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UniProtKB - Q15928 (ZN141_HUMAN)
Protein
Zinc finger protein 141
Gene
ZNF141
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 193 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- limb morphogenesis Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of transcription, DNA-templated Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15928 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 141 |
Gene namesi | Name:ZNF141 Synonyms:D4S90 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12926, ZNF141 |
MIMi | 194648, gene |
neXtProti | NX_Q15928 |
VEuPathDBi | HostDB:ENSG00000131127 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Polydactyly, postaxial A6 (PAPA6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069637 | 474 | T → I in PAPA6. 1 PublicationCorresponds to variant dbSNP:rs587776959EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7700 |
MalaCardsi | ZNF141 |
MIMi | 615226, phenotype |
OpenTargetsi | ENSG00000131127 |
Orphaneti | 93334, Postaxial polydactyly type A |
PharmGKBi | PA37513 |
Miscellaneous databases
Pharosi | Q15928, Tbio |
Genetic variation databases
BioMutai | ZNF141 |
DMDMi | 2501717 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047424 | 1 – 474 | Zinc finger protein 141Add BLAST | 474 |
Proteomic databases
EPDi | Q15928 |
jPOSTi | Q15928 |
MassIVEi | Q15928 |
PaxDbi | Q15928 |
PeptideAtlasi | Q15928 |
PRIDEi | Q15928 |
ProteomicsDBi | 60818 |
PTM databases
iPTMneti | Q15928 |
PhosphoSitePlusi | Q15928 |
Expressioni
Tissue specificityi
Ubiquitously low expression.
Gene expression databases
Bgeei | ENSG00000131127, Expressed in adrenal tissue and 178 other tissues |
ExpressionAtlasi | Q15928, baseline and differential |
Genevisiblei | Q15928, HS |
Organism-specific databases
HPAi | ENSG00000131127, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000240499 |
Miscellaneous databases
RNActi | Q15928, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 193 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q15928 |
OMAi | CEHELSR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15928 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q15928-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP
60 70 80 90 100
DLVTCLEQRK EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL
110 120 130 140 150
RRYEKCGHDN LQLRKGCKSL NECKLQKGGY NEFNECLSTT QSKILQCKAS
160 170 180 190 200
VKVVSKFSNS NKRKTRHTGE KHFKECGKSF QKFSHLTQHK VIHAGEKPYT
210 220 230 240 250
CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS HFAKHKIIHT
260 270 280 290 300
GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK
310 320 330 340 350
HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ
360 370 380 390 400
SSKLNEHKKV HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC
410 420 430 440 450
GKAFRRSTDR SQHKKIHSAD KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP
460 470
YKCKDCDKAF KRFSHLNKHK KIHT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RIY0 | D6RIY0_HUMAN | Zinc finger protein 141 | ZNF141 hCG_34448 | 201 | Annotation score: | ||
D6RB60 | D6RB60_HUMAN | Zinc finger protein 141 | ZNF141 | 113 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019973 | 124 | K → E. Corresponds to variant dbSNP:rs2229296EnsemblClinVar. | 1 | |
Natural variantiVAR_012026 | 349 | R → K. Corresponds to variant dbSNP:rs955417Ensembl. | 1 | |
Natural variantiVAR_012027 | 358 | K → N. Corresponds to variant dbSNP:rs2018645Ensembl. | 1 | |
Natural variantiVAR_069637 | 474 | T → I in PAPA6. 1 PublicationCorresponds to variant dbSNP:rs587776959EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15309 mRNA Translation: AAC37529.1 BC074853 mRNA Translation: AAH74853.3 |
CCDSi | CCDS33931.1 |
PIRi | I54338 |
RefSeqi | NP_003432.1, NM_003441.3 |
Genome annotation databases
Ensembli | ENST00000240499; ENSP00000240499; ENSG00000131127 |
GeneIDi | 7700 |
KEGGi | hsa:7700 |
MANE-Selecti | ENST00000240499.8; ENSP00000240499.7; NM_003441.4; NP_003432.1 |
UCSCi | uc003gaa.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15309 mRNA Translation: AAC37529.1 BC074853 mRNA Translation: AAH74853.3 |
CCDSi | CCDS33931.1 |
PIRi | I54338 |
RefSeqi | NP_003432.1, NM_003441.3 |
3D structure databases
SMRi | Q15928 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000240499 |
PTM databases
iPTMneti | Q15928 |
PhosphoSitePlusi | Q15928 |
Genetic variation databases
BioMutai | ZNF141 |
DMDMi | 2501717 |
Proteomic databases
EPDi | Q15928 |
jPOSTi | Q15928 |
MassIVEi | Q15928 |
PaxDbi | Q15928 |
PeptideAtlasi | Q15928 |
PRIDEi | Q15928 |
ProteomicsDBi | 60818 |
Protocols and materials databases
Antibodypediai | 7954, 59 antibodies from 14 providers |
DNASUi | 7700 |
Genome annotation databases
Ensembli | ENST00000240499; ENSP00000240499; ENSG00000131127 |
GeneIDi | 7700 |
KEGGi | hsa:7700 |
MANE-Selecti | ENST00000240499.8; ENSP00000240499.7; NM_003441.4; NP_003432.1 |
UCSCi | uc003gaa.3, human |
Organism-specific databases
CTDi | 7700 |
DisGeNETi | 7700 |
GeneCardsi | ZNF141 |
HGNCi | HGNC:12926, ZNF141 |
HPAi | ENSG00000131127, Low tissue specificity |
MalaCardsi | ZNF141 |
MIMi | 194648, gene 615226, phenotype |
neXtProti | NX_Q15928 |
OpenTargetsi | ENSG00000131127 |
Orphaneti | 93334, Postaxial polydactyly type A |
PharmGKBi | PA37513 |
VEuPathDBi | HostDB:ENSG00000131127 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q15928 |
OMAi | CEHELSR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15928 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q15928 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7700, 100 hits in 1025 CRISPR screens |
ChiTaRSi | ZNF141, human |
GenomeRNAii | 7700 |
Pharosi | Q15928, Tbio |
PROi | PR:Q15928 |
RNActi | Q15928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131127, Expressed in adrenal tissue and 178 other tissues |
ExpressionAtlasi | Q15928, baseline and differential |
Genevisiblei | Q15928, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN141_HUMAN | |
Accessioni | Q15928Primary (citable) accession number: Q15928 Secondary accession number(s): Q6DK07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families