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Protein

Nuclear factor erythroid 2-related factor 2

Gene

NFE2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q16236

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 2
Short name:
NF-E2-related factor 2
Short name:
NFE2-related factor 2
Alternative name(s):
HEBP1
Nuclear factor, erythroid derived 2, like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFE2L2
Synonyms:NRF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000116044.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7782 NFE2L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600492 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16236

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency, developmental delay, and hypohomocysteinemia (IMDDHH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early onset multisystem disorder characterized by immunodeficiency, recurrent infections, developmental delay, poor growth, intellectual disability, and hypohomocysteinemia. Some patients manifest congenital cardiac defects. IMDDHH inheritance pattern is autosomal dominant.
See also OMIM:617744
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08049231G → R in IMDDHH. 1 Publication1
Natural variantiVAR_08049379E → K in IMDDHH. 1 Publication1
Natural variantiVAR_08049480T → K in IMDDHH; increased protein abundance; increased positive regulation of transcription of target genes; changed cell redox homeostasis. 1 Publication1
Natural variantiVAR_08049581G → S in IMDDHH. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi80T → A: Loss of interaction with KEAP1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4780

MalaCards human disease database

More...
MalaCardsi
NFE2L2
MIMi617744 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116044

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31588

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075094

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFE2L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25453452

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764491 – 605Nuclear factor erythroid 2-related factor 2Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40Phosphoserine; by PKCBy similarity1
Modified residuei215PhosphoserineCombined sources1
Modified residuei596N6-acetyllysine; by CREBBP1 Publication1
Modified residuei599N6-acetyllysine; by CREBBP1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.By similarity
Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.1 Publication
Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16236

MaxQB - The MaxQuant DataBase

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MaxQBi
Q16236

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16236

PeptideAtlas

More...
PeptideAtlasi
Q16236

PRoteomics IDEntifications database

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PRIDEi
Q16236

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60843
60844 [Q16236-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16236

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16236

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q16236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by ENC1 via a proteasomal ubiquitin-independent protein catabolic process.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116044 Expressed in 244 organ(s), highest expression level in epithelium of nasopharynx

CleanEx database of gene expression profiles

More...
CleanExi
HS_NFE2L2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16236 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16236 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020317
HPA002990
HPA043438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. Interacts with EEF1D at heat shock promoter elements (HSE). Interacts (via the bZIP domain) with MAFK; required for binding to antioxidant response (ARE) elements on DNA. Interacts with CHD6; involved in activation of the transcription. Interacts with ESRRB; represses NFE2L2 transcriptional activity (By similarity).By similarity4 Publications
(Microbial infection) Interacts with herpes virus 8 protein LANA1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110852, 72 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q16236

Database of interacting proteins

More...
DIPi
DIP-29971N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q16236

Protein interaction database and analysis system

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IntActi
Q16236, 27 interactors

Molecular INTeraction database

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MINTi
Q16236

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380252

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16236

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1605
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16236

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16236

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16236

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini497 – 560bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni499 – 518Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni522 – 529Leucine-zipperPROSITE-ProRule annotation8
Regioni591 – 596Mediates interaction with CHD6 and is necessary to activate transcriptionBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISV3 Eukaryota
ENOG41100FB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153355

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234410

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052609

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16236

KEGG Orthology (KO)

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KOi
K05638

Identification of Orthologs from Complete Genome Data

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OMAi
NGPKTQP

Database of Orthologous Groups

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OrthoDBi
EOG091G02EB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16236

TreeFam database of animal gene trees

More...
TreeFami
TF326681

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029845 Nrf2
IPR008917 TF_DNA-bd_sf

The PANTHER Classification System

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PANTHERi
PTHR24411:SF3 PTHR24411:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03131 bZIP_Maf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47454 SSF47454, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16236-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK
60 70 80 90 100
QKKLEKERQE QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA
110 120 130 140 150
NYSQVAHIPK SDALYFDDCM QLLAQTFPFV DDNEVSSATF QSLVPDIPGH
160 170 180 190 200
IESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL
210 220 230 240 250
NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG NCSPHFLNAF
260 270 280 290 300
EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP
310 320 330 340 350
SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT
360 370 380 390 400
SPSVASPEHS VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS
410 420 430 440 450
GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTP FTKDKHSSRL
460 470 480 490 500
EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD
510 520 530 540 550
IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL
560 570 580 590 600
HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP

DVKKN
Length:605
Mass (Da):67,827
Last modified:November 25, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99FAFD811B6C1416
GO
Isoform 2 (identifier: Q16236-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:589
Mass (Da):66,076
Checksum:iC0154E60AC7C138C
GO
Isoform 3 (identifier: Q16236-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     135-141: Missing.

