UniProtKB - Q16512 (PKN1_HUMAN)
Serine/threonine-protein kinase N1
PKN1
Functioni
Catalytic activityi
Activity regulationi
Kineticsi
- KM=20.6 µM for HDAC51 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 644 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 740 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 621 – 629 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- chromatin binding Source: UniProtKB
- GTP-Rho binding Source: UniProtKB
- histone binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- histone kinase activity (H3-T11 specific) Source: UniProtKB
- nuclear receptor transcription coactivator activity Source: UniProtKB
- protein kinase activity Source: ProtInc
- protein kinase C binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- Rac GTPase binding Source: UniProtKB
GO - Biological processi
- activation of JUN kinase activity Source: ProtInc
- B cell apoptotic process Source: Ensembl
- B cell homeostasis Source: Ensembl
- epithelial cell migration Source: UniProtKB
- histone H3-T11 phosphorylation Source: UniProtKB
- hyperosmotic response Source: Ensembl
- intracellular signal transduction Source: GO_Central
- negative regulation of B cell proliferation Source: Ensembl
- negative regulation of protein kinase activity Source: Ensembl
- peptidyl-serine phosphorylation Source: GO_Central
- protein phosphorylation Source: UniProtKB
- regulation of cell motility Source: UniProtKB
- regulation of germinal center formation Source: Ensembl
- regulation of immunoglobulin production Source: Ensembl
- regulation of transcription by RNA polymerase II Source: UniProtKB
- renal system process Source: Ensembl
- signal transduction Source: ProtInc
- spleen development Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q16512 |
Reactomei | R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
SABIO-RKi | Q16512 |
SignaLinki | Q16512 |
SIGNORi | Q16512 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase N1 (EC:2.7.11.131 Publication)Alternative name(s): Protease-activated kinase 1 Short name: PAK-1 Protein kinase C-like 1 Protein kinase C-like PKN Protein kinase PKN-alpha Protein-kinase C-related kinase 1 Serine-threonine protein kinase N |
Gene namesi | Name:PKN1 Synonyms:PAK1, PKN, PRK1, PRKCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000123143.12 |
HGNCi | HGNC:9405, PKN1 |
MIMi | 601032, gene |
neXtProti | NX_Q16512 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Endosome
- Endosome 1 Publication
Other locations
- Cytoplasm 2 Publications
- Cleavage furrow 1 Publication
- Midbody 1 Publication
Note: Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.By similarity1 Publication
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- cleavage furrow Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- midbody Source: UniProtKB
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | D → A: Abolishes cleavage by caspase-3 and formation of AF1 fragment. 1 Publication | 1 | |
Mutagenesisi | 181 | R → A: Abolishes interaction with bacterial SspH1. 1 Publication | 1 | |
Mutagenesisi | 181 | R → K: Decreases interaction with bacterial SspH1. 1 Publication | 1 | |
Mutagenesisi | 185 | R → A: Abolishes interaction with bacterial SspH1. 1 Publication | 1 | |
Mutagenesisi | 451 | D → A: Abolishes cleavage by caspase-3 and formation of 70 kDa fragment. 1 Publication | 1 | |
Mutagenesisi | 454 | D → A: Abolishes cleavage by caspase-3 and formation of 70 kDa fragment. 1 Publication | 1 | |
Mutagenesisi | 558 | D → A: Abolishes cleavage by caspase-3 and formation of AF3 fragment. 1 Publication | 1 | |
Mutagenesisi | 560 | D → A: Abolishes cleavage by caspase-3 and formation of AF3 fragment. 1 Publication | 1 | |
Mutagenesisi | 644 | K → E: Abolishes Serine/threonine-protein kinase activity. 2 Publications | 1 | |
Mutagenesisi | 644 | K → R: Substantial reduction of autophosphorylation. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 5585 |
OpenTargetsi | ENSG00000123143 |
PharmGKBi | PA33769 |
Miscellaneous databases
Pharosi | Q16512, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3384 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q16512 |
GuidetoPHARMACOLOGYi | 1520 |
Polymorphism and mutation databases
BioMutai | PKN1 |
DMDMi | 259016304 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000055719 | 2 – 942 | Serine/threonine-protein kinase N1Add BLAST | 941 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 69 | PhosphoserineCombined sources | 1 | |
Modified residuei | 205 | PhosphoserineCombined sources | 1 | |
Modified residuei | 374 | PhosphoserineBy similarity | 1 | |
Modified residuei | 448 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 533 | PhosphoserineCombined sources | 1 | |
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 540 | PhosphoserineCombined sources | 1 | |
Modified residuei | 559 | PhosphoserineCombined sources | 1 | |
Modified residuei | 562 | PhosphoserineCombined sources | 1 | |
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Modified residuei | 774 | Phosphothreonine; by PDPK11 Publication | 1 | |
Modified residuei | 778 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 914 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 916 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 108 – 109 | Cleavage; by caspase-3 | 2 | |
Sitei | 454 – 455 | Cleavage; by caspase-3 | 2 | |
Sitei | 558 – 559 | Cleavage; by caspase-3 | 2 |
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q16512 |
jPOSTi | Q16512 |
MassIVEi | Q16512 |
MaxQBi | Q16512 |
PaxDbi | Q16512 |
PeptideAtlasi | Q16512 |
PRIDEi | Q16512 |
ProteomicsDBi | 60877 [Q16512-1] 60878 [Q16512-2] 60879 [Q16512-3] |
PTM databases
GlyConnecti | 1737, 1 N-Linked glycan (1 site) |
GlyGeni | Q16512, 1 site |
iPTMneti | Q16512 |
MetOSitei | Q16512 |
PhosphoSitePlusi | Q16512 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000123143, Expressed in apex of heart and 198 other tissues |
ExpressionAtlasi | Q16512, baseline and differential |
Genevisiblei | Q16512, HS |
Organism-specific databases
HPAi | ENSG00000123143, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ZFAND6 (By similarity).
