Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (13 Feb 2019)
Sequence version 3 (05 Jul 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

UDP-N-acetylhexosamine pyrophosphorylase

Gene

UAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-N-acetylhexosamine pyrophosphorylase (UAP1)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate, the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei122UTPBy similarity1
Binding sitei196UTPBy similarity1
Binding sitei222UTP; via amide nitrogenBy similarity1
Binding sitei223Substrate1 Publication1
Binding sitei253UTPBy similarity1
Binding sitei377UTPBy similarity1
Binding sitei407Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: Ensembl
  • identical protein binding Source: IntAct
  • UDP-N-acetylglucosamine diphosphorylase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.83 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q16222

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00113;UER00533

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-N-acetylhexosamine pyrophosphorylase
Alternative name(s):
Antigen X
Short name:
AGX
Sperm-associated antigen 2
Including the following 2 domains:
UDP-N-acetylgalactosamine pyrophosphorylase (EC:2.7.7.83)
Alternative name(s):
AGX-1
UDP-N-acetylglucosamine pyrophosphorylase (EC:2.7.7.23)
Alternative name(s):
AGX-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UAP1
Synonyms:SPAG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117143.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12457 UAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602862 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16222

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6675

Open Targets

More...
OpenTargetsi
ENSG00000117143

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37107

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02196 Uridine-Diphosphate-N-Acetylgalactosamine
DB03397 Uridine-Diphosphate-N-Acetylglucosamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68846235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857671 – 522UDP-N-acetylhexosamine pyrophosphorylaseAdd BLAST522

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16222

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16222

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16222

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16222

PeptideAtlas

More...
PeptideAtlasi
Q16222

PRoteomics IDEntifications database

More...
PRIDEi
Q16222

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60840
60841 [Q16222-2]
60842 [Q16222-3]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00217816

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16222

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117143 Expressed in 232 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16222 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16222 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014659

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Isoform AGX1 is a homodimer. Isoform AGX2 is a monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10237564,EBI-10237564

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112557, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q16222, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356903

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JV1X-ray1.90A/B1-522[»]
1JV3X-ray2.20A/B1-522[»]
1JVDX-ray2.40A/B1-522[»]
1JVGX-ray2.30A/B1-522[»]

Database of protein disorder

More...
DisProti
DP00363
DP01098

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16222

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16222

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16222

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 111UTP bindingBy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi108 – 111Substrate binding4
Motifi303 – 304Substrate binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2388 Eukaryota
COG4284 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156373

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186273

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018024

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16222

KEGG Orthology (KO)

More...
KOi
K00972

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHIARKK

Database of Orthologous Groups

More...
OrthoDBi
888726at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16222

TreeFam database of animal gene trees

More...
TreeFami
TF300611

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR039741 UDP-sugar_pyrophosphorylase
IPR002618 UDPGP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11952 PTHR11952, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01704 UDPGP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform AGX2 (identifier: Q16222-1) [UniParc]FASTAAdd to basket
Also known as: AGX-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ
60 70 80 90 100
KAIEGFNQSS HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ
110 120 130 140 150
NKVAVLLLAG GQGTRLGVAY PKGMYDVGLP SRKTLFQIQA ERILKLQQVA
160 170 180 190 200
EKYYGNKCII PWYIMTSGRT MESTKEFFTK HKYFGLKKEN VIFFQQGMLP
210 220 230 240 250
AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME QRGIWSIHVY
260 270 280 290 300
CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ
310 320 330 340 350
VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ
360 370 380 390 400
HHVAQKKIPY VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE
410 420 430 440 450
DEFSPLKNAD SQNGKDNPTT ARHALMSLHH CWVLNAGGHF IDENGSRLPA
460 470 480 490 500
IPRSATNGKS ETITADVNHN LKDANDVPIQ CEISPLISYA GEGLESYVAD
510 520
KEFHAPLIID ENGVHELVKN GI
Length:522
Mass (Da):58,769
Last modified:July 5, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A69B36D852B9472
GO
Isoform AGX1 (identifier: Q16222-2) [UniParc]FASTAAdd to basket
Also known as: AGX-1

The sequence of this isoform differs from the canonical sequence as follows:
     454-470: Missing.

Show »
Length:505
Mass (Da):57,028
Checksum:i6BDB4DA54D637317
GO
Isoform 3 (identifier: Q16222-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-454: Missing.

