CCDC6

Functionⁱ

GO - Molecular functionⁱ

SH3 domain binding Source: UniProtKB-KW
structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- 8058316

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SIGNORⁱ	Q16204

SIGNORⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 6 Alternative name(s): Papillary thyroid carcinoma-encoded protein Protein H4
Gene namesⁱ	Name:CCDC6 Synonyms:D10S170, TST1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108091.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18782 CCDC6
MIMⁱ	601985 gene
neXtProtⁱ	NX_Q16204

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	101 – 102	Breakpoint for translocation to form RET-CCDC6 oncogene		2

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8030
MalaCards human disease database More...MalaCardsⁱ	CCDC6
Open Targets More...OpenTargetsⁱ	ENSG00000108091
Orphanetⁱ	146 Differentiated thyroid carcinoma
PharmGKBⁱ	PA134904022

Polymorphism and mutation databases

BioMutaⁱ	CCDC6
DMDMⁱ	292494979

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000089398	2 – 474	Coiled-coil domain-containing protein 6Add BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	52	PhosphoserineCombined sources	1
Modified residueⁱ	240	PhosphoserineCombined sources	1
Modified residueⁱ	244	PhosphoserineCombined sources	1
Modified residueⁱ	249	PhosphoserineCombined sources	1
Modified residueⁱ	254	PhosphoserineCombined sources	1
Modified residueⁱ	284	PhosphoserineCombined sources	1
Modified residueⁱ	323	PhosphoserineCombined sources	1
Modified residueⁱ	349	PhosphothreonineCombined sources	1
Modified residueⁱ	363	PhosphoserineCombined sources	1
Modified residueⁱ	367	PhosphoserineCombined sources	1
Modified residueⁱ	387	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	395	PhosphoserineCombined sources	1
Modified residueⁱ	413	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q16204
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16204
PaxDbⁱ	Q16204
PeptideAtlas More...PeptideAtlasⁱ	Q16204
PRIDEⁱ	Q16204
ProteomicsDBⁱ	60837

PTM databases

iPTMnetⁱ	Q16204
PhosphoSitePlusⁱ	Q16204

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000108091 Expressed in 215 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCDC6
Genevisibleⁱ	Q16204 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019049 HPA019051

HPAⁱ

HPA019049
HPA019051

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FBXW7	Q969H0	9	EBI-1045350,EBI-359574
PIN1	Q13526	4	EBI-1045350,EBI-714158
RALBP1	Q15311	4	EBI-1045350,EBI-749285

GO - Molecular functionⁱ

SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113725, 69 interactors
IntActⁱ	Q16204, 44 interactors
Molecular INTeraction database More...MINTⁱ	Q16204
STRINGⁱ	9606.ENSP00000263102

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16204
SMRⁱ	Q16204
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	106 – 134	1Add BLAST	29
Repeatⁱ	135 – 163	2Add BLAST	29
Repeatⁱ	164 – 192	3Add BLAST	29
Repeatⁱ	193 – 206	4; approximateAdd BLAST	14
Repeatⁱ	207 – 235	5Add BLAST	29

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	106 – 235	5 X 29 AA tandem repeatsAdd BLAST		130

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	53 – 237	Sequence analysisAdd BLAST		185
Coiled coilⁱ	253 – 332	Sequence analysisAdd BLAST		80

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	442 – 451	SH3-bindingSequence analysis		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	17 – 20	Poly-Ser	4
Compositional biasⁱ	32 – 44	Poly-GlyAdd BLAST	13
Compositional biasⁱ	440 – 448	Poly-Pro	9

Domainⁱ

The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.

Keywords - Domainⁱ

Coiled coil, Repeat, SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG2129 Eukaryota ENOG410XR5H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013594
HOGENOMⁱ	HOG000091755
HOVERGENⁱ	HBG050823
InParanoidⁱ	Q16204
KEGG Orthology (KO) More...KOⁱ	K09288
OMAⁱ	QNRCYAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07PT
PhylomeDBⁱ	Q16204
TreeFamⁱ	TF321211

Family and domain databases

InterProⁱ	View protein in InterPro IPR019152 DUF2046
PANTHERⁱ	PTHR15276 PTHR15276, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09755 DUF2046, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q16204-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV 
        60         70         80         90        100
ISPFRLEELT NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT 
       110        120        130        140        150
IQARAEQEEE FISNTLFKKI QALQKEKETL AVNYEKEEEF LTNELSRKLM 
       160        170        180        190        200
QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK LENDTISKQL TLEQLRREKI 
       210        220        230        240        250
DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS APPSPRDISM 
       260        270        280        290        300
EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE 
       310        320        330        340        350
NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV 
       360        370        380        390        400
SSPIPYTPSP SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV 
       410        420        430        440        450
QHMGTSHGIT RPSPRRSNSP DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ 
       460        470 
PTVPSAATSQ PTPSQHSAHP SSQP

