UniProtKB - Q16384 (SSX1_HUMAN)
Protein
Protein SSX1
Gene
SSX1
Organism
Homo sapiens (Human)
Status
Functioni
Could act as a modulator of transcription.
GO - Molecular functioni
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q16384 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SSX1Alternative name(s): Cancer/testis antigen 5.1 Short name: CT5.1 Synovial sarcoma, X breakpoint 1 |
Gene namesi | Name:SSX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11335, SSX1 |
MIMi | 312820, gene+phenotype |
neXtProti | NX_Q16384 |
VEuPathDBi | HostDB:ENSG00000126752.7 |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 62 – 63 | Breakpoint for translocation to form the SSXT-SSX1 fusion protein (rare)1 Publication | 2 | |
Sitei | 110 – 111 | Breakpoint for translocation to form the SSXT-SSX1 fusion protein1 Publication | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 6756 |
MalaCardsi | SSX1 |
MIMi | 312820, gene+phenotype |
OpenTargetsi | ENSG00000126752 |
Orphaneti | 3273, Synovial sarcoma |
PharmGKBi | PA36159 |
Miscellaneous databases
Pharosi | Q16384, Tbio |
Genetic variation databases
BioMutai | SSX1 |
DMDMi | 3915027 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181828 | 1 – 188 | Protein SSX1Add BLAST | 188 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q16384 |
PaxDbi | Q16384 |
PeptideAtlasi | Q16384 |
PRIDEi | Q16384 |
ProteomicsDBi | 60866 |
PTM databases
iPTMneti | Q16384 |
PhosphoSitePlusi | Q16384 |
Expressioni
Tissue specificityi
Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
Gene expression databases
Bgeei | ENSG00000126752, Expressed in buccal mucosa cell and 56 other tissues |
Genevisiblei | Q16384, HS |
Organism-specific databases
HPAi | ENSG00000126752, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ16384
With | #Exp. | IntAct |
---|---|---|
CDCA7L [Q96GN5] | 3 | EBI-10237585,EBI-5278764 |
MAGEC2 [Q9UBF1] | 3 | EBI-10237585,EBI-5651487 |
MTURN [Q8N3F0] | 3 | EBI-10237585,EBI-11980301 |
Protein-protein interaction databases
BioGRIDi | 112634, 7 interactors |
IntActi | Q16384, 4 interactors |
STRINGi | 9606.ENSP00000366118 |
Miscellaneous databases
RNActi | Q16384, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 83 | KRAB-relatedPROSITE-ProRule annotationAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the SSX family.Curated
Phylogenomic databases
eggNOGi | ENOG502RU1A, Eukaryota |
GeneTreei | ENSGT00390000012484 |
HOGENOMi | CLU_097196_1_0_1 |
InParanoidi | Q16384 |
OMAi | NTHDIDQ |
OrthoDBi | 1270676at2759 |
PhylomeDBi | Q16384 |
TreeFami | TF338517 |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003655, Krueppel-associated_box-rel IPR028804, SSX IPR019041, SSXRD_motif |
PANTHERi | PTHR14112, PTHR14112, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF09514, SSXRD, 1 hit |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit |
SUPFAMi | SSF109640, SSF109640, 1 hit |
PROSITEi | View protein in PROSITE PS50806, KRAB_RELATED, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16384-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGDDTFAKR PRDDAKASEK RSKAFDDIAT YFSKKEWKKM KYSEKISYVY
60 70 80 90 100
MKRNYKAMTK LGFKVTLPPF MCNKQATDFQ GNDFDNDHNR RIQVEHPQMT
110 120 130 140 150
FGRLHRIIPK IMPKKPAEDE NDSKGVSEAS GPQNDGKQLH PPGKANISEK
160 170 180
