UniProtKB - Q16082 (HSPB2_HUMAN)
Protein
Heat shock protein beta-2
Gene
HSPB2
Organism
Homo sapiens (Human)
Status
Functioni
May regulate the kinase DMPK.1 Publication
GO - Molecular functioni
- enzyme activator activity Source: ProtInc
- structural constituent of eye lens Source: InterPro
GO - Biological processi
- response to unfolded protein Source: ProtInc
Keywordsi
Biological process | Stress response |
Enzyme and pathway databases
PathwayCommonsi | Q16082 |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-2Short name: HspB2 Alternative name(s): DMPK-binding protein Short name: MKBP |
Gene namesi | Name:HSPB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5247, HSPB2 |
MIMi | 602179, gene |
neXtProti | NX_Q16082 |
VEuPathDBi | HostDB:ENSG00000170276.5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3316 |
OpenTargetsi | ENSG00000170276 |
PharmGKBi | PA29512 |
Miscellaneous databases
Pharosi | Q16082, Tbio |
Genetic variation databases
BioMutai | HSPB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125933 | 1 – 182 | Heat shock protein beta-2Add BLAST | 182 |
Proteomic databases
MassIVEi | Q16082 |
MaxQBi | Q16082 |
PaxDbi | Q16082 |
PeptideAtlasi | Q16082 |
PRIDEi | Q16082 |
ProteomicsDBi | 60830 |
PTM databases
iPTMneti | Q16082 |
PhosphoSitePlusi | Q16082 |
Expressioni
Tissue specificityi
Expressed preferentially in skeletal muscle and heart but not in the lens.
Gene expression databases
Bgeei | ENSG00000170276, Expressed in right atrium auricular region and 107 other tissues |
Genevisiblei | Q16082, HS |
Organism-specific databases
HPAi | ENSG00000170276, Tissue enhanced (breast, heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with DMPK; may enhance its kinase activity.
1 PublicationBinary interactionsi
Hide detailsQ16082
Protein-protein interaction databases
BioGRIDi | 109548, 130 interactors |
IntActi | Q16082, 175 interactors |
MINTi | Q16082 |
STRINGi | 9606.ENSP00000302476 |
Miscellaneous databases
RNActi | Q16082, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 163 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Sequence similaritiesi
Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000161288 |
HOGENOMi | CLU_095001_1_0_1 |
InParanoidi | Q16082 |
OMAi | PHAYPMS |
OrthoDBi | 1187096at2759 |
PhylomeDBi | Q16082 |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR001436, Alpha-crystallin/sHSP_animal IPR003090, Alpha-crystallin_N IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00525, Crystallin, 1 hit PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16082-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRSVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAAPAGEGS RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEAAIV EP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016316 | 111 | G → S1 PublicationCorresponds to variant dbSNP:rs4252589EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75898 Genomic DNA Translation: AAB82757.1 D89617 mRNA Translation: BAA24004.1 CR457408 mRNA Translation: CAG33689.1 AY208910 Genomic DNA Translation: AAO18081.1 BC109393 mRNA Translation: AAI09394.1 S67070 mRNA Translation: AAB28816.1 |
CCDSi | CCDS8352.1 |
RefSeqi | NP_001532.1, NM_001541.3 |
Genome annotation databases
Ensembli | ENST00000304298; ENSP00000302476; ENSG00000170276 |
GeneIDi | 3316 |
KEGGi | hsa:3316 |
UCSCi | uc001pmg.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75898 Genomic DNA Translation: AAB82757.1 D89617 mRNA Translation: BAA24004.1 CR457408 mRNA Translation: CAG33689.1 AY208910 Genomic DNA Translation: AAO18081.1 BC109393 mRNA Translation: AAI09394.1 S67070 mRNA Translation: AAB28816.1 |
CCDSi | CCDS8352.1 |
RefSeqi | NP_001532.1, NM_001541.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6F2R | X-ray | 3.90 | A/C/D/E/F/G/I/J/K | 1-182 | [»] | |
SMRi | Q16082 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109548, 130 interactors |
IntActi | Q16082, 175 interactors |
MINTi | Q16082 |
STRINGi | 9606.ENSP00000302476 |
PTM databases
iPTMneti | Q16082 |
PhosphoSitePlusi | Q16082 |
Genetic variation databases
BioMutai | HSPB2 |
Proteomic databases
MassIVEi | Q16082 |
MaxQBi | Q16082 |
PaxDbi | Q16082 |
PeptideAtlasi | Q16082 |
PRIDEi | Q16082 |
ProteomicsDBi | 60830 |
Protocols and materials databases
Antibodypediai | 32089, 540 antibodies |
Genome annotation databases
Ensembli | ENST00000304298; ENSP00000302476; ENSG00000170276 |
GeneIDi | 3316 |
KEGGi | hsa:3316 |
UCSCi | uc001pmg.3, human |
Organism-specific databases
CTDi | 3316 |
DisGeNETi | 3316 |
GeneCardsi | HSPB2 |
HGNCi | HGNC:5247, HSPB2 |
HPAi | ENSG00000170276, Tissue enhanced (breast, heart muscle, skeletal muscle) |
MIMi | 602179, gene |
neXtProti | NX_Q16082 |
OpenTargetsi | ENSG00000170276 |
PharmGKBi | PA29512 |
VEuPathDBi | HostDB:ENSG00000170276.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000161288 |
HOGENOMi | CLU_095001_1_0_1 |
InParanoidi | Q16082 |
OMAi | PHAYPMS |
OrthoDBi | 1187096at2759 |
PhylomeDBi | Q16082 |
Enzyme and pathway databases
PathwayCommonsi | Q16082 |
Miscellaneous databases
BioGRID-ORCSi | 3316, 1 hit in 971 CRISPR screens |
GeneWikii | HSPB2 |
GenomeRNAii | 3316 |
Pharosi | Q16082, Tbio |
PROi | PR:Q16082 |
RNActi | Q16082, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170276, Expressed in right atrium auricular region and 107 other tissues |
Genevisiblei | Q16082, HS |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR001436, Alpha-crystallin/sHSP_animal IPR003090, Alpha-crystallin_N IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00525, Crystallin, 1 hit PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSPB2_HUMAN | |
Accessioni | Q16082Primary (citable) accession number: Q16082 Secondary accession number(s): Q6I9U7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families