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Entry version 172 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Beta-synuclein

Gene

SNCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5660489 MTF1 activates gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16143

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.77.1.2 the synuclein (synuclein) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-synuclein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNCB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11140 SNCB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602569 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16143

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6620

MalaCards human disease database

More...
MalaCardsi
SNCB

Open Targets

More...
OpenTargetsi
ENSG00000074317

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1648 NON RARE IN EUROPE: Dementia with Lewy body

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35988

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNCB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2501105

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001840351 – 134Beta-synucleinAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118Phosphoserine; by BARK1, CK2 and GRK51 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16143

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16143

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16143

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16143

PeptideAtlas

More...
PeptideAtlasi
Q16143

PRoteomics IDEntifications database

More...
PRIDEi
Q16143

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60833

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16143

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16143

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074317 Expressed in 109 organ(s), highest expression level in anterior cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16143 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16143 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002681
HPA035876

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112504, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q16143, 5 interactors

Molecular INTeraction database

More...
MINTi
Q16143

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308057

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16143

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008691

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16143

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPSDMNP

Database of Orthologous Groups

More...
OrthoDBi
1544450at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16143

TreeFam database of animal gene trees

More...
TreeFami
TF332776

Family and domain databases

Database of protein disorder

More...
DisProti
DP00555

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta

The PANTHER Classification System

More...
PANTHERi
PTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01387 Synuclein, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01213 BSYNUCLEIN
PR01211 SYNUCLEIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q16143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Length:134
Mass (Da):14,288
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BCA9FCA615AC4EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G4Y816G4Y816_HUMAN
Beta-synuclein
SNCB
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S69965 mRNA Translation: AAB30860.1
AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1
BT006627 mRNA Translation: AAP35273.1
CR457027 mRNA Translation: CAG33308.1
BC002902 mRNA Translation: AAH02902.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4406.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S44430

NCBI Reference Sequences

More...
RefSeqi
NP_001001502.1, NM_001001502.2
NP_003076.1, NM_003085.4
XP_006714979.1, XM_006714916.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310112; ENSP00000308057; ENSG00000074317
ENST00000393693; ENSP00000377296; ENSG00000074317
ENST00000506696; ENSP00000422223; ENSG00000074317
ENST00000510387; ENSP00000424073; ENSG00000074317

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6620

UCSC genome browser

More...
UCSCi
uc003mep.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69965 mRNA Translation: AAB30860.1
AF053136, AF053134, AF053135 Genomic DNA Translation: AAC80286.1
BT006627 mRNA Translation: AAP35273.1
CR457027 mRNA Translation: CAG33308.1
BC002902 mRNA Translation: AAH02902.1
CCDSiCCDS4406.1
PIRiS44430
RefSeqiNP_001001502.1, NM_001001502.2
NP_003076.1, NM_003085.4
XP_006714979.1, XM_006714916.2

3D structure databases

SMRiQ16143
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112504, 17 interactors
IntActiQ16143, 5 interactors
MINTiQ16143
STRINGi9606.ENSP00000308057

Protein family/group databases

TCDBi1.C.77.1.2 the synuclein (synuclein) family

PTM databases

iPTMnetiQ16143
PhosphoSitePlusiQ16143

Polymorphism and mutation databases

BioMutaiSNCB
DMDMi2501105

Proteomic databases

EPDiQ16143
jPOSTiQ16143
MaxQBiQ16143
PaxDbiQ16143
PeptideAtlasiQ16143
PRIDEiQ16143
ProteomicsDBi60833

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6620
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310112; ENSP00000308057; ENSG00000074317
ENST00000393693; ENSP00000377296; ENSG00000074317
ENST00000506696; ENSP00000422223; ENSG00000074317
ENST00000510387; ENSP00000424073; ENSG00000074317
GeneIDi6620
KEGGihsa:6620
UCSCiuc003mep.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6620
DisGeNETi6620

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNCB
HGNCiHGNC:11140 SNCB
HPAiCAB002681
HPA035876
MalaCardsiSNCB
MIMi602569 gene
neXtProtiNX_Q16143
OpenTargetsiENSG00000074317
Orphaneti1648 NON RARE IN EUROPE: Dementia with Lewy body
PharmGKBiPA35988

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA
GeneTreeiENSGT00950000183175
HOGENOMiHOG000008691
InParanoidiQ16143
OMAiFPSDMNP
OrthoDBi1544450at2759
PhylomeDBiQ16143
TreeFamiTF332776

Enzyme and pathway databases

ReactomeiR-HSA-5660489 MTF1 activates gene expression
SIGNORiQ16143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNCB human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Beta-synuclein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6620

Protein Ontology

More...
PROi
PR:Q16143

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074317 Expressed in 109 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasiQ16143 baseline and differential
GenevisibleiQ16143 HS

Family and domain databases

DisProtiDP00555
InterProiView protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01213 BSYNUCLEIN
PR01211 SYNUCLEIN

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYUB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16143
Secondary accession number(s): Q6IAX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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