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Entry version 170 (17 Jun 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427975 Proton/oligopeptide cotransporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.17.4.8 the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC15A2
Synonyms:PEPT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163406.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10921 SLC15A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602339 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16348

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 83ExtracellularCurated5
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 113CytoplasmicCurated9
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 139ExtracellularCurated5
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 674ExtracellularCurated10
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6565

Open Targets

More...
OpenTargetsi
ENSG00000163406

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35812

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16348 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743125

Drug and drug target database

More...
DrugBanki
DB00855 Aminolevulinic acid
DB01060 Amoxicillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00542 Benazepril
DB01053 Benzylpenicillin
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB00535 Cefdinir
DB01413 Cefepime
DB00671 Cefixime
DB00274 Cefmetazole
DB00493 Cefotaxime
DB01333 Cefradine
DB00438 Ceftazidime
DB01415 Ceftibuten
DB01212 Ceftriaxone
DB01112 Cefuroxime
DB00567 Cephalexin
DB00672 Chlorpropamide
DB01340 Cilazapril
DB01147 Cloxacillin
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00492 Fosinopril
DB01016 Glyburide
DB00722 Lisinopril
DB00447 Loracarbef
DB00691 Moexipril
DB00731 Nateglinide
DB00713 Oxacillin
DB00790 Perindopril
DB00781 Polymyxin B
DB00881 Quinapril
DB00178 Ramipril
DB01348 Spirapril
DB01124 Tolbutamide
DB00519 Trandolapril
DB00302 Tranexamic acid
DB03424 Ubenimex
DB00577 Valaciclovir
DB01610 Valganciclovir

DrugCentral

More...
DrugCentrali
Q16348

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
985

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC15A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643081 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei28PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi435N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi567N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16348

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16348

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q16348

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16348

PeptideAtlas

More...
PeptideAtlasi
Q16348

PRoteomics IDEntifications database

More...
PRIDEi
Q16348

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60859 [Q16348-1]
60860 [Q16348-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16348

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16348

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney. Not detected in intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163406 Expressed in nasal cavity epithelium and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16348 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16348 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163406 Tissue enhanced (cervix, uterine, ductus deferens)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112453, 1 interactor

Protein interaction database and analysis system

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IntActi
Q16348, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417085

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16348

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16348 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16348

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1237 Eukaryota
COG3104 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004790_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16348

KEGG Orthology (KO)

More...
KOi
K14637

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYEFAYS

Database of Orthologous Groups

More...
OrthoDBi
365203at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16348

TreeFam database of animal gene trees

More...
TreeFami
TF330897

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11654 PTHR11654, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00854 PTR2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit
SSF75217 SSF75217, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00926 2A1704, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF
210 220 230 240 250
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN
260 270 280 290 300
IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL
360 370 380 390 400
LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK
410 420 430 440 450
INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP
460 470 480 490 500
HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS
510 520 530 540 550
MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT
560 570 580 590 600
VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED
610 620 630 640 650
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK
710 720
TEDMRGPADK HIPHIQGNMI KLETKKTKL
Length:729
Mass (Da):81,783
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0169DC150BD35BC3
GO
Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Show »
Length:698
Mass (Da):78,527
Checksum:i5FBE321D4F1911D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZ38C9IZ38_HUMAN
Solute carrier family 15 member 2
SLC15A2
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278 – 279QH → HD in AAB34388 (PubMed:7756356).Curated2
Sequence conflicti396A → R in AAB34388 (PubMed:7756356).Curated1
Sequence conflicti609A → R in AAB34388 (PubMed:7756356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04700157R → H. Corresponds to variant dbSNP:rs1920305Ensembl.1
Natural variantiVAR_04700273Y → C. Corresponds to variant dbSNP:rs1143667Ensembl.1
Natural variantiVAR_047003350L → F. Corresponds to variant dbSNP:rs2257212Ensembl.1
Natural variantiVAR_047004409P → S. Corresponds to variant dbSNP:rs1143671Ensembl.1
Natural variantiVAR_047005509R → K. Corresponds to variant dbSNP:rs1143672Ensembl.1
Natural variantiVAR_047006609A → G. Corresponds to variant dbSNP:rs1143668Ensembl.1
Natural variantiVAR_047008704M → L. Corresponds to variant dbSNP:rs1920314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043084113 – 143Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S78203 mRNA Translation: AAB34388.1
AK289820 mRNA Translation: BAF82509.1
AK304189 mRNA Translation: BAG65069.1
AC072031 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79496.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3007.1 [Q16348-1]
CCDS54631.1 [Q16348-2]

Protein sequence database of the Protein Information Resource

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PIRi
I52481

NCBI Reference Sequences

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RefSeqi
NP_001139470.1, NM_001145998.1 [Q16348-2]
NP_066568.3, NM_021082.3 [Q16348-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295605; ENSP00000295605; ENSG00000163406 [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406 [Q16348-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6565

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6565

UCSC genome browser

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UCSCi
uc003eep.3 human [Q16348-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78203 mRNA Translation: AAB34388.1
AK289820 mRNA Translation: BAF82509.1
AK304189 mRNA Translation: BAG65069.1
AC072031 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79496.1
CCDSiCCDS3007.1 [Q16348-1]
CCDS54631.1 [Q16348-2]
PIRiI52481
RefSeqiNP_001139470.1, NM_001145998.1 [Q16348-2]
NP_066568.3, NM_021082.3 [Q16348-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EZIX-ray1.50B720-729[»]
SMRiQ16348
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112453, 1 interactor
IntActiQ16348, 26 interactors
STRINGi9606.ENSP00000417085

Chemistry databases

BindingDBiQ16348
ChEMBLiCHEMBL1743125
DrugBankiDB00855 Aminolevulinic acid
DB01060 Amoxicillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00542 Benazepril
DB01053 Benzylpenicillin
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB00535 Cefdinir
DB01413 Cefepime
DB00671 Cefixime
DB00274 Cefmetazole
DB00493 Cefotaxime
DB01333 Cefradine
DB00438 Ceftazidime
DB01415 Ceftibuten
DB01212 Ceftriaxone
DB01112 Cefuroxime
DB00567 Cephalexin
DB00672 Chlorpropamide
DB01340 Cilazapril
DB01147 Cloxacillin
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00492 Fosinopril
DB01016 Glyburide
DB00722 Lisinopril
DB00447 Loracarbef
DB00691 Moexipril
DB00731 Nateglinide
DB00713 Oxacillin
DB00790 Perindopril
DB00781 Polymyxin B
DB00881 Quinapril
DB00178 Ramipril
DB01348 Spirapril
DB01124 Tolbutamide
DB00519 Trandolapril
DB00302 Tranexamic acid
DB03424 Ubenimex
DB00577 Valaciclovir
DB01610 Valganciclovir
DrugCentraliQ16348
GuidetoPHARMACOLOGYi985

Protein family/group databases

TCDBi2.A.17.4.8 the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

iPTMnetiQ16348
PhosphoSitePlusiQ16348

Polymorphism and mutation databases

BioMutaiSLC15A2
DMDMi209572672

Proteomic databases

EPDiQ16348
jPOSTiQ16348
MassIVEiQ16348
PaxDbiQ16348
PeptideAtlasiQ16348
PRIDEiQ16348
ProteomicsDBi60859 [Q16348-1]
60860 [Q16348-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32862 70 antibodies

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406 [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406 [Q16348-1]
GeneIDi6565
KEGGihsa:6565
UCSCiuc003eep.3 human [Q16348-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6565
DisGeNETi6565
EuPathDBiHostDB:ENSG00000163406.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC15A2
HGNCiHGNC:10921 SLC15A2
HPAiENSG00000163406 Tissue enhanced (cervix, uterine, ductus deferens)
MIMi602339 gene
neXtProtiNX_Q16348
OpenTargetsiENSG00000163406
PharmGKBiPA35812

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00940000156507
HOGENOMiCLU_004790_3_0_1
InParanoidiQ16348
KOiK14637
OMAiGYEFAYS
OrthoDBi365203at2759
PhylomeDBiQ16348
TreeFamiTF330897

Enzyme and pathway databases

ReactomeiR-HSA-427975 Proton/oligopeptide cotransporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6565 1 hit in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC15A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC15A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6565
PharosiQ16348 Tchem

Protein Ontology

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PROi
PR:Q16348
RNActiQ16348 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163406 Expressed in nasal cavity epithelium and 179 other tissues
ExpressionAtlasiQ16348 baseline and differential
GenevisibleiQ16348 HS

Family and domain databases

InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
SSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00926 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: June 17, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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