UniProtKB - Q16204 (CCDC6_HUMAN)
Protein
Coiled-coil domain-containing protein 6
Gene
CCDC6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- SH3 domain binding Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q16204 |
SIGNORi | Q16204 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 6Alternative name(s): Papillary thyroid carcinoma-encoded protein Protein H4 |
Gene namesi | Name:CCDC6 Synonyms:D10S170, TST1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18782, CCDC6 |
MIMi | 601985, gene |
neXtProti | NX_Q16204 |
VEuPathDBi | HostDB:ENSG00000108091.10 |
Subcellular locationi
Cytoplasm and Cytosol
Cytoskeleton
- cytoskeleton Curated
Note: May be a cytoskeletal protein.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 101 – 102 | Breakpoint for translocation to form RET-CCDC6 oncogene | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8030 |
MalaCardsi | CCDC6 |
OpenTargetsi | ENSG00000108091 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA134904022 |
Miscellaneous databases
Pharosi | Q16204, Tbio |
Genetic variation databases
BioMutai | CCDC6 |
DMDMi | 292494979 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000089398 | 2 – 474 | Coiled-coil domain-containing protein 6Add BLAST | 473 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Modified residuei | 244 | PhosphoserineCombined sources | 1 | |
Modified residuei | 249 | PhosphoserineCombined sources | 1 | |
Modified residuei | 254 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 349 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources | 1 | |
Modified residuei | 367 | PhosphoserineCombined sources | 1 | |
Modified residuei | 387 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q16204 |
jPOSTi | Q16204 |
MassIVEi | Q16204 |
MaxQBi | Q16204 |
PaxDbi | Q16204 |
PeptideAtlasi | Q16204 |
PRIDEi | Q16204 |
ProteomicsDBi | 60837 |
PTM databases
iPTMneti | Q16204 |
PhosphoSitePlusi | Q16204 |
Expressioni
Tissue specificityi
Ubiquitously expressed.
Gene expression databases
Bgeei | ENSG00000108091, Expressed in secondary oocyte and 229 other tissues |
Genevisiblei | Q16204, HS |
Organism-specific databases
HPAi | ENSG00000108091, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ16204
GO - Molecular functioni
- identical protein binding Source: IntAct
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 113725, 104 interactors |
IntActi | Q16204, 70 interactors |
MINTi | Q16204 |
STRINGi | 9606.ENSP00000263102 |
Chemistry databases
BindingDBi | Q16204 |
Miscellaneous databases
RNActi | Q16204, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 106 – 134 | 1Add BLAST | 29 | |
Repeati | 135 – 163 | 2Add BLAST | 29 | |
Repeati | 164 – 192 | 3Add BLAST | 29 | |
Repeati | 193 – 206 | 4; approximateAdd BLAST | 14 | |
Repeati | 207 – 235 | 5Add BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 235 | 5 X 29 AA tandem repeatsAdd BLAST | 130 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 53 – 237 | Sequence analysisAdd BLAST | 185 | |
Coiled coili | 253 – 332 | Sequence analysisAdd BLAST | 80 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 442 – 451 | SH3-bindingSequence analysis | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 20 | Poly-Ser | 4 | |
Compositional biasi | 32 – 44 | Poly-GlyAdd BLAST | 13 | |
Compositional biasi | 440 – 448 | Poly-Pro | 9 |
Domaini
The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
Keywords - Domaini
Coiled coil, Repeat, SH3-bindingPhylogenomic databases
eggNOGi | KOG2129, Eukaryota |
GeneTreei | ENSGT00390000013594 |
HOGENOMi | CLU_033433_2_0_1 |
InParanoidi | Q16204 |
OMAi | FYNENLM |
OrthoDBi | 1142037at2759 |
PhylomeDBi | Q16204 |
TreeFami | TF321211 |
Family and domain databases
InterProi | View protein in InterPro IPR019152, DUF2046 |
PANTHERi | PTHR15276, PTHR15276, 1 hit |
Pfami | View protein in Pfam PF09755, DUF2046, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q16204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV
60 70 80 90 100
ISPFRLEELT NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT
110 120 130 140 150
IQARAEQEEE FISNTLFKKI QALQKEKETL AVNYEKEEEF LTNELSRKLM
160 170 180 190 200
QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK LENDTISKQL TLEQLRREKI
210 220 230 240 250
DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS APPSPRDISM
260 270 280 290 300
EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE
310 320 330 340 350
NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV
360 370 380 390 400
SSPIPYTPSP SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV
410 420 430 440 450
QHMGTSHGIT RPSPRRSNSP DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ
460 470
PTVPSAATSQ PTPSQHSAHP SSQP
Sequence cautioni
The sequence AAC60637 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | A → G in AAC60637 (PubMed:8058316).Curated | 1 | |
Sequence conflicti | 228 | K → T in AAC60637 (PubMed:8058316).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062971 | 470 | P → T4 PublicationsCorresponds to variant dbSNP:rs1053266Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S72869 mRNA Translation: AAC60637.1 Frameshift. AK292593 mRNA Translation: BAF85282.1 AC060231 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54196.1 BC036757 mRNA Translation: AAH36757.2 BC064391 mRNA Translation: AAH64391.1 M31213 mRNA Translation: AAA36524.1 Different termination. |
CCDSi | CCDS7257.1 |
PIRi | I58403 |
RefSeqi | NP_005427.2, NM_005436.4 |
Genome annotation databases
Ensembli | ENST00000263102; ENSP00000263102; ENSG00000108091 |
GeneIDi | 8030 |
KEGGi | hsa:8030 |
UCSCi | uc001jks.5, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S72869 mRNA Translation: AAC60637.1 Frameshift. AK292593 mRNA Translation: BAF85282.1 AC060231 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54196.1 BC036757 mRNA Translation: AAH36757.2 BC064391 mRNA Translation: AAH64391.1 M31213 mRNA Translation: AAA36524.1 Different termination. |
CCDSi | CCDS7257.1 |
PIRi | I58403 |
RefSeqi | NP_005427.2, NM_005436.4 |
3D structure databases
SMRi | Q16204 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113725, 104 interactors |
IntActi | Q16204, 70 interactors |
MINTi | Q16204 |
STRINGi | 9606.ENSP00000263102 |
Chemistry databases
BindingDBi | Q16204 |
PTM databases
iPTMneti | Q16204 |
PhosphoSitePlusi | Q16204 |
Genetic variation databases
BioMutai | CCDC6 |
DMDMi | 292494979 |
Proteomic databases
EPDi | Q16204 |
jPOSTi | Q16204 |
MassIVEi | Q16204 |
MaxQBi | Q16204 |
PaxDbi | Q16204 |
PeptideAtlasi | Q16204 |
PRIDEi | Q16204 |
ProteomicsDBi | 60837 |
Protocols and materials databases
Antibodypediai | 14268, 216 antibodies |
Genome annotation databases
Ensembli | ENST00000263102; ENSP00000263102; ENSG00000108091 |
GeneIDi | 8030 |
KEGGi | hsa:8030 |
UCSCi | uc001jks.5, human |
Organism-specific databases
CTDi | 8030 |
DisGeNETi | 8030 |
GeneCardsi | CCDC6 |
HGNCi | HGNC:18782, CCDC6 |
HPAi | ENSG00000108091, Low tissue specificity |
MalaCardsi | CCDC6 |
MIMi | 601985, gene |
neXtProti | NX_Q16204 |
OpenTargetsi | ENSG00000108091 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA134904022 |
VEuPathDBi | HostDB:ENSG00000108091.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2129, Eukaryota |
GeneTreei | ENSGT00390000013594 |
HOGENOMi | CLU_033433_2_0_1 |
InParanoidi | Q16204 |
OMAi | FYNENLM |
OrthoDBi | 1142037at2759 |
PhylomeDBi | Q16204 |
TreeFami | TF321211 |
Enzyme and pathway databases
PathwayCommonsi | Q16204 |
SIGNORi | Q16204 |
Miscellaneous databases
BioGRID-ORCSi | 8030, 70 hits in 1000 CRISPR screens |
ChiTaRSi | CCDC6, human |
GeneWikii | CCDC6 |
GenomeRNAii | 8030 |
Pharosi | Q16204, Tbio |
PROi | PR:Q16204 |
RNActi | Q16204, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108091, Expressed in secondary oocyte and 229 other tissues |
Genevisiblei | Q16204, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019152, DUF2046 |
PANTHERi | PTHR15276, PTHR15276, 1 hit |
Pfami | View protein in Pfam PF09755, DUF2046, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCDC6_HUMAN | |
Accessioni | Q16204Primary (citable) accession number: Q16204 Secondary accession number(s): Q15250, Q6GSG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 23, 2010 | |
Last modified: | April 7, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot