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Protein

Beta-synuclein

Gene

SNCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • cuprous ion binding Source: CAFA
  • phospholipase inhibitor activity Source: ProtInc
  • transition metal ion binding Source: CAFA

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5660489 MTF1 activates gene expression
SIGNORiQ16143

Protein family/group databases

TCDBi1.C.77.1.2 the synuclein (synuclein) family

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Gene namesi
Name:SNCB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000074317.10
HGNCiHGNC:11140 SNCB
MIMi602569 gene
neXtProtiNX_Q16143

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6620
MalaCardsiSNCB
OpenTargetsiENSG00000074317
Orphaneti1648 NON RARE IN EUROPE: Dementia with Lewy body
PharmGKBiPA35988

Polymorphism and mutation databases

BioMutaiSNCB
DMDMi2501105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840351 – 134Beta-synucleinAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118Phosphoserine; by BARK1, CK2 and GRK51 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16143
MaxQBiQ16143
PaxDbiQ16143
PeptideAtlasiQ16143
PRIDEiQ16143
ProteomicsDBi60833

PTM databases

iPTMnetiQ16143
PhosphoSitePlusiQ16143

Expressioni

Tissue specificityi

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Gene expression databases

BgeeiENSG00000074317 Expressed in 109 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SNCB
ExpressionAtlasiQ16143 baseline and differential
GenevisibleiQ16143 HS

Organism-specific databases

HPAiCAB002681
HPA035876

Interactioni

Protein-protein interaction databases

BioGridi112504, 17 interactors
IntActiQ16143, 4 interactors
MINTiQ16143
STRINGi9606.ENSP00000308057

Structurei

3D structure databases

DisProtiDP00555
ProteinModelPortaliQ16143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ16143
OMAiDPEGETY
OrthoDBiEOG091G11PA
PhylomeDBiQ16143
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01213 BSYNUCLEIN
PR01211 SYNUCLEIN

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q16143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Length:134
Mass (Da):14,288
Last modified:November 1, 1996 - v1
Checksum:i5BCA9FCA615AC4EF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G4Y816G4Y816_HUMAN
Beta-synuclein
SNCB
120Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA Translation: AAB30860.1
AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1
BT006627 mRNA Translation: AAP35273.1
CR457027 mRNA Translation: CAG33308.1
BC002902 mRNA Translation: AAH02902.1
CCDSiCCDS4406.1
PIRiS44430
RefSeqiNP_001001502.1, NM_001001502.2
NP_003076.1, NM_003085.4
XP_006714979.1, XM_006714916.2
UniGeneiHs.90297

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317
ENST00000393693; ENSP00000377296; ENSG00000074317
ENST00000506696; ENSP00000422223; ENSG00000074317
ENST00000510387; ENSP00000424073; ENSG00000074317
GeneIDi6620
KEGGihsa:6620
UCSCiuc003mep.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA Translation: AAB30860.1
AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1
BT006627 mRNA Translation: AAP35273.1
CR457027 mRNA Translation: CAG33308.1
BC002902 mRNA Translation: AAH02902.1
CCDSiCCDS4406.1
PIRiS44430
RefSeqiNP_001001502.1, NM_001001502.2
NP_003076.1, NM_003085.4
XP_006714979.1, XM_006714916.2
UniGeneiHs.90297

3D structure databases

DisProtiDP00555
ProteinModelPortaliQ16143
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112504, 17 interactors
IntActiQ16143, 4 interactors
MINTiQ16143
STRINGi9606.ENSP00000308057

Protein family/group databases

TCDBi1.C.77.1.2 the synuclein (synuclein) family

PTM databases

iPTMnetiQ16143
PhosphoSitePlusiQ16143

Polymorphism and mutation databases

BioMutaiSNCB
DMDMi2501105

Proteomic databases

EPDiQ16143
MaxQBiQ16143
PaxDbiQ16143
PeptideAtlasiQ16143
PRIDEiQ16143
ProteomicsDBi60833

Protocols and materials databases

DNASUi6620
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317
ENST00000393693; ENSP00000377296; ENSG00000074317
ENST00000506696; ENSP00000422223; ENSG00000074317
ENST00000510387; ENSP00000424073; ENSG00000074317
GeneIDi6620
KEGGihsa:6620
UCSCiuc003mep.4 human

Organism-specific databases

CTDi6620
DisGeNETi6620
EuPathDBiHostDB:ENSG00000074317.10
GeneCardsiSNCB
HGNCiHGNC:11140 SNCB
HPAiCAB002681
HPA035876
MalaCardsiSNCB
MIMi602569 gene
neXtProtiNX_Q16143
OpenTargetsiENSG00000074317
Orphaneti1648 NON RARE IN EUROPE: Dementia with Lewy body
PharmGKBiPA35988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ16143
OMAiDPEGETY
OrthoDBiEOG091G11PA
PhylomeDBiQ16143
TreeFamiTF332776

Enzyme and pathway databases

ReactomeiR-HSA-5660489 MTF1 activates gene expression
SIGNORiQ16143

Miscellaneous databases

ChiTaRSiSNCB human
GeneWikiiBeta-synuclein
GenomeRNAii6620
PROiPR:Q16143
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074317 Expressed in 109 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SNCB
ExpressionAtlasiQ16143 baseline and differential
GenevisibleiQ16143 HS

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01213 BSYNUCLEIN
PR01211 SYNUCLEIN
ProtoNetiSearch...

Entry informationi

Entry nameiSYUB_HUMAN
AccessioniPrimary (citable) accession number: Q16143
Secondary accession number(s): Q6IAX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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