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Protein

Zinc finger protein 79

Gene

ZNF79

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 79
Alternative name(s):
ZNFpT7
Gene namesi
Name:ZNF79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196152.10
HGNCiHGNC:13153 ZNF79
MIMi194552 gene
neXtProtiNX_Q15937

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7633
OpenTargetsiENSG00000196152
PharmGKBiPA37727

Polymorphism and mutation databases

BioMutaiZNF79
DMDMi85681870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473881 – 498Zinc finger protein 79Add BLAST498

Proteomic databases

MaxQBiQ15937
PaxDbiQ15937
PeptideAtlasiQ15937
PRIDEiQ15937
ProteomicsDBi60821

PTM databases

iPTMnetiQ15937
PhosphoSitePlusiQ15937

Expressioni

Gene expression databases

BgeeiENSG00000196152 Expressed in 172 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF79
ExpressionAtlasiQ15937 baseline and differential
GenevisibleiQ15937 HS

Organism-specific databases

HPAiHPA028977

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113451, 3 interactors
IntActiQ15937, 9 interactors
STRINGi9606.ENSP00000362446

Structurei

3D structure databases

ProteinModelPortaliQ15937
SMRiQ15937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 109KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144031
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ15937
KOiK09228
OMAiAFRHSAN
OrthoDBiEOG091G02KC
PhylomeDBiQ15937
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q15937-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEEGVLPSP GPALPQEENT GEEGMAAGLL TAGPRGSTFF SSVTVAFAQE
60 70 80 90 100
RWRCLVSTPR DRFKEGIPGK SRSLVLLGLP VSQPGMNSQL EQREGAWMLE
110 120 130 140 150
GEDLRSPSPG WKIISGSPPE QALSEASFQD PCVEMPPGDS DHGTSDLEKS
160 170 180 190 200
FNLRPVLSPQ QRVPVEARPR KCETHTESFK NSEILKPHRA KPYACNECGK
210 220 230 240 250
AFSYCSSLSQ HQKSHTGEKP YECSECGKAF SQSSSLIQHQ RIHTGEKPYK
260 270 280 290 300
CSECGRAFSQ NANLTKHQRT HTGEKPYRCS ECEKAFSDCS ALVQHQRIHT
310 320 330 340 350
GEKPYECSDC GKAFRHSANL TNHQRTHTGE KPYKCSECGK AFSYCAAFIQ
360 370 380 390 400
HQRIHTGEKP YRCAACGKAF SQSANLTNHQ RTHTGEKPYK CSECGKAFSQ
410 420 430 440 450
STNLIIHQKT HTGEKPYKCN ECGKFFSESS ALIRHHIIHT GEKPYECNEC
460 470 480 490
GKAFNQSSSL SQHQRIHTGV KPYECSECGK AFRCSSAFVR HQRLHAGE
Length:498
Mass (Da):55,350
Last modified:January 10, 2006 - v2
Checksum:i6E4A9F5AE680BF0C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H032F5H032_HUMAN
Zinc finger protein 79
ZNF79
474Annotation score:
A0A087X2B0A0A087X2B0_HUMAN
Zinc finger protein 79
ZNF79
364Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345C → G in CAA46339 (PubMed:8478004).Curated1
Sequence conflicti375 – 377Missing in CAA46339 (PubMed:8478004).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02484131T → I2 PublicationsCorresponds to variant dbSNP:rs13292096Ensembl.1
Natural variantiVAR_02484251R → G2 PublicationsCorresponds to variant dbSNP:rs4504745Ensembl.1
Natural variantiVAR_059896401S → N. Corresponds to variant dbSNP:rs3210752Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA Translation: BAB70771.1
AL445222 Genomic DNA No translation available.
BC062309 mRNA Translation: AAH62309.1
X65232 mRNA Translation: CAA46339.1
CCDSiCCDS6871.1
PIRiI39315
RefSeqiNP_009066.2, NM_007135.2
UniGeneiHs.522399

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152
GeneIDi7633
KEGGihsa:7633
UCSCiuc004bqw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054606 mRNA Translation: BAB70771.1
AL445222 Genomic DNA No translation available.
BC062309 mRNA Translation: AAH62309.1
X65232 mRNA Translation: CAA46339.1
CCDSiCCDS6871.1
PIRiI39315
RefSeqiNP_009066.2, NM_007135.2
UniGeneiHs.522399

3D structure databases

ProteinModelPortaliQ15937
SMRiQ15937
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113451, 3 interactors
IntActiQ15937, 9 interactors
STRINGi9606.ENSP00000362446

PTM databases

iPTMnetiQ15937
PhosphoSitePlusiQ15937

Polymorphism and mutation databases

BioMutaiZNF79
DMDMi85681870

Proteomic databases

MaxQBiQ15937
PaxDbiQ15937
PeptideAtlasiQ15937
PRIDEiQ15937
ProteomicsDBi60821

Protocols and materials databases

DNASUi7633
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342483; ENSP00000362446; ENSG00000196152
GeneIDi7633
KEGGihsa:7633
UCSCiuc004bqw.5 human

Organism-specific databases

CTDi7633
DisGeNETi7633
EuPathDBiHostDB:ENSG00000196152.10
GeneCardsiZNF79
HGNCiHGNC:13153 ZNF79
HPAiHPA028977
MIMi194552 gene
neXtProtiNX_Q15937
OpenTargetsiENSG00000196152
PharmGKBiPA37727
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144031
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ15937
KOiK09228
OMAiAFRHSAN
OrthoDBiEOG091G02KC
PhylomeDBiQ15937
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF79 human
GeneWikiiZNF79
GenomeRNAii7633
PROiPR:Q15937
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196152 Expressed in 172 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF79
ExpressionAtlasiQ15937 baseline and differential
GenevisibleiQ15937 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF79_HUMAN
AccessioniPrimary (citable) accession number: Q15937
Secondary accession number(s): Q5VVW1, Q96NV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 10, 2006
Last modified: October 10, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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