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Entry version 212 (16 Oct 2019)
Sequence version 2 (06 Mar 2007)
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Protein

NT-3 growth factor receptor

Gene

NTRK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei572ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei679Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi544 – 552ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
R-HSA-9603505 NTRK3 as a dependence receptor

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q16288

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16288

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NT-3 growth factor receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkC
Short name:
Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTRK3
Synonyms:TRKC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8033 NTRK3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191316 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16288

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 429ExtracellularSequence analysisAdd BLAST398
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei430 – 453HelicalSequence analysisAdd BLAST24
Topological domaini454 – 839CytoplasmicSequence analysisAdd BLAST386

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi572K → N: Loss of autophosphorylation and loss of NTRK3 signaling. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4916

MalaCards human disease database

More...
MalaCardsi
NTRK3

Open Targets

More...
OpenTargetsi
ENSG00000140538

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2665 Congenital mesoblastic nephroma
146 Differentiated thyroid carcinoma
2030 Fibrosarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31819

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16288

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5608

Drug and drug target database

More...
DrugBanki
DB12010 Fostamatinib
DB14723 Larotrectinib

DrugCentral

More...
DrugCentrali
Q16288

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1819

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NTRK3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134035335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Add BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001673132 – 839NT-3 growth factor receptorAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 38By similarity
Disulfide bondi36 ↔ 45By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 189By similarity
Disulfide bondi166 ↔ 207By similarity
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi231 ↔ 284By similarity
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi320 ↔ 362PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei493PhosphoserineBy similarity1
Modified residuei516Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei705Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei709Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei710Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ligand-mediated auto-phosphorylation.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16288

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16288

PeptideAtlas

More...
PeptideAtlasi
Q16288

PRoteomics IDEntifications database

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PRIDEi
Q16288

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20249
40524
60850 [Q16288-1]
60851 [Q16288-2]
60852 [Q16288-3]
60853 [Q16288-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16288

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16288

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140538 Expressed in 199 organ(s), highest expression level in primary visual cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16288 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16288 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009233
HPA027484
HPA048065

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2.

Interacts with SQSTM1 and KIDINS220 (By similarity).

Interacts with PTPRS (PubMed:25385546).

Interacts with MAPK8IP3/JIP3 (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei516Interaction with SHC1By similarity1
Sitei834Interaction with PLC-gamma-1By similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110971, 46 interactors

Database of interacting proteins

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DIPi
DIP-5723N

Protein interaction database and analysis system

More...
IntActi
Q16288, 35 interactors

Molecular INTeraction database

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MINTi
Q16288

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354207

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16288

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1839
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16288

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16288

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati104 – 125LRR 1Add BLAST22
Repeati128 – 149LRR 2Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 209LRRCTAdd BLAST50
Domaini210 – 300Ig-like C2-type 1Add BLAST91
Domaini309 – 382Ig-like C2-type 2Add BLAST74
Domaini538 – 839Protein kinasePROSITE-ProRule annotationAdd BLAST302

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1026 Eukaryota
ENOG410YGKQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155645

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000264255

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16288

KEGG Orthology (KO)

More...
KOi
K05101

Database of Orthologous Groups

More...
OrthoDBi
754662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16288

TreeFam database of animal gene trees

More...
TreeFami
TF106465

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020446 Tyr_kin_neurotrophic_rcpt_3
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01939 NTKRECEPTOR
PR01942 NTKRECEPTOR3
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16288-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD
60 70 80 90 100
GNLFPLLEGQ DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME
110 120 130 140 150
LYTGLQKLTI KNSGLRSIQP RAFAKNPHLR YINLSSNRLT TLSWQLFQTL
160 170 180 190 200
SLRELQLEQN FFNCSCDIRW MQLWQEQGEA KLNSQNLYCI NADGSQLPLF
210 220 230 240 250
RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD VDWIVTGLQS
260 270 280 290 300
INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT
310 320 330 340 350
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV
360 370 380 390 400
EYYQEGEISE GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF
410 420 430 440 450
PESTDNFILF DEVSPTPPIT VTHKPEEDTF GVSIAVGLAA FACVLLVVLF
460 470 480 490 500
VMINKYGRRS KFGMKGPVAV ISGEEDSASP LHHINHGITT PSSLDAGPDT
510 520 530 540 550
VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL KRELGEGAFG
560 570 580 590 600
KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI
610 620 630 640 650
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE
660 670 680 690 700
LGLSQMLHIA SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM
710 720 730 740 750
SRDVYSTDYY RLFNPSGNDF CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE
760 770 780 790 800
SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI ECITQGRVLE RPRVCPKEVY
810 820 830
DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG
Length:839
Mass (Da):94,428
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FE8846830083C08
GO
Isoform 2 (identifier: Q16288-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     529-612: YVQHIKRRDI...FYGVCGDGDP → WVFSNIDNHG...VYFSKGRHGF
     613-839: Missing.

Show »
Length:612
Mass (Da):68,452
Checksum:iF2E84DC71B8E4DB3
GO
Isoform 3 (identifier: Q16288-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     712-725: Missing.