Interacts with ANDR (PubMed:12514133).
Interacts with PRKCB (PubMed:20228790).
Interacts (via REM 1 and REM 2 repeats) with RAC1 (PubMed:14514689, PubMed:18006505).
Interacts (via REM 1 repeat) with RHOA (PubMed:10619026, PubMed:8571126).
Interacts with RHOB (PubMed:9478917).
Interacts (via C-terminus) with PDPK1 (PubMed:10792047).
Interacts with CCNT2; enhances MYOD1-dependent transcription (PubMed:16331689).
Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).
By similarity10 PublicationsBinary interactionsi
Q16512
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- GTP-Rho binding Source: UniProtKB
- histone binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- protein kinase C binding Source: UniProtKB
- Rac GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111571, 109 interactors |
CORUMi | Q16512 |
DIPi | DIP-34240N |
ELMi | Q16512 |
IntActi | Q16512, 83 interactors |
MINTi | Q16512 |
STRINGi | 9606.ENSP00000343325 |
Chemistry databases
BindingDBi | Q16512 |
Miscellaneous databases
RNActi | Q16512, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16512 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16512 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 100 | REM-1 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 112 – 193 | REM-1 2PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 201 – 280 | REM-1 3PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 307 – 470 | C2PROSITE-ProRule annotationAdd BLAST | 164 | |
Domaini | 615 – 874 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 875 – 942 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 181 – 185 | Important for interaction with bacterial SspH1 and SspH1-mediated polyubiquitination1 Publication | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000154990 |
HOGENOMi | CLU_000288_132_1_1 |
InParanoidi | Q16512 |
OMAi | WNPSPSG |
OrthoDBi | 520651at2759 |
PhylomeDBi | Q16512 |
TreeFami | TF102005 |
Family and domain databases
CDDi | cd08687, C2_PKN-like, 1 hit cd11630, HR1_PKN1_2, 1 hit cd11622, HR1_PKN_1, 1 hit |
IDEALi | IID00416 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR037784, C2_PKN IPR011072, HR1_rho-bd IPR036274, HR1_rpt_sf IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR037317, PKN1_HR1_2 IPR037313, PKN_HR1_1 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF02185, HR1, 3 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00742, Hr1, 3 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF46585, SSF46585, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51860, REM_1, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL
60 70 80 90 100
KLKEGAENLR RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL
110 120 130 140 150
PDPAATHDGP QSPGAGGPTC SATNLSRVAG LEKQLAIELK VKQGAENMIQ
160 170 180 190 200
TYSNGSTKDR KLLLTAQQML QDSKTKIDII RMQLRRALQA GQLENQAAPD
210 220 230 240 250
DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS AAKAPDRKAV
260 270 280 290 300
SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF
310 320 330 340 350
STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG
360 370 380 390 400
PGTPDSRPPF LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT
410 420 430 440 450
VVGQTSWKPC GPNAWDQSFT LELERARELE LAVFWRDQRG LCALKFLKLE
460 470 480 490 500
DFLDNERHEV QLDMEPQGCL VAEVTFRNPV IERIPRLRRQ KKIFSKQQGK
510 520 530 540 550
AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS EARTTGDISV
560 570 580 590 600
EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA
610 620 630 640 650
LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD
660 670 680 690 700
IVARDEVESL MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG
710 720 730 740 750
GDLMLHIHSD VFSEPRAIFY SACVVLGLQF LHEHKIVYRD LKLDNLLLDT
760 770 780 790 800
EGYVKIADFG LCKEGMGYGD RTSTFCGTPE FLAPEVLTDT SYTRAVDWWG
810 820 830 840 850
LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA EAIGIMRRLL
860 870 880 890 900
RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD
910 920 930 940
VSNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EM57 | K7EM57_HUMAN | Protein kinase C | PKN1 | 263 | Annotation score: | ||
K7EKY9 | K7EKY9_HUMAN | Protein kinase C | PKN1 | 255 | Annotation score: | ||
K7EL10 | K7EL10_HUMAN | Serine/threonine-protein kinase N1 | PKN1 | 198 | Annotation score: | ||
K7EN76 | K7EN76_HUMAN | Serine/threonine-protein kinase N1 | PKN1 | 151 | Annotation score: | ||
K7ES10 | K7ES10_HUMAN | Serine/threonine-protein kinase N1 | PKN1 | 226 | Annotation score: | ||
K7EPK3 | K7EPK3_HUMAN | Serine/threonine-protein kinase N1 | PKN1 | 14 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | G → D in AAB33345 (PubMed:7851406).Curated | 1 | |
Sequence conflicti | 191 | G → D in AAC50209 (PubMed:7851406).Curated | 1 | |
Sequence conflicti | 562 | S → P in BAG36611 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 736 | I → T no nucleotide entry (PubMed:7988719).Curated | 1 | |
Sequence conflicti | 750 | T → A no nucleotide entry (PubMed:7988719).Curated | 1 | |
Sequence conflicti | 800 | G → A no nucleotide entry (PubMed:7988719).Curated | 1 | |
Sequence conflicti | 812 | E → G in BAG36611 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 887 | L → P in BAG53845 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042337 | 185 | R → C in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267605306Ensembl. | 1 | |
Natural variantiVAR_042338 | 197 | A → E1 PublicationCorresponds to variant dbSNP:rs1287763348Ensembl. | 1 | |
Natural variantiVAR_042339 | 436 | R → W1 PublicationCorresponds to variant dbSNP:rs35132656Ensembl. | 1 | |
Natural variantiVAR_042340 | 520 | R → Q1 PublicationCorresponds to variant dbSNP:rs56273055Ensembl. | 1 | |
Natural variantiVAR_042341 | 555 | L → I2 PublicationsCorresponds to variant dbSNP:rs34309238EnsemblClinVar. | 1 | |
Natural variantiVAR_042342 | 635 | R → Q1 PublicationCorresponds to variant dbSNP:rs35416389Ensembl. | 1 | |
Natural variantiVAR_042343 | 718 | I → V2 PublicationsCorresponds to variant dbSNP:rs2230539Ensembl. | 1 | |
Natural variantiVAR_042344 | 873 | F → L in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_014937 | 901 | V → I3 PublicationsCorresponds to variant dbSNP:rs10846Ensembl. | 1 | |
Natural variantiVAR_042345 | 921 | A → V in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038143 | 1 – 7 | MASDAVQ → MAEANNPSEQELE in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_039213 | 603 | S → R in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_039214 | 604 – 942 | Missing in isoform 3. 1 PublicationAdd BLAST | 339 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26181 mRNA Translation: BAA05169.1 S75546 mRNA Translation: AAB33345.1 U33053 mRNA Translation: AAC50209.1 AK123007 mRNA Translation: BAG53845.1 AK292130 mRNA Translation: BAF84819.1 AK313886 mRNA Translation: BAG36611.1 AC008569 Genomic DNA No translation available. BC040061 mRNA Translation: AAH40061.1 BC094766 mRNA Translation: AAH94766.1 |
CCDSi | CCDS42513.1 [Q16512-1] CCDS42514.1 [Q16512-2] |
PIRi | JC2129 S51162 |
RefSeqi | NP_002732.3, NM_002741.3 [Q16512-1] NP_998725.1, NM_213560.1 [Q16512-2] |
Genome annotation databases
Ensembli | ENST00000242783; ENSP00000242783; ENSG00000123143 [Q16512-1] ENST00000342216; ENSP00000343325; ENSG00000123143 [Q16512-2] |
GeneIDi | 5585 |
KEGGi | hsa:5585 |
UCSCi | uc002myp.4, human [Q16512-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26181 mRNA Translation: BAA05169.1 S75546 mRNA Translation: AAB33345.1 U33053 mRNA Translation: AAC50209.1 AK123007 mRNA Translation: BAG53845.1 AK292130 mRNA Translation: BAF84819.1 AK313886 mRNA Translation: BAG36611.1 AC008569 Genomic DNA No translation available. BC040061 mRNA Translation: AAH40061.1 BC094766 mRNA Translation: AAH94766.1 |
