TAF12

Functionⁱ

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15601843
protein heterodimerization activity Source: InterPro
RNA polymerase II activating transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
TBP-class protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11564863
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17264123

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA-templated transcription, initiation
Source: UniProtKB
Inferred from direct assayⁱ
- 9603525
histone H3 acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11564863
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15735663
regulation of signal transduction by p53 class mediator Source: Reactome
RNA polymerase II preinitiation complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II Source: Reactome
transcription initiation from RNA polymerase II promoter
Source: UniProtKB
Inferred from direct assayⁱ
- 9603525

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-3214847 HATs acetylate histones R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORⁱ	Q16514

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-3214847 HATs acetylate histones
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

SIGNORⁱ

Q16514

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 12 Alternative name(s): Transcription initiation factor TFIID 20/15 kDa subunits Short name: TAFII-20/TAFII-15 Short name: TAFII20/TAFII15
Gene namesⁱ	Name:TAF12 Synonyms:TAF15, TAF2J, TAFII20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120656.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11545 TAF12
MIMⁱ	600773 gene
neXtProtⁱ	NX_Q16514

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6883
Open Targets More...OpenTargetsⁱ	ENSG00000120656
PharmGKBⁱ	PA36320

Polymorphism and mutation databases

BioMutaⁱ	TAF12
DMDMⁱ	3024708

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000033580	1 – 161	Transcription initiation factor TFIID subunit 12Add BLAST		161

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	19	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	43	PhosphothreonineCombined sources	1
Modified residueⁱ	51	PhosphoserineCombined sources	1
Modified residueⁱ	59	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q16514
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16514
PaxDbⁱ	Q16514
PeptideAtlas More...PeptideAtlasⁱ	Q16514
PRIDEⁱ	Q16514
ProteomicsDBⁱ	60885 60886 [Q16514-2]

PTM databases

iPTMnetⁱ	Q16514
PhosphoSitePlusⁱ	Q16514

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000120656 Expressed in 210 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TAF12 HS_TAF15
Genevisibleⁱ	Q16514 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008519

HPAⁱ

HPA008519

Interactionⁱ

Subunit structureⁱ

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the transactivation of ATF7.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PRKAR2B	Q6DHZ2	3	EBI-1034238,EBI-10185196
TAF1C	Q15572	2	EBI-1034238,EBI-2510659
TAF4	O00268	16	EBI-1034253,EBI-1034261
TBP	P20226	2	EBI-1034238,EBI-355371

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro
RNA polymerase II activating transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
TBP-class protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17264123

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112746, 68 interactors
ComplexPortalⁱ	CPX-900 SAGA complex CPX-903 TFTC histone acetylation complex CPX-915 General transcription factor complex TFIID CPX-930 General transcription factor complex TFIID, TAF4B variant CPX-989 PCAF histone acetylase complex
CORUMⁱ	Q16514
Database of interacting proteins More...DIPⁱ	DIP-496N
IntActⁱ	Q16514, 28 interactors
Molecular INTeraction database More...MINTⁱ	Q16514
STRINGⁱ	9606.ENSP00000263974

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	60 – 70	Combined sources	11
Helixⁱ	78 – 105	Combined sources	28
Helixⁱ	113 – 123	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16514
SMRⁱ	Q16514
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q16514

EvolutionaryTraceⁱ

Q16514

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	59 – 126	Histone-foldSequence analysisAdd BLAST		68

Sequence similaritiesⁱ

Belongs to the TAF12 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1142 Eukaryota COG5624 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002144
HOGENOMⁱ	HOG000035092
HOVERGENⁱ	HBG055174
InParanoidⁱ	Q16514
KEGG Orthology (KO) More...KOⁱ	K03126
OMAⁱ	QASMANS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q1X
PhylomeDBⁱ	Q16514
TreeFamⁱ	TF323652

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07981 TAF12, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR037794 TAF12 IPR003228 TFIID_TAF12_dom
PANTHERⁱ	PTHR12264 PTHR12264, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03847 TFIID_20kDa, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD012998 PD012998, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

Isoform TAFII20 (identifier: Q16514-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL 
        60         70         80         90        100
SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC 
       110        120        130        140        150
QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ 
       160 
RMALIRKTTK K

Length:161

Mass (Da):17,924

Last modified:November 1, 1996 - v1

Checksum:ⁱ054B017CD7BF99CE

GO

Isoform TAFII15 (identifier: Q16514-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-30: Missing.

« Hide

        10         20         30         40         50
MANSTAVVKI PGTPGAGGRL SPENNQVLTK KKLQDLVREV DPNEQLDEDV 
        60         70         80         90        100
EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL ERQWNMWIPG 
       110        120        130 
FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K

Show »

Length:131

Mass (Da):14,825

Checksum:ⁱ655B769918311CE1

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018888	1 – 30	Missing in isoform TAFII15. 1 PublicationAdd BLAST		30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57693 mRNA Translation: AAC50600.1 U57693 mRNA Translation: AAC50601.1 D50544 mRNA Translation: BAA09112.1 X84002 mRNA Translation: CAA58826.1 BT007031 mRNA Translation: AAP35678.1 AY206865 Genomic DNA Translation: AAO13491.1 AL513497 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07682.1 CH471059 Genomic DNA Translation: EAX07683.1 BC011986 mRNA Translation: AAH11986.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS326.1 [Q16514-1]
PIRⁱ	JC4676
NCBI Reference Sequences More...RefSeqⁱ	NP_001128690.1, NM_001135218.1 [Q16514-1] NP_005635.1, NM_005644.3 [Q16514-1]
UniGeneⁱ	Hs.530251

