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Protein

Acid-sensing ion channel 2

Gene

ASIC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Miscellaneous

Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn2+.By similarity

GO - Molecular functioni

  • acid-sensing ion channel activity Source: Reactome
  • ligand-gated sodium channel activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 21 Publication
Short name:
ASIC21 Publication
Alternative name(s):
Amiloride-sensitive brain sodium channel
Amiloride-sensitive cation channel 1, neuronal
Amiloride-sensitive cation channel neuronal 1
Brain sodium channel 11 Publication
Short name:
BNC11 Publication
Short name:
BNaC11 Publication
Mammalian degenerin homolog1 Publication
Short name:
MDEG1 Publication
Gene namesi
Name:ASIC2
Synonyms:ACCN, ACCN1, BNAC1, MDEG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108684.14
HGNCiHGNC:99 ASIC2
MIMi601784 gene
neXtProtiNX_Q16515

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicBy similarityAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 427ExtracellularBy similarityAdd BLAST369
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 512CytoplasmicBy similarityAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi40
OpenTargetsiENSG00000108684
PharmGKBiPA24433

Chemistry databases

DrugBankiDB00594 Amiloride
GuidetoPHARMACOLOGYi685

Polymorphism and mutation databases

BioMutaiASIC2
DMDMi2500840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812901 – 512Acid-sensing ion channel 2Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Disulfide bondi92 ↔ 193By similarity
Disulfide bondi171 ↔ 178By similarity
Disulfide bondi289 ↔ 364By similarity
Disulfide bondi307 ↔ 360By similarity
Disulfide bondi311 ↔ 358By similarity
Disulfide bondi320 ↔ 342By similarity
Disulfide bondi322 ↔ 334By similarity
Glycosylationi365N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi392N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiQ16515
PRIDEiQ16515
ProteomicsDBi60887
60888 [Q16515-2]

PTM databases

iPTMnetiQ16515
PhosphoSitePlusiQ16515

Expressioni

Tissue specificityi

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.2 Publications

Gene expression databases

BgeeiENSG00000108684 Expressed in 88 organ(s), highest expression level in frontal cortex
CleanExiHS_ACCN1
GenevisibleiQ16515 HS

Organism-specific databases

HPAiHPA052112

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1 (PubMed:23034652). Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PICK1Q9NRD53EBI-79149,EBI-79165

Protein-protein interaction databases

BioGridi106558, 4 interactors
IntActiQ16515, 1 interactor
MINTiQ16515

Structurei

3D structure databases

ProteinModelPortaliQ16515
SMRiQ16515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119120
HOGENOMiHOG000247010
HOVERGENiHBG004150
InParanoidiQ16515
KOiK04828
OMAiHPNTRYE
OrthoDBiEOG091G053J
PhylomeDBiQ16515
TreeFamiTF330663

Family and domain databases

InterProiView protein in InterPro
IPR001873 ENaC
IPR004724 ENaC_chordates
IPR020903 ENaC_CS
PANTHERiPTHR11690 PTHR11690, 1 hit
PfamiView protein in Pfam
PF00858 ASC, 1 hit
PRINTSiPR01078 AMINACHANNEL
TIGRFAMsiTIGR00859 ENaC, 1 hit
PROSITEiView protein in PROSITE
PS01206 ASC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16515-1) [UniParc]FASTAAdd to basket
Also known as: Asic2a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV
60 70 80 90 100
GSLGLLLVES SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS
110 120 130 140 150
RLTTNDLYHA GELLALLDVN LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ
160 170 180 190 200
FSMLEFLHRV GHDLKDMMLY CKFKGQECGH QDFTTVFTKY GKCYMFNSGE
210 220 230 240 250
DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF EAGVKVQIHS
260 270 280 290 300
QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP
310 320 330 340 350
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL
360 370 380 390 400
AEKDSNYCLC RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE
410 420 430 440 450
NILVLDIFFE ALNYETIEQK KAYEVAALLG DIGGQMGLFI GASILTILEL
460 470 480 490 500
FDYIYELIKE KLLDLLGKEE DEGSHDENVS TCDTMPNHSE TISHTVNVPL
510
QTTLGTLEEI AC
Length:512
Mass (Da):57,709
Last modified:November 1, 1997 - v1
Checksum:i7C95B0B32EFF2814
GO
Isoform 2 (identifier: Q16515-2) [UniParc]FASTAAdd to basket
Also known as: Asic2b, MDEG2

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     185-185: T → MSRIGGAGLP...ELCGPHNFSS

