa:4826
UCSCiuc002xhd.4 human [Q16517-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25033 mRNA Translation: AAA93224.1
U25034 mRNA Translation: AAA93225.1
U31767 Genomic DNA Translation: AAC50627.1
U31767 Genomic DNA Translation: AAC50626.1
AB002392 mRNA Translation: BAA25016.1
AK312069 mRNA Translation: BAG35005.1
BT019426 mRNA Translation: AAV38233.1
AL109614 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76059.1
CH471077 Genomic DNA Translation: EAW76060.1
BC001768 mRNA Translation: AAH01768.1
CCDSiCCDS13296.1 [Q16517-1]
CCDS13297.1 [Q16517-2]
PIRiG01783
RefSeqiNP_001309731.1, NM_001322802.1
NP_005377.1, NM_005386.3 [Q16517-1]
NP_859017.1, NM_181689.2 [Q16517-2]
UniGeneiHs.504703

3D structure databases

ProteinModelPortaliQ16517
SMRiQ16517
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110890, 2 interactors
IntActiQ16517, 1 interactor
STRINGi9606.ENSP00000062104

PTM databases

iPTMnetiQ16517
PhosphoSitePlusiQ16517

Polymorphism and mutation databases

BioMutaiNNAT

Proteomic databases

PaxDbiQ16517
PeptideAtlasiQ16517
PRIDEiQ16517
ProteomicsDBi60889
60890 [Q16517-2]
TopDownProteomicsiQ16517-1 [Q16517-1]

Protocols and materials databases

DNASUi4826
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000062104; ENSP00000062104; ENSG00000053438 [Q16517-1]
ENST00000346199; ENSP00000335497; ENSG00000053438 [Q16517-2]
GeneIDi4826
KEGGihsa:4826
UCSCiuc002xhd.4 human [Q16517-1]

Organism-specific databases

CTDi4826
DisGeNETi4826
EuPathDBiHostDB:ENSG00000053438.8
GeneCardsiNNAT
HGNCiHGNC:7860 NNAT
MIMi603106 gene
neXtProtiNX_Q16517
OpenTargetsiENSG00000053438
PharmGKBiPA31665
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOVERGENiHBG001605
InParanoidiQ16517
OMAiMGERRQR
OrthoDBiEOG091G1AP2
PhylomeDBiQ16517
TreeFamiTF338710

Miscellaneous databases

GenomeRNAii4826
PROiPR:Q16517
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000053438 Expressed in 207 organ(s), highest expression level in adenohypophysis
CleanExiHS_NNAT
GenevisibleiQ16517 HS

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNAT_HUMAN
AccessioniPrimary (citable) accession number: Q16517
Secondary accession number(s): B2R558
, E1P5V6, Q16596, Q5U0N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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