Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Laminin subunit alpha-4

Gene

LAMA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Caution

Gene LAMA4 was formerly called LAMA3.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-8874081 MET activates PTK2 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16363

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit alpha-4
Alternative name(s):
Laminin-14 subunit alpha
Laminin-8 subunit alpha
Laminin-9 subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112769.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6484 LAMA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600133 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16363

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, dilated 1JJ (CMD1JJ)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:615235
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069708950P → L in CMD1JJ; loss of integrin-binding capacity. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3910

MalaCards human disease database

More...
MalaCardsi
LAMA4
MIMi615235 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112769

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30273

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAMA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495093

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001706025 – 1823Laminin subunit alpha-4Add BLAST1799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi82 ↔ 91By similarity
Disulfide bondi84 ↔ 98By similarity
Disulfide bondi101 ↔ 110By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 129By similarity
Disulfide bondi132 ↔ 146By similarity
Disulfide bondi134 ↔ 155By similarity
Disulfide bondi157 ↔ 166By similarity
Disulfide bondi169 ↔ 184By similarity
Disulfide bondi187 ↔ 202By similarity
Disulfide bondi189 ↔ 209By similarity
Disulfide bondi212 ↔ 221By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 238By similarity
Disulfide bondi273InterchainCurated
Disulfide bondi276InterchainCurated
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi557N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi578N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi581N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi638N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi646N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi758N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi761N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi810N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1005 ↔ 1035By similarity
Glycosylationi1093N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1201 ↔ 1227By similarity
Glycosylationi1288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1370 ↔ 1402By similarity
Glycosylationi1418N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1617 ↔ 1640By similarity
Disulfide bondi1792 ↔ 1820By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16363

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16363

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16363

PeptideAtlas

More...
PeptideAtlasi
Q16363

PRoteomics IDEntifications database

More...
PRIDEi
Q16363

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60862
60863 [Q16363-2]
60864 [Q16363-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1440

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16363

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16363

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q16363

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112769 Expressed in 221 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_LAMA4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16363 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16363 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB078156
HPA015693

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046372EBI-711505,EBI-366083

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110104, 23 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1777 Laminin-411 complex
CPX-1778 Laminin-421 complex
CPX-1782 Laminin-423 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q16363

Protein interaction database and analysis system

More...
IntActi
Q16363, 21 interactors

Molecular INTeraction database

More...
MINTi
Q16363

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16363

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16363

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 131Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST50
Domaini132 – 186Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST55
Domaini187 – 240Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST54
Domaini241 – 255Laminin EGF-like 4; truncatedPROSITE-ProRule annotationAdd BLAST15
Domaini833 – 1035Laminin G-like 1PROSITE-ProRule annotationAdd BLAST203
Domaini1047 – 1227Laminin G-like 2PROSITE-ProRule annotationAdd BLAST181
Domaini1234 – 1402Laminin G-like 3PROSITE-ProRule annotationAdd BLAST169
Domaini1469 – 1640Laminin G-like 4PROSITE-ProRule annotationAdd BLAST172
Domaini1647 – 1820Laminin G-like 5PROSITE-ProRule annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni256 – 832Domain II and IAdd BLAST577

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili320 – 403Sequence analysisAdd BLAST84
Coiled coili473 – 528Sequence analysisAdd BLAST56
Coiled coili581 – 614Sequence analysisAdd BLAST34
Coiled coili662 – 724Sequence analysisAdd BLAST63
Coiled coili777 – 806Sequence analysisAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi724 – 726Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain G is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP6G Eukaryota
ENOG410Z3D5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159970

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052299

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16363

KEGG Orthology (KO)

