UniProtKB - Q16342 (PDCD2_HUMAN)
Protein
Programmed cell death protein 2
Gene
PDCD2
Organism
Homo sapiens (Human)
Status
Functioni
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 172 | MYND-typePROSITE-ProRule annotationAdd BLAST | 38 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- enzyme binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- apoptotic process Source: ProtInc
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of hematopoietic stem cell proliferation Source: UniProtKB
- regulation of hematopoietic progenitor cell differentiation Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Apoptosis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q16342 |
Names & Taxonomyi
Protein namesi | Recommended name: Programmed cell death protein 2Alternative name(s): Zinc finger MYND domain-containing protein 7 Zinc finger protein Rp-8 |
Gene namesi | Name:PDCD2 Synonyms:RP8, ZMYND7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000071994.10 |
HGNCi | HGNC:8762, PDCD2 |
MIMi | 600866, gene |
neXtProti | NX_Q16342 |
Subcellular locationi
Nucleus
- Nucleus Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5134 |
OpenTargetsi | ENSG00000071994 |
PharmGKBi | PA33112 |
Miscellaneous databases
Pharosi | Q16342, Tbio |
Polymorphism and mutation databases
BioMutai | PDCD2 |
DMDMi | 28202261 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218304 | 1 – 344 | Programmed cell death protein 2Add BLAST | 344 |
Post-translational modificationi
Ubiquitinated by PRKN, promoting proteasomal degradation.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q16342 |
jPOSTi | Q16342 |
MassIVEi | Q16342 |
MaxQBi | Q16342 |
PaxDbi | Q16342 |
PeptideAtlasi | Q16342 |
PRIDEi | Q16342 |
ProteomicsDBi | 19518 24829 60856 [Q16342-1] 60857 [Q16342-2] 60858 [Q16342-3] |
PTM databases
iPTMneti | Q16342 |
PhosphoSitePlusi | Q16342 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000071994, Expressed in body of pancreas and 236 other tissues |
ExpressionAtlasi | Q16342, baseline and differential |
Genevisiblei | Q16342, HS |
Organism-specific databases
HPAi | ENSG00000071994, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111161, 16 interactors |
CORUMi | Q16342 |
DIPi | DIP-27594N |
IntActi | Q16342, 12 interactors |
MINTi | Q16342 |
STRINGi | 9606.ENSP00000439467 |
Miscellaneous databases
RNActi | Q16342, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 172 | MYND-typePROSITE-ProRule annotationAdd BLAST | 38 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2061, Eukaryota |
GeneTreei | ENSGT00940000156603 |
HOGENOMi | CLU_034893_2_0_1 |
InParanoidi | Q16342 |
OMAi | RYFPSKL |
OrthoDBi | 1181470at2759 |
PhylomeDBi | Q16342 |
TreeFami | TF313722 |
Family and domain databases
InterProi | View protein in InterPro IPR007320, PDCD2_C IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF04194, PDCD2_C, 1 hit PF01753, zf-MYND, 1 hit |
PROSITEi | View protein in PROSITE PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q16342-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA
60 70 80 90 100
CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL
110 120 130 140 150
PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH
160 170 180 190 200
KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED
210 220 230 240 250
EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL
260 270 280 290 300
EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY
310 320 330 340
LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H4V9 | F5H4V9_HUMAN | Programmed cell death protein 2 | PDCD2 | 298 | Annotation score: | ||
A0A087WYJ3 | A0A087WYJ3_HUMAN | Programmed cell death protein 2 | PDCD2 | 221 | Annotation score: | ||
J3QK82 | J3QK82_HUMAN | Programmed cell death 2, isoform CR... | PDCD2 hCG_2029505 | 221 | Annotation score: | ||
H0YFS8 | H0YFS8_HUMAN | Programmed cell death protein 2 | PDCD2 | 46 | Annotation score: | ||
H0YFM2 | H0YFM2_HUMAN | Programmed cell death protein 2 | PDCD2 | 40 | Annotation score: | ||
H0YFZ5 | H0YFZ5_HUMAN | Programmed cell death protein 2 | PDCD2 | 35 | Annotation score: | ||
F5GWT2 | F5GWT2_HUMAN | Programmed cell death protein 2 | PDCD2 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 226 | E → G in AAB34865 (PubMed:7606924).Curated | 1 | |
Sequence conflicti | 317 | V → A in AAB34865 (PubMed:7606924).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042828 | 31 – 63 | Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_042829 | 221 – 344 | EALEE…VTDTP → KQFQDFIH in isoform 2. 2 PublicationsAdd BLAST | 124 | |
Alternative sequenceiVSP_055159 | 221 – 228 | EALEEELD → KQFQDFIH in isoform 4. Curated | 8 | |
