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UniProtKB - Q16099 (GRIK4_HUMAN)
Protein
Glutamate receptor ionotropic, kainate 4
Gene
GRIK4
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
GO - Molecular functioni
- glutamate receptor activity Source: GO_Central
- kainate selective glutamate receptor activity Source: GO_Central
- ligand-gated ion channel activity Source: GO_Central
- signaling receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- glutamate receptor signaling pathway Source: ProtInc
- modulation of chemical synaptic transmission Source: GO_Central
- synaptic transmission, glutamatergic Source: GO_Central
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q16099 |
Reactomei | R-HSA-451308, Activation of Ca-permeable Kainate Receptor |
SignaLinki | Q16099 |
SIGNORi | Q16099 |
Protein family/group databases
TCDBi | 1.A.10.1.9, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor ionotropic, kainate 4Short name: GluK4 Alternative name(s): Excitatory amino acid receptor 1 Short name: EAA1 Glutamate receptor KA-1 Short name: KA1 |
Gene namesi | Name:GRIK4 Synonyms:GRIK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4582, GRIK4 |
MIMi | 600282, gene |
neXtProti | NX_Q16099 |
VEuPathDBi | HostDB:ENSG00000149403 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- kainate selective glutamate receptor complex Source: GO_Central
- plasma membrane Source: GO_Central
- postsynaptic membrane Source: GO_Central
- presynaptic membrane Source: GO_Central
Other locations
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 545 | ExtracellularSequence analysisAdd BLAST | 525 | |
Transmembranei | 546 – 566 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 567 – 623 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 624 – 644 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 645 – 804 | ExtracellularSequence analysisAdd BLAST | 160 | |
Transmembranei | 805 – 825 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 826 – 956 | CytoplasmicSequence analysisAdd BLAST | 131 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 2900 |
OpenTargetsi | ENSG00000149403 |
PharmGKBi | PA28976 |
Miscellaneous databases
Pharosi | Q16099, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2109241 |
DrugBanki | DB00237, Butabarbital DB00142, Glutamic acid DB00273, Topiramate |
DrugCentrali | Q16099 |
Genetic variation databases
BioMutai | GRIK4 |
DMDMi | 209572625 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000011549 | 21 – 956 | Glutamate receptor ionotropic, kainate 4Add BLAST | 936 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 272 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 286 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 415 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 736 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q16099 |
PeptideAtlasi | Q16099 |
PRIDEi | Q16099 |
ProteomicsDBi | 60831 |
PTM databases
GlyGeni | Q16099, 9 sites |
iPTMneti | Q16099 |
PhosphoSitePlusi | Q16099 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149403, Expressed in C1 segment of cervical spinal cord and 105 other tissues |
Genevisiblei | Q16099, HS |
Organism-specific databases
HPAi | ENSG00000149403, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Forms a heteromeric channel with GRIK1 or GRIK3.
Protein-protein interaction databases
BioGRIDi | 109157, 3 interactors |
STRINGi | 9606.ENSP00000435648 |
Chemistry databases
BindingDBi | Q16099 |
Miscellaneous databases
RNActi | Q16099, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 863 – 889 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 931 – 956 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 938 – 956 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1052, Eukaryota |
GeneTreei | ENSGT00940000159111 |
HOGENOMi | CLU_007257_1_0_1 |
InParanoidi | Q16099 |
OMAi | PAXVELE |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q16099 |
TreeFami | TF334668 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q16099-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN
60 70 80 90 100
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS
110 120 130 140 150
PASSSIISNI CGEKEVPHFK VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV
160 170 180 190 200
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP
210 220 230 240 250
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF
260 270 280 290 300
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG
310 320 330 340 350
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY
360 370 380 390 400