CCDSi | CCDS42513.1 [Q16512-1] CCDS42514.1 [Q16512-2] |
PIRi | JC2129 S51162 |
RefSeqi | NP_002732.3, NM_002741.3 [Q16512-1] NP_998725.1, NM_213560.1 [Q16512-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CXZ | X-ray | 2.20 | B | 13-98 | [»] | |
1URF | NMR | - | A | 122-199 | [»] | |
2RMK | NMR | - | B | 122-199 | [»] | |
4NKG | X-ray | 2.90 | B/D | 122-199 | [»] | |
4OTD | X-ray | 2.00 | A | 605-942 | [»] | |
4OTG | X-ray | 2.60 | A | 605-942 | [»] | |
4OTH | X-ray | 1.80 | A | 605-942 | [»] | |
4OTI | X-ray | 1.93 | A | 605-942 | [»] | |
SMRi | Q16512 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111571, 109 interactors |
CORUMi | Q16512 |
DIPi | DIP-34240N |
ELMi | Q16512 |
IntActi | Q16512, 83 interactors |
MINTi | Q16512 |
STRINGi | 9606.ENSP00000343325 |
Chemistry databases
BindingDBi | Q16512 |
ChEMBLi | CHEMBL3384 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q16512 |
GuidetoPHARMACOLOGYi | 1520 |
PTM databases
GlyConnecti | 1737, 1 N-Linked glycan (1 site) |
GlyGeni | Q16512, 1 site |
iPTMneti | Q16512 |
MetOSitei | Q16512 |
PhosphoSitePlusi | Q16512 |
Polymorphism and mutation databases
BioMutai | PKN1 |
DMDMi | 259016304 |
Proteomic databases
EPDi | Q16512 |
jPOSTi | Q16512 |
MassIVEi | Q16512 |
MaxQBi | Q16512 |
PaxDbi | Q16512 |
PeptideAtlasi | Q16512 |
PRIDEi | Q16512 |
ProteomicsDBi | 60877 [Q16512-1] 60878 [Q16512-2] 60879 [Q16512-3] |
Protocols and materials databases
Antibodypediai | 1296, 243 antibodies |
DNASUi | 5585 |
Genome annotation databases
Ensembli | ENST00000242783; ENSP00000242783; ENSG00000123143 [Q16512-1] ENST00000342216; ENSP00000343325; ENSG00000123143 [Q16512-2] |
GeneIDi | 5585 |
KEGGi | hsa:5585 |
UCSCi | uc002myp.4, human [Q16512-1] |
Organism-specific databases
CTDi | 5585 |
DisGeNETi | 5585 |
EuPathDBi | HostDB:ENSG00000123143.12 |
GeneCardsi | PKN1 |
HGNCi | HGNC:9405, PKN1 |
HPAi | ENSG00000123143, Low tissue specificity |
MIMi | 601032, gene |
neXtProti | NX_Q16512 |
OpenTargetsi | ENSG00000123143 |
PharmGKBi | PA33769 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000154990 |
HOGENOMi | CLU_000288_132_1_1 |
InParanoidi | Q16512 |
OMAi | WNPSPSG |
OrthoDBi | 520651at2759 |
PhylomeDBi | Q16512 |
TreeFami | TF102005 |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q16512 |
Reactomei | R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
SABIO-RKi | Q16512 |
SignaLinki | Q16512 |
SIGNORi | Q16512 |
Miscellaneous databases
BioGRID-ORCSi | 5585, 8 hits in 875 CRISPR screens |
ChiTaRSi | PKN1, human |
EvolutionaryTracei | Q16512 |
GeneWikii | Protein_kinase_N1 |
GenomeRNAii | 5585 |
Pharosi | Q16512, Tchem |
PROi | PR:Q16512 |
RNActi | Q16512, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123143, Expressed in apex of heart and 198 other tissues |
ExpressionAtlasi | Q16512, baseline and differential |
Genevisiblei | Q16512, HS |
Family and domain databases
CDDi | cd08687, C2_PKN-like, 1 hit cd11630, HR1_PKN1_2, 1 hit cd11622, HR1_PKN_1, 1 hit |
IDEALi | IID00416 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR037784, C2_PKN IPR011072, HR1_rho-bd IPR036274, HR1_rpt_sf IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR037317, PKN1_HR1_2 IPR037313, PKN_HR1_1 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF02185, HR1, 3 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00742, Hr1, 3 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF46585, SSF46585, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51860, REM_1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PKN1_HUMAN | |
Accessioni | Q16512Primary (citable) accession number: Q16512 Secondary accession number(s): A8K7W5 Q9UD44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index