Alternative sequenceiVSP_055160 | 221 | E → I in isoform 5. Curated | 1 | |
Alternative sequenceiVSP_055161 | 222 – 344 | Missing in isoform 5. CuratedAdd BLAST | 123 | |
Alternative sequenceiVSP_055162 | 229 – 344 | Missing in isoform 4. CuratedAdd BLAST | 116 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78085 mRNA Translation: AAB34865.1 AY948416 mRNA Translation: AAX51225.1 AY948417 mRNA Translation: AAX51226.1 AK297343 mRNA Translation: BAG59795.1 AL031259 Genomic DNA No translation available. BC008378 mRNA Translation: AAH08378.1 |
CCDSi | CCDS47521.1 [Q16342-4] CCDS5316.1 [Q16342-1] CCDS56460.1 [Q16342-2] CCDS56461.1 [Q16342-3] CCDS56462.1 [Q16342-5] |
PIRi | I52969 |
RefSeqi | NP_001186391.1, NM_001199462.1 [Q16342-3] NP_001186392.1, NM_001199463.1 [Q16342-2] NP_001186393.1, NM_001199464.1 [Q16342-5] NP_002589.2, NM_002598.3 [Q16342-1] NP_659005.1, NM_144781.2 [Q16342-4] |
Genome annotation databases
Ensembli | ENST00000392090; ENSP00000375940; ENSG00000071994 [Q16342-3] ENST00000443345; ENSP00000397272; ENSG00000071994 [Q16342-2] ENST00000453163; ENSP00000402524; ENSG00000071994 [Q16342-4] ENST00000537445; ENSP00000440572; ENSG00000071994 [Q16342-5] ENST00000541970; ENSP00000439467; ENSG00000071994 [Q16342-1] |
GeneIDi | 5134 |
KEGGi | hsa:5134 |
UCSCi | uc003qxv.4, human [Q16342-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78085 mRNA Translation: AAB34865.1 AY948416 mRNA Translation: AAX51225.1 AY948417 mRNA Translation: AAX51226.1 AK297343 mRNA Translation: BAG59795.1 AL031259 Genomic DNA No translation available. BC008378 mRNA Translation: AAH08378.1 |
CCDSi | CCDS47521.1 [Q16342-4] CCDS5316.1 [Q16342-1] CCDS56460.1 [Q16342-2] CCDS56461.1 [Q16342-3] CCDS56462.1 [Q16342-5] |
PIRi | I52969 |
RefSeqi | NP_001186391.1, NM_001199462.1 [Q16342-3] NP_001186392.1, NM_001199463.1 [Q16342-2] NP_001186393.1, NM_001199464.1 [Q16342-5] NP_002589.2, NM_002598.3 [Q16342-1] NP_659005.1, NM_144781.2 [Q16342-4] |
3D structure databases
SMRi | Q16342 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111161, 16 interactors |
CORUMi | Q16342 |
DIPi | DIP-27594N |
IntActi | Q16342, 12 interactors |
MINTi | Q16342 |
STRINGi | 9606.ENSP00000439467 |
PTM databases
iPTMneti | Q16342 |
PhosphoSitePlusi | Q16342 |
Polymorphism and mutation databases
BioMutai | PDCD2 |
DMDMi | 28202261 |
Proteomic databases
EPDi | Q16342 |
jPOSTi | Q16342 |
MassIVEi | Q16342 |
MaxQBi | Q16342 |
PaxDbi | Q16342 |
PeptideAtlasi | Q16342 |
PRIDEi | Q16342 |
ProteomicsDBi | 19518 24829 60856 [Q16342-1] 60857 [Q16342-2] 60858 [Q16342-3] |
Protocols and materials databases
Antibodypediai | 20097, 101 antibodies |
DNASUi | 5134 |
Genome annotation databases
Ensembli | ENST00000392090; ENSP00000375940; ENSG00000071994 [Q16342-3] ENST00000443345; ENSP00000397272; ENSG00000071994 [Q16342-2] ENST00000453163; ENSP00000402524; ENSG00000071994 [Q16342-4] ENST00000537445; ENSP00000440572; ENSG00000071994 [Q16342-5] ENST00000541970; ENSP00000439467; ENSG00000071994 [Q16342-1] |
GeneIDi | 5134 |
KEGGi | hsa:5134 |
UCSCi | uc003qxv.4, human [Q16342-1] |
Organism-specific databases
CTDi | 5134 |
DisGeNETi | 5134 |
EuPathDBi | HostDB:ENSG00000071994.10 |
GeneCardsi | PDCD2 |
HGNCi | HGNC:8762, PDCD2 |
HPAi | ENSG00000071994, Low tissue specificity |
MIMi | 600866, gene |
neXtProti | NX_Q16342 |
OpenTargetsi | ENSG00000071994 |
PharmGKBi | PA33112 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2061, Eukaryota |
GeneTreei | ENSGT00940000156603 |
HOGENOMi | CLU_034893_2_0_1 |
InParanoidi | Q16342 |
OMAi | RYFPSKL |
OrthoDBi | 1181470at2759 |
PhylomeDBi | Q16342 |
TreeFami | TF313722 |
Enzyme and pathway databases
PathwayCommonsi | Q16342 |
Miscellaneous databases
BioGRID-ORCSi | 5134, 491 hits in 831 CRISPR screens |
ChiTaRSi | PDCD2, human |
GeneWikii | PDCD2 |
GenomeRNAii | 5134 |
Pharosi | Q16342, Tbio |
PROi | PR:Q16342 |
RNActi | Q16342, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000071994, Expressed in body of pancreas and 236 other tissues |
ExpressionAtlasi | Q16342, baseline and differential |
Genevisiblei | Q16342, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007320, PDCD2_C IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF04194, PDCD2_C, 1 hit PF01753, zf-MYND, 1 hit |
PROSITEi | View protein in PROSITE PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDCD2_HUMAN | |
Accessioni | Q16342Primary (citable) accession number: Q16342 Secondary accession number(s): E9PCU7 Q9UH12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | February 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot