Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (29 Sep 2021)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Proline-rich protein 4

Gene

PRR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 4
Alternative name(s):
Lacrimal proline-rich protein
Nasopharyngeal carcinoma-associated proline-rich protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR4
Synonyms:LPRP, PROL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18020, PRR4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605359, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16378

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11272

MalaCards human disease database

More...
MalaCardsi
PRR4

Open Targets

More...
OpenTargetsi
ENSG00000111215

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33806

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16378, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRR4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373525

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002211517 – 134Proline-rich protein 4Add BLAST118

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16378

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16378

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16378

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16378

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16378

PeptideAtlas

More...
PeptideAtlasi
Q16378

PRoteomics IDEntifications database

More...
PRIDEi
Q16378

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
25310
60865 [Q16378-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16378

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16378

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111215, Expressed in saliva-secreting gland and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16378, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16378, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111215, Tissue enriched (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116428, 34 interactors

Protein interaction database and analysis system

More...
IntActi
Q16378, 14 interactors

Molecular INTeraction database

More...
MINTi
Q16378

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228811

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16378, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 134DisorderedSequence analysisAdd BLAST107

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TED7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000112173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2849034_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16378

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHHYPLP

Database of Orthologous Groups

More...
OrthoDBi
1638319at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16378

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026086, Pro-rich

The PANTHER Classification System

More...
PANTHERi
PTHR23203, PTHR23203, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15240, Pro-rich, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01412, Pro-rich, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16378-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLVLLSVVL LALSSAQSTD NDVNYEDFTF TIPDVEDSSQ RPDQGPQRPP
60 70 80 90 100
PEGLLPRPPG DSGNQDDGPQ QRPPKPGGHH RHPPPPPFQN QQRPPRRGHR
110 120 130
QLSLPRFPSV SLQEASSFFQ RDRPARHPQE QPLW
Length:134
Mass (Da):15,097
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57BB0DCA10938CC8
GO
Isoform 2 (identifier: Q16378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-134: DVEDSSQRPD...ARHPQEQPLW → ACRKHHHSSRGTDQQDIPRSNHSGNLEFSGRK

Show »
Length:65
Mass (Da):7,256
Checksum:i6291D846DF039085
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q16378-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43R → G in DB198298 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02792696R → Q3 PublicationsCorresponds to variant dbSNP:rs1063193Ensembl.1
Natural variantiVAR_027927120Q → R3 PublicationsCorresponds to variant dbSNP:rs1047699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04463534 – 134DVEDS…EQPLW → ACRKHHHSSRGTDQQDIPRS NHSGNLEFSGRK in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S79048 mRNA Translation: AAB35174.1
AF530472 mRNA Translation: AAM94338.1
AK292934 mRNA Translation: BAF85623.1
AK292991 mRNA Translation: BAF85680.1
DB198298 mRNA No translation available.
AC006518 Genomic DNA No translation available.
AC018630 Genomic DNA No translation available.
AC134349 Genomic DNA No translation available.
AC217021 Genomic DNA No translation available.
AC242308 Genomic DNA No translation available.
BC058035 mRNA Translation: AAH58035.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41756.1 [Q16378-1]
CCDS55804.1 [Q16378-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I54810

NCBI Reference Sequences

More...
RefSeqi
NP_001092008.2, NM_001098538.2 [Q16378-2]
NP_009175.2, NM_007244.2 [Q16378-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228811; ENSP00000228811; ENSG00000111215 [Q16378-1]
ENST00000544994; ENSP00000438046; ENSG00000111215 [Q16378-2]
ENST00000574424; ENSP00000459468; ENSG00000263247 [Q16378-1]
ENST00000576999; ENSP00000461695; ENSG00000263247 [Q16378-2]
ENST00000614435; ENSP00000477689; ENSG00000282269 [Q16378-1]
ENST00000632373; ENSP00000487830; ENSG00000282269 [Q16378-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11272

UCSC genome browser

More...
UCSCi
uc001qyz.5, human [Q16378-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79048 mRNA Translation: AAB35174.1
AF530472 mRNA Translation: AAM94338.1
AK292934 mRNA Translation: BAF85623.1
AK292991 mRNA Translation: BAF85680.1
DB198298 mRNA No translation available.
AC006518 Genomic DNA No translation available.
AC018630 Genomic DNA No translation available.
AC134349 Genomic DNA No translation available.
AC217021 Genomic DNA No translation available.
AC242308 Genomic DNA No translation available.
BC058035 mRNA Translation: AAH58035.1
CCDSiCCDS41756.1 [Q16378-1]
CCDS55804.1 [Q16378-2]
PIRiI54810
RefSeqiNP_001092008.2, NM_001098538.2 [Q16378-2]
NP_009175.2, NM_007244.2 [Q16378-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116428, 34 interactors
IntActiQ16378, 14 interactors
MINTiQ16378
STRINGi9606.ENSP00000228811

PTM databases

iPTMnetiQ16378
PhosphoSitePlusiQ16378

Genetic variation databases

BioMutaiPRR4
DMDMi317373525

Proteomic databases

EPDiQ16378
jPOSTiQ16378
MassIVEiQ16378
MaxQBiQ16378
PaxDbiQ16378
PeptideAtlasiQ16378
PRIDEiQ16378
ProteomicsDBi25310
60865 [Q16378-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50960, 20 antibodies

The DNASU plasmid repository

More...
DNASUi
11272

Genome annotation databases

EnsembliENST00000228811; ENSP00000228811; ENSG00000111215 [Q16378-1]
ENST00000544994; ENSP00000438046; ENSG00000111215 [Q16378-2]
ENST00000574424; ENSP00000459468; ENSG00000263247 [Q16378-1]
ENST00000576999; ENSP00000461695; ENSG00000263247 [Q16378-2]
ENST00000614435; ENSP00000477689; ENSG00000282269 [Q16378-1]
ENST00000632373; ENSP00000487830; ENSG00000282269 [Q16378-2]
GeneIDi11272
KEGGihsa:11272
UCSCiuc001qyz.5, human [Q16378-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11272
DisGeNETi11272

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRR4
HGNCiHGNC:18020, PRR4
HPAiENSG00000111215, Tissue enriched (salivary)
MalaCardsiPRR4
MIMi605359, gene
neXtProtiNX_Q16378
OpenTargetsiENSG00000111215
PharmGKBiPA33806
VEuPathDBiHostDB:ENSG00000111215

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TED7, Eukaryota
GeneTreeiENSGT00730000112173
HOGENOMiCLU_2849034_0_0_1
InParanoidiQ16378
OMAiHHHYPLP
OrthoDBi1638319at2759
PhylomeDBiQ16378

Enzyme and pathway databases

PathwayCommonsiQ16378

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11272, 5 hits in 1014 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PRR4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11272
PharosiQ16378, Tbio

Protein Ontology

More...
PROi
PR:Q16378
RNActiQ16378, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111215, Expressed in saliva-secreting gland and 118 other tissues
ExpressionAtlasiQ16378, baseline and differential
GenevisibleiQ16378, HS

Family and domain databases

InterProiView protein in InterPro
IPR026086, Pro-rich
PANTHERiPTHR23203, PTHR23203, 1 hit
PfamiView protein in Pfam
PF15240, Pro-rich, 1 hit
SMARTiView protein in SMART
SM01412, Pro-rich, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16378
Secondary accession number(s): A8KA69, F5H0D7, Q8NFB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again