INA

Functionⁱ

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

GO - Molecular functionⁱ

structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- 7769995

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
cellular response to leukemia inhibitory factor Source: Ensembl
neurofilament cytoskeleton organization Source: Ensembl
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-internexin Short name: Alpha-Inx Alternative name(s): 66 kDa neurofilament protein Short name: NF-66 Short name: Neurofilament-66 Neurofilament 5
Gene namesⁱ	Name:INA Synonyms:NEF5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148798.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6057 INA
MIMⁱ	605338 gene
neXtProtⁱ	NX_Q16352

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9118
Open Targets More...OpenTargetsⁱ	ENSG00000148798
PharmGKBⁱ	PA29867

Polymorphism and mutation databases

BioMutaⁱ	INA
DMDMⁱ	20141266

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063783	1 – 499	Alpha-internexinAdd BLAST		499

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	290	N6-acetyllysineCombined sources	1
Modified residueⁱ	335	PhosphoserineBy similarity	1
Modified residueⁱ	469	PhosphoserineBy similarity	1
Modified residueⁱ	496	PhosphoserineCombined sources	1

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q16352
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16352
PaxDbⁱ	Q16352
PeptideAtlas More...PeptideAtlasⁱ	Q16352
PRIDEⁱ	Q16352
ProteomicsDBⁱ	60861

PTM databases

iPTMnetⁱ	Q16352
PhosphoSitePlusⁱ	Q16352
SwissPalmⁱ	Q16352

Expressionⁱ

Tissue specificityⁱ

Found predominantly in adult CNS.

Developmental stageⁱ

Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.

Gene expression databases

Bgeeⁱ	ENSG00000148798
CleanExⁱ	HS_INA
Genevisibleⁱ	Q16352 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002059 HPA008057

HPAⁱ

CAB002059
HPA008057

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114566, 41 interactors
IntActⁱ	Q16352, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q16352
STRINGⁱ	9606.ENSP00000358865

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16352
SMRⁱ	Q16352
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	94 – 407	IF rodPROSITE-ProRule annotationAdd BLAST		314

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 87	HeadAdd BLAST	87
Regionⁱ	88 – 129	Coil 1AAdd BLAST	42
Regionⁱ	130 – 142	Linker 1Add BLAST	13
Regionⁱ	143 – 238	Coil 1BAdd BLAST	96
Regionⁱ	239 – 262	Linker 2Add BLAST	24
Regionⁱ	263 – 408	Coil 2Add BLAST	146
Regionⁱ	409 – 499	TailAdd BLAST	91

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	449 – 454	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143989
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q16352
KEGG Orthology (KO) More...KOⁱ	K07608
OMAⁱ	NDYRHRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12MK
PhylomeDBⁱ	Q16352
TreeFamⁱ	TF330122

Family and domain databases

InterProⁱ	View protein in InterPro IPR027703 Alpha-Inx IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit PTHR23239:SF132 PTHR23239:SF132, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16352-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFGSEHYLC SSSSYRKVFG DGSRLSARLS GAGGAGGFRS QSLSRSNVAS 
        60         70         80         90        100
SAACSSASSL GLGLAYRRPP ASDGLDLSQA AARTNEYKII RTNEKEQLQG 
       110        120        130        140        150
LNDRFAVFIE KVHQLETQNR ALEAELAALR QRHAEPSRVG ELFQRELRDL 
       160        170        180        190        200
RAQLEEASSA RSQALLERDG LAEEVQRLRA RCEEESRGRE GAERALKAQQ 
       210        220        230        240        250
RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA TLQASSQAAA 
       260        270        280        290        300
EVDVTVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR 
       310        320        330        340        350
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE 
       360        370        380        390        400
VAGYQDSIGQ LENDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL 
       410        420        430        440        450
EGEETRFSTS GLSISGLNPL PNPSYLLPPR ILSATTSKVS STGLSLKKEE 
       460        470        480        490 
EEEEASKVAS KKTSQIGESF EEILEETVIS TKKTEKSNIE ETTISSQKI