INKRSGPKRG KHAWTHRLRE RKQLVIYEEI SDPEEDDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86174 mRNA Translation: CAA60110.1 AL683817 Genomic DNA Translation: CAI41141.1 BC001003 mRNA Translation: AAH01003.1 BC125151 mRNA Translation: AAI25152.1 BC128611 mRNA Translation: AAI28612.1 BC133693 mRNA Translation: AAI33694.1 BC150487 mRNA Translation: AAI50488.1 S79325 mRNA Translation: AAB35378.1 |
CCDSi | CCDS14290.1 |
PIRi | S55057 |
RefSeqi | NP_001265620.1, NM_001278691.1 NP_005626.1, NM_005635.3 |
Genome annotation databases
Ensembli | ENST00000376919; ENSP00000366118; ENSG00000126752 |
GeneIDi | 6756 |
KEGGi | hsa:6756 |
UCSCi | uc004djb.2, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86174 mRNA Translation: CAA60110.1 AL683817 Genomic DNA Translation: CAI41141.1 BC001003 mRNA Translation: AAH01003.1 BC125151 mRNA Translation: AAI25152.1 BC128611 mRNA Translation: AAI28612.1 BC133693 mRNA Translation: AAI33694.1 BC150487 mRNA Translation: AAI50488.1 S79325 mRNA Translation: AAB35378.1 |
CCDSi | CCDS14290.1 |
PIRi | S55057 |
RefSeqi | NP_001265620.1, NM_001278691.1 NP_005626.1, NM_005635.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112634, 7 interactors |
IntActi | Q16384, 4 interactors |
STRINGi | 9606.ENSP00000366118 |
PTM databases
iPTMneti | Q16384 |
PhosphoSitePlusi | Q16384 |
Genetic variation databases
BioMutai | SSX1 |
DMDMi | 3915027 |
Proteomic databases
MassIVEi | Q16384 |
PaxDbi | Q16384 |
PeptideAtlasi | Q16384 |
PRIDEi | Q16384 |
ProteomicsDBi | 60866 |
Protocols and materials databases
Antibodypediai | 25598, 205 antibodies |
DNASUi | 6756 |
Genome annotation databases
Ensembli | ENST00000376919; ENSP00000366118; ENSG00000126752 |
GeneIDi | 6756 |
KEGGi | hsa:6756 |
UCSCi | uc004djb.2, human |
Organism-specific databases
CTDi | 6756 |
DisGeNETi | 6756 |
GeneCardsi | SSX1 |
HGNCi | HGNC:11335, SSX1 |
HPAi | ENSG00000126752, Tissue enriched (testis) |
MalaCardsi | SSX1 |
MIMi | 312820, gene+phenotype |
neXtProti | NX_Q16384 |
OpenTargetsi | ENSG00000126752 |
Orphaneti | 3273, Synovial sarcoma |
PharmGKBi | PA36159 |
VEuPathDBi | HostDB:ENSG00000126752.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU1A, Eukaryota |
GeneTreei | ENSGT00390000012484 |
HOGENOMi | CLU_097196_1_0_1 |
InParanoidi | Q16384 |
OMAi | NTHDIDQ |
OrthoDBi | 1270676at2759 |
PhylomeDBi | Q16384 |
TreeFami | TF338517 |
Enzyme and pathway databases
PathwayCommonsi | Q16384 |
Miscellaneous databases
BioGRID-ORCSi | 6756, 44 hits in 553 CRISPR screens |
ChiTaRSi | SSX1, human |
GeneWikii | SSX1 |
GenomeRNAii | 6756 |
Pharosi | Q16384, Tbio |
PROi | PR:Q16384 |
RNActi | Q16384, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126752, Expressed in buccal mucosa cell and 56 other tissues |
Genevisiblei | Q16384, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003655, Krueppel-associated_box-rel IPR028804, SSX IPR019041, SSXRD_motif |
PANTHERi | PTHR14112, PTHR14112, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF09514, SSXRD, 1 hit |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit |
SUPFAMi | SSF109640, SSF109640, 1 hit |
PROSITEi | View protein in PROSITE PS50806, KRAB_RELATED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSX1_HUMAN | |
Accessioni | Q16384Primary (citable) accession number: Q16384 Secondary accession number(s): A3KN76, Q08AJ2, Q5JQ64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families