More...
KOi
K06241

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16363

TreeFam database of animal gene trees

More...
TreeFami
TF335359

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 3 hits
SM00282 LamG, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 3 hits
PS50025 LAM_G_DOMAIN, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16363-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET
60 70 80 90 100
SEPRVALGRL PPAAEKCNAG FFHTLSGECV PCDCNGNSNE CLDGSGYCVH
110 120 130 140 150
CQRNTTGEHC EKCLDGYIGD SIRGAPQFCQ PCPCPLPHLA NFAESCYRKN
160 170 180 190 200
GAVRCICNEN YAGPNCERCA PGYYGNPLLI GSTCKKCDCS GNSDPNLIFE
210 220 230 240 250
DCDEVTGQCR NCLRNTTGFK CERCAPGYYG DARIAKNCAV CNCGGGPCDS
260 270 280 290 300
VTGECLEEGF EPPTGMDCPT ISCDKCVWDL TDALRLAALS IEEGKSGVLS
310 320 330 340 350
VSSGAAAHRH VNEINATIYL LKTKLSEREN QYALRKIQIN NAENTMKSLL
360 370 380 390 400
SDVEELVEKE NQASRKGQLV QKESMDTINH ASQLVEQAHD MRDKIQEINN
410 420 430 440 450
KMLYYGEEHE LSPKEISEKL VLAQKMLEEI RSRQPFFTQR ELVDEEADEA
460 470 480 490 500
YELLSQAESW QRLHNETRTL FPVVLEQLDD YNAKLSDLQE ALDQALNYVR
510 520 530 540 550
DAEDMNRATA ARQRDHEKQQ ERVREQMEVV NMSLSTSADS LTTPRLTLSE
560 570 580 590 600
LDDIIKNASG IYAEIDGAKS ELQVKLSNLS NLSHDLVQEA IDHAQDLQQE
610 620 630 640 650
ANELSRKLHS SDMNGLVQKA LDASNVYENI VNYVSEANET AEFALNTTDR
660 670 680 690 700
IYDAVSGIDT QIIYHKDESE NLLNQARELQ AKAESSSDEA VADTSRRVGG
710 720 730 740 750
ALARKSALKT RLSDAVKQLQ AAERGDAQQR LGQSRLITEE ANRTTMEVQQ
760 770 780 790 800
ATAPMANNLT NWSQNLQHFD SSAYNTAVNS ARDAVRNLTE VVPQLLDQLR
810 820 830 840 850
TVEQKRPASN VSASIQRIRE LIAQTRSVAS KIQVSMMFDG QSAVEVHSRT
860 870 880 890 900
SMDDLKAFTS LSLYMKPPVK RPELTETADQ FILYLGSKNA KKEYMGLAIK
910 920 930 940 950
NDNLVYVYNL GTKDVEIPLD SKPVSSWPAY FSIVKIERVG KHGKVFLTVP
960 970 980 990 1000
SLSSTAEEKF IKKGEFSGDD SLLDLDPEDT VFYVGGVPSN FKLPTSLNLP
1010 1020 1030 1040 1050
GFVGCLELAT LNNDVISLYN FKHIYNMDPS TSVPCARDKL AFTQSRAASY
1060 1070 1080 1090 1100
FFDGSGYAVV RDITRRGKFG QVTRFDIEVR TPADNGLILL MVNGSMFFRL
1110 1120 1130 1140 1150
EMRNGYLHVF YDFGFSGGPV HLEDTLKKAQ INDAKYHEIS IIYHNDKKMI
1160 1170 1180 1190 1200
LVVDRRHVKS MDNEKMKIPF TDIYIGGAPP EILQSRALRA HLPLDINFRG
1210 1220 1230 1240 1250
CMKGFQFQKK DFNLLEQTET LGVGYGCPED SLISRRAYFN GQSFIASIQK
1260 1270 1280 1290 1300
ISFFDGFEGG FNFRTLQPNG LLFYYASGSD VFSISLDNGT VIMDVKGIKV
1310 1320 1330 1340 1350
QSVDKQYNDG LSHFVISSVS PTRYELIVDK SRVGSKNPTK GKIEQTQASE
1360 1370 1380 1390 1400
KKFYFGGSPI SAQYANFTGC ISNAYFTRVD RDVEVEDFQR YTEKVHTSLY
1410 1420 1430 1440 1450
ECPIESSPLF LLHKKGKNLS KPKASQNKKG GKSKDAPSWD PVALKLPERN
1460 1470 1480 1490 1500
TPRNSHCHLS NSPRAIEHAY QYGGTANSRQ EFEHLKGDFG AKSQFSIRLR
1510 1520 1530 1540 1550
TRSSHGMIFY VSDQEENDFM TLFLAHGRLV YMFNVGHKKL KIRSQEKYND
1560 1570 1580 1590 1600
GLWHDVIFIR ERSSGRLVID GLRVLEESLP PTEATWKIKG PIYLGGVAPG
1610 1620 1630 1640 1650
KAVKNVQINS IYSFSGCLSN LQLNGASITS ASQTFSVTPC FEGPMETGTY
1660 1670 1680 1690 1700
FSTEGGYVVL DESFNIGLKF EIAFEVRPRS SSGTLVHGHS VNGEYLNVHM
1710 1720 1730 1740 1750
KNGQVIVKVN NGIRDFSTSV TPKQSLCDGR WHRITVIRDS NVVQLDVDSE
1760 1770 1780 1790 1800
VNHVVGPLNP KPIDHREPVF VGGVPESLLT PRLAPSKPFT GCIRHFVIDG
1810 1820
HPVSFSKAAL VSGAVSINSC PAA
Length:1,823
Mass (Da):202,524
Last modified:March 23, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25BFB6120C2A86F1
GO
Isoform 2 (identifier: Q16363-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-272: Missing.

