UniProtKB - Q16082 (HSPB2_HUMAN)

BLAST

>sp|Q16082|HSPB2_HUMAN Heat shock protein beta-2 OS=Homo sapiens OX=9606 GN=HSPB2 PE=1 SV=2
MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGS
RAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRT
YVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIV
EP

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History
Entry version 157 (10 Oct 2018)
Sequence version 2 (01 Nov 1998)
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Protein

Heat shock protein beta-2

Gene

HSPB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May regulate the kinase DMPK.1 Publication

GO - Molecular functionⁱ

enzyme activator activity
Source: ProtInc
Traceable author statementⁱ
- 9490724

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

response to unfolded protein
Source: ProtInc
Non-traceable author statementⁱ
- 9344664

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Stress response

Biological process

Stress response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock protein beta-2 Short name: HspB2 Alternative name(s): DMPK-binding protein Short name: MKBP
Gene namesⁱ	Name:HSPB2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170276.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5247 HSPB2
MIMⁱ	602179 gene
neXtProtⁱ	NX_Q16082

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3316
Open Targets More...OpenTargetsⁱ	ENSG00000170276
PharmGKBⁱ	PA29512

Polymorphism and mutation databases

BioMutaⁱ	HSPB2

BioMutaⁱ

HSPB2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000125933	1 – 182	Heat shock protein beta-2Add BLAST		182

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16082
PaxDbⁱ	Q16082
PeptideAtlas More...PeptideAtlasⁱ	Q16082
PRIDEⁱ	Q16082
ProteomicsDBⁱ	60830

PTM databases

iPTMnetⁱ	Q16082
PhosphoSitePlusⁱ	Q16082

Expressionⁱ

Tissue specificityⁱ

Expressed preferentially in skeletal muscle and heart but not in the lens.

Gene expression databases

Bgeeⁱ	ENSG00000170276 Expressed in 91 organ(s), highest expression level in right atrium auricular region
CleanExⁱ	HS_HSPB2
Genevisibleⁱ	Q16082 HS

Interactionⁱ

Subunit structureⁱ

Interacts with DMPK; may enhance its kinase activity.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP19	Q96LK0	4	EBI-739395,EBI-741885
CRYAB	P02511	3	EBI-739395,EBI-739060
HSPB8	Q9UJY1	3	EBI-739395,EBI-739074

Protein-protein interaction databases

BioGridⁱ	109548, 111 interactors
IntActⁱ	Q16082, 174 interactors
Molecular INTeraction database More...MINTⁱ	Q16082
STRINGⁱ	9606.ENSP00000457706

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16082
SMRⁱ	Q16082
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	55 – 163	sHSPPROSITE-ProRule annotationAdd BLAST		109

Sequence similaritiesⁱ

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119238
HOGENOMⁱ	HOG000233954
HOVERGENⁱ	HBG054766
InParanoidⁱ	Q16082
KEGG Orthology (KO) More...KOⁱ	K09543
OMAⁱ	HGYYIRP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0USC
PhylomeDBⁱ	Q16082

Family and domain databases

Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16082-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR 
        60         70         80         90        100
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS 
       110        120        130        140        150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG 
       160        170        180 
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP

Length:182

Mass (Da):20,233

Last modified:November 1, 1998 - v2

Checksum:ⁱ7586DCE8FBD19F6D

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016316	111	G → S1 PublicationCorresponds to variant dbSNP:rs4252589Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U75898 Genomic DNA Translation: AAB82757.1 D89617 mRNA Translation: BAA24004.1 CR457408 mRNA Translation: CAG33689.1 AY208910 Genomic DNA Translation: AAO18081.1 BC109393 mRNA Translation: AAI09394.1 S67070 mRNA Translation: AAB28816.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8352.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001532.1, NM_001541.3
UniGeneⁱ	Hs.709660

