GRIK4

Functionⁱ

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functionⁱ

glutamate receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
kainate selective glutamate receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ligand-gated ion channel activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 8263508
glutamate receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8263508
modulation of chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic transmission, glutamatergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-451308 Activation of Ca-permeable Kainate Receptor

Reactomeⁱ

R-HSA-451308 Activation of Ca-permeable Kainate Receptor

Protein family/group databases

TCDBⁱ	1.A.10.1.9 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

TCDBⁱ

1.A.10.1.9 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate receptor ionotropic, kainate 4 Short name: GluK4 Alternative name(s): Excitatory amino acid receptor 1 Short name: EAA1 Glutamate receptor KA-1 Short name: KA1
Gene namesⁱ	Name:GRIK4 Synonyms:GRIK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149403.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4582 GRIK4
MIMⁱ	600282 gene
neXtProtⁱ	NX_Q16099

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 545	ExtracellularSequence analysisAdd BLAST	525
Transmembraneⁱ	546 – 566	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	567 – 623	CytoplasmicSequence analysisAdd BLAST	57
Transmembraneⁱ	624 – 644	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	645 – 804	ExtracellularSequence analysisAdd BLAST	160
Transmembraneⁱ	805 – 825	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	826 – 956	CytoplasmicSequence analysisAdd BLAST	131

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2900
Open Targets More...OpenTargetsⁱ	ENSG00000149403
PharmGKBⁱ	PA28976

Chemistry databases

ChEMBLⁱ	CHEMBL2109241
Drug and drug target database More...DrugBankⁱ	DB00142 L-Glutamic Acid

Polymorphism and mutation databases

BioMutaⁱ	GRIK4
DMDMⁱ	209572625

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000011549	21 – 956	Glutamate receptor ionotropic, kainate 4Add BLAST		936

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	158	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	272	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	286	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	323	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	408	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	415	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	479	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q16099
PeptideAtlas More...PeptideAtlasⁱ	Q16099
PRIDEⁱ	Q16099
ProteomicsDBⁱ	60831

PTM databases

iPTMnetⁱ	Q16099
PhosphoSitePlusⁱ	Q16099

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149403 Expressed in 70 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_GRIK4
Genevisibleⁱ	Q16099 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074453

HPAⁱ

HPA074453

Interactionⁱ

Subunit structureⁱ

Forms a heteromeric channel with GRIK1 or GRIK3.

Protein-protein interaction databases

BioGridⁱ	109157, 3 interactors
STRINGⁱ	9606.ENSP00000404063

Chemistry databases

BindingDBⁱ

Q16099

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16099
SMRⁱ	Q16099
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	862 – 865	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410KDI6 Eukaryota ENOG4110PNJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143978
HOGENOMⁱ	HOG000234371
HOVERGENⁱ	HBG051839
InParanoidⁱ	Q16099
KEGG Orthology (KO) More...KOⁱ	K05204
OMAⁱ	MVACSPH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02LN
PhylomeDBⁱ	Q16099
TreeFamⁱ	TF334668

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q16099-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN 
        60         70         80         90        100
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS 
       110        120        130        140        150
PASSSIISNI CGEKEVPHFK VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV 
       160        170        180        190        200
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP 
       210        220        230        240        250
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF 
       260        270        280        290        300
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 
       310        320        330        340        350
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY 
       360        370        380        390        400
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM 
       410        420        430        440        450
DSHLYASNIS DTLFNTTLVV TTILENPYLM LKGNHQEMEG NDRYEGFCVD 
       460        470        480        490        500
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG 
       510        520        530        540        550
LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL DPFSPGVWLF 
       560        570        580        590        600
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 
       610        620        630        640        650
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD 
       660        670        680        690        700
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS 
       710        720        730        740        750
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG 
       760        770        780        790        800
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL 
       810        820        830        840        850
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS VCQEMVTELR 
       860        870        880        890        900
SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 
       910        920        930        940        950
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT 

NSSEPE

Length:956

Mass (Da):107,246

Last modified:October 14, 2008 - v2

Checksum:ⁱB7CBEA402A79397A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	255	M → T in AAB29311 (PubMed:8263508).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046998	528	V → I1 PublicationCorresponds to variant dbSNP:rs2230298Ensembl.		1
Natural variantⁱVAR_046999	824	M → T. Corresponds to variant dbSNP:rs9988907Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S67803 mRNA Translation: AAB29311.1 AK292726 mRNA Translation: BAF85415.1 CH471065 Genomic DNA Translation: EAW67512.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8433.1
PIRⁱ	JH0826
NCBI Reference Sequences More...RefSeqⁱ	NP_001269399.1, NM_001282470.2 NP_055434.2, NM_014619.4
UniGeneⁱ	Hs.538738 Hs.568901

