Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q16342 (PDCD2_HUMAN)

Entry version 177 (02 Dec 2020)
Sequence version 2 (01 Feb 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Programmed cell death protein 2

Gene

PDCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri135 – 172MYND-typePROSITE-ProRule annotationAdd BLAST38

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16342

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger MYND domain-containing protein 7
Zinc finger protein Rp-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDCD2
Synonyms:RP8, ZMYND7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000071994.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:8762, PDCD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600866, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16342

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5134

Open Targets

More...OpenTargetsi		ENSG00000071994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33112

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16342, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDCD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		28202261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002183041 – 344Programmed cell death protein 2Add BLAST344

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by PRKN, promoting proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16342

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16342

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16342

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16342

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16342

PeptideAtlas

More...PeptideAtlasi		Q16342

PRoteomics IDEntifications database

More...PRIDEi		Q16342

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19518
24829
60856 [Q16342-1]
60857 [Q16342-2]
60858 [Q16342-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16342

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16342

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000071994, Expressed in body of pancreas and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16342, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16342, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000071994, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111161, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q16342

Database of interacting proteins

More...DIPi		DIP-27594N

Protein interaction database and analysis system

More...IntActi		Q16342, 12 interactors

Molecular INTeraction database

More...MINTi		Q16342

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439467

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16342, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16342

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 172MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2061, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156603

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034893_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16342

Identification of Orthologs from Complete Genome Data

More...OMAi		RYFPSKL

Database of Orthologous Groups

More...OrthoDBi		1181470at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16342

TreeFam database of animal gene trees

More...TreeFami		TF313722

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007320, PDCD2_C
IPR002893, Znf_MYND

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04194, PDCD2_C, 1 hit
PF01753, zf-MYND, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16342-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA 
        60         70         80         90        100
CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL 
       110        120        130        140        150
PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH 
       160        170        180        190        200
KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED 
       210        220        230        240        250
EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL 
       260        270        280        290        300
EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY 
       310        320        330        340 
LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP
Length:344
Mass (Da):38,592
Last modified:February 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3E7BA2C9FBAFD0E
GO
Isoform 2 (identifier: Q16342-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.
     221-344: EALEEELDSM...VWKQDVTDTP → KQFQDFIH

Show »
Length:195
Mass (Da):22,230
Checksum:i2A29B0D0A276CB6D
GO
Isoform 3 (identifier: Q16342-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.

Show »
Length:311
Mass (Da):35,290
Checksum:i2690DDD960B82B1C
GO
Isoform 4 (identifier: Q16342-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-228: EALEEELD → KQFQDFIH
     229-344: Missing.

Show »
Length:228
Mass (Da):25,532
Checksum:i7BE1A0F6BE9306FD
GO
Isoform 5 (identifier: Q16342-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.
     221-221: E → I
     222-344: Missing.

Show »
Length:188
Mass (Da):21,299
Checksum:iDE1D2BC8F2529930
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4V9F5H4V9_HUMAN
Programmed cell death protein 2
PDCD2
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYJ3A0A087WYJ3_HUMAN
Programmed cell death protein 2
PDCD2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QK82J3QK82_HUMAN
Programmed cell death 2, isoform CR...
PDCD2 hCG_2029505
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFS8H0YFS8_HUMAN
Programmed cell death protein 2
PDCD2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFM2H0YFM2_HUMAN
Programmed cell death protein 2
PDCD2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFZ5H0YFZ5_HUMAN
Programmed cell death protein 2
PDCD2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWT2F5GWT2_HUMAN
Programmed cell death protein 2
PDCD2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226E → G in AAB34865 (PubMed:7606924).Curated1
Sequence conflicti317V → A in AAB34865 (PubMed:7606924).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04282831 – 63Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_042829221 – 344EALEE…VTDTP → KQFQDFIH in isoform 2. 2 PublicationsAdd BLAST124
Alternative sequenceiVSP_055159221 – 228EALEEELD → KQFQDFIH in isoform 4. Curated8
Alternative sequenceiVSP_055160221E → I in isoform 5. Curated1
Alternative sequenceiVSP_055161222 – 344Missing in isoform 5. CuratedAdd BLAST123
Alternative sequenceiVSP_055162229 – 344Missing in isoform 4. CuratedAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S78085 mRNA Translation: AAB34865.1
AY948416 mRNA Translation: AAX51225.1
AY948417 mRNA Translation: AAX51226.1
AK297343 mRNA Translation: BAG59795.1
AL031259 Genomic DNA No translation available.
BC008378 mRNA Translation: AAH08378.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47521.1 [Q16342-4]
CCDS5316.1 [Q16342-1]
CCDS56460.1 [Q16342-2]
CCDS56461.1 [Q16342-3]
CCDS56462.1 [Q16342-5]