Show »
Length:521
Mass (Da):58,682
Checksum:i64D0360EFB15A528
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61H → Y in AAH09377 (PubMed:15489334).Curated1
Sequence conflicti445G → S (PubMed:8025165).Curated1
Sequence conflicti445G → S (PubMed:9603950).Curated1
Sequence conflicti454S → Q (PubMed:8025165).Curated1
Sequence conflicti454S → Q (PubMed:9603950).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014935418P → H. Corresponds to variant dbSNP:rs1128539Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004483454 – 470Missing in isoform AGX1. 4 PublicationsAdd BLAST17
Alternative sequenceiVSP_014523454Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S73498 mRNA Translation: AAB31210.2
AB011004 mRNA Translation: BAA31202.1
AK312685 mRNA Translation: BAG35565.1
AL596325 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90710.1
BC009377 mRNA Translation: AAH09377.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1240.1 [Q16222-2]
CCDS81393.1 [Q16222-1]
CCDS81394.1 [Q16222-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001311042.1, NM_001324113.1 [Q16222-2]
NP_001311043.1, NM_001324114.1 [Q16222-2]
NP_001311044.1, NM_001324115.1 [Q16222-2]
NP_001311045.1, NM_001324116.1 [Q16222-1]
NP_001311046.1, NM_001324117.1 [Q16222-3]
NP_003106.3, NM_003115.4 [Q16222-2]
XP_011508215.1, XM_011509913.2 [Q16222-1]
XP_011508216.1, XM_011509914.2 [Q16222-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.492859

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271469; ENSP00000271469; ENSG00000117143 [Q16222-1]
ENST00000367924; ENSP00000356901; ENSG00000117143 [Q16222-3]
ENST00000367925; ENSP00000356902; ENSG00000117143 [Q16222-1]
ENST00000367926; ENSP00000356903; ENSG00000117143 [Q16222-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6675

UCSC genome browser

More...
UCSCi
uc001gce.5 human [Q16222-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73498 mRNA Translation: AAB31210.2
AB011004 mRNA Translation: BAA31202.1
AK312685 mRNA Translation: BAG35565.1
AL596325 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90710.1
BC009377 mRNA Translation: AAH09377.1
CCDSiCCDS1240.1 [Q16222-2]
CCDS81393.1 [Q16222-1]
CCDS81394.1 [Q16222-3]
RefSeqiNP_001311042.1, NM_001324113.1 [Q16222-2]
NP_001311043.1, NM_001324114.1 [Q16222-2]
NP_001311044.1, NM_001324115.1 [Q16222-2]
NP_001311045.1, NM_001324116.1 [Q16222-1]
NP_001311046.1, NM_001324117.1 [Q16222-3]
NP_003106.3, NM_003115.4 [Q16222-2]
XP_011508215.1, XM_011509913.2 [Q16222-1]
XP_011508216.1, XM_011509914.2 [Q16222-1]
UniGeneiHs.492859

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JV1X-ray1.90A/B1-522[»]
1JV3X-ray2.20A/B1-522[»]
1JVDX-ray2.40A/B1-522[»]
1JVGX-ray2.30A/B1-522[»]
DisProtiDP00363
DP01098
ProteinModelPortaliQ16222
SMRiQ16222
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112557, 20 interactors
IntActiQ16222, 7 interactors
STRINGi9606.ENSP00000356903

Chemistry databases

DrugBankiDB02196 Uridine-Diphosphate-N-Acetylgalactosamine
DB03397 Uridine-Diphosphate-N-Acetylglucosamine

PTM databases

iPTMnetiQ16222
PhosphoSitePlusiQ16222

Polymorphism and mutation databases

BioMutaiUAP1
DMDMi68846235

2D gel databases

REPRODUCTION-2DPAGEiIPI00217816

Proteomic databases

EPDiQ16222
jPOSTiQ16222
MaxQBiQ16222
PaxDbiQ16222
PeptideAtlasiQ16222
PRIDEiQ16222
ProteomicsDBi60840
60841 [Q16222-2]
60842 [Q16222-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271469; ENSP00000271469; ENSG00000117143 [Q16222-1]
ENST00000367924; ENSP00000356901; ENSG00000117143 [Q16222-3]
ENST00000367925; ENSP00000356902; ENSG00000117143 [Q16222-1]
ENST00000367926; ENSP00000356903; ENSG00000117143 [Q16222-2]
GeneIDi6675
KEGGihsa:6675
UCSCiuc001gce.5 human [Q16222-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6675
DisGeNETi6675
EuPathDBiHostDB:ENSG00000117143.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UAP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0001264
HGNCiHGNC:12457 UAP1
HPAiHPA014659
MIMi602862 gene
neXtProtiNX_Q16222
OpenTargetsiENSG00000117143
PharmGKBiPA37107

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2388 Eukaryota
COG4284 LUCA
GeneTreeiENSGT00940000156373
HOGENOMiHOG000186273
HOVERGENiHBG018024
InParanoidiQ16222
KOiK00972
OMAiFHIARKK
OrthoDBi888726at2759
PhylomeDBiQ16222
TreeFamiTF300611

Enzyme and pathway databases

UniPathwayi
UPA00113;UER00533

BRENDAi2.7.7.83 2681
ReactomeiR-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine
SABIO-RKiQ16222

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UAP1 human
EvolutionaryTraceiQ16222

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
UAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6675

Protein Ontology

More...
PROi
PR:Q16222

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117143 Expressed in 232 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ16222 baseline and differential
GenevisibleiQ16222 HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR039741 UDP-sugar_pyrophosphorylase
IPR002618 UDPGP_fam
PANTHERiPTHR11952 PTHR11952, 1 hit
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16222
Secondary accession number(s): B2R6R8
, Q5VTA9, Q5VTB0, Q5VTB1, Q96GM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 5, 2005
Last modified: February 13, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again