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Protein

Insulin-like growth factor-binding protein 7

Gene

IGFBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
IGFBP-rP1
MAC25 protein
PGI2-stimulating factor
Prostacyclin-stimulating factor
Tumor-derived adhesion factor
Short name:
TAF
Gene namesi
Name:IGFBP7
Synonyms:MAC25, PSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163453.11
HGNCiHGNC:5476 IGFBP7
MIMi602867 gene
neXtProtiNX_Q16270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
See also OMIM:614224

Organism-specific databases

DisGeNETi3490
MalaCardsiIGFBP7
MIMi614224 phenotype
OpenTargetsiENSG00000163453
Orphaneti284247 Familial retinal arterial macroaneurysm
PharmGKBiPA29709

Chemistry databases

DrugBankiDB00030 Insulin Human
DB00071 Insulin Pork

Polymorphism and mutation databases

BioMutaiIGFBP7
DMDMi23396609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000001439227 – 282Insulin-like growth factor-binding protein 7Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 156PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi181 ↔ 248PROSITE-ProRule annotation
Modified residuei239Phosphoserine; by FAM20C1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ16270
MaxQBiQ16270
PaxDbiQ16270
PeptideAtlasiQ16270
PRIDEiQ16270
ProteomicsDBi60846

PTM databases

iPTMnetiQ16270
PhosphoSitePlusiQ16270

Expressioni

Gene expression databases

BgeeiENSG00000163453
CleanExiHS_IGFBP7
GenevisibleiQ16270 HS

Organism-specific databases

HPAiCAB020668
HPA002196

Interactioni

Subunit structurei

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109711, 10 interactors
IntActiQ16270, 9 interactors
MINTiQ16270
STRINGi9606.ENSP00000295666

Structurei

3D structure databases

ProteinModelPortaliQ16270
SMRiQ16270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 106IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST79
Domaini105 – 158Kazal-likePROSITE-ProRule annotationAdd BLAST54
Domaini160 – 264Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVG7 Eukaryota
ENOG4111RFI LUCA
GeneTreeiENSGT00530000063555
HOGENOMiHOG000261684
HOVERGENiHBG031621
InParanoidiQ16270
OMAiHCAPGME
OrthoDBiEOG091G0QK5
PhylomeDBiQ16270
TreeFamiTF331645

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 2 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16270-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL
60 70 80 90 100
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA
110 120 130 140 150
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ
160 170 180 190 200
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH
210 220 230 240 250
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA
260 270 280
SNSQGQASAS AKITVVDALH EIPVKKGEGA EL
Length:282
Mass (Da):29,130
Last modified:November 1, 1996 - v1
Checksum:i75F96EBC3B444D37
GO
Isoform 2 (identifier: Q16270-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-282: EGAEL → TQ

Show »
Length:279
Mass (Da):28,860
Checksum:i3281F44D371F721E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → A in AAA16187 (PubMed:7694637).Curated1
Sequence conflicti13A → P in AAA16187 (PubMed:7694637).Curated1
Sequence conflicti69E → G in BAH14453 (PubMed:14702039).Curated1
Sequence conflicti273 – 282PVKKGEGAEL → ASEKR in AAA16187 (PubMed:7694637).Curated10

RNA editingi

Edited at positions 78 and 95.1 Publication
Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01895911L → F2 PublicationsCorresponds to variant dbSNP:rs11573021Ensembl.1
Natural variantiVAR_06363878R → G in RNA edited version. Corresponds to variant dbSNP:rs11555284Ensembl.1
Natural variantiVAR_06363995K → R in RNA edited version. Corresponds to variant dbSNP:rs1133243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045297278 – 282EGAEL → TQ in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19182 mRNA Translation: AAA16187.1
S75725 mRNA Translation: AAB32370.1
AY518539 Genomic DNA Translation: AAR89912.1
BT006654 mRNA Translation: AAP35300.1
AK303915 mRNA Translation: BAG64844.1
AK316082 mRNA Translation: BAH14453.1
AC069307 Genomic DNA No translation available.
AC111197 Genomic DNA No translation available.
BC017201 mRNA Translation: AAH17201.1
BC066339 mRNA Translation: AAH66339.1
CCDSiCCDS3512.1 [Q16270-1]
CCDS58900.1 [Q16270-2]
PIRiI52825
PC2030
S50031
RefSeqiNP_001240764.1, NM_001253835.1 [Q16270-2]
NP_001544.1, NM_001553.2 [Q16270-1]
UniGeneiHs.479808
Hs.691061

Genome annotation databases

EnsembliENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1]
ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2]
GeneIDi3490
KEGGihsa:3490
UCSCiuc003hcn.4 human [Q16270-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Similar proteinsi

Entry informationi

Entry nameiIBP7_HUMAN
AccessioniPrimary (citable) accession number: Q16270
Secondary accession number(s): B4E1N2
, B7Z9W7, Q07822, Q53YE6, Q9UCA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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