UniProtKB - Q16143 (SYUB_HUMAN)
Protein
Beta-synuclein
Gene
SNCB
Organism
Homo sapiens (Human)
Status
Functioni
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- cuprous ion binding Source: CAFA
- phospholipase inhibitor activity Source: ProtInc
- transition metal ion binding Source: CAFA
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- dopamine metabolic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- regulation of neuron death Source: GO_Central
- response to metal ion Source: Reactome
- synapse organization Source: GO_Central
- synaptic vesicle endocytosis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q16143 |
Reactomei | R-HSA-5660489, MTF1 activates gene expression |
SIGNORi | Q16143 |
Protein family/group databases
TCDBi | 1.C.77.1.2, the synuclein (synuclein) family |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-synuclein |
Gene namesi | Name:SNCB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000074317.10 |
HGNCi | HGNC:11140, SNCB |
MIMi | 602569, gene |
neXtProti | NX_Q16143 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: Reactome
Other locations
- axon terminus Source: GO_Central
- cytoplasm Source: GO_Central
- inclusion body Source: ParkinsonsUK-UCL
- neuronal cell body Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 6620 |
MalaCardsi | SNCB |
OpenTargetsi | ENSG00000074317 |
Orphaneti | 1648, NON RARE IN EUROPE: Dementia with Lewy body |
PharmGKBi | PA35988 |
Miscellaneous databases
Pharosi | Q16143, Tbio |
Polymorphism and mutation databases
BioMutai | SNCB |
DMDMi | 2501105 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184035 | 1 – 134 | Beta-synucleinAdd BLAST | 134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 118 | Phosphoserine; by BARK1, CK2 and GRK51 Publication | 1 |
Post-translational modificationi
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q16143 |
jPOSTi | Q16143 |
MassIVEi | Q16143 |
MaxQBi | Q16143 |
PaxDbi | Q16143 |
PeptideAtlasi | Q16143 |
PRIDEi | Q16143 |
ProteomicsDBi | 60833 |
PTM databases
iPTMneti | Q16143 |
PhosphoSitePlusi | Q16143 |
Expressioni
Tissue specificityi
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Gene expression databases
Bgeei | ENSG00000074317, Expressed in anterior cingulate cortex and 135 other tissues |
ExpressionAtlasi | Q16143, baseline and differential |
Genevisiblei | Q16143, HS |
Organism-specific databases
HPAi | ENSG00000074317, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Q16143
With | #Exp. | IntAct |
---|---|---|
MORN4 [Q8NDC4] | 3 | EBI-727106,EBI-10269566 |
Protein-protein interaction databases
BioGRIDi | 112504, 18 interactors |
IntActi | Q16143, 9 interactors |
MINTi | Q16143 |
STRINGi | 9606.ENSP00000308057 |
Miscellaneous databases
RNActi | Q16143, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 20 – 30 | 1Add BLAST | 11 | |
Repeati | 31 – 41 | 2Add BLAST | 11 | |
Repeati | 42 – 56 | 3; approximateAdd BLAST | 15 | |
Repeati | 57 – 67 | 4Add BLAST | 11 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 67 | 4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST | 48 |
Sequence similaritiesi
Belongs to the synuclein family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S0N5, Eukaryota |
GeneTreei | ENSGT00950000183175 |
HOGENOMi | CLU_129378_1_0_1 |
InParanoidi | Q16143 |
OMAi | AYDENQQ |
OrthoDBi | 1544450at2759 |
PhylomeDBi | Q16143 |
TreeFami | TF332776 |
Family and domain databases
DisProti | DP00555 |
InterProi | View protein in InterPro IPR001058, Synuclein IPR002461, Synuclein_beta |
PANTHERi | PTHR13820, PTHR13820, 1 hit PTHR13820:SF4, PTHR13820:SF4, 1 hit |
Pfami | View protein in Pfam PF01387, Synuclein, 1 hit |
