IGFBP7

Functionⁱ

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.2 Publications

GO - Molecular functionⁱ

extracellular matrix structural constituent
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 20551380
- 27559042
insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 8117260
cellular protein metabolic process Source: Reactome
cellular response to hormone stimulus Source: Ensembl
embryo implantation Source: Ensembl
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8939990
post-translational protein modification Source: Reactome
regulation of cell growth Source: InterPro
regulation of steroid biosynthetic process Source: Ensembl
response to cortisol Source: Ensembl
response to heat Source: Ensembl
response to retinoic acid Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding
Biological process	Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 7 Short name: IBP-7 Short name: IGF-binding protein 7 Short name: IGFBP-7 Alternative name(s): IGFBP-rP1 MAC25 protein PGI2-stimulating factor Prostacyclin-stimulating factor Tumor-derived adhesion factor Short name: TAF
Gene namesⁱ	Name:IGFBP7 Synonyms:MAC25, PSF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163453.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5476 IGFBP7
MIMⁱ	602867 gene
neXtProtⁱ	NX_Q16270

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3490
MalaCards human disease database More...MalaCardsⁱ	IGFBP7
MIMⁱ	614224 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163453
Orphanetⁱ	284247 Familial retinal arterial macroaneurysm
PharmGKBⁱ	PA29709

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00030 Insulin Human DB00071 Insulin Pork

DrugBankⁱ

DB00030 Insulin Human
DB00071 Insulin Pork

Polymorphism and mutation databases

BioMutaⁱ	IGFBP7
DMDMⁱ	23396609

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	3 PublicationsAdd BLAST		26
ChainⁱPRO_0000014392	27 – 282	Insulin-like growth factor-binding protein 7Add BLAST		256

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	120 ↔ 156	PROSITE-ProRule annotation
Glycosylationⁱ	171	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	181 ↔ 248	PROSITE-ProRule annotation
Modified residueⁱ	239	Phosphoserine; by FAM20C1 Publication	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q16270
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16270
PaxDbⁱ	Q16270
PeptideAtlas More...PeptideAtlasⁱ	Q16270
PRIDEⁱ	Q16270
ProteomicsDBⁱ	60846

PTM databases

iPTMnetⁱ	Q16270
PhosphoSitePlusⁱ	Q16270

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163453 Expressed in 244 organ(s), highest expression level in blood vessel layer
CleanExⁱ	HS_IGFBP7
Genevisibleⁱ	Q16270 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020668 HPA002196

HPAⁱ

CAB020668
HPA002196

Interactionⁱ

Subunit structureⁱ

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109711, 10 interactors
IntActⁱ	Q16270, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q16270
STRINGⁱ	9606.ENSP00000295666

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16270
SMRⁱ	Q16270
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 106	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	105 – 158	Kazal-likePROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	160 – 264	Ig-like C2-typeAdd BLAST	105

Keywords - Domainⁱ

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVG7 Eukaryota ENOG4111RFI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063555
HOGENOMⁱ	HOG000261684
HOVERGENⁱ	HBG031621
InParanoidⁱ	Q16270
OMAⁱ	HCAPGME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QK5
PhylomeDBⁱ	Q16270
TreeFamⁱ	TF331645

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR000867 IGFBP-like IPR011390 IGFBP_rP_mac25 IPR002350 Kazal_dom IPR036058 Kazal_dom_sf
PANTHERⁱ	PTHR14186 PTHR14186, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF07648 Kazal_2, 1 hit
PIRSFⁱ	PIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00409 IG, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF48726 SSF48726, 2 hits SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51323 IGFBP_N_2, 1 hit PS51465 KAZAL_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q16270-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL 
        60         70         80         90        100
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA 
       110        120        130        140        150
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ 
       160        170        180        190        200
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH 
       210        220        230        240        250
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA 
       260        270        280 
SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

Length:282

Mass (Da):29,130

Last modified:November 1, 1996 - v1

Checksum:ⁱ75F96EBC3B444D37

GO

Isoform 2 (identifier: Q16270-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-282: EGAEL → TQ

