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UniProtKB - Q16514 (TAF12_HUMAN)

Entry version 213 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Transcription initiation factor TFIID subunit 12

Gene

TAF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).

TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).

The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).

Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574).

7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16514

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-3214847, HATs acetylate histones
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16514

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16514

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 12Curated
Alternative name(s):
Transcription initiation factor TFIID 20/15 kDa subunitsCurated
Short name:
TAFII-20/TAFII-15Curated
Short name:
TAFII20/TAFII15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF12Imported
Synonyms:TAF15, TAF2JImported, TAFII20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11545, TAF12

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600773, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16514

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi87 – 91IADDF → EADDK: Drastically reduces binding to TAF4. 1 Publication5
Mutagenesisi95 – 96VV → EK: Drastically reduces binding to TAF4. 1 Publication2
Mutagenesisi99 – 103ACQLA → RCQLR: Drastically reduces binding to TAF4. 1 Publication5

Organism-specific databases

DisGeNET

More...DisGeNETi		6883

Open Targets

More...OpenTargetsi		ENSG00000120656

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36320

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16514, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAF12

Domain mapping of disease mutations (DMDM)

More...DMDMi		3024708

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000335801 – 161Transcription initiation factor TFIID subunit 12Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16514

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16514

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16514

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16514

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16514

PeptideAtlas

More...PeptideAtlasi		Q16514

PRoteomics IDEntifications database

More...PRIDEi		Q16514

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60885 [Q16514-1]
60886 [Q16514-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16514

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16514

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120656, Expressed in oocyte and 222 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16514, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120656, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).

Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:9885574, PubMed:10594036).

Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574).

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:11564863, PubMed:10594036).

Interacts with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 (PubMed:15735663).

6 Publications

Interacts with TBP; the interaction is direct (PubMed:7729427).

Interacts with TAF10; the interaction is direct (PubMed:7729427).

Interacts with ATF7, promoting transactivation by ATF7 (PubMed:15735663).

2 Publications

Does not promote the transactivation of ATF7.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112746, 83 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6802, SAGA complex, KAT2B variant
CPX-900, SAGA complex, KAT2A variant
CPX-903, TFTC histone acetylation complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CPX-989, PCAF histone acetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q16514

Database of interacting proteins

More...DIPi		DIP-496N

Protein interaction database and analysis system

More...IntActi		Q16514, 50 interactors

Molecular INTeraction database

More...MINTi		Q16514

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263974

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16514, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q16514

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16514

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16514

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 126Histone-foldSequence analysisAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 55DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 37Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1142, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_093619_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16514

Identification of Orthologs from Complete Genome Data

More...OMAi		HRRDTTV

Database of Orthologous Groups

More...OrthoDBi		1569957at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16514

TreeFam database of animal gene trees

More...TreeFami		TF323652

Family and domain databases

Conserved Domains Database

More...CDDi		cd07981, TAF12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00248

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009072, Histone-fold
IPR037794, TAF12
IPR003228, TFIID_TAF12_dom

The PANTHER Classification System

More...PANTHERi		PTHR12264, PTHR12264, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03847, TFIID_20kDa, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform TAFII20 (identifier: Q16514-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL 
        60         70         80         90        100
SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC 
       110        120        130        140        150
QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ 
       160 
RMALIRKTTK K
Length:161
Mass (Da):17,924
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i054B017CD7BF99CE
GO
Isoform TAFII15 (identifier: Q16514-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:131
Mass (Da):14,825
Checksum:i655B769918311CE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A804HLG9A0A804HLG9_HUMAN
Transcription initiation factor TFI...
TAF12 hCG_1747308
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KP17A0A8I5KP17_HUMAN
Transcription initiation factor TFI...
TAF12
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KPH6A0A8I5KPH6_HUMAN
Transcription initiation factor TFI...
TAF12
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KTB6A0A8I5KTB6_HUMAN
Transcription initiation factor TFI...
TAF12
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KU09A0A8I5KU09_HUMAN
Transcription initiation factor TFI...
TAF12
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KWX5A0A8I5KWX5_HUMAN
Transcription initiation factor TFI...
TAF12
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KXE7A0A8I5KXE7_HUMAN
Transcription initiation factor TFI...
TAF12
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KYJ9A0A8I5KYJ9_HUMAN
Transcription initiation factor TFI...
TAF12
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KYW6A0A8I5KYW6_HUMAN
Transcription initiation factor TFI...
TAF12
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5QKX2A0A8I5QKX2_HUMAN
Transcription initiation factor TFI...
TAF12
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188881 – 30Missing in isoform TAFII15. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U57693 mRNA Translation: AAC50600.1
U57693 mRNA Translation: AAC50601.1
D50544 mRNA Translation: BAA09112.1
X84002 mRNA Translation: CAA58826.1
BT007031 mRNA Translation: AAP35678.1
AY206865 Genomic DNA Translation: AAO13491.1
AL513497 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07682.1
CH471059 Genomic DNA Translation: EAX07683.1
BC011986 mRNA Translation: AAH11986.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS326.1 [Q16514-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC4676

NCBI Reference Sequences

More...RefSeqi		NP_001128690.1, NM_001135218.1 [Q16514-1]
NP_005635.1, NM_005644.3 [Q16514-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263974.4; ENSP00000263974.4; ENSG00000120656.14
ENST00000373824.9; ENSP00000362930.4; ENSG00000120656.14
ENST00000685312.1; ENSP00000509153.1; ENSG00000120656.14
ENST00000689843.1; ENSP00000509370.1; ENSG00000120656.14
ENST00000692098.1; ENSP00000509051.1; ENSG00000120656.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6883

