Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q16270 (IBP7_HUMAN)

Entry version 180 (05 Jun 2019)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Insulin-like growth factor-binding protein 7

Gene

IGFBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
IGFBP-rP1
MAC25 protein
PGI2-stimulating factor
Prostacyclin-stimulating factor
Tumor-derived adhesion factor
Short name:
TAF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGFBP7
Synonyms:MAC25, PSF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5476 IGFBP7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602867 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		3490

MalaCards human disease database

More...MalaCardsi		IGFBP7
MIMi614224 phenotype

Open Targets

More...OpenTargetsi		ENSG00000163453

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		284247 Familial retinal arterial macroaneurysm

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29709

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00030 Insulin Human
DB00071 Insulin Pork

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IGFBP7

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 263 PublicationsAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001439227 – 282Insulin-like growth factor-binding protein 7Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 156PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi171N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi181 ↔ 248PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei239Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16270

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16270

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16270

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16270

PeptideAtlas

More...PeptideAtlasi		Q16270

PRoteomics IDEntifications database

More...PRIDEi		Q16270

ProteomicsDB human proteome resource

More...ProteomicsDBi		60846

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16270

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16270

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163453 Expressed in 244 organ(s), highest expression level in blood vessel layer

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16270 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB020668
HPA002196

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109711, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q16270, 10 interactors

Molecular INTeraction database

More...MINTi		Q16270

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295666

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16270

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 106IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST79
Domaini105 – 158Kazal-likePROSITE-ProRule annotationAdd BLAST54
Domaini160 – 264Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IVG7 Eukaryota
ENOG4111RFI LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063555

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000261684

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16270

Identification of Orthologs from Complete Genome Data

More...OMAi		TPVLTWK

Database of Orthologous Groups

More...OrthoDBi		994901at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16270

TreeFam database of animal gene trees

More...TreeFami		TF331645

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14186 PTHR14186, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679 I-set, 1 hit
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF018239 IGFBP_rP_mac25, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00280 KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16270-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL 
        60         70         80         90        100
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA 
       110        120        130        140        150
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ 
       160        170        180        190        200
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH 
       210        220        230        240        250
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA 
       260        270        280 
SNSQGQASAS AKITVVDALH EIPVKKGEGA EL
Length:282
Mass (Da):29,130
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75F96EBC3B444D37
GO
Isoform 2 (identifier: Q16270-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-282: EGAEL → TQ

Show »
Length:279
Mass (Da):28,860
Checksum:i3281F44D371F721E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4P → A in AAA16187 (PubMed:7694637).Curated1
Sequence conflicti13A → P in AAA16187 (PubMed:7694637).Curated1
Sequence conflicti69E → G in BAH14453 (PubMed:14702039).Curated1
Sequence conflicti273 – 282PVKKGEGAEL → ASEKR in AAA16187 (PubMed:7694637).Curated10

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 78 and 95.1 Publication
Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01895911L → F2 PublicationsCorresponds to variant dbSNP:rs11573021Ensembl.1
Natural variantiVAR_06363878R → G in RNA edited version. Corresponds to variant dbSNP:rs11555284Ensembl.1
Natural variantiVAR_06363995K → R in RNA edited version. Corresponds to variant dbSNP:rs1133243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045297278 – 282EGAEL → TQ in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L19182 mRNA Translation: AAA16187.1
S75725 mRNA Translation: AAB32370.1
AY518539 Genomic DNA Translation: AAR89912.1
BT006654 mRNA Translation: AAP35300.1
AK303915 mRNA Translation: BAG64844.1
AK316082 mRNA Translation: BAH14453.1
AC069307 Genomic DNA No translation available.
AC111197 Genomic DNA No translation available.
BC017201 mRNA Translation: AAH17201.1
BC066339 mRNA Translation: AAH66339.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3512.1 [Q16270-1]
CCDS58900.1 [Q16270-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I52825
PC2030
S50031

NCBI Reference Sequences

More...RefSeqi		NP_001240764.1, NM_001253835.1 [Q16270-2]
NP_001544.1, NM_001553.2 [Q16270-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1]
ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3490

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3490

UCSC genome browser

More...UCSCi		uc003hcn.4 human [Q16270-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19182 mRNA Translation: AAA16187.1
S75725 mRNA Translation: AAB32370.1
AY518539 Genomic DNA Translation: AAR89912.1
BT006654 mRNA Translation: AAP35300.1
AK303915 mRNA Translation: BAG64844.1
AK316082 mRNA Translation: BAH14453.1
AC069307 Genomic DNA No translation available.
AC111197 Genomic DNA No translation available.
BC017201 mRNA Translation: AAH17201.1
BC066339 mRNA Translation: AAH66339.1
CCDSiCCDS3512.1 [Q16270-1]
CCDS58900.1 [Q16270-2]
PIRiI52825
PC2030
S50031
RefSeqiNP_001240764.1, NM_001253835.1 [Q16270-2]
NP_001544.1, NM_001553.2 [Q16270-1]

3D structure databases

SMRiQ16270
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109711, 10 interactors
IntActiQ16270, 10 interactors
MINTiQ16270
STRINGi9606.ENSP00000295666

Chemistry databases

DrugBankiDB00030 Insulin Human
DB00071 Insulin Pork

PTM databases

iPTMnetiQ16270
PhosphoSitePlusiQ16270

Polymorphism and mutation databases

BioMutaiIGFBP7
DMDMi23396609

Proteomic databases

EPDiQ16270
jPOSTiQ16270
MaxQBiQ16270
PaxDbiQ16270
PeptideAtlasiQ16270
PRIDEiQ16270
ProteomicsDBi60846

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3490
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1]
ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2]
GeneIDi3490
KEGGihsa:3490
UCSCiuc003hcn.4 human [Q16270-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3490
DisGeNETi3490

GeneCards: human genes, protein and diseases

More...GeneCardsi		IGFBP7
HGNCiHGNC:5476 IGFBP7
HPAiCAB020668
HPA002196
MalaCardsiIGFBP7
MIMi602867 gene
614224 phenotype
neXtProtiNX_Q16270
OpenTargetsiENSG00000163453
Orphaneti284247 Familial retinal arterial macroaneurysm
PharmGKBiPA29709

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IVG7 Eukaryota
ENOG4111RFI LUCA
GeneTreeiENSGT00530000063555
HOGENOMiHOG000261684
InParanoidiQ16270
OMAiTPVLTWK
OrthoDBi994901at2759
PhylomeDBiQ16270
TreeFamiTF331645

Enzyme and pathway databases

ReactomeiR-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IGFBP7 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IGFBP7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3490

Protein Ontology

More...PROi		PR:Q16270

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163453 Expressed in 244 organ(s), highest expression level in blood vessel layer
GenevisibleiQ16270 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBP7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16270
Secondary accession number(s): B4E1N2
, B7Z9W7, Q07822, Q53YE6, Q9UCA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1996
Last modified: June 5, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again