ZBTB6

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	301 – 323	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 405	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 7958847
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q15916

SignaLinkⁱ

Q15916

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 6 Alternative name(s): Zinc finger protein 482 Zinc finger protein with interaction domain
Gene namesⁱ	Name:ZBTB6 Synonyms:ZID, ZNF482
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186130.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16764 ZBTB6
MIMⁱ	605976 gene
neXtProtⁱ	NX_Q15916

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000186130
PharmGKBⁱ	PA134939601

Polymorphism and mutation databases

BioMutaⁱ	ZBTB6
DMDMⁱ	46577664

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047608	1 – 424	Zinc finger and BTB domain-containing protein 6Add BLAST		424

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	202	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15916
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15916
PaxDbⁱ	Q15916
PeptideAtlas More...PeptideAtlasⁱ	Q15916
PRIDEⁱ	Q15916
ProteomicsDBⁱ	60817

PTM databases

iPTMnetⁱ	Q15916
PhosphoSitePlusⁱ	Q15916

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000186130 Expressed in 135 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_ZBTB6
Genevisibleⁱ	Q15916 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054111 HPA076894

HPAⁱ

HPA054111
HPA076894

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	G2XKQ0	5	EBI-7227791,EBI-10175576
PLEKHF2	Q9H8W4	4	EBI-7227791,EBI-742388
SUMO1	P63165	3	EBI-7227791,EBI-80140
ZBTB26	Q9HCK0	5	EBI-7227791,EBI-3918996

Protein-protein interaction databases

BioGridⁱ	115991, 7 interactors
Database of interacting proteins More...DIPⁱ	DIP-2653N
IntActⁱ	Q15916, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q15916
STRINGⁱ	9606.ENSP00000362763

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15916
SMRⁱ	Q15916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 97	BTBPROSITE-ProRule annotationAdd BLAST		65

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	301 – 323	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 405	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119063
HOGENOMⁱ	HOG000232051
HOVERGENⁱ	HBG056199
InParanoidⁱ	Q15916
KEGG Orthology (KO) More...KOⁱ	K10493
OMAⁱ	GQGLFCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04SQ
PhylomeDBⁱ	Q15916
TreeFamⁱ	TF333162

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15916-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI 
        60         70         80         90        100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL 
       110        120        130        140        150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNNQHT DLCQSSDPDV 
       160        170        180        190        200
KNEDENSDKD CEIIEISEDS PVNIDFHVKE EESNALQSTV ESLTSERKEM 
       210        220        230        240        250
KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT SSKASMYFSE 
       260        270        280        290        300
TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR 
       310        320        330        340        350
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG 
       360        370        380        390        400
IRPFQCTVCL KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH 
       410        420 
LTSVHGRSSG EKLSRPDLKR QSLL

Length:424

Mass (Da):48,236

Last modified:November 1, 1996 - v1

Checksum:ⁱ304AE4BCAE62A3BC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82018 mRNA Translation: CAA57543.1 AK292401 mRNA Translation: BAF85090.1 CH471090 Genomic DNA Translation: EAW87552.1 BC037282 mRNA Translation: AAH37282.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6846.1
PIRⁱ	I39310
NCBI Reference Sequences More...RefSeqⁱ	NP_006617.1, NM_006626.5
UniGeneⁱ	Hs.654596

Genome annotation databases

Ensemblⁱ	ENST00000373659; ENSP00000362763; ENSG00000186130
GeneIDⁱ	10773
KEGGⁱ	hsa:10773
UCSC genome browser More...UCSCⁱ	uc004bnh.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15916	ZBTB6 isoform 1		PANTR		424	UniRef100_Q15916
Uncharacterized protein		PANPA		424
Uncharacterized protein		NOMLE		424
Zinc finger and BTB domain containing 6		GORGO		424

Protein	Similar proteins		Species	Score	Length	Source
Q15916	Zinc finger and BTB domain-containing protein 6		BOVIN		424	UniRef90_Q15916
Zinc finger and BTB domain-containing protein 6		MOUSE		423
ZBTB6 isoform 1		PANTR		424
Uncharacterized protein		PANPA		424
Uncharacterized protein		NOMLE		424
+114

Protein	Similar proteins		Species	Score	Length	Source
Q15916	Zinc finger and BTB domain-containing protein 6		BOVIN		424	UniRef50_Q15916
Zinc finger and BTB domain-containing protein 6		MOUSE		423
ZBTB6 isoform 1		PANTR		424
Uncharacterized protein		PANPA		424
Uncharacterized protein		NOMLE		424
+221

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82018 mRNA Translation: CAA57543.1 AK292401 mRNA Translation: BAF85090.1 CH471090 Genomic DNA Translation: EAW87552.1 BC037282 mRNA Translation: AAH37282.1
CCDSⁱ	CCDS6846.1
PIRⁱ	I39310
RefSeqⁱ	NP_006617.1, NM_006626.5
UniGeneⁱ	Hs.654596

3D structure databases

ProteinModelPortalⁱ	Q15916
SMRⁱ	Q15916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115991, 7 interactors
DIPⁱ	DIP-2653N
IntActⁱ	Q15916, 10 interactors
MINTⁱ	Q15916
STRINGⁱ	9606.ENSP00000362763

PTM databases

iPTMnetⁱ	Q15916
PhosphoSitePlusⁱ	Q15916

Polymorphism and mutation databases

BioMutaⁱ	ZBTB6
DMDMⁱ	46577664

Proteomic databases

EPDⁱ	Q15916
MaxQBⁱ	Q15916
PaxDbⁱ	Q15916
PeptideAtlasⁱ	Q15916
PRIDEⁱ	Q15916
ProteomicsDBⁱ	60817

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10773
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373659; ENSP00000362763; ENSG00000186130
GeneIDⁱ	10773
KEGGⁱ	hsa:10773
UCSCⁱ	uc004bnh.5 human

Organism-specific databases

CTDⁱ	10773
EuPathDBⁱ	HostDB:ENSG00000186130.4
GeneCardsⁱ	ZBTB6
HGNCⁱ	HGNC:16764 ZBTB6
HPAⁱ	HPA054111 HPA076894
MIMⁱ	605976 gene
neXtProtⁱ	NX_Q15916
OpenTargetsⁱ	ENSG00000186130
PharmGKBⁱ	PA134939601
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000119063
HOGENOMⁱ	HOG000232051
HOVERGENⁱ	HBG056199
InParanoidⁱ	Q15916
KOⁱ	K10493
OMAⁱ	GQGLFCE
OrthoDBⁱ	EOG091G04SQ
PhylomeDBⁱ	Q15916
TreeFamⁱ	TF333162

Enzyme and pathway databases

SignaLinkⁱ	Q15916

SignaLinkⁱ

Q15916

Miscellaneous databases

GenomeRNAiⁱ	10773
Protein Ontology More...PROⁱ	PR:Q15916
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186130 Expressed in 135 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_ZBTB6
Genevisibleⁱ	Q15916 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBTB6_HUMAN
Accessionⁱ	Q15916Primary (citable) accession number: Q15916 Secondary accession number(s): A8K8N6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15916 (ZBTB6_HUMAN)

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Zinc finger and BTB domain-containing protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