Show »
Length:1,816
Mass (Da):201,776
Checksum:iAEC1A024B5A180ED
GO
Isoform 3 (identifier: Q16363-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-120: KCNAGFFHTL...EKCLDGYIGD → VQCPCHCHPA...RKLEIKSFPL
     121-1823: Missing.

Show »
Length:120
Mass (Da):12,819
Checksum:i6ABF63CBA663BF3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS9A0A0A0MQS9_HUMAN
Laminin subunit alpha-4
LAMA4
1,823Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTC7A0A0A0MTC7_HUMAN
Laminin subunit alpha-4
LAMA4
1,816Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y351H0Y351_HUMAN
Laminin subunit alpha-4
LAMA4
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAQ5H0YAQ5_HUMAN
Laminin subunit alpha-4
LAMA4
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFQ2E5RFQ2_HUMAN
Laminin subunit alpha-4
LAMA4
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHF3E5RHF3_HUMAN
Laminin subunit alpha-4
LAMA4
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6LET9Q6LET9_HUMAN
LAMA4 protein
LAMA4 hCG_32955
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK79E5RK79_HUMAN
Laminin subunit alpha-4
LAMA4
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFD7E5RFD7_HUMAN
Laminin subunit alpha-4
LAMA4
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAP9H0YAP9_HUMAN
Laminin subunit alpha-4
LAMA4
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06109 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143A → P in AAB34635 (PubMed:7781776).Curated1
Sequence conflicti178L → F in AAB34635 (PubMed:7781776).Curated1
Sequence conflicti283A → D in AAB34635 (PubMed:7781776).Curated1
Sequence conflicti283A → D in CAA62596 (PubMed:8706685).Curated1
Sequence conflicti283A → D in BAE06109 (Ref. 3) Curated1
Sequence conflicti283A → D in CAA54258 (PubMed:7959779).Curated1
Sequence conflicti1064T → P in AAB34635 (PubMed:7781776).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05614094G → S. Corresponds to variant dbSNP:rs35349917EnsemblClinVar.1
Natural variantiVAR_056141154R → W. Corresponds to variant dbSNP:rs11757455EnsemblClinVar.1
Natural variantiVAR_061348283A → E. Corresponds to variant dbSNP:rs9400522Ensembl.1
Natural variantiVAR_056142492L → H. Corresponds to variant dbSNP:rs3752579Ensembl.1
Natural variantiVAR_025550498Y → H2 PublicationsCorresponds to variant dbSNP:rs1050348Ensembl.1
Natural variantiVAR_069708950P → L in CMD1JJ; loss of integrin-binding capacity. 1 Publication1
Natural variantiVAR_0255511117G → S3 PublicationsCorresponds to variant dbSNP:rs2032567Ensembl.1
Natural variantiVAR_0255521119P → R3 PublicationsCorresponds to variant dbSNP:rs1050349Ensembl.1
Natural variantiVAR_0561431549N → S1 PublicationCorresponds to variant dbSNP:rs12110554Ensembl.1
Natural variantiVAR_0561441815V → I. Corresponds to variant dbSNP:rs3734292Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03885366 – 120KCNAG…GYIGD → VQCPCHCHPAGAPAPPRAVP HSSFSLSPPLSSPQCLESFT WARSVRKLEIKSFPL in isoform 3. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_038854121 – 1823Missing in isoform 3. 2 PublicationsAdd BLAST1703
Alternative sequenceiVSP_017542266 – 272Missing in isoform 2. 3 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S78569 mRNA Translation: AAB34635.1
X91171 mRNA Translation: CAA62596.1
X70904 mRNA Translation: CAA50261.1
AB210027 mRNA Translation: BAE06109.1 Different initiation.
BT006690 mRNA Translation: AAP35336.1
AL590106 Genomic DNA No translation available.
Z99289 Genomic DNA No translation available.
BC004241 mRNA Translation: AAH04241.1
Y14240 Genomic DNA Translation: CAA74636.1
X76939 mRNA Translation: CAA54258.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34514.1 [Q16363-2]
CCDS43491.1 [Q16363-1]
CCDS43492.1 [Q16363-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68960