Show »
Length:825
Mass (Da):92,801
Checksum:i7ADBE1AF6DB280BF
GO
Isoform 4 (identifier: Q16288-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V

Show »
Length:831
Mass (Da):93,460
Checksum:i4823FA200F88433F
GO
Isoform 5 (identifier: Q16288-5) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     402-410: ESTDNFILF → V
     712-725: Missing.

Note: No experimental confirmation.
Show »
Length:817
Mass (Da):91,833
Checksum:i674CC49828F86789
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM90H0YM90_HUMAN
Tyrosine-protein kinase receptor
NTRK3
705Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFP6A0A0D9SFP6_HUMAN
Tyrosine-protein kinase receptor
NTRK3
864Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z7U4B7Z7U4_HUMAN
Tyrosine-protein kinase receptor
NTRK3
617Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMR8R4GMR8_HUMAN
NT-3 growth factor receptor
NTRK3
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN40R4GN40_HUMAN
NT-3 growth factor receptor
NTRK3
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX31A0A087WX31_HUMAN
NT-3 growth factor receptor
NTRK3
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNH5R4GNH5_HUMAN
NT-3 growth factor receptor
NTRK3
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65S → G in BAH12511 (PubMed:14702039).Curated1
Sequence conflicti70S → N in AAB33111 (PubMed:7823156).Curated1
Sequence conflicti70S → N in AAB33112 (PubMed:7823156).Curated1
Sequence conflicti635D → N in AAA75374 (PubMed:7806211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07460121V → F Rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs200822610Ensembl.1
Natural variantiVAR_07460271I → V Found in patients with CHD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200923715Ensembl.1
Natural variantiVAR_07460393T → M Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; significantly reduced autophosphorylation; decreased NTRK3 signaling associated with decreased apoptosis in absence of NTF3. 1 PublicationCorresponds to variant dbSNP:rs147992979Ensembl.1
Natural variantiVAR_041471149T → R in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs368222977Ensembl.1
Natural variantiVAR_074604163N → I Found in patients with CHD; unknown pathological significance; no change in autophosphorylation; no effect on NTRK3 signaling. 1 PublicationCorresponds to variant dbSNP:rs547862658Ensembl.1
Natural variantiVAR_041472306R → C1 PublicationCorresponds to variant dbSNP:rs56386352Ensembl.1
Natural variantiVAR_041473307V → L in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1388363572Ensembl.1
Natural variantiVAR_041474336L → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_074605533I → F Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; no change in autophosphorylation; changed NTRK3 signaling with decreased apoptosis in absence of NTF3. 1 PublicationCorresponds to variant dbSNP:rs869112057Ensembl.1
Natural variantiVAR_046521664A → S in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041475677H → Y in a lung adenocarcinoma sample; somatic mutation. 2 Publications1
Natural variantiVAR_041476678R → Q1 PublicationCorresponds to variant dbSNP:rs55890138Ensembl.1
Natural variantiVAR_046770735R → F in a lung large cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions. 1
Natural variantiVAR_046522736W → C in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046523745R → P in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046524766Y → F in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046771768K → R1 PublicationCorresponds to variant dbSNP:rs55770052Ensembl.1
Natural variantiVAR_046772781E → K1 PublicationCorresponds to variant dbSNP:rs56393451Ensembl.1
Natural variantiVAR_074606817I → M Probable disease-associated mutation found in patients with CHD; associated with CHD susceptibility; no change in autophosphorylation; changed NTRK3 signaling with decreased apoptosis in absence of NTF3. 1 PublicationCorresponds to variant dbSNP:rs869209165Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002924402 – 410ESTDNFILF → V in isoform 4 and isoform 5. 1 Publication9
Alternative sequenceiVSP_002925529 – 612YVQHI…GDGDP → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGEVS YPRSHGFREIMLNPISLPGH SKPLNHGIYVEDVNVYFSKG RHGF in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_002926613 – 839Missing in isoform 2. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_002927712 – 725Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U05012 mRNA Translation: AAA75374.1
S76475 mRNA Translation: AAB33111.1
S76476 mRNA Translation: AAB33112.1
AJ224521
, AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA Translation: CAA12029.1
AK297160 mRNA Translation: BAH12511.1
AC009711 Genomic DNA No translation available.
AC011966 Genomic DNA No translation available.
AC021677 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10340.1 [Q16288-3]
CCDS32322.1 [Q16288-1]
CCDS32323.1 [Q16288-2]
CCDS58399.1 [Q16288-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A55178
I73632
I73633

NCBI Reference Sequences

More...
RefSeqi
NP_001012338.1, NM_001012338.2 [Q16288-1]
NP_001307063.1, NM_001320134.1
NP_001307064.1, NM_001320135.1
NP_002521.2, NM_002530.3 [Q16288-3]
XP_016877742.1, XM_017022253.1 [Q16288-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317501; ENSP00000318328; ENSG00000140538 [Q16288-2]
ENST00000355254; ENSP00000347397; ENSG00000140538 [Q16288-5]
ENST00000357724; ENSP00000350356; ENSG00000140538 [Q16288-4]
ENST00000360948; ENSP00000354207; ENSG00000140538 [Q16288-1]
ENST00000394480; ENSP00000377990; ENSG00000140538 [Q16288-3]
ENST00000540489; ENSP00000444673; ENSG00000140538 [Q16288-2]
ENST00000557856; ENSP00000453959; ENSG00000140538 [Q16288-5]
ENST00000629765; ENSP00000485864; ENSG00000140538 [Q16288-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4916

UCSC genome browser

More...
UCSCi
uc059mwc.1 human [Q16288-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05012 mRNA Translation: AAA75374.1
S76475 mRNA Translation: AAB33111.1
S76476 mRNA Translation: AAB33112.1
AJ224521
, AJ224522, AJ224523, AJ224524, AJ224525, AJ224526, AJ224527, AJ224528, AJ224529, AJ224530, AJ224531, AJ224532, AJ224533, AJ224534, AJ224535 Genomic DNA Translation: CAA12029.1
AK297160 mRNA Translation: BAH12511.1
AC009711 Genomic DNA No translation available.
AC011966 Genomic DNA No translation available.
AC021677 Genomic DNA No translation available.
CCDSiCCDS10340.1 [Q16288-3]
CCDS32322.1 [Q16288-1]
CCDS32323.1 [Q16288-2]
CCDS58399.1 [Q16288-5]
PIRiA55178
I73632
I73633
RefSeqiNP_001012338.1, NM_001012338.2 [Q16288-1]
NP_001307063.1, NM_001320134.1
NP_001307064.1, NM_001320135.1
NP_002521.2, NM_002530.3 [Q16288-3]
XP_016877742.1, XM_017022253.1 [Q16288-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWCX-ray1.90A297-422[»]
3V5QX-ray2.20A/B530-832[»]
4YMJX-ray2.00A/B530-839[»]
SMRiQ16288
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110971, 46 interactors
DIPiDIP-5723N
IntActiQ16288, 35 interactors
MINTiQ16288
STRINGi9606.ENSP00000354207

Chemistry databases

BindingDBiQ16288
ChEMBLiCHEMBL5608
DrugBankiDB12010 Fostamatinib
DB14723 Larotrectinib
DrugCentraliQ16288
GuidetoPHARMACOLOGYi1819

PTM databases

iPTMnetiQ16288
PhosphoSitePlusiQ16288

Polymorphism and mutation databases

BioMutaiNTRK3
DMDMi134035335

Proteomic databases

MassIVEiQ16288
PaxDbiQ16288
PeptideAtlasiQ16288
PRIDEiQ16288
ProteomicsDBi20249
40524
60850 [Q16288-1]
60851 [Q16288-2]
60852 [Q16288-3]
60853 [Q16288-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q16288

The DNASU plasmid repository

More...
DNASUi
4916

Genome annotation databases

EnsembliENST00000317501; ENSP00000318328; ENSG00000140538 [Q16288-2]
ENST00000355254; ENSP00000347397; ENSG00000140538 [Q16288-5]
ENST00000357724; ENSP00000350356; ENSG00000140538 [Q16288-4]
ENST00000360948; ENSP00000354207; ENSG00000140538 [Q16288-1]
ENST00000394480; ENSP00000377990; ENSG00000140538 [Q16288-3]
ENST00000540489; ENSP00000444673; ENSG00000140538 [Q16288-2]
ENST00000557856; ENSP00000453959; ENSG00000140538 [Q16288-5]
ENST00000629765; ENSP00000485864; ENSG00000140538 [Q16288-1]
GeneIDi4916
KEGGihsa:4916
UCSCiuc059mwc.1 human [Q16288-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4916
DisGeNETi4916

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NTRK3
HGNCiHGNC:8033 NTRK3
HPAiCAB009233
HPA027484
HPA048065
MalaCardsiNTRK3
MIMi191316 gene
neXtProtiNX_Q16288
OpenTargetsiENSG00000140538
Orphaneti2665 Congenital mesoblastic nephroma
146 Differentiated thyroid carcinoma
2030 Fibrosarcoma
PharmGKBiPA31819

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00940000155645
HOGENOMiHOG000264255
InParanoidiQ16288
KOiK05101
OrthoDBi754662at2759
PhylomeDBiQ16288
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
R-HSA-9603505 NTRK3 as a dependence receptor
SignaLinkiQ16288
SIGNORiQ16288

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NTRK3 human
EvolutionaryTraceiQ16288

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TrkC_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4916
PharosiQ16288

Protein Ontology

More...
PROi
PR:Q16288

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140538 Expressed in 199 organ(s), highest expression level in primary visual cortex
ExpressionAtlasiQ16288 baseline and differential
GenevisibleiQ16288 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020446 Tyr_kin_neurotrophic_rcpt_3
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01942 NTKRECEPTOR3
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTRK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16288
Secondary accession number(s): B7Z4C5
, E9PG56, H0YND1, O75682, Q12827, Q16289
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: October 16, 2019
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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