UniProtKB - Q16270 (IBP7_HUMAN)
Protein
Insulin-like growth factor-binding protein 7
Gene
IGFBP7
Organism
Homo sapiens (Human)
Status
Functioni
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- cellular response to hormone stimulus Source: Ensembl
- embryo implantation Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- post-translational protein modification Source: Reactome
- regulation of cell growth Source: InterPro
- regulation of signal transduction Source: GO_Central
- regulation of steroid biosynthetic process Source: Ensembl
- response to cortisol Source: Ensembl
- response to heat Source: Ensembl
- response to retinoic acid Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q16270 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 7Short name: IBP-7 Short name: IGF-binding protein 7 Short name: IGFBP-7 Alternative name(s): IGFBP-rP1 MAC25 protein PGI2-stimulating factor Prostacyclin-stimulating factor Tumor-derived adhesion factor Short name: TAF |
Gene namesi | Name:IGFBP7 Synonyms:MAC25, PSF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163453.11 |
HGNCi | HGNC:5476, IGFBP7 |
MIMi | 602867, gene |
neXtProti | NX_Q16270 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
Related information in OMIMOrganism-specific databases
DisGeNETi | 3490 |
MalaCardsi | IGFBP7 |
MIMi | 614224, phenotype |
OpenTargetsi | ENSG00000163453 |
Orphaneti | 284247, Familial retinal arterial macroaneurysm |
PharmGKBi | PA29709 |
Miscellaneous databases
Pharosi | Q16270, Tbio |
Chemistry databases
DrugBanki | DB00071, Insulin pork |
Polymorphism and mutation databases
BioMutai | IGFBP7 |
DMDMi | 23396609 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 3 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000014392 | 27 – 282 | Insulin-like growth factor-binding protein 7Add BLAST | 256 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 120 ↔ 156 | PROSITE-ProRule annotation | ||
Glycosylationi | 171 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 181 ↔ 248 | PROSITE-ProRule annotation | ||
Modified residuei | 239 | Phosphoserine; by FAM20C1 Publication | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q16270 |
jPOSTi | Q16270 |
MassIVEi | Q16270 |
MaxQBi | Q16270 |
PaxDbi | Q16270 |
PeptideAtlasi | Q16270 |
PRIDEi | Q16270 |
ProteomicsDBi | 5772 60846 [Q16270-1] |
PTM databases
GlyGeni | Q16270, 4 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q16270 |
PhosphoSitePlusi | Q16270 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163453, Expressed in blood vessel layer and 252 other tissues |
Genevisiblei | Q16270, HS |
Organism-specific databases
HPAi | ENSG00000163453, Low tissue specificity |
Interactioni
Subunit structurei
May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 109711, 11 interactors |
IntActi | Q16270, 11 interactors |
MINTi | Q16270 |
STRINGi | 9606.ENSP00000295666 |
Miscellaneous databases
RNActi | Q16270, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 106 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 105 – 158 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 160 – 264 | Ig-like C2-typeAdd BLAST | 105 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | ENOG502RACD, Eukaryota |
GeneTreei | ENSGT00530000063555 |
InParanoidi | Q16270 |
OMAi | YLSCEAV |
OrthoDBi | 994901at2759 |
PhylomeDBi | Q16270 |
TreeFami | TF331645 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR000867, IGFBP-like IPR011390, IGFBP_rP_mac25 IPR002350, Kazal_dom IPR036058, Kazal_dom_sf |
PANTHERi | PTHR14186, PTHR14186, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF00219, IGFBP, 1 hit PF07648, Kazal_2, 1 hit |
PIRSFi | PIRSF018239, IGFBP_rP_mac25, 1 hit |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00409, IG, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF48726, SSF48726, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51323, IGFBP_N_2, 1 hit PS51465, KAZAL_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q16270-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL
60 70 80 90 100
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA
110 120 130 140 150
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ
160 170 180 190 200
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH
210 220 230 240 250
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA
260 270 280
SNSQGQASAS AKITVVDALH EIPVKKGEGA EL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | P → A in AAA16187 (PubMed:7694637).Curated | 1 | |
Sequence conflicti | 13 | A → P in AAA16187 (PubMed:7694637).Curated | 1 | |
Sequence conflicti | 69 | E → G in BAH14453 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 273 – 282 | PVKKGEGAEL → ASEKR in AAA16187 (PubMed:7694637).Curated | 10 |
RNA editingi
Edited at positions 78 and 95.1 Publication
Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.
Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018959 | 11 | L → F2 PublicationsCorresponds to variant dbSNP:rs11573021Ensembl. | 1 | |
Natural variantiVAR_063638 | 78 | R → G in RNA edited version. Corresponds to variant dbSNP:rs11555284Ensembl. | 1 | |
Natural variantiVAR_063639 | 95 | K → R in RNA edited version. Corresponds to variant dbSNP:rs1133243Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045297 | 278 – 282 | EGAEL → TQ in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19182 mRNA Translation: AAA16187.1 S75725 mRNA Translation: AAB32370.1 AY518539 Genomic DNA Translation: AAR89912.1 BT006654 mRNA Translation: AAP35300.1 AK303915 mRNA Translation: BAG64844.1 AK316082 mRNA Translation: BAH14453.1 AC069307 Genomic DNA No translation available. AC111197 Genomic DNA No translation available. BC017201 mRNA Translation: AAH17201.1 BC066339 mRNA Translation: AAH66339.1 |
CCDSi | CCDS3512.1 [Q16270-1] CCDS58900.1 [Q16270-2] |
PIRi | I52825 PC2030 S50031 |
RefSeqi | NP_001240764.1, NM_001253835.1 [Q16270-2] NP_001544.1, NM_001553.2 [Q16270-1] |
Genome annotation databases
Ensembli | ENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1] ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2] |
GeneIDi | 3490 |
KEGGi | hsa:3490 |
UCSCi | uc003hcn.4, human [Q16270-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Polymorphism, RNA editingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19182 mRNA Translation: AAA16187.1 S75725 mRNA Translation: AAB32370.1 AY518539 Genomic DNA Translation: AAR89912.1 BT006654 mRNA Translation: AAP35300.1 AK303915 mRNA Translation: BAG64844.1 AK316082 mRNA Translation: BAH14453.1 AC069307 Genomic DNA No translation available. AC111197 Genomic DNA No translation available. BC017201 mRNA Translation: AAH17201.1 BC066339 mRNA Translation: AAH66339.1 |
CCDSi | CCDS3512.1 [Q16270-1] CCDS58900.1 [Q16270-2] |
PIRi | I52825 PC2030 S50031 |
RefSeqi | NP_001240764.1, NM_001253835.1 [Q16270-2] NP_001544.1, NM_001553.2 [Q16270-1] |
3D structure databases
SMRi | Q16270 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109711, 11 interactors |
IntActi | Q16270, 11 interactors |
MINTi | Q16270 |
STRINGi | 9606.ENSP00000295666 |
Chemistry databases
DrugBanki | DB00071, Insulin pork |
PTM databases
GlyGeni | Q16270, 4 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q16270 |
PhosphoSitePlusi | Q16270 |
Polymorphism and mutation databases
BioMutai | IGFBP7 |
DMDMi | 23396609 |
Proteomic databases
EPDi | Q16270 |
jPOSTi | Q16270 |
MassIVEi | Q16270 |
MaxQBi | Q16270 |
PaxDbi | Q16270 |
PeptideAtlasi | Q16270 |
PRIDEi | Q16270 |
ProteomicsDBi | 5772 60846 [Q16270-1] |
Protocols and materials databases
Antibodypediai | 997, 520 antibodies |
DNASUi | 3490 |
Genome annotation databases
Ensembli | ENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1] ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2] |
GeneIDi | 3490 |
KEGGi | hsa:3490 |
UCSCi | uc003hcn.4, human [Q16270-1] |
Organism-specific databases
CTDi | 3490 |
DisGeNETi | 3490 |
EuPathDBi | HostDB:ENSG00000163453.11 |
GeneCardsi | IGFBP7 |
HGNCi | HGNC:5476, IGFBP7 |
HPAi | ENSG00000163453, Low tissue specificity |
MalaCardsi | IGFBP7 |
MIMi | 602867, gene 614224, phenotype |
neXtProti | NX_Q16270 |
OpenTargetsi | ENSG00000163453 |
Orphaneti | 284247, Familial retinal arterial macroaneurysm |
PharmGKBi | PA29709 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RACD, Eukaryota |
GeneTreei | ENSGT00530000063555 |
InParanoidi | Q16270 |
OMAi | YLSCEAV |
OrthoDBi | 994901at2759 |
PhylomeDBi | Q16270 |
TreeFami | TF331645 |
Enzyme and pathway databases
PathwayCommonsi | Q16270 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 3490, 3 hits in 846 CRISPR screens |
ChiTaRSi | IGFBP7, human |
GeneWikii | IGFBP7 |
GenomeRNAii | 3490 |
Pharosi | Q16270, Tbio |
PROi | PR:Q16270 |
RNActi | Q16270, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163453, Expressed in blood vessel layer and 252 other tissues |
Genevisiblei | Q16270, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR000867, IGFBP-like IPR011390, IGFBP_rP_mac25 IPR002350, Kazal_dom IPR036058, Kazal_dom_sf |
PANTHERi | PTHR14186, PTHR14186, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF00219, IGFBP, 1 hit PF07648, Kazal_2, 1 hit |
PIRSFi | PIRSF018239, IGFBP_rP_mac25, 1 hit |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00409, IG, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF48726, SSF48726, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51323, IGFBP_N_2, 1 hit PS51465, KAZAL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP7_HUMAN | |
Accessioni | Q16270Primary (citable) accession number: Q16270 Secondary accession number(s): B4E1N2 Q9UCA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations