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UniProtKB - Q15928 (ZN141_HUMAN)

Entry version 180 (23 Feb 2022)
Sequence version 1 (01 Nov 1997)
Previous versions | rss
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Protein

Zinc finger protein 141

Gene

ZNF141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri171 – 193C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15928

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 141
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF141
Synonyms:D4S90
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12926, ZNF141

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		194648, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15928

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polydactyly, postaxial A6 (PAPA6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069637474T → I in PAPA6. 1 PublicationCorresponds to variant dbSNP:rs587776959EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7700

MalaCards human disease database

More...MalaCardsi		ZNF141
MIMi615226, phenotype

Open Targets

More...OpenTargetsi		ENSG00000131127

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93334, Postaxial polydactyly type A

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37513

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15928, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF141

Domain mapping of disease mutations (DMDM)

More...DMDMi		2501717

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474241 – 474Zinc finger protein 141Add BLAST474

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15928

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15928

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15928

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15928

PeptideAtlas

More...PeptideAtlasi		Q15928

PRoteomics IDEntifications database

More...PRIDEi		Q15928

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60818

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15928

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15928

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously low expression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131127, Expressed in adrenal tissue and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15928, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15928, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131127, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000240499

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15928, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15928

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15928

Identification of Orthologs from Complete Genome Data

More...OMAi		CEHELSR

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15928

TreeFam database of animal gene trees

More...TreeFami		TF342117

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 10 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q15928-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP 
        60         70         80         90        100
DLVTCLEQRK EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL 
       110        120        130        140        150
RRYEKCGHDN LQLRKGCKSL NECKLQKGGY NEFNECLSTT QSKILQCKAS 
       160        170        180        190        200
VKVVSKFSNS NKRKTRHTGE KHFKECGKSF QKFSHLTQHK VIHAGEKPYT 
       210        220        230        240        250
CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS HFAKHKIIHT 
       260        270        280        290        300
GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK 
       310        320        330        340        350
HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ 
       360        370        380        390        400
SSKLNEHKKV HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC 
       410        420        430        440        450
GKAFRRSTDR SQHKKIHSAD KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP 
       460        470 
YKCKDCDKAF KRFSHLNKHK KIHT
Length:474
Mass (Da):55,249
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6133202F1DB207E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIY0D6RIY0_HUMAN
Zinc finger protein 141
ZNF141 hCG_34448
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB60D6RB60_HUMAN
Zinc finger protein 141
ZNF141
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019973124K → E. Corresponds to variant dbSNP:rs2229296EnsemblClinVar.1
Natural variantiVAR_012026349R → K. Corresponds to variant dbSNP:rs955417Ensembl.1
Natural variantiVAR_012027358K → N. Corresponds to variant dbSNP:rs2018645Ensembl.1
Natural variantiVAR_069637474T → I in PAPA6. 1 PublicationCorresponds to variant dbSNP:rs587776959EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L15309 mRNA Translation: AAC37529.1
BC074853 mRNA Translation: AAH74853.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33931.1

Protein sequence database of the Protein Information Resource

More...PIRi		I54338

NCBI Reference Sequences

More...RefSeqi		NP_003432.1, NM_003441.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000240499; ENSP00000240499; ENSG00000131127

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7700

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000240499.8; ENSP00000240499.7; NM_003441.4; NP_003432.1

UCSC genome browser

More...UCSCi		uc003gaa.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15309 mRNA Translation: AAC37529.1
BC074853 mRNA Translation: AAH74853.3
CCDSiCCDS33931.1
PIRiI54338
RefSeqiNP_003432.1, NM_003441.3

3D structure databases

SMRiQ15928
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000240499

PTM databases

iPTMnetiQ15928
PhosphoSitePlusiQ15928

Genetic variation databases

BioMutaiZNF141
DMDMi2501717

Proteomic databases

EPDiQ15928
jPOSTiQ15928
MassIVEiQ15928
PaxDbiQ15928
PeptideAtlasiQ15928
PRIDEiQ15928
ProteomicsDBi60818

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7954, 59 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		7700

Genome annotation databases

EnsembliENST00000240499; ENSP00000240499; ENSG00000131127
GeneIDi7700
KEGGihsa:7700
MANE-SelectiENST00000240499.8; ENSP00000240499.7; NM_003441.4; NP_003432.1
UCSCiuc003gaa.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7700
DisGeNETi7700

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF141
HGNCiHGNC:12926, ZNF141
HPAiENSG00000131127, Low tissue specificity
MalaCardsiZNF141
MIMi194648, gene
615226, phenotype
neXtProtiNX_Q15928
OpenTargetsiENSG00000131127
Orphaneti93334, Postaxial polydactyly type A
PharmGKBiPA37513
VEuPathDBiHostDB:ENSG00000131127

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161765
HOGENOMiCLU_002678_44_0_1
InParanoidiQ15928
OMAiCEHELSR
OrthoDBi1318335at2759
PhylomeDBiQ15928
TreeFamiTF342117

Enzyme and pathway databases

PathwayCommonsiQ15928
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7700, 100 hits in 1025 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF141, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7700
PharosiQ15928, Tbio

Protein Ontology

More...PROi		PR:Q15928
RNActiQ15928, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131127, Expressed in adrenal tissue and 178 other tissues
ExpressionAtlasiQ15928, baseline and differential
GenevisibleiQ15928, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 10 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN141_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15928
Secondary accession number(s): Q6DK07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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