Protein sequence database of the Protein Information Resource

More...PIRi		I52969

NCBI Reference Sequences

More...RefSeqi		NP_001186391.1, NM_001199462.1 [Q16342-3]
NP_001186392.1, NM_001199463.1 [Q16342-2]
NP_001186393.1, NM_001199464.1 [Q16342-5]
NP_002589.2, NM_002598.3 [Q16342-1]
NP_659005.1, NM_144781.2 [Q16342-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000392090; ENSP00000375940; ENSG00000071994 [Q16342-3]
ENST00000443345; ENSP00000397272; ENSG00000071994 [Q16342-2]
ENST00000453163; ENSP00000402524; ENSG00000071994 [Q16342-4]
ENST00000537445; ENSP00000440572; ENSG00000071994 [Q16342-5]
ENST00000541970; ENSP00000439467; ENSG00000071994 [Q16342-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5134

UCSC genome browser

More...UCSCi		uc003qxv.4, human [Q16342-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78085 mRNA Translation: AAB34865.1
AY948416 mRNA Translation: AAX51225.1
AY948417 mRNA Translation: AAX51226.1
AK297343 mRNA Translation: BAG59795.1
AL031259 Genomic DNA No translation available.
BC008378 mRNA Translation: AAH08378.1
CCDSiCCDS47521.1 [Q16342-4]
CCDS5316.1 [Q16342-1]
CCDS56460.1 [Q16342-2]
CCDS56461.1 [Q16342-3]
CCDS56462.1 [Q16342-5]
PIRiI52969
RefSeqiNP_001186391.1, NM_001199462.1 [Q16342-3]
NP_001186392.1, NM_001199463.1 [Q16342-2]
NP_001186393.1, NM_001199464.1 [Q16342-5]
NP_002589.2, NM_002598.3 [Q16342-1]
NP_659005.1, NM_144781.2 [Q16342-4]

3D structure databases

SMRiQ16342
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111161, 16 interactors
CORUMiQ16342
DIPiDIP-27594N
IntActiQ16342, 12 interactors
MINTiQ16342
STRINGi9606.ENSP00000439467

PTM databases

iPTMnetiQ16342
PhosphoSitePlusiQ16342

Polymorphism and mutation databases

BioMutaiPDCD2
DMDMi28202261

Proteomic databases

EPDiQ16342
jPOSTiQ16342
MassIVEiQ16342
MaxQBiQ16342
PaxDbiQ16342
PeptideAtlasiQ16342
PRIDEiQ16342
ProteomicsDBi19518
24829
60856 [Q16342-1]
60857 [Q16342-2]
60858 [Q16342-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20097, 101 antibodies

The DNASU plasmid repository

More...DNASUi		5134

Genome annotation databases

EnsembliENST00000392090; ENSP00000375940; ENSG00000071994 [Q16342-3]
ENST00000443345; ENSP00000397272; ENSG00000071994 [Q16342-2]
ENST00000453163; ENSP00000402524; ENSG00000071994 [Q16342-4]
ENST00000537445; ENSP00000440572; ENSG00000071994 [Q16342-5]
ENST00000541970; ENSP00000439467; ENSG00000071994 [Q16342-1]
GeneIDi5134
KEGGihsa:5134
UCSCiuc003qxv.4, human [Q16342-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5134
DisGeNETi5134
EuPathDBiHostDB:ENSG00000071994.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDCD2
HGNCiHGNC:8762, PDCD2
HPAiENSG00000071994, Low tissue specificity
MIMi600866, gene
neXtProtiNX_Q16342
OpenTargetsiENSG00000071994
PharmGKBiPA33112

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2061, Eukaryota
GeneTreeiENSGT00940000156603
HOGENOMiCLU_034893_2_0_1
InParanoidiQ16342
OMAiRYFPSKL
OrthoDBi1181470at2759
PhylomeDBiQ16342
TreeFamiTF313722

Enzyme and pathway databases

PathwayCommonsiQ16342

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5134, 491 hits in 831 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDCD2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PDCD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5134
PharosiQ16342, Tbio

Protein Ontology

More...PROi		PR:Q16342
RNActiQ16342, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000071994, Expressed in body of pancreas and 236 other tissues
ExpressionAtlasiQ16342, baseline and differential
GenevisibleiQ16342, HS

Family and domain databases

InterProiView protein in InterPro
IPR007320, PDCD2_C
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF04194, PDCD2_C, 1 hit
PF01753, zf-MYND, 1 hit
PROSITEiView protein in PROSITE
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDCD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16342
Secondary accession number(s): E9PCU7
, F5GYS7, Q58HM9, Q58HN0, Q9UH12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2003
Last modified: December 2, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again