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM
410 420 430 440 450
DSHLYASNIS DTLFNTTLVV TTILENPYLM LKGNHQEMEG NDRYEGFCVD
460 470 480 490 500
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG
510 520 530 540 550
LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL DPFSPGVWLF
560 570 580 590 600
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP
610 620 630 640 650
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD
660 670 680 690 700
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS
710 720 730 740 750
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG
760 770 780 790 800
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL
810 820 830 840 850
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS VCQEMVTELR
860 870 880 890 900
SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ
910 920 930 940 950
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT
NSSEPE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 255 | M → T in AAB29311 (PubMed:8263508).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046998 | 528 | V → I1 PublicationCorresponds to variant dbSNP:rs2230298EnsemblClinVar. | 1 | |
Natural variantiVAR_046999 | 824 | M → T. Corresponds to variant dbSNP:rs9988907EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S67803 mRNA Translation: AAB29311.1 AK292726 mRNA Translation: BAF85415.1 CH471065 Genomic DNA Translation: EAW67512.1 |
CCDSi | CCDS8433.1 |
PIRi | JH0826 |
RefSeqi | NP_001269399.1, NM_001282470.2 NP_055434.2, NM_014619.4 |
Genome annotation databases
Ensembli | ENST00000438375.2; ENSP00000404063.2; ENSG00000149403.13 ENST00000527524.8; ENSP00000435648.2; ENSG00000149403.13 ENST00000638419.1; ENSP00000492086.1; ENSG00000149403.13 |
GeneIDi | 2900 |
KEGGi | hsa:2900 |
MANE-Selecti | ENST00000527524.8; ENSP00000435648.2; NM_014619.5; NP_055434.2 |
UCSCi | uc001pxn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S67803 mRNA Translation: AAB29311.1 AK292726 mRNA Translation: BAF85415.1 CH471065 Genomic DNA Translation: EAW67512.1 |
CCDSi | CCDS8433.1 |
PIRi | JH0826 |
RefSeqi | NP_001269399.1, NM_001282470.2 NP_055434.2, NM_014619.4 |
3D structure databases
AlphaFoldDBi | Q16099 |
SMRi | Q16099 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109157, 3 interactors |
STRINGi | 9606.ENSP00000435648 |
Chemistry databases
BindingDBi | Q16099 |
ChEMBLi | CHEMBL2109241 |
DrugBanki | DB00237, Butabarbital DB00142, Glutamic acid DB00273, Topiramate |
DrugCentrali | Q16099 |
Protein family/group databases
TCDBi | 1.A.10.1.9, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
PTM databases
GlyGeni | Q16099, 9 sites |
iPTMneti | Q16099 |
PhosphoSitePlusi | Q16099 |
Genetic variation databases
BioMutai | GRIK4 |
DMDMi | 209572625 |
Proteomic databases
PaxDbi | Q16099 |
PeptideAtlasi | Q16099 |
PRIDEi | Q16099 |
ProteomicsDBi | 60831 |
Protocols and materials databases
Antibodypediai | 32769, 157 antibodies from 28 providers |
DNASUi | 2900 |
Genome annotation databases
Ensembli | ENST00000438375.2; ENSP00000404063.2; ENSG00000149403.13 ENST00000527524.8; ENSP00000435648.2; ENSG00000149403.13 ENST00000638419.1; ENSP00000492086.1; ENSG00000149403.13 |
GeneIDi | 2900 |
KEGGi | hsa:2900 |
MANE-Selecti | ENST00000527524.8; ENSP00000435648.2; NM_014619.5; NP_055434.2 |
UCSCi | uc001pxn.4, human |
Organism-specific databases
CTDi | 2900 |
DisGeNETi | 2900 |
GeneCardsi | GRIK4 |
HGNCi | HGNC:4582, GRIK4 |
HPAi | ENSG00000149403, Tissue enhanced (brain) |
MIMi | 600282, gene |
neXtProti | NX_Q16099 |
OpenTargetsi | ENSG00000149403 |
PharmGKBi | PA28976 |
VEuPathDBi | HostDB:ENSG00000149403 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1052, Eukaryota |
GeneTreei | ENSGT00940000159111 |
HOGENOMi | CLU_007257_1_0_1 |
InParanoidi | Q16099 |
OMAi | PAXVELE |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q16099 |
TreeFami | TF334668 |
Enzyme and pathway databases
PathwayCommonsi | Q16099 |
Reactomei | R-HSA-451308, Activation of Ca-permeable Kainate Receptor |
SignaLinki | Q16099 |
SIGNORi | Q16099 |
Miscellaneous databases
BioGRID-ORCSi | 2900, 9 hits in 1074 CRISPR screens |
ChiTaRSi | GRIK4, human |
GenomeRNAii | 2900 |
Pharosi | Q16099, Tclin |
PROi | PR:Q16099 |
RNActi | Q16099, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149403, Expressed in C1 segment of cervical spinal cord and 105 other tissues |
Genevisiblei | Q16099, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GRIK4_HUMAN | |
Accessioni | Q16099Primary (citable) accession number: Q16099 Secondary accession number(s): A8K9L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families