NCBI Reference Sequences

More...
RefSeqi
NP_001098676.2, NM_001105206.2
NP_001098677.2, NM_001105207.2
NP_001098678.1, NM_001105208.2 [Q16363-3]
NP_001098679.1, NM_001105209.2 [Q16363-3]
NP_002281.3, NM_002290.4
XP_005267040.2, XM_005266983.3
XP_005267041.2, XM_005266984.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654572

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368638; ENSP00000357627; ENSG00000112769 [Q16363-3]
ENST00000453937; ENSP00000398226; ENSG00000112769 [Q16363-3]
ENST00000455073; ENSP00000408604; ENSG00000112769 [Q16363-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3910

UCSC genome browser

More...
UCSCi
uc010kdz.3 human [Q16363-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78569 mRNA Translation: AAB34635.1
X91171 mRNA Translation: CAA62596.1
X70904 mRNA Translation: CAA50261.1
AB210027 mRNA Translation: BAE06109.1 Different initiation.
BT006690 mRNA Translation: AAP35336.1
AL590106 Genomic DNA No translation available.
Z99289 Genomic DNA No translation available.
BC004241 mRNA Translation: AAH04241.1
Y14240 Genomic DNA Translation: CAA74636.1
X76939 mRNA Translation: CAA54258.1
CCDSiCCDS34514.1 [Q16363-2]
CCDS43491.1 [Q16363-1]
CCDS43492.1 [Q16363-3]
PIRiS68960
RefSeqiNP_001098676.2, NM_001105206.2
NP_001098677.2, NM_001105207.2
NP_001098678.1, NM_001105208.2 [Q16363-3]
NP_001098679.1, NM_001105209.2 [Q16363-3]
NP_002281.3, NM_002290.4
XP_005267040.2, XM_005266983.3
XP_005267041.2, XM_005266984.3
UniGeneiHs.654572

3D structure databases

ProteinModelPortaliQ16363
SMRiQ16363
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110104, 23 interactors
ComplexPortaliCPX-1777 Laminin-411 complex
CPX-1778 Laminin-421 complex
CPX-1782 Laminin-423 complex
CORUMiQ16363
IntActiQ16363, 21 interactors
MINTiQ16363
STRINGi9606.ENSP00000230538

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

GlyConnecti1440
iPTMnetiQ16363
PhosphoSitePlusiQ16363
SwissPalmiQ16363

Polymorphism and mutation databases

BioMutaiLAMA4
DMDMi292495093

Proteomic databases

EPDiQ16363
MaxQBiQ16363
PaxDbiQ16363
PeptideAtlasiQ16363
PRIDEiQ16363
ProteomicsDBi60862
60863 [Q16363-2]
60864 [Q16363-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368638; ENSP00000357627; ENSG00000112769 [Q16363-3]
ENST00000453937; ENSP00000398226; ENSG00000112769 [Q16363-3]
ENST00000455073; ENSP00000408604; ENSG00000112769 [Q16363-3]
GeneIDi3910
KEGGihsa:3910
UCSCiuc010kdz.3 human [Q16363-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3910
DisGeNETi3910
EuPathDBiHostDB:ENSG00000112769.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMA4
HGNCiHGNC:6484 LAMA4
HPAiCAB078156
HPA015693
MalaCardsiLAMA4
MIMi600133 gene
615235 phenotype
neXtProtiNX_Q16363
OpenTargetsiENSG00000112769
Orphaneti154 Familial isolated dilated cardiomyopathy
PharmGKBiPA30273

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IP6G Eukaryota
ENOG410Z3D5 LUCA
GeneTreeiENSGT00940000159970
HOVERGENiHBG052299
InParanoidiQ16363
KOiK06241
PhylomeDBiQ16363
TreeFamiTF335359

Enzyme and pathway databases

ReactomeiR-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-8874081 MET activates PTK2 signaling
SIGNORiQ16363

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMA4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Laminin,_alpha_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3910

Protein Ontology

More...
PROi
PR:Q16363

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112769 Expressed in 221 organ(s), highest expression level in lung
CleanExiHS_LAMA4
ExpressionAtlasiQ16363 baseline and differential
GenevisibleiQ16363 HS

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 3 hits
SM00282 LamG, 5 hits
SUPFAMiSSF49899 SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 3 hits
PS50025 LAM_G_DOMAIN, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMA4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16363
Secondary accession number(s): Q14731
, Q14735, Q15335, Q4LE44, Q5SZG8, Q9BTB8, Q9UE18, Q9UJN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: December 5, 2018
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again