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Protein

Heat shock protein beta-2

Gene

HSPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the kinase DMPK.1 Publication

GO - Molecular functioni

  • enzyme activator activity Source: ProtInc

GO - Biological processi

  • response to unfolded protein Source: ProtInc

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Alternative name(s):
DMPK-binding protein
Short name:
MKBP
Gene namesi
Name:HSPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170276.5
HGNCiHGNC:5247 HSPB2
MIMi602179 gene
neXtProtiNX_Q16082

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3316
OpenTargetsiENSG00000170276
PharmGKBiPA29512

Polymorphism and mutation databases

BioMutaiHSPB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259331 – 182Heat shock protein beta-2Add BLAST182

Proteomic databases

MaxQBiQ16082
PaxDbiQ16082
PeptideAtlasiQ16082
PRIDEiQ16082
ProteomicsDBi60830

PTM databases

iPTMnetiQ16082
PhosphoSitePlusiQ16082

Expressioni

Tissue specificityi

Expressed preferentially in skeletal muscle and heart but not in the lens.

Gene expression databases

BgeeiENSG00000170276 Expressed in 91 organ(s), highest expression level in right atrium auricular region
CleanExiHS_HSPB2
GenevisibleiQ16082 HS

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi109548, 111 interactors
IntActiQ16082, 174 interactors
MINTiQ16082
STRINGi9606.ENSP00000457706

Structurei

3D structure databases

ProteinModelPortaliQ16082
SMRiQ16082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 163sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiQ16082
KOiK09543
OMAiHGYYIRP
OrthoDBiEOG091G0USC
PhylomeDBiQ16082

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q16082-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP
Length:182
Mass (Da):20,233
Last modified:November 1, 1998 - v2
Checksum:i7586DCE8FBD19F6D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016316111G → S1 PublicationCorresponds to variant dbSNP:rs4252589Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA Translation: AAB82757.1
D89617 mRNA Translation: BAA24004.1
CR457408 mRNA Translation: CAG33689.1
AY208910 Genomic DNA Translation: AAO18081.1
BC109393 mRNA Translation: AAI09394.1
S67070 mRNA Translation: AAB28816.1
CCDSiCCDS8352.1
RefSeqiNP_001532.1, NM_001541.3
UniGeneiHs.709660

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276
GeneIDi3316
KEGGihsa:3316
UCSCiuc001pmg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75898 Genomic DNA Translation: AAB82757.1
D89617 mRNA Translation: BAA24004.1
CR457408 mRNA Translation: CAG33689.1
AY208910 Genomic DNA Translation: AAO18081.1
BC109393 mRNA Translation: AAI09394.1
S67070 mRNA Translation: AAB28816.1
CCDSiCCDS8352.1
RefSeqiNP_001532.1, NM_001541.3
UniGeneiHs.709660

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F2RX-ray3.90A/C/D/E/F/G/I/J/K1-182[»]
ProteinModelPortaliQ16082
SMRiQ16082
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109548, 111 interactors
IntActiQ16082, 174 interactors
MINTiQ16082
STRINGi9606.ENSP00000457706

PTM databases

iPTMnetiQ16082
PhosphoSitePlusiQ16082

Polymorphism and mutation databases

BioMutaiHSPB2

Proteomic databases

MaxQBiQ16082
PaxDbiQ16082
PeptideAtlasiQ16082
PRIDEiQ16082
ProteomicsDBi60830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304298; ENSP00000302476; ENSG00000170276
GeneIDi3316
KEGGihsa:3316
UCSCiuc001pmg.3 human

Organism-specific databases

CTDi3316
DisGeNETi3316
EuPathDBiHostDB:ENSG00000170276.5
GeneCardsiHSPB2
HGNCiHGNC:5247 HSPB2
MIMi602179 gene
neXtProtiNX_Q16082
OpenTargetsiENSG00000170276
PharmGKBiPA29512
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiQ16082
KOiK09543
OMAiHGYYIRP
OrthoDBiEOG091G0USC
PhylomeDBiQ16082

Miscellaneous databases

GeneWikiiHSPB2
GenomeRNAii3316
PROiPR:Q16082
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170276 Expressed in 91 organ(s), highest expression level in right atrium auricular region
CleanExiHS_HSPB2
GenevisibleiQ16082 HS

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB2_HUMAN
AccessioniPrimary (citable) accession number: Q16082
Secondary accession number(s): Q6I9U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 10, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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