Genome annotation databases

Ensemblⁱ	ENST00000304298; ENSP00000302476; ENSG00000170276
GeneIDⁱ	3316
KEGGⁱ	hsa:3316
UCSC genome browser More...UCSCⁱ	uc001pmg.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16082	Uncharacterized protein (Fragment)		MACFA		151	UniRef100_Q16082
Heat shock 27kDa protein 2, isoform CRA_a		HUMAN		182
Heat shock protein beta-2		CALJA		182
HSPB2 isoform 1		PANTR		182
Uncharacterized protein		COLAP		182
+10

Protein	Similar proteins		Species	Score	Length	Source
Q16082	Uncharacterized protein (Fragment)		MACFA		151	UniRef90_Q16082
Heat shock 27kDa protein 2, isoform CRA_a		HUMAN		182
Heat shock protein beta-2		CALJA		182
HSPB2 isoform 1		PANTR		182
Uncharacterized protein		COLAP		182
+13

Protein	Similar proteins		Species	Score	Length	Source
Q16082	Uncharacterized protein (Fragment)		MACFA		151	UniRef50_Q16082
Heat shock 27kDa protein 2, isoform CRA_a		HUMAN		182
Heat shock protein beta-2		CALJA		182
HSPB2 isoform 1		PANTR		182
Uncharacterized protein		COLAP		182
+22

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U75898 Genomic DNA Translation: AAB82757.1 D89617 mRNA Translation: BAA24004.1 CR457408 mRNA Translation: CAG33689.1 AY208910 Genomic DNA Translation: AAO18081.1 BC109393 mRNA Translation: AAI09394.1 S67070 mRNA Translation: AAB28816.1
CCDSⁱ	CCDS8352.1
RefSeqⁱ	NP_001532.1, NM_001541.3
UniGeneⁱ	Hs.709660

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6F2R	X-ray	3.90	A/C/D/E/F/G/I/J/K	1-182	[»]
ProteinModelPortalⁱ	Q16082
SMRⁱ	Q16082
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109548, 111 interactors
IntActⁱ	Q16082, 174 interactors
MINTⁱ	Q16082
STRINGⁱ	9606.ENSP00000457706

PTM databases

iPTMnetⁱ	Q16082
PhosphoSitePlusⁱ	Q16082

Polymorphism and mutation databases

BioMutaⁱ	HSPB2

BioMutaⁱ

HSPB2

Proteomic databases

MaxQBⁱ	Q16082
PaxDbⁱ	Q16082
PeptideAtlasⁱ	Q16082
PRIDEⁱ	Q16082
ProteomicsDBⁱ	60830

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000304298; ENSP00000302476; ENSG00000170276
GeneIDⁱ	3316
KEGGⁱ	hsa:3316
UCSCⁱ	uc001pmg.3 human

Organism-specific databases

CTDⁱ	3316
DisGeNETⁱ	3316
EuPathDBⁱ	HostDB:ENSG00000170276.5
GeneCardsⁱ	HSPB2
HGNCⁱ	HGNC:5247 HSPB2
MIMⁱ	602179 gene
neXtProtⁱ	NX_Q16082
OpenTargetsⁱ	ENSG00000170276
PharmGKBⁱ	PA29512
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
GeneTreeⁱ	ENSGT00760000119238
HOGENOMⁱ	HOG000233954
HOVERGENⁱ	HBG054766
InParanoidⁱ	Q16082
KOⁱ	K09543
OMAⁱ	HGYYIRP
OrthoDBⁱ	EOG091G0USC
PhylomeDBⁱ	Q16082

Miscellaneous databases

GeneWikiⁱ	HSPB2
GenomeRNAiⁱ	3316
Protein Ontology More...PROⁱ	PR:Q16082
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170276 Expressed in 91 organ(s), highest expression level in right atrium auricular region
CleanExⁱ	HS_HSPB2
Genevisibleⁱ	Q16082 HS

Family and domain databases

Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSPB2_HUMAN
Accessionⁱ	Q16082Primary (citable) accession number: Q16082 Secondary accession number(s): Q6I9U7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	November 1, 1998
	Last modified:	October 10, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q16082 (HSPB2_HUMAN)

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Heat shock protein beta-2

HSPB2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