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Protein

Zinc finger and BTB domain-containing protein 6

Gene

ZBTB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ15916

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 6
Alternative name(s):
Zinc finger protein 482
Zinc finger protein with interaction domain
Gene namesi
Name:ZBTB6
Synonyms:ZID, ZNF482
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186130.4
HGNCiHGNC:16764 ZBTB6
MIMi605976 gene
neXtProtiNX_Q15916

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186130
PharmGKBiPA134939601

Polymorphism and mutation databases

BioMutaiZBTB6
DMDMi46577664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476081 – 424Zinc finger and BTB domain-containing protein 6Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15916
MaxQBiQ15916
PaxDbiQ15916
PeptideAtlasiQ15916
PRIDEiQ15916
ProteomicsDBi60817

PTM databases

iPTMnetiQ15916
PhosphoSitePlusiQ15916

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000186130 Expressed in 135 organ(s), highest expression level in leukocyte
CleanExiHS_ZBTB6
GenevisibleiQ15916 HS

Organism-specific databases

HPAiHPA054111
HPA076894

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115991, 7 interactors
DIPiDIP-2653N
IntActiQ15916, 10 interactors
MINTiQ15916
STRINGi9606.ENSP00000362763

Structurei

3D structure databases

ProteinModelPortaliQ15916
SMRiQ15916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ15916
KOiK10493
OMAiGQGLFCE
OrthoDBiEOG091G04SQ
PhylomeDBiQ15916
TreeFamiTF333162

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q15916-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNNQHT DLCQSSDPDV
160 170 180 190 200
KNEDENSDKD CEIIEISEDS PVNIDFHVKE EESNALQSTV ESLTSERKEM
210 220 230 240 250
KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT SSKASMYFSE
260 270 280 290 300
TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
310 320 330 340 350
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG
360 370 380 390 400
IRPFQCTVCL KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH
410 420
LTSVHGRSSG EKLSRPDLKR QSLL
Length:424
Mass (Da):48,236
Last modified:November 1, 1996 - v1
Checksum:i304AE4BCAE62A3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82018 mRNA Translation: CAA57543.1
AK292401 mRNA Translation: BAF85090.1
CH471090 Genomic DNA Translation: EAW87552.1
BC037282 mRNA Translation: AAH37282.1
CCDSiCCDS6846.1
PIRiI39310
RefSeqiNP_006617.1, NM_006626.5
UniGeneiHs.654596

Genome annotation databases

EnsembliENST00000373659; ENSP00000362763; ENSG00000186130
GeneIDi10773
KEGGihsa:10773
UCSCiuc004bnh.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82018 mRNA Translation: CAA57543.1
AK292401 mRNA Translation: BAF85090.1
CH471090 Genomic DNA Translation: EAW87552.1
BC037282 mRNA Translation: AAH37282.1
CCDSiCCDS6846.1
PIRiI39310
RefSeqiNP_006617.1, NM_006626.5
UniGeneiHs.654596

3D structure databases

ProteinModelPortaliQ15916
SMRiQ15916
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115991, 7 interactors
DIPiDIP-2653N
IntActiQ15916, 10 interactors
MINTiQ15916
STRINGi9606.ENSP00000362763

PTM databases

iPTMnetiQ15916
PhosphoSitePlusiQ15916

Polymorphism and mutation databases

BioMutaiZBTB6
DMDMi46577664

Proteomic databases

EPDiQ15916
MaxQBiQ15916
PaxDbiQ15916
PeptideAtlasiQ15916
PRIDEiQ15916
ProteomicsDBi60817

Protocols and materials databases

DNASUi10773
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373659; ENSP00000362763; ENSG00000186130
GeneIDi10773
KEGGihsa:10773
UCSCiuc004bnh.5 human

Organism-specific databases

CTDi10773
EuPathDBiHostDB:