Genome annotation databases

Ensemblⁱ	ENST00000263974; ENSP00000263974; ENSG00000120656 [Q16514-1] ENST00000373824; ENSP00000362930; ENSG00000120656 [Q16514-1]
GeneIDⁱ	6883
KEGGⁱ	hsa:6883
UCSC genome browser More...UCSCⁱ	uc001bqx.5 human [Q16514-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16514	Isoform TAFII15 of Transcription initiation factor TFIID subunit 12		HUMAN		131	UniRef100_Q16514
UPI000387C714		HUMAN		241

Protein	Similar proteins		Species	Score	Length	Source
Q16514	Transcription initiation factor TFIID subunit 12		BOVIN		161	UniRef90_Q16514
Isoform TAFII15 of Transcription initiation factor TFIID subunit 12		HUMAN		131
Uncharacterized protein		CALJA		213
transcription initiation factor TFIID subunit 12 isoform X1		BALAS		213
Uncharacterized protein		PROCO		213
+49

Protein	Similar proteins		Species	Score	Length	Source
Q16514	Transcription initiation factor TFIID subunit 12		BOVIN		161	UniRef50_Q16514
Transcription initiation factor TFIID subunit 12		XENLA		164
Transcription initiation factor TFIID subunit 12		MOUSE		161
Isoform TAFII15 of Transcription initiation factor TFIID subunit 12		HUMAN		131
Transcription initiation factor TFIID subunit 12		FUKDA		213
+201

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57693 mRNA Translation: AAC50600.1 U57693 mRNA Translation: AAC50601.1 D50544 mRNA Translation: BAA09112.1 X84002 mRNA Translation: CAA58826.1 BT007031 mRNA Translation: AAP35678.1 AY206865 Genomic DNA Translation: AAO13491.1 AL513497 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07682.1 CH471059 Genomic DNA Translation: EAX07683.1 BC011986 mRNA Translation: AAH11986.1
CCDSⁱ	CCDS326.1 [Q16514-1]
PIRⁱ	JC4676
RefSeqⁱ	NP_001128690.1, NM_001135218.1 [Q16514-1] NP_005635.1, NM_005644.3 [Q16514-1]
UniGeneⁱ	Hs.530251

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1H3O	X-ray	2.30	B/D	57-128	[»]
ProteinModelPortalⁱ	Q16514
SMRⁱ	Q16514
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112746, 68 interactors
ComplexPortalⁱ	CPX-900 SAGA complex CPX-903 TFTC histone acetylation complex CPX-915 General transcription factor complex TFIID CPX-930 General transcription factor complex TFIID, TAF4B variant CPX-989 PCAF histone acetylase complex
CORUMⁱ	Q16514
DIPⁱ	DIP-496N
IntActⁱ	Q16514, 28 interactors
MINTⁱ	Q16514
STRINGⁱ	9606.ENSP00000263974

PTM databases

iPTMnetⁱ	Q16514
PhosphoSitePlusⁱ	Q16514

Polymorphism and mutation databases

BioMutaⁱ	TAF12
DMDMⁱ	3024708

Proteomic databases

EPDⁱ	Q16514
MaxQBⁱ	Q16514
PaxDbⁱ	Q16514
PeptideAtlasⁱ	Q16514
PRIDEⁱ	Q16514
ProteomicsDBⁱ	60885 60886 [Q16514-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6883
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263974; ENSP00000263974; ENSG00000120656 [Q16514-1] ENST00000373824; ENSP00000362930; ENSG00000120656 [Q16514-1]
GeneIDⁱ	6883
KEGGⁱ	hsa:6883
UCSCⁱ	uc001bqx.5 human [Q16514-1]

Organism-specific databases

CTDⁱ	6883
DisGeNETⁱ	6883
EuPathDBⁱ	HostDB:ENSG00000120656.11
GeneCardsⁱ	TAF12
HGNCⁱ	HGNC:11545 TAF12
HPAⁱ	HPA008519
MIMⁱ	600773 gene
neXtProtⁱ	NX_Q16514
OpenTargetsⁱ	ENSG00000120656
PharmGKBⁱ	PA36320
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1142 Eukaryota COG5624 LUCA
GeneTreeⁱ	ENSGT00390000002144
HOGENOMⁱ	HOG000035092
HOVERGENⁱ	HBG055174
InParanoidⁱ	Q16514
KOⁱ	K03126
OMAⁱ	QASMANS
OrthoDBⁱ	EOG091G0Q1X
PhylomeDBⁱ	Q16514
TreeFamⁱ	TF323652

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-3214847 HATs acetylate histones R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORⁱ	Q16514

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-3214847 HATs acetylate histones
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

SIGNORⁱ

Q16514

Miscellaneous databases

ChiTaRSⁱ	TAF12 human
EvolutionaryTraceⁱ	Q16514
GeneWikiⁱ	TAF12
GenomeRNAiⁱ	6883
Protein Ontology More...PROⁱ	PR:Q16514
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120656 Expressed in 210 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TAF12 HS_TAF15
Genevisibleⁱ	Q16514 HS

Family and domain databases

CDDⁱ	cd07981 TAF12, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR037794 TAF12 IPR003228 TFIID_TAF12_dom
PANTHERⁱ	PTHR12264 PTHR12264, 1 hit
Pfamⁱ	View protein in Pfam PF03847 TFIID_20kDa, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD012998 PD012998, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF12_HUMAN
Accessionⁱ	Q16514Primary (citable) accession number: Q16514 Secondary accession number(s): D3DPM5, Q15775, Q5T077
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16514 (TAF12_HUMAN)

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Transcription initiation factor TFIID subunit 12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