« Hide

        10         20         30         40         50
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL 
        60         70         80         90        100
GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA 
       110        120        130        140        150
AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ 
       160        170        180        190        200
VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH 
       210        220        230        240        250
YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA 
       260        270 
SNSQGQASAS AKITVVDALH EIPVKKGTQ

Show »

Length:279

Mass (Da):28,860

Checksum:ⁱ3281F44D371F721E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	P → A in AAA16187 (PubMed:7694637).Curated	1
Sequence conflictⁱ	13	A → P in AAA16187 (PubMed:7694637).Curated	1
Sequence conflictⁱ	69	E → G in BAH14453 (PubMed:14702039).Curated	1
Sequence conflictⁱ	273 – 282	PVKKGEGAEL → ASEKR in AAA16187 (PubMed:7694637).Curated	10

RNA editingⁱ

Edited at positions 78 and 95.1 Publication
Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018959	11	L → F2 PublicationsCorresponds to variant dbSNP:rs11573021Ensembl.	1
Natural variantⁱVAR_063638	78	R → G in RNA edited version. Corresponds to variant dbSNP:rs11555284Ensembl.	1
Natural variantⁱVAR_063639	95	K → R in RNA edited version. Corresponds to variant dbSNP:rs1133243Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045297	278 – 282	EGAEL → TQ in isoform 2. 1 Publication		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19182 mRNA Translation: AAA16187.1 S75725 mRNA Translation: AAB32370.1 AY518539 Genomic DNA Translation: AAR89912.1 BT006654 mRNA Translation: AAP35300.1 AK303915 mRNA Translation: BAG64844.1 AK316082 mRNA Translation: BAH14453.1 AC069307 Genomic DNA No translation available. AC111197 Genomic DNA No translation available. BC017201 mRNA Translation: AAH17201.1 BC066339 mRNA Translation: AAH66339.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3512.1 [Q16270-1] CCDS58900.1 [Q16270-2]
PIRⁱ	I52825 PC2030 S50031
NCBI Reference Sequences More...RefSeqⁱ	NP_001240764.1, NM_001253835.1 [Q16270-2] NP_001544.1, NM_001553.2 [Q16270-1]
UniGeneⁱ	Hs.479808 Hs.691061

Genome annotation databases

Ensemblⁱ	ENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1] ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2]
GeneIDⁱ	3490
KEGGⁱ	hsa:3490
UCSC genome browser More...UCSCⁱ	uc003hcn.4 human [Q16270-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism, RNA editing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16270	IGFBP7 isoform 1		PANTR		282	UniRef100_Q16270
Insulin like growth factor binding protein 7		GORGO		282
Q16270-2	IGFBP7 isoform 3		PANTR		279	UniRef100_A0A2J8PEW1

Protein	Similar proteins		Species	Score	Length	Source
Q16270	IGFBP7 isoform 1		PANTR		282	UniRef90_Q16270
Insulin like growth factor binding protein 7		GORGO		282
Uncharacterized protein		MONDO		287
Insulin like growth factor binding protein 7		SARHA		284
Uncharacterized protein		NOMLE		284
+15
Q16270-2	Insulin like growth factor binding protein 7		CANLF		282	UniRef90_E2RNL2
Uncharacterized protein		CAVPO		296
Insulin-like growth factor-binding protein 7 isoform 1		HETGA		287
Insulin like growth factor binding protein 7		LOXAF		283
Uncharacterized protein		PROCO		282
+28

Protein	Similar proteins		Species	Score	Length	Source
Q16270	IGFBP7 isoform 1		PANTR		282	UniRef50_Q16270
Insulin like growth factor binding protein 7		GORGO		282
Uncharacterized protein		MONDO		287
Uncharacterized protein		NOMLE		284
Insulin like growth factor binding protein 7		SARHA		284
+101
Q16270-2	Insulin-like growth factor-binding protein 7		MOUSE		281	UniRef50_Q61581
Insulin-like growth factor binding protein 7		RAT		281
insulin-like growth factor-binding protein 7		Yangtze finless porpoise		279
Insulin like growth factor binding protein 7		AILME		216
Uncharacterized protein		COLAP		251
+57