PRINTSi | PR01213, BSYNUCLEIN PR01211, SYNUCLEIN |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q16143-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG4Y816 | G4Y816_HUMAN | Beta-synuclein | SNCB | 120 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S69965 mRNA Translation: AAB30860.1 AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1 BT006627 mRNA Translation: AAP35273.1 CR457027 mRNA Translation: CAG33308.1 BC002902 mRNA Translation: AAH02902.1 |
CCDSi | CCDS4406.1 |
PIRi | S44430 |
RefSeqi | NP_001001502.1, NM_001001502.2 NP_003076.1, NM_003085.4 XP_006714979.1, XM_006714916.2 |
Genome annotation databases
Ensembli | ENST00000310112; ENSP00000308057; ENSG00000074317 ENST00000393693; ENSP00000377296; ENSG00000074317 ENST00000506696; ENSP00000422223; ENSG00000074317 ENST00000510387; ENSP00000424073; ENSG00000074317 |
GeneIDi | 6620 |
KEGGi | hsa:6620 |
UCSCi | uc003mep.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S69965 mRNA Translation: AAB30860.1 AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1 BT006627 mRNA Translation: AAP35273.1 CR457027 mRNA Translation: CAG33308.1 BC002902 mRNA Translation: AAH02902.1 |
CCDSi | CCDS4406.1 |
PIRi | S44430 |
RefSeqi | NP_001001502.1, NM_001001502.2 NP_003076.1, NM_003085.4 XP_006714979.1, XM_006714916.2 |
3D structure databases
BMRBi | Q16143 |
SMRi | Q16143 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112504, 18 interactors |
IntActi | Q16143, 9 interactors |
MINTi | Q16143 |
STRINGi | 9606.ENSP00000308057 |
Protein family/group databases
TCDBi | 1.C.77.1.2, the synuclein (synuclein) family |
PTM databases
iPTMneti | Q16143 |
PhosphoSitePlusi | Q16143 |
Polymorphism and mutation databases
BioMutai | SNCB |
DMDMi | 2501105 |
Proteomic databases
EPDi | Q16143 |
jPOSTi | Q16143 |
MassIVEi | Q16143 |
MaxQBi | Q16143 |
PaxDbi | Q16143 |
PeptideAtlasi | Q16143 |
PRIDEi | Q16143 |
ProteomicsDBi | 60833 |
Protocols and materials databases
Antibodypediai | 3634, 357 antibodies |
DNASUi | 6620 |
Genome annotation databases
Ensembli | ENST00000310112; ENSP00000308057; ENSG00000074317 ENST00000393693; ENSP00000377296; ENSG00000074317 ENST00000506696; ENSP00000422223; ENSG00000074317 ENST00000510387; ENSP00000424073; ENSG00000074317 |
GeneIDi | 6620 |
KEGGi | hsa:6620 |
UCSCi | uc003mep.4, human |
Organism-specific databases
CTDi | 6620 |
DisGeNETi | 6620 |
EuPathDBi | HostDB:ENSG00000074317.10 |
GeneCardsi | SNCB |
HGNCi | HGNC:11140, SNCB |
HPAi | ENSG00000074317, Tissue enriched (brain) |
MalaCardsi | SNCB |
MIMi | 602569, gene |
neXtProti | NX_Q16143 |
OpenTargetsi | ENSG00000074317 |
Orphaneti | 1648, NON RARE IN EUROPE: Dementia with Lewy body |
PharmGKBi | PA35988 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0N5, Eukaryota |
GeneTreei | ENSGT00950000183175 |
HOGENOMi | CLU_129378_1_0_1 |
InParanoidi | Q16143 |
OMAi | AYDENQQ |
OrthoDBi | 1544450at2759 |
PhylomeDBi | Q16143 |
TreeFami | TF332776 |
Enzyme and pathway databases
PathwayCommonsi | Q16143 |
Reactomei | R-HSA-5660489, MTF1 activates gene expression |
SIGNORi | Q16143 |
Miscellaneous databases
BioGRID-ORCSi | 6620, 10 hits in 849 CRISPR screens |
ChiTaRSi | SNCB, human |
GeneWikii | Beta-synuclein |
GenomeRNAii | 6620 |
Pharosi | Q16143, Tbio |
PROi | PR:Q16143 |
RNActi | Q16143, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000074317, Expressed in anterior cingulate cortex and 135 other tissues |
ExpressionAtlasi | Q16143, baseline and differential |
Genevisiblei | Q16143, HS |
Family and domain databases
DisProti | DP00555 |
InterProi | View protein in InterPro IPR001058, Synuclein IPR002461, Synuclein_beta |
PANTHERi | PTHR13820, PTHR13820, 1 hit PTHR13820:SF4, PTHR13820:SF4, 1 hit |
Pfami | View protein in Pfam PF01387, Synuclein, 1 hit |
PRINTSi | PR01213, BSYNUCLEIN PR01211, SYNUCLEIN |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYUB_HUMAN | |
Accessioni | Q16143Primary (citable) accession number: Q16143 Secondary accession number(s): Q6IAX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families