Length:499

Mass (Da):55,391

Last modified:January 23, 2002 - v2

Checksum:ⁱ4C972764E9E68D3E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	37 – 41	GFRSQ → ASVE in AAB34482 (PubMed:7769995).Curated	5
Sequence conflictⁱ	67	R → A in AAB34482 (PubMed:7769995).Curated	1
Sequence conflictⁱ	128 – 132	ALRQR → RCDT in AAB34482 (PubMed:7769995).Curated	5
Sequence conflictⁱ	141	E → Q in AAB34482 (PubMed:7769995).Curated	1
Sequence conflictⁱ	147 – 152	LRDLRA → PRHLP in AAB34482 (PubMed:7769995).Curated	6
Sequence conflictⁱ	191 – 198	GAERALKA → RRARLKR in AAB34482 (PubMed:7769995).Curated	8
Sequence conflictⁱ	244	A → R in AAB34482 (PubMed:7769995).Curated	1
Sequence conflictⁱ	263	S → A in AAB34482 (PubMed:7769995).Curated	1
Sequence conflictⁱ	301	S → T in AAB34482 (PubMed:7769995).Curated	1
Sequence conflictⁱ	310 – 311	EE → DQ in AAB34482 (PubMed:7769995).Curated	2
Sequence conflictⁱ	318	Missing in AAB34482 (PubMed:7769995).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049808	92	T → S1 PublicationCorresponds to variant dbSNP:rs1063455Ensembl.	1
Natural variantⁱVAR_036369	110	E → Q in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_033497	149	D → H. Corresponds to variant dbSNP:rs1063456Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78296 mRNA Translation: AAB34482.1 AL591408 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49653.1 BC006359 mRNA Translation: AAH06359.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7545.1
PIRⁱ	I52658
NCBI Reference Sequences More...RefSeqⁱ	NP_116116.1, NM_032727.3
UniGeneⁱ	Hs.500916

Genome annotation databases

Ensemblⁱ	ENST00000369849; ENSP00000358865; ENSG00000148798
GeneIDⁱ	9118
KEGGⁱ	hsa:9118
UCSC genome browser More...UCSCⁱ	uc001kws.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
Q16352	cDNA FLJ57501, highly similar to Alpha-internexin		HUMAN		128
Uncharacterized protein		NEOLE		511
Alpha-internexin		RAT		506
UPI0003332899		JACJA		505
UPI00057B008E		CAMBA		505
+81

Protein	Similar proteins		Species	Score	Length
Q16352	cDNA FLJ57501, highly similar to Alpha-internexin		HUMAN		128
Uncharacterized protein		NEOLE		511
Alpha-internexin		RAT		506
UPI00057B008E		CAMBA		505
UPI0003332899		JACJA		505
+215

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78296 mRNA Translation: AAB34482.1 AL591408 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49653.1 BC006359 mRNA Translation: AAH06359.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7545.1
PIRⁱ	I52658
NCBI Reference Sequences More...RefSeqⁱ	NP_116116.1, NM_032727.3
UniGeneⁱ	Hs.500916

3D structure databases

ProteinModelPortalⁱ	Q16352
SMRⁱ	Q16352
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114566, 41 interactors
IntActⁱ	Q16352, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q16352
STRINGⁱ	9606.ENSP00000358865

PTM databases

iPTMnetⁱ	Q16352
PhosphoSitePlusⁱ	Q16352
SwissPalmⁱ	Q16352

Polymorphism and mutation databases

BioMutaⁱ	INA
DMDMⁱ	20141266

Proteomic databases

EPDⁱ	Q16352
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16352
PaxDbⁱ	Q16352
PeptideAtlas More...PeptideAtlasⁱ	Q16352
PRIDEⁱ	Q16352
ProteomicsDBⁱ	60861

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9118
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369849; ENSP00000358865; ENSG00000148798
GeneIDⁱ	9118
KEGGⁱ	hsa:9118
UCSC genome browser More...UCSCⁱ	uc001kws.3 human

Organism-specific databases

CTDⁱ	9118
DisGeNET More...DisGeNETⁱ	9118
EuPathDBⁱ	HostDB:ENSG00000148798.9
GeneCardsⁱ	INA
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6057 INA
Human Protein Atlas More...HPAⁱ	CAB002059 HPA008057
MIMⁱ	605338 gene
neXtProtⁱ	NX_Q16352
Open Targets More...OpenTargetsⁱ	ENSG00000148798
PharmGKBⁱ	PA29867
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143989
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q16352
KEGG Orthology (KO) More...KOⁱ	K07608
OMAⁱ	NDYRHRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12MK
PhylomeDBⁱ	Q16352
TreeFamⁱ	TF330122

Miscellaneous databases

ChiTaRSⁱ	INA human
GenomeRNAiⁱ	9118
Protein Ontology More...PROⁱ	PR:Q16352
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148798
CleanExⁱ	HS_INA
Genevisibleⁱ	Q16352 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027703 Alpha-Inx IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit PTHR23239:SF132 PTHR23239:SF132, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AINX_HUMAN
Accessionⁱ	Q16352Primary (citable) accession number: Q16352 Secondary accession number(s): B1AQK0, Q9BRC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 23, 2002
	Last modified:	June 20, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16352 (AINX_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alpha-internexin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