Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 163 (16 Oct 2019)
Sequence version 2 (19 Sep 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ecto-NOX disulfide-thiol exchanger 2

Gene

ENOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.2 Publications

Miscellaneous

Has several properties associated with prions including resistance to proteases, resistance to cyanogen bromide digestion, and the ability to form amyloid filaments resembling those of spongiform encephalopathies.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processBiological rhythms, Electron transport, Growth regulation, Transport
LigandCopper, NAD

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16206

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecto-NOX disulfide-thiol exchanger 2
Alternative name(s):
APK1 antigen
Cytosolic ovarian carcinoma antigen 1
Tumor-associated hydroquinone oxidase
Short name:
tNOX
Including the following 2 domains:
Hydroquinone [NADH] oxidase (EC:1.-.-.-)
Protein disulfide-thiol oxidoreductase (EC:1.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENOX2
Synonyms:COVA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2259 ENOX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300282 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16206

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi396M → A: No effect on activity but response to capsaicin is lost. 1 Publication1
Mutagenesisi505C → A: No effect on activity. 1 Publication1
Mutagenesisi510C → A: Loss of activity. 1 Publication1
Mutagenesisi546H → A: Loss of activity. 1 Publication1
Mutagenesisi558C → A: Period length of activity extended to 42 minutes. 1 Publication1
Mutagenesisi562H → A: Loss of activity. 1 Publication1
Mutagenesisi569C → A: Loss of activity. 1 Publication1
Mutagenesisi575C → A: Period length of activity extended to 36 minutes. 1 Publication1
Mutagenesisi592G → V: Loss of activity. 1 Publication1
Mutagenesisi602C → A: Period length of activity extended to 36 minutes. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10495

Open Targets

More...
OpenTargetsi
ENSG00000165675

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385106

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16206

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3714292

Drug and drug target database

More...
DrugBanki
DB04915 Idronoxil

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENOX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34978371

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792751 – 610Ecto-NOX disulfide-thiol exchanger 2Add BLAST610

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16206

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16206

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16206

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16206

PeptideAtlas

More...
PeptideAtlasi
Q16206

PRoteomics IDEntifications database

More...
PRIDEi
Q16206

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60838 [Q16206-1]
60839 [Q16206-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16206

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16206

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165675 Expressed in 217 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16206 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16206 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000514

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115758, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q16206, 12 interactors

Molecular INTeraction database

More...
MINTi
Q16206

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16206

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 207RRMPROSITE-ProRule annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili293 – 328Sequence analysisAdd BLAST36
Coiled coili381 – 505Sequence analysisAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 125Pro-richAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ENOX family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITYH Eukaryota
ENOG4110UUI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006788

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16206

Identification of Orthologs from Complete Genome Data

More...
OMAi
KATHEKD

Database of Orthologous Groups

More...
OrthoDBi
357901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16206

TreeFam database of animal gene trees

More...
TreeFami
TF323802

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12228 RRM_ENOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038876 ENOX
IPR034140 ENOX_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR16001 PTHR16001, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16206-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRDFRWLWV YEIGYAADNS RTLNVDSTAM TLPMSDPTAW ATAMNNLGMA
60 70 80 90 100
PLGIAGQPIL PDFDPALGMM TGIPPITPMM PGLGIVPPPI PPDMPVVKEI
110 120 130 140 150
IHCKSCTLFP PNPNLPPPAT RERPPGCKTV FVGGLPENGT EQIIVEVFEQ
160 170 180 190 200
CGEIIAIRKS KKNFCHIRFA EEYMVDKALY LSGYRIRLGS STDKKDTGRL
210 220 230 240 250
HVDFAQARDD LYEWECKQRM LAREERHRRR MEEERLRPPS PPPVVHYSDH
260 270 280 290 300
ECSIVAEKLK DDSKFSEAVQ TLLTWIERGE VNRRSANNFY SMIQSANSHV
310 320 330 340 350
RRLVNEKAAH EKDMEEAKEK FKQALSGILI QFEQIVAVYH SASKQKAWDH
360 370 380 390 400
FTKAQRKNIS VWCKQAEEIR NIHNDELMGI RREEEMEMSD DEIEEMTETK
410 420 430 440 450
ETEESALVSQ AEALKEENDS LRWQLDAYRN EVELLKQEQG KVHREDDPNK
460 470 480 490 500
EQQLKLLQQA LQGMQQHLLK VQEEYKKKEA ELEKLKDDKL QVEKMLENLK
510 520 530 540 550
EKESCASRLC ASNQDSEYPL EKTMNSSPIK SEREALLVGI ISTFLHVHPF
560 570 580 590 600
GASIEYICSY LHRLDNKICT SDVECLMGRL QHTFKQEMTG VGASLEKRWK
610
FCGFEGLKLT
Length:610
Mass (Da):70,082
Last modified:September 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC30BC45730B62A57
GO
Isoform 2 (identifier: Q16206-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:581
Mass (Da):66,621
Checksum:iA0252986B74DC11C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKF7B1AKF7_HUMAN
Ecto-NOX disulfide-thiol exchanger ...
ENOX2
376Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGT9A0A0C4DGT9_HUMAN
Ecto-NOX disulfide-thiol exchanger ...
ENOX2
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB30428 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123R → G in AK000353 (PubMed:14702039).Curated1
Sequence conflicti311E → G in AK000353 (PubMed:14702039).Curated1
Sequence conflicti326S → V AA sequence (PubMed:11437345).Curated1
Sequence conflicti328I → V AA sequence (PubMed:11437345).Curated1
Sequence conflicti332F → A AA sequence (PubMed:11437345).Curated1
Sequence conflicti406 – 407Missing in AAH19254 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069427202V → I1 PublicationCorresponds to variant dbSNP:rs754363472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157191 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF207881 mRNA Translation: AAF20934.2
AK000353 mRNA No translation available.
AK289837 mRNA Translation: BAF82526.1
AK289812 mRNA Translation: BAF82501.1
AL049733 Genomic DNA No translation available.
AL591908 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11796.1
CH471107 Genomic DNA Translation: EAX11797.1
BC019254 mRNA Translation: AAH19254.2
BC140874 mRNA Translation: AAI40875.1
AL133207 mRNA Translation: CAB61581.2
S72904 mRNA Translation: AAB30428.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14626.1 [Q16206-1]
CCDS14627.1 [Q16206-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I54780