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373824.9; ENSP00000362930.4; NM_005644.4; NP_005635.1

UCSC genome browser

More...UCSCi		uc001bqx.5, human [Q16514-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57693 mRNA Translation: AAC50600.1
U57693 mRNA Translation: AAC50601.1
D50544 mRNA Translation: BAA09112.1
X84002 mRNA Translation: CAA58826.1
BT007031 mRNA Translation: AAP35678.1
AY206865 Genomic DNA Translation: AAO13491.1
AL513497 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07682.1
CH471059 Genomic DNA Translation: EAX07683.1
BC011986 mRNA Translation: AAH11986.1
CCDSiCCDS326.1 [Q16514-1]
PIRiJC4676
RefSeqiNP_001128690.1, NM_001135218.1 [Q16514-1]
NP_005635.1, NM_005644.3 [Q16514-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H3OX-ray2.30B/D57-128[»]
6MZCelectron microscopy4.50R1-161[»]
6MZDelectron microscopy9.80Q1-161[»]
6MZLelectron microscopy23.00Q/R1-161[»]
6MZMelectron microscopy7.50R1-161[»]
7EDXelectron microscopy4.50L/l1-161[»]
7EG7electron microscopy6.20L/l1-161[»]
7EG8electron microscopy7.40L/l1-161[»]
7EG9electron microscopy3.70L/l1-161[»]
7EGAelectron microscopy4.10L/l1-161[»]
7EGBelectron microscopy3.30L/l1-161[»]
7EGCelectron microscopy3.90L/l1-161[»]
7EGDelectron microscopy6.75L/l1-161[»]
7EGEelectron microscopy9.00L/l1-161[»]
7EGFelectron microscopy3.16l1-161[»]
7EGGelectron microscopy2.77L1-161[»]
7EGIelectron microscopy9.82L/l1-161[»]
7EGJelectron microscopy8.64L/l1-161[»]
7ENAelectron microscopy4.07DL/Dl1-161[»]
7ENCelectron microscopy4.13DL/Dl1-161[»]
7KTRelectron microscopy2.93G1-161[»]
7KTSelectron microscopy19.09G1-161[»]
AlphaFoldDBiQ16514
SMRiQ16514
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112746, 83 interactors
ComplexPortaliCPX-6802, SAGA complex, KAT2B variant
CPX-900, SAGA complex, KAT2A variant
CPX-903, TFTC histone acetylation complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CPX-989, PCAF histone acetylase complex
CORUMiQ16514
DIPiDIP-496N
IntActiQ16514, 50 interactors
MINTiQ16514
STRINGi9606.ENSP00000263974

PTM databases

iPTMnetiQ16514
PhosphoSitePlusiQ16514

Genetic variation databases

BioMutaiTAF12
DMDMi3024708

Proteomic databases

EPDiQ16514
jPOSTiQ16514
MassIVEiQ16514
MaxQBiQ16514
PaxDbiQ16514
PeptideAtlasiQ16514
PRIDEiQ16514
ProteomicsDBi60885 [Q16514-1]
60886 [Q16514-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1777, 212 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		6883

Genome annotation databases

EnsembliENST00000263974.4; ENSP00000263974.4; ENSG00000120656.14
ENST00000373824.9; ENSP00000362930.4; ENSG00000120656.14
ENST00000685312.1; ENSP00000509153.1; ENSG00000120656.14
ENST00000689843.1; ENSP00000509370.1; ENSG00000120656.14
ENST00000692098.1; ENSP00000509051.1; ENSG00000120656.14
GeneIDi6883
KEGGihsa:6883
MANE-SelectiENST00000373824.9; ENSP00000362930.4; NM_005644.4; NP_005635.1
UCSCiuc001bqx.5, human [Q16514-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6883
DisGeNETi6883

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAF12
HGNCiHGNC:11545, TAF12
HPAiENSG00000120656, Low tissue specificity
MIMi600773, gene
neXtProtiNX_Q16514
OpenTargetsiENSG00000120656
PharmGKBiPA36320
VEuPathDBiHostDB:ENSG00000120656

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1142, Eukaryota
GeneTreeiENSGT00390000002144
HOGENOMiCLU_093619_3_1_1
InParanoidiQ16514
OMAiHRRDTTV
OrthoDBi1569957at2759
PhylomeDBiQ16514
TreeFamiTF323652

Enzyme and pathway databases

PathwayCommonsiQ16514
ReactomeiR-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-3214847, HATs acetylate histones
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
SignaLinkiQ16514
SIGNORiQ16514

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6883, 422 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TAF12, human
EvolutionaryTraceiQ16514

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAF12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6883
PharosiQ16514, Tbio

Protein Ontology

More...PROi		PR:Q16514
RNActiQ16514, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120656, Expressed in oocyte and 222 other tissues
GenevisibleiQ16514, HS

Family and domain databases

CDDicd07981, TAF12, 1 hit
Gene3Di1.10.20.10, 1 hit
IDEALiIID00248
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR037794, TAF12
IPR003228, TFIID_TAF12_dom
PANTHERiPTHR12264, PTHR12264, 1 hit
PfamiView protein in Pfam
PF03847, TFIID_20kDa, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16514
Secondary accession number(s): D3DPM5, Q15775, Q5T077
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 213 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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