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Protein

Proteasomal ubiquitin receptor ADRM1

Gene

ADRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.8 Publications

Caution

Although initially described as a cell membrane glycoprotein, ADRM1 is intracellular and non-glycosylated, and has probably no direct role in cell adhesion.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endopeptidase activator activity Source: UniProtKB
  • protease binding Source: UniProtKB
  • proteasome binding Source: UniProtKB
  • ubiquitin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasomal ubiquitin receptor ADRM1
Alternative name(s):
110 kDa cell membrane glycoprotein
Short name:
Gp110
Adhesion-regulating molecule 1
Short name:
ARM-1
Proteasome regulatory particle non-ATPase 13
Short name:
hRpn13
Rpn13 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRM1
Synonyms:GP110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130706.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15759 ADRM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610650 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16186

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11047

Open Targets

More...
OpenTargetsi
ENSG00000130706

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24599

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364701

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADRM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141265

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000206312 – 407Proteasomal ubiquitin receptor ADRM1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei15PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei127PhosphotyrosineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei217PhosphothreonineCombined sources1
Modified residuei405PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16186

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16186

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16186

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16186

PeptideAtlas

More...
PeptideAtlasi
Q16186

PRoteomics IDEntifications database

More...
PRIDEi
Q16186

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16186

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16186

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130706 Expressed in 214 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADRM1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16186 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16186 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042266

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (PubMed:16990800). Interacts with the proteasomal scaffolding protein PSMD1 (PubMed:16990800,PubMed:16815440, PubMed:16906146, PubMed:20471946). Interacts with deubiquitinase UCHL5; this interaction activates the auto-inhibited UCHL5 by deoligomerizing it (PubMed:17139257, PubMed:24752541, PubMed:25702870, PubMed:25702872). Interacts with UBQLN2 and ubiquitin (PubMed:27396824).9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116235, 86 interactors

Database of interacting proteins

More...
DIPi
DIP-42668N

Protein interaction database and analysis system

More...
IntActi
Q16186, 60 interactors

Molecular INTeraction database

More...
MINTi
Q16186

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253003

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQZNMR-A253-407[»]
2KR0NMR-A1-407[»]
2L5VNMR-A260-407[»]
2MKZNMR-A270-407[»]
2NBVNMR-A1-150[»]
4UELX-ray2.30C266-388[»]
4UEMX-ray2.82B266-388[»]
4WLQX-ray2.85B286-384[»]
4WLRX-ray2.00B285-386[»]
5IRSX-ray1.80A2-150[»]
5V1YX-ray1.42A/B19-132[»]
5V1ZX-ray2.00A/B19-132[»]
6CO4NMR-A1-150[»]

Database of protein disorder

More...
DisProti
DP00839

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16186

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16186

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16186

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 130Pru (pleckstrin-like receptor for ubiquitin) domain1 PublicationAdd BLAST109
Regioni253 – 407Interaction with UCHL51 PublicationAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 202Gly-richAdd BLAST68
Compositional biasi193 – 257Ser-richAdd BLAST65
Compositional biasi203 – 213Poly-SerAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADRM1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3037 Eukaryota
ENOG410XSJJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000005947

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG073518

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16186

KEGG Orthology (KO)

More...
KOi
K06691

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCRRINE

Database of Orthologous Groups

More...
OrthoDBi
1479349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16186

TreeFam database of animal gene trees

More...
TreeFami
TF313410

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.70, 1 hit
3.40.190.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006773 Rpn13/ADRM1
IPR038633 Rpn13/ADRM1_sf
IPR032368 RPN13_C
IPR038108 RPN13_C_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12225 PTHR12225, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04683 Proteasom_Rpn13, 1 hit
PF16550 RPN13_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q16186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSGALFPS LVPGSRGASN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ
60 70 80 90 100
QTDDSLIHFC WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA
110 120 130 140 150
GSKRLFFWMQ EPKTDQDEEH CRKVNEYLNN PPMPGALGAS GSSGHELSAL
160 170 180 190 200
GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL GGLGALTGPG LASLLGSSGP
210 220 230 240 250
PGSSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASAT SPSPAPSSGN
260 270 280 290 300
GASTAASPTQ PIQLSDLQSI LATMNVPAGP AGGQQVDLAS VLTPEIMAPI
310 320 330 340 350
LANADVQERL LPYLPSGESL PQTADEIQNT LTSPQFQQAL GMFSAALASG
360 370 380 390 400
QLGPLMCQFG LPAEAVEAAN KGDVEAFAKA MQNNAKPEQK EGDTKDKKDE