Genome annotation databases

Ensemblⁱ	ENST00000438375; ENSP00000404063; ENSG00000149403 ENST00000527524; ENSP00000435648; ENSG00000149403 ENST00000638419; ENSP00000492086; ENSG00000149403
GeneIDⁱ	2900
KEGGⁱ	hsa:2900
UCSC genome browser More...UCSCⁱ	uc001pxn.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16099	Glutamate receptor ionotropic, kainate 4	)	RAT		956	UniRef90_Q01812
Glutamate receptor ionotropic, kainate 4		MOUSE		956
Glutamate receptor ionotropic, kainate 4		PANTR		956
Glutamate ionotropic receptor kainate type subunit 4		CALJA		978
Glutamate receptor, ionotropic kainate 4 (Fragment)		MACMU		400
+242

Protein	Similar proteins		Species	Score	Length	Source
Q16099	Glutamate receptor ionotropic, kainate 4	)	RAT		956	UniRef50_Q01812
Glutamate receptor ionotropic, kainate 4		MOUSE		956
Glutamate receptor ionotropic, kainate 4		PANTR		956
Glutamate ionotropic receptor kainate type subunit 4		CALJA		978
Glutamate receptor, ionotropic kainate 4 (Fragment)		MACMU		400
+309

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S67803 mRNA Translation: AAB29311.1 AK292726 mRNA Translation: BAF85415.1 CH471065 Genomic DNA Translation: EAW67512.1
CCDSⁱ	CCDS8433.1
PIRⁱ	JH0826
RefSeqⁱ	NP_001269399.1, NM_001282470.2 NP_055434.2, NM_014619.4
UniGeneⁱ	Hs.538738 Hs.568901

3D structure databases

ProteinModelPortalⁱ	Q16099
SMRⁱ	Q16099
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109157, 3 interactors
STRINGⁱ	9606.ENSP00000404063

Chemistry databases

BindingDBⁱ	Q16099
ChEMBLⁱ	CHEMBL2109241
DrugBankⁱ	DB00142 L-Glutamic Acid

Protein family/group databases

TCDBⁱ	1.A.10.1.9 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

TCDBⁱ

1.A.10.1.9 the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

iPTMnetⁱ	Q16099
PhosphoSitePlusⁱ	Q16099

Polymorphism and mutation databases

BioMutaⁱ	GRIK4
DMDMⁱ	209572625

Proteomic databases

PaxDbⁱ	Q16099
PeptideAtlasⁱ	Q16099
PRIDEⁱ	Q16099
ProteomicsDBⁱ	60831

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000438375; ENSP00000404063; ENSG00000149403 ENST00000527524; ENSP00000435648; ENSG00000149403 ENST00000638419; ENSP00000492086; ENSG00000149403
GeneIDⁱ	2900
KEGGⁱ	hsa:2900
UCSCⁱ	uc001pxn.4 human

Organism-specific databases

CTDⁱ	2900
DisGeNETⁱ	2900
EuPathDBⁱ	HostDB:ENSG00000149403.11
GeneCardsⁱ	GRIK4
H-InvDBⁱ	HIX0036043
HGNCⁱ	HGNC:4582 GRIK4
HPAⁱ	HPA074453
MIMⁱ	600282 gene
neXtProtⁱ	NX_Q16099
OpenTargetsⁱ	ENSG00000149403
PharmGKBⁱ	PA28976
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KDI6 Eukaryota ENOG4110PNJ LUCA
GeneTreeⁱ	ENSGT00910000143978
HOGENOMⁱ	HOG000234371
HOVERGENⁱ	HBG051839
InParanoidⁱ	Q16099
KOⁱ	K05204
OMAⁱ	MVACSPH
OrthoDBⁱ	EOG091G02LN
PhylomeDBⁱ	Q16099
TreeFamⁱ	TF334668

Enzyme and pathway databases

Reactomeⁱ	R-HSA-451308 Activation of Ca-permeable Kainate Receptor

Reactomeⁱ

R-HSA-451308 Activation of Ca-permeable Kainate Receptor

Miscellaneous databases

ChiTaRSⁱ	GRIK4 human
GenomeRNAiⁱ	2900
Protein Ontology More...PROⁱ	PR:Q16099
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149403 Expressed in 70 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_GRIK4
Genevisibleⁱ	Q16099 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRIK4_HUMAN
Accessionⁱ	Q16099Primary (citable) accession number: Q16099 Secondary accession number(s): A8K9L1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	October 14, 2008
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q16099 (GRIK4_HUMAN)

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Glutamate receptor ionotropic, kainate 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