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UniProtKB - Q16204 (CCDC6_HUMAN)

Entry version 182 (12 Aug 2020)
Sequence version 2 (23 Mar 2010)
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Protein

Coiled-coil domain-containing protein 6

Gene

CCDC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SH3 domain binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: ProtInc
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16204

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16204

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 6
Alternative name(s):
Papillary thyroid carcinoma-encoded protein
Protein H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC6
Synonyms:D10S170, TST1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108091.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:18782, CCDC6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601985, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16204

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei101 – 102Breakpoint for translocation to form RET-CCDC6 oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		8030

MalaCards human disease database

More...MalaCardsi		CCDC6

Open Targets

More...OpenTargetsi		ENSG00000108091

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		146, Differentiated thyroid carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134904022

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16204, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC6

Domain mapping of disease mutations (DMDM)

More...DMDMi		292494979

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893982 – 474Coiled-coil domain-containing protein 6Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei349PhosphothreonineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei387Omega-N-methylarginineBy similarity1
Modified residuei395PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16204

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16204

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16204

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16204

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16204

PeptideAtlas

More...PeptideAtlasi		Q16204

PRoteomics IDEntifications database

More...PRIDEi		Q16204

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60837

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16204

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16204

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108091, Expressed in secondary oocyte and 229 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16204, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108091, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113725, 78 interactors

Protein interaction database and analysis system

More...IntActi		Q16204, 70 interactors

Molecular INTeraction database

More...MINTi		Q16204

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263102

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16204

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16204, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16204

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati106 – 1341Add BLAST29
Repeati135 – 1632Add BLAST29
Repeati164 – 1923Add BLAST29
Repeati193 – 2064; approximateAdd BLAST14
Repeati207 – 2355Add BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 2355 X 29 AA tandem repeatsAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili53 – 237Sequence analysisAdd BLAST185
Coiled coili253 – 332Sequence analysisAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi442 – 451SH3-bindingSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 20Poly-Ser4
Compositional biasi32 – 44Poly-GlyAdd BLAST13
Compositional biasi440 – 448Poly-Pro9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.

Keywords - Domaini

Coiled coil, Repeat, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2129, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033433_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16204

KEGG Orthology (KO)

More...KOi		K09288

Identification of Orthologs from Complete Genome Data

More...OMAi		FYNENLM

Database of Orthologous Groups

More...OrthoDBi		1142037at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16204

TreeFam database of animal gene trees

More...TreeFami		TF321211

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019152, DUF2046

The PANTHER Classification System

More...PANTHERi		PTHR15276, PTHR15276, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09755, DUF2046, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q16204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV 
        60         70         80         90        100
ISPFRLEELT NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT 
       110        120        130        140        150
IQARAEQEEE FISNTLFKKI QALQKEKETL AVNYEKEEEF LTNELSRKLM 
       160        170        180        190        200
QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK LENDTISKQL TLEQLRREKI 
       210        220        230        240        250
DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS APPSPRDISM 
       260        270        280        290        300
EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE 
       310        320        330        340        350
NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV 
       360        370        380        390        400
SSPIPYTPSP SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV 
       410        420        430        440        450
QHMGTSHGIT RPSPRRSNSP DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ 
       460        470 
PTVPSAATSQ PTPSQHSAHP SSQP
Length:474
Mass (Da):53,291
Last modified:March 23, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF055DBF20304D26
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC60637 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157A → G in AAC60637 (PubMed:8058316).Curated1
Sequence conflicti228K → T in AAC60637 (PubMed:8058316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062971470P → T4 PublicationsCorresponds to variant dbSNP:rs1053266Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S72869 mRNA Translation: AAC60637.1 Frameshift.
AK292593 mRNA Translation: BAF85282.1
AC060231 Genomic DNA No translation available.
AC023904 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54196.1
BC036757 mRNA Translation: AAH36757.2
BC064391 mRNA Translation: AAH64391.1
M31213 mRNA Translation: AAA36524.1 Different termination.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7257.1

Protein sequence database of the Protein Information Resource

More...PIRi		I58403

NCBI Reference Sequences

More...RefSeqi		NP_005427.2, NM_005436.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263102; ENSP00000263102; ENSG00000108091

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8030

UCSC genome browser

More...UCSCi		uc001jks.5, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72869 mRNA Translation: AAC60637.1 Frameshift.
AK292593 mRNA Translation: BAF85282.1
AC060231 Genomic DNA No translation available.
AC023904 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54196.1
BC036757 mRNA Translation: AAH36757.2
BC064391 mRNA Translation: AAH64391.1
M31213 mRNA Translation: AAA36524.1 Different termination.
CCDSiCCDS7257.1
PIRiI58403
RefSeqiNP_005427.2, NM_005436.4

3D structure databases

SMRiQ16204
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113725, 78 interactors
IntActiQ16204, 70 interactors
MINTiQ16204
STRINGi9606.ENSP00000263102

Chemistry databases

BindingDBiQ16204

PTM databases

iPTMnetiQ16204
PhosphoSitePlusiQ16204

Polymorphism and mutation databases

BioMutaiCCDC6
DMDMi292494979

Proteomic databases

EPDiQ16204
jPOSTiQ16204
MassIVEiQ16204
MaxQBiQ16204
PaxDbiQ16204
PeptideAtlasiQ16204
PRIDEiQ16204
ProteomicsDBi60837

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14268, 215 antibodies

Genome annotation databases

EnsembliENST00000263102; ENSP00000263102; ENSG00000108091
GeneIDi8030
KEGGihsa:8030
UCSCiuc001jks.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8030
DisGeNETi8030
EuPathDBiHostDB:ENSG00000108091.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC6
HGNCiHGNC:18782, CCDC6
HPAiENSG00000108091, Low tissue specificity
MalaCardsiCCDC6
MIMi601985, gene
neXtProtiNX_Q16204
OpenTargetsiENSG00000108091
Orphaneti146, Differentiated thyroid carcinoma
PharmGKBiPA134904022

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2129, Eukaryota
GeneTreeiENSGT00390000013594
HOGENOMiCLU_033433_2_0_1
InParanoidiQ16204
KOiK09288
OMAiFYNENLM
OrthoDBi1142037at2759
PhylomeDBiQ16204
TreeFamiTF321211

Enzyme and pathway databases

PathwayCommonsiQ16204
SIGNORiQ16204

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8030, 60 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCDC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8030
PharosiQ16204, Tbio

Protein Ontology

More...PROi		PR:Q16204
RNActiQ16204, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108091, Expressed in secondary oocyte and 229 other tissues
GenevisibleiQ16204, HS

Family and domain databases

InterProiView protein in InterPro
IPR019152, DUF2046
PANTHERiPTHR15276, PTHR15276, 1 hit
PfamiView protein in Pfam
PF09755, DUF2046, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCDC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16204
Secondary accession number(s): Q15250, Q6GSG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: August 12, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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