EEDMSLD
Length:407
Mass (Da):42,153
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D38811DCA231864
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX59A0A087WX59_HUMAN
Proteasomal ubiquitin receptor ADRM...
ADRM1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUX6A0A087WUX6_HUMAN
Proteasomal ubiquitin receptor ADRM...
ADRM1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142S → T in BAA11023 (PubMed:8033103).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D64154 mRNA Translation: BAA11023.1
AL354836 Genomic DNA No translation available.
BR000321 mRNA Translation: FAA00246.1
BC010733 mRNA Translation: AAH10733.1
BC017245 mRNA Translation: AAH17245.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13496.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I52703

NCBI Reference Sequences

More...
RefSeqi
NP_001268366.1, NM_001281437.1
NP_001268367.1, NM_001281438.1
NP_008933.2, NM_007002.3
NP_783163.1, NM_175573.2
XP_005260314.1, XM_005260257.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.90107

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253003; ENSP00000253003; ENSG00000130706
ENST00000491935; ENSP00000478877; ENSG00000130706

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11047

UCSC genome browser

More...
UCSCi
uc002ycn.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64154 mRNA Translation: BAA11023.1
AL354836 Genomic DNA No translation available.
BR000321 mRNA Translation: FAA00246.1
BC010733 mRNA Translation: AAH10733.1
BC017245 mRNA Translation: AAH17245.1
CCDSiCCDS13496.1
PIRiI52703
RefSeqiNP_001268366.1, NM_001281437.1
NP_001268367.1, NM_001281438.1
NP_008933.2, NM_007002.3
NP_783163.1, NM_175573.2
XP_005260314.1, XM_005260257.1
UniGeneiHs.90107

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQZNMR-A253-407[»]
2KR0NMR-A1-407[»]
2L5VNMR-A260-407[»]
2MKZNMR-A270-407[»]
2NBVNMR-A1-150[»]
4UELX-ray2.30C266-388[»]
4UEMX-ray2.82B266-388[»]
4WLQX-ray2.85B286-384[»]
4WLRX-ray2.00B285-386[»]
5IRSX-ray1.80A2-150[»]
5V1YX-ray1.42A/B19-132[»]
5V1ZX-ray2.00A/B19-132[»]
6CO4NMR-A1-150[»]
DisProtiDP00839
ProteinModelPortaliQ16186
SMRiQ16186
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116235, 86 interactors
DIPiDIP-42668N
IntActiQ16186, 60 interactors
MINTiQ16186
STRINGi9606.ENSP00000253003

Chemistry databases

ChEMBLiCHEMBL2364701

PTM databases

iPTMnetiQ16186
PhosphoSitePlusiQ16186

Polymorphism and mutation databases

BioMutaiADRM1
DMDMi20141265

Proteomic databases

EPDiQ16186
jPOSTiQ16186
MaxQBiQ16186
PaxDbiQ16186
PeptideAtlasiQ16186
PRIDEiQ16186
ProteomicsDBi60836

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
11047
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253003; ENSP00000253003; ENSG00000130706
ENST00000491935; ENSP00000478877; ENSG00000130706
GeneIDi11047
KEGGihsa:11047
UCSCiuc002ycn.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11047
DisGeNETi11047
EuPathDBiHostDB:ENSG00000130706.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ADRM1
HGNCiHGNC:15759 ADRM1
HPAiHPA042266
MIMi610650 gene
neXtProtiNX_Q16186
OpenTargetsiENSG00000130706
PharmGKBiPA24599

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3037 Eukaryota
ENOG410XSJJ LUCA
GeneTreeiENSGT00390000013839
HOGENOMiHOG000005947
HOVERGENiHBG073518
InParanoidiQ16186
KOiK06691
OMAiHCRRINE
OrthoDBi1479349at2759
PhylomeDBiQ16186
TreeFamiTF313410

Enzyme and pathway databases

ReactomeiR-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADRM1 human
EvolutionaryTraceiQ16186

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADRM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11047

Protein Ontology

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PROi
PR:Q16186

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130706 Expressed in 214 organ(s), highest expression level in gastrocnemius
CleanExiHS_ADRM1
ExpressionAtlasiQ16186 baseline and differential
GenevisibleiQ16186 HS

Family and domain databases

Gene3Di2.30.29.70, 1 hit
3.40.190.140, 1 hit
InterProiView protein in InterPro
IPR006773 Rpn13/ADRM1
IPR038633 Rpn13/ADRM1_sf
IPR032368 RPN13_C
IPR038108 RPN13_C_sf
PANTHERiPTHR12225 PTHR12225, 1 hit
PfamiView protein in Pfam
PF04683 Proteasom_Rpn13, 1 hit
PF16550 RPN13_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADRM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16186
Secondary accession number(s): A0PKB1, Q96FJ7, Q9H1P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: January 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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