Note: No experimental confirmation available.
Show »
Length:582
Mass (Da):65,356
Checksum:i8C560533CEB5E2F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBM0C9JBM0_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
265Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1A8C9J1A8_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Y1C9J0Y1_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIW5K7EIW5_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
265Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFL6C9JFL6_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER33K7ER33_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3K4C9J3K4_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C498H7C498_HUMAN
Nuclear factor erythroid 2-related ...
NFE2L2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB32188 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92023 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72A → T in AAB32188 (PubMed:7937919).Curated1
Sequence conflicti92I → T in AAB32188 (PubMed:7937919).Curated1
Sequence conflicti178D → Y in AL135266 (PubMed:15815621).Curated1
Sequence conflicti521N → D in BAG65350 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08049231G → R in IMDDHH. 1 Publication1
Natural variantiVAR_03211043R → Q. Corresponds to variant dbSNP:rs35248500EnsemblClinVar.1
Natural variantiVAR_08049379E → K in IMDDHH. 1 Publication1
Natural variantiVAR_08049480T → K in IMDDHH; increased protein abundance; increased positive regulation of transcription of target genes; changed cell redox homeostasis. 1 Publication1
Natural variantiVAR_08049581G → S in IMDDHH. 1 Publication1
Natural variantiVAR_02032299S → P. Corresponds to variant dbSNP:rs5031039Ensembl.1
Natural variantiVAR_032111268V → M. Corresponds to variant dbSNP:rs34154613EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0250451 – 16Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_046168135 – 141Missing in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK304555 mRNA Translation: BAG65350.1
AK314816 mRNA Translation: BAG37339.1
AB208786 mRNA Translation: BAD92023.1 Different initiation.
AC019080 Genomic DNA No translation available.
AC079305 Genomic DNA Translation: AAY14710.1
CH471058 Genomic DNA Translation: EAX11062.1
BC011558 mRNA Translation: AAH11558.1
AL135266 mRNA No translation available.
S74017 mRNA Translation: AAB32188.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42782.1 [Q16236-1]
CCDS46457.1 [Q16236-2]
CCDS46458.1 [Q16236-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001138884.1, NM_001145412.3 [Q16236-2]
NP_001138885.1, NM_001145413.3 [Q16236-3]
NP_001300829.1, NM_001313900.1 [Q16236-2]
NP_001300830.1, NM_001313901.1 [Q16236-2]
NP_006155.2, NM_006164.4 [Q16236-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744006

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397062; ENSP00000380252; ENSG00000116044 [Q16236-1]
ENST00000397063; ENSP00000380253; ENSG00000116044 [Q16236-2]
ENST00000446151; ENSP00000411575; ENSG00000116044 [Q16236-3]
ENST00000464747; ENSP00000467401; ENSG00000116044 [Q16236-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4780

UCSC genome browser

More...
UCSCi
uc002ulg.6 human [Q16236-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304555 mRNA Translation: BAG65350.1
AK314816 mRNA Translation: BAG37339.1
AB208786 mRNA Translation: BAD92023.1 Different initiation.
AC019080 Genomic DNA No translation available.
AC079305 Genomic DNA Translation: AAY14710.1
CH471058 Genomic DNA Translation: EAX11062.1
BC011558 mRNA Translation: AAH11558.1
AL135266 mRNA No translation available.
S74017 mRNA Translation: AAB32188.1 Different initiation.
CCDSiCCDS42782.1 [Q16236-1]
CCDS46457.1 [Q16236-2]
CCDS46458.1 [Q16236-3]
RefSeqiNP_001138884.1, NM_001145412.3 [Q16236-2]
NP_001138885.1, NM_001145413.3 [Q16236-3]
NP_001300829.1, NM_001313900.1 [Q16236-2]
NP_001300830.1, NM_001313901.1 [Q16236-2]
NP_006155.2, NM_006164.4 [Q16236-1]
UniGeneiHs.744006

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FLUX-ray1.50P69-84[»]
2LZ1NMR-A445-523[»]
3ZGCX-ray2.20C76-82[»]
4IFLX-ray1.80P69-84[»]
ProteinModelPortaliQ16236
SMRiQ16236
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110852, 72 interactors
CORUMiQ16236
DIPiDIP-29971N
ELMiQ16236
IntActiQ16236, 27 interactors
MINTiQ16236
STRINGi9606.ENSP00000380252

Chemistry databases

BindingDBiQ16236
ChEMBLiCHEMBL1075094

PTM databases

iPTMnetiQ16236
PhosphoSitePlusiQ16236

Polymorphism and mutation databases

BioMutaiNFE2L2
DMDMi25453452

Proteomic databases

EPDiQ16236
MaxQBiQ16236
PaxDbiQ16236
PeptideAtlasiQ16236
PRIDEiQ16236
ProteomicsDBi60843
60844 [Q16236-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397062; ENSP00000380252; ENSG00000116044 [Q16236-1]
ENST00000397063; ENSP00000380253; ENSG00000116044 [Q16236-2]
ENST00000446151; ENSP00000411575; ENSG00000116044 [Q16236-3]
ENST00000464747; ENSP00000467401; ENSG00000116044 [Q16236-2]
GeneIDi4780
KEGGihsa:4780
UCSCiuc002ulg.6 human [Q16236-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4780
DisGeNETi4780
EuPathDBiHostDB:ENSG00000116044.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NFE2L2
HGNCiHGNC:7782 NFE2L2
HPAiCAB020317
HPA002990
HPA043438
MalaCardsiNFE2L2
MIMi600492 gene
617744 phenotype
neXtProtiNX_Q16236
OpenTargetsiENSG00000116044
PharmGKBiPA31588

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISV3 Eukaryota
ENOG41100FB LUCA
GeneTreeiENSGT00940000153355
HOGENOMiHOG000234410
HOVERGENiHBG052609
InParanoidiQ16236
KOiK05638
OMAiNGPKTQP
OrthoDBiEOG091G02EB
PhylomeDBiQ16236
TreeFamiTF326681

Enzyme and pathway databases

SignaLinkiQ16236
SIGNORiQ16236

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFE2L2 human
EvolutionaryTraceiQ16236

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NFE2L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4780
PMAP-CutDBiQ16236

Protein Ontology

More...
PROi
PR:Q16236

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116044 Expressed in 244 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_NFE2L2
ExpressionAtlasiQ16236 baseline and differential
GenevisibleiQ16236 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029845 Nrf2
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF3 PTHR24411:SF3, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNF2L2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16236
Secondary accession number(s): B2RBU2
, B4E338, E9PGJ7, Q53RW6, Q59HH2, Q96F71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 25, 2002
Last modified: December 5, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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