Length:474

Mass (Da):53,291

Last modified:March 23, 2010 - v2

Checksum:ⁱDF055DBF20304D26

GO

Sequence cautionⁱ

The sequence AAC60637 differs from that shown. Reason: Frameshift at position 456.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	157	A → G in AAC60637 (PubMed:8058316).Curated		1
Sequence conflictⁱ	228	K → T in AAC60637 (PubMed:8058316).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_062971	470	P → T4 PublicationsCorresponds to variant dbSNP:rs1053266Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S72869 mRNA Translation: AAC60637.1 Frameshift. AK292593 mRNA Translation: BAF85282.1 AC060231 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54196.1 BC036757 mRNA Translation: AAH36757.2 BC064391 mRNA Translation: AAH64391.1 M31213 mRNA Translation: AAA36524.1 Different termination.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7257.1
PIRⁱ	I58403
NCBI Reference Sequences More...RefSeqⁱ	NP_005427.2, NM_005436.4
UniGeneⁱ	Hs.591360

Genome annotation databases

Ensemblⁱ	ENST00000263102; ENSP00000263102; ENSG00000108091
GeneIDⁱ	8030
KEGGⁱ	hsa:8030
UCSC genome browser More...UCSCⁱ	uc001jks.5 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16204	CCDC6 isoform 1		PANTR		474	UniRef100_Q16204
CCDC6 isoform 1		PONAB		474
Coiled-coil domain containing 6		GORGO		474
Uncharacterized protein		PANPA		462
Coiled-coil domain-containing protein 6		PANTR		325

Protein	Similar proteins		Species	Score	Length	Source
Q16204	Coiled-coil domain-containing protein 6		MOUSE		469	UniRef90_Q16204
CCDC6 isoform 1		PANTR		474
CCDC6 isoform 1		PONAB		474
Coiled-coil domain containing 6		GORGO		474
Uncharacterized protein		PANPA		462
+81

Protein	Similar proteins		Species	Score	Length	Source
Q16204	Coiled-coil domain-containing protein 6		MOUSE		469	UniRef50_Q16204
CCDC6 isoform 1		PANTR		474
CCDC6 isoform 1		PONAB		474
Coiled-coil domain containing 6		GORGO		474
Uncharacterized protein		PANPA		462
+123

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S72869 mRNA Translation: AAC60637.1 Frameshift. AK292593 mRNA Translation: BAF85282.1 AC060231 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54196.1 BC036757 mRNA Translation: AAH36757.2 BC064391 mRNA Translation: AAH64391.1 M31213 mRNA Translation: AAA36524.1 Different termination.
CCDSⁱ	CCDS7257.1
PIRⁱ	I58403
RefSeqⁱ	NP_005427.2, NM_005436.4
UniGeneⁱ	Hs.591360

3D structure databases

ProteinModelPortalⁱ	Q16204
SMRⁱ	Q16204
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113725, 69 interactors
IntActⁱ	Q16204, 44 interactors
MINTⁱ	Q16204
STRINGⁱ	9606.ENSP00000263102

PTM databases

iPTMnetⁱ	Q16204
PhosphoSitePlusⁱ	Q16204

Polymorphism and mutation databases

BioMutaⁱ	CCDC6
DMDMⁱ	292494979

Proteomic databases

EPDⁱ	Q16204
MaxQBⁱ	Q16204
PaxDbⁱ	Q16204
PeptideAtlasⁱ	Q16204
PRIDEⁱ	Q16204
ProteomicsDBⁱ	60837

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263102; ENSP00000263102; ENSG00000108091
GeneIDⁱ	8030
KEGGⁱ	hsa:8030
UCSCⁱ	uc001jks.5 human

Organism-specific databases

CTDⁱ	8030
DisGeNETⁱ	8030
EuPathDBⁱ	HostDB:ENSG00000108091.10
GeneCardsⁱ	CCDC6
H-InvDBⁱ	HIX0008848
HGNCⁱ	HGNC:18782 CCDC6
HPAⁱ	HPA019049 HPA019051
MalaCardsⁱ	CCDC6
MIMⁱ	601985 gene
neXtProtⁱ	NX_Q16204
OpenTargetsⁱ	ENSG00000108091
Orphanetⁱ	146 Differentiated thyroid carcinoma
PharmGKBⁱ	PA134904022
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2129 Eukaryota ENOG410XR5H LUCA
GeneTreeⁱ	ENSGT00390000013594
HOGENOMⁱ	HOG000091755
HOVERGENⁱ	HBG050823
InParanoidⁱ	Q16204
KOⁱ	K09288
OMAⁱ	QNRCYAC
OrthoDBⁱ	EOG091G07PT
PhylomeDBⁱ	Q16204
TreeFamⁱ	TF321211

Enzyme and pathway databases

SIGNORⁱ	Q16204

SIGNORⁱ

Q16204

Miscellaneous databases

ChiTaRSⁱ	CCDC6 human
GeneWikiⁱ	CCDC6
GenomeRNAiⁱ	8030
Protein Ontology More...PROⁱ	PR:Q16204
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108091 Expressed in 215 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCDC6
Genevisibleⁱ	Q16204 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019152 DUF2046
PANTHERⁱ	PTHR15276 PTHR15276, 1 hit
Pfamⁱ	View protein in Pfam PF09755 DUF2046, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCDC6_HUMAN
Accessionⁱ	Q16204Primary (citable) accession number: Q16204 Secondary accession number(s): Q15250, Q6GSG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	March 23, 2010
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - Q16204 (CCDC6_HUMAN)

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Coiled-coil domain-containing protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Sites

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