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19182 mRNA Translation: AAA16187.1 S75725 mRNA Translation: AAB32370.1 AY518539 Genomic DNA Translation: AAR89912.1 BT006654 mRNA Translation: AAP35300.1 AK303915 mRNA Translation: BAG64844.1 AK316082 mRNA Translation: BAH14453.1 AC069307 Genomic DNA No translation available. AC111197 Genomic DNA No translation available. BC017201 mRNA Translation: AAH17201.1 BC066339 mRNA Translation: AAH66339.1
CCDSⁱ	CCDS3512.1 [Q16270-1] CCDS58900.1 [Q16270-2]
PIRⁱ	I52825 PC2030 S50031
RefSeqⁱ	NP_001240764.1, NM_001253835.1 [Q16270-2] NP_001544.1, NM_001553.2 [Q16270-1]
UniGeneⁱ	Hs.479808 Hs.691061

3D structure databases

ProteinModelPortalⁱ	Q16270
SMRⁱ	Q16270
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109711, 10 interactors
IntActⁱ	Q16270, 9 interactors
MINTⁱ	Q16270
STRINGⁱ	9606.ENSP00000295666

Chemistry databases

DrugBankⁱ	DB00030 Insulin Human DB00071 Insulin Pork

DrugBankⁱ

DB00030 Insulin Human
DB00071 Insulin Pork

PTM databases

iPTMnetⁱ	Q16270
PhosphoSitePlusⁱ	Q16270

Polymorphism and mutation databases

BioMutaⁱ	IGFBP7
DMDMⁱ	23396609

Proteomic databases

EPDⁱ	Q16270
MaxQBⁱ	Q16270
PaxDbⁱ	Q16270
PeptideAtlasⁱ	Q16270
PRIDEⁱ	Q16270
ProteomicsDBⁱ	60846

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3490
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295666; ENSP00000295666; ENSG00000163453 [Q16270-1] ENST00000514062; ENSP00000486293; ENSG00000163453 [Q16270-2]
GeneIDⁱ	3490
KEGGⁱ	hsa:3490
UCSCⁱ	uc003hcn.4 human [Q16270-1]

Organism-specific databases

CTDⁱ	3490
DisGeNETⁱ	3490
EuPathDBⁱ	HostDB:ENSG00000163453.11
GeneCardsⁱ	IGFBP7
HGNCⁱ	HGNC:5476 IGFBP7
HPAⁱ	CAB020668 HPA002196
MalaCardsⁱ	IGFBP7
MIMⁱ	602867 gene 614224 phenotype
neXtProtⁱ	NX_Q16270
OpenTargetsⁱ	ENSG00000163453
Orphanetⁱ	284247 Familial retinal arterial macroaneurysm
PharmGKBⁱ	PA29709
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVG7 Eukaryota ENOG4111RFI LUCA
GeneTreeⁱ	ENSGT00530000063555
HOGENOMⁱ	HOG000261684
HOVERGENⁱ	HBG031621
InParanoidⁱ	Q16270
OMAⁱ	HCAPGME
OrthoDBⁱ	EOG091G0QK5
PhylomeDBⁱ	Q16270
TreeFamⁱ	TF331645

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSⁱ	IGFBP7 human
GeneWikiⁱ	IGFBP7
GenomeRNAiⁱ	3490
Protein Ontology More...PROⁱ	PR:Q16270
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163453 Expressed in 244 organ(s), highest expression level in blood vessel layer
CleanExⁱ	HS_IGFBP7
Genevisibleⁱ	Q16270 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR000867 IGFBP-like IPR011390 IGFBP_rP_mac25 IPR002350 Kazal_dom IPR036058 Kazal_dom_sf
PANTHERⁱ	PTHR14186 PTHR14186, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF07648 Kazal_2, 1 hit
PIRSFⁱ	PIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00409 IG, 1 hit SM00280 KAZAL, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF48726 SSF48726, 2 hits SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51323 IGFBP_N_2, 1 hit PS51465 KAZAL_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP7_HUMAN
Accessionⁱ	Q16270Primary (citable) accession number: Q16270 Secondary accession number(s): B4E1N2 , B7Z9W7, Q07822, Q53YE6, Q9UCA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - Q16270 (IBP7_HUMAN)

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Insulin-like growth factor-binding protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