NCBI Reference Sequences

More...
RefSeqi
NP_001268665.1, NM_001281736.1 [Q16206-2]
NP_006366.2, NM_006375.3 [Q16206-2]
NP_872114.1, NM_182314.2 [Q16206-1]
XP_005262411.1, XM_005262354.3 [Q16206-1]
XP_011529549.1, XM_011531247.2 [Q16206-1]
XP_011529551.1, XM_011531249.2 [Q16206-1]
XP_011529553.1, XM_011531251.2 [Q16206-2]
XP_016884715.1, XM_017029226.1 [Q16206-1]
XP_016884716.1, XM_017029227.1 [Q16206-1]
XP_016884717.1, XM_017029228.1 [Q16206-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338144; ENSP00000337146; ENSG00000165675 [Q16206-1]
ENST00000370927; ENSP00000359965; ENSG00000165675 [Q16206-1]
ENST00000370935; ENSP00000359973; ENSG00000165675 [Q16206-2]
ENST00000394363; ENSP00000377890; ENSG00000165675 [Q16206-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10495

UCSC genome browser

More...
UCSCi
uc004evw.5 human [Q16206-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207881 mRNA Translation: AAF20934.2
AK000353 mRNA No translation available.
AK289837 mRNA Translation: BAF82526.1
AK289812 mRNA Translation: BAF82501.1
AL049733 Genomic DNA No translation available.
AL591908 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11796.1
CH471107 Genomic DNA Translation: EAX11797.1
BC019254 mRNA Translation: AAH19254.2
BC140874 mRNA Translation: AAI40875.1
AL133207 mRNA Translation: CAB61581.2
S72904 mRNA Translation: AAB30428.1 Frameshift.
CCDSiCCDS14626.1 [Q16206-1]
CCDS14627.1 [Q16206-2]
PIRiI54780
RefSeqiNP_001268665.1, NM_001281736.1 [Q16206-2]
NP_006366.2, NM_006375.3 [Q16206-2]
NP_872114.1, NM_182314.2 [Q16206-1]
XP_005262411.1, XM_005262354.3 [Q16206-1]
XP_011529549.1, XM_011531247.2 [Q16206-1]
XP_011529551.1, XM_011531249.2 [Q16206-1]
XP_011529553.1, XM_011531251.2 [Q16206-2]
XP_016884715.1, XM_017029226.1 [Q16206-1]
XP_016884716.1, XM_017029227.1 [Q16206-1]
XP_016884717.1, XM_017029228.1 [Q16206-1]

3D structure databases

SMRiQ16206
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115758, 17 interactors
IntActiQ16206, 12 interactors
MINTiQ16206
STRINGi9606.ENSP00000337146

Chemistry databases

ChEMBLiCHEMBL3714292
DrugBankiDB04915 Idronoxil

PTM databases

iPTMnetiQ16206
PhosphoSitePlusiQ16206

Polymorphism and mutation databases

BioMutaiENOX2
DMDMi34978371

Proteomic databases

jPOSTiQ16206
MassIVEiQ16206
MaxQBiQ16206
PaxDbiQ16206
PeptideAtlasiQ16206
PRIDEiQ16206
ProteomicsDBi60838 [Q16206-1]
60839 [Q16206-2]

Genome annotation databases

EnsembliENST00000338144; ENSP00000337146; ENSG00000165675 [Q16206-1]
ENST00000370927; ENSP00000359965; ENSG00000165675 [Q16206-1]
ENST00000370935; ENSP00000359973; ENSG00000165675 [Q16206-2]
ENST00000394363; ENSP00000377890; ENSG00000165675 [Q16206-2]
GeneIDi10495
KEGGihsa:10495
UCSCiuc004evw.5 human [Q16206-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10495
DisGeNETi10495

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENOX2
HGNCiHGNC:2259 ENOX2
HPAiHPA000514
MIMi300282 gene
neXtProtiNX_Q16206
OpenTargetsiENSG00000165675
PharmGKBiPA162385106

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITYH Eukaryota
ENOG4110UUI LUCA
GeneTreeiENSGT00390000006788
InParanoidiQ16206
OMAiKATHEKD
OrthoDBi357901at2759
PhylomeDBiQ16206
TreeFamiTF323802

Enzyme and pathway databases

SIGNORiQ16206

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ENOX2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ENOX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10495
PharosiQ16206

Protein Ontology

More...
PROi
PR:Q16206

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165675 Expressed in 217 organ(s), highest expression level in tendon
ExpressionAtlasiQ16206 baseline and differential
GenevisibleiQ16206 HS

Family and domain databases

CDDicd12228 RRM_ENOX, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038876 ENOX
IPR034140 ENOX_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR16001 PTHR16001, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENOX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16206
Secondary accession number(s): A8K197
, A8K1C2, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 19, 2003
Last modified: October 16, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again