Note: No experimental confirmation available.Curated
Show »
Length:563
Mass (Da):62,887
Checksum:i821B2B1956DDB563
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495T → A in AAC50432 (PubMed:8626462).Curated1
Isoform 2 (identifier: Q16515-2)
Sequence conflicti67H → R in CAD38879 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052036354D → G. Corresponds to variant dbSNP:rs16967895Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0155901 – 184Missing in isoform 2. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_015591185T → MSRIGGAGLPAAALTGPGRF RMAREEPAPAALAAAGQPGG GRGGERALQGPGVARRGRPS LSRAKLHGLRHMCAGRTAAG GSFQRRALWVLAFCTSFGLL LSWSSNRLLYWLSFPSHTRV HREWSRQLPFPAVTVCNNNP LRFPRLSKGDLYYAGHWLGL LLPNRTARPLVSELLRGDEP RRQWFRKLADFRLFLPPRHF EGISAAFMDRLGHQLEDMLL SCKYRGELCGPHNFSS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50352 mRNA Translation: AAC50432.1
U53212 mRNA Translation: AAC50498.1
U57352 mRNA Translation: AAB49182.1
AL834182 mRNA Translation: CAD38879.1
AC003687 Genomic DNA No translation available.
AC004147 Genomic DNA No translation available.
AC005549 Genomic DNA No translation available.
AC008133 Genomic DNA No translation available.
AC011824 Genomic DNA No translation available.
AC015751 Genomic DNA No translation available.
AC024610 Genomic DNA No translation available.
AC024614 Genomic DNA No translation available.
AC025898 Genomic DNA No translation available.
AC027233 Genomic DNA No translation available.
AC078907 Genomic DNA No translation available.
AC123769 Genomic DNA No translation available.
BC075042 mRNA Translation: AAH75042.1
BC075043 mRNA Translation: AAH75043.1
CCDSiCCDS11276.1 [Q16515-2]
CCDS42296.1 [Q16515-1]
RefSeqiNP_001085.2, NM_001094.4 [Q16515-1]
NP_899233.1, NM_183377.1 [Q16515-2]
UniGeneiHs.368417

Genome annotation databases

EnsembliENST00000225823; ENSP00000225823; ENSG00000108684 [Q16515-2]
ENST00000359872; ENSP00000352934; ENSG00000108684 [Q16515-1]
GeneIDi40
KEGGihsa:40
UCSCiuc002hht.4 human [Q16515-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50352 mRNA Translation: AAC50432.1
U53212 mRNA Translation: AAC50498.1
U57352 mRNA Translation: AAB49182.1
AL834182 mRNA Translation: CAD38879.1
AC003687 Genomic DNA No translation available.
AC004147 Genomic DNA No translation available.
AC005549 Genomic DNA No translation available.
AC008133 Genomic DNA No translation available.
AC011824 Genomic DNA No translation available.
AC015751 Genomic DNA No translation available.
AC024610 Genomic DNA No translation available.
AC024614 Genomic DNA No translation available.
AC025898 Genomic DNA No translation available.
AC027233 Genomic DNA No translation available.
AC078907 Genomic DNA No translation available.
AC123769 Genomic DNA No translation available.
BC075042 mRNA Translation: AAH75042.1
BC075043 mRNA Translation: AAH75043.1
CCDSiCCDS11276.1 [Q16515-2]
CCDS42296.1 [Q16515-1]
RefSeqiNP_001085.2, NM_001094.4 [Q16515-1]
NP_899233.1, NM_183377.1 [Q16515-2]
UniGeneiHs.368417

3D structure databases

ProteinModelPortaliQ16515
SMRiQ16515
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106558, 4 interactors
IntActiQ16515, 1 interactor
MINTiQ16515

Chemistry databases

DrugBankiDB00594 Amiloride
GuidetoPHARMACOLOGYi685

PTM databases

iPTMnetiQ16515
PhosphoSitePlusiQ16515

Polymorphism and mutation databases

BioMutaiASIC2
DMDMi2500840

Proteomic databases

PeptideAtlasiQ16515
PRIDEiQ16515
ProteomicsDBi60887
60888 [Q16515-2]

Protocols and materials databases

DNASUi40
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225823; ENSP00000225823; ENSG00000108684 [Q16515-2]
ENST00000359872; ENSP00000352934; ENSG00000108684 [Q16515-1]
GeneIDi40
KEGGihsa:40
UCSCiuc002hht.4 human [Q16515-1]

Organism-specific databases

CTDi40
DisGeNETi40
EuPathDBiHostDB:ENSG00000108684.14
GeneCardsiASIC2
HGNCiHGNC:99 ASIC2
HPAiHPA052112
MIMi601784 gene
neXtProtiNX_Q16515
OpenTargetsiENSG00000108684
PharmGKBiPA24433
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119120
HOGENOMiHOG000247010
HOVERGENiHBG004150
InParanoidiQ16515
KOiK04828
OMAiHPNTRYE
OrthoDBiEOG091G053J
PhylomeDBiQ16515
TreeFamiTF330663

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRSiASIC2 human
GeneWikiiACCN1
GenomeRNAii40
PROiPR:Q16515
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108684 Expressed in 88 organ(s), highest expression level in frontal cortex
CleanExiHS_ACCN1
GenevisibleiQ16515 HS

Family and domain databases

InterProiView protein in InterPro
IPR001873 ENaC
IPR004724 ENaC_chordates
IPR020903 ENaC_CS
PANTHERiPTHR11690 PTHR11690, 1 hit
PfamiView protein in Pfam
PF00858 ASC, 1 hit
PRINTSiPR01078 AMINACHANNEL
TIGRFAMsiTIGR00859 ENaC, 1 hit
PROSITEiView protein in PROSITE
PS01206 ASC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASIC2_HUMAN
AccessioniPrimary (citable) accession number: Q16515
Secondary accession number(s): E9PBX2
, Q13553, Q6DJU1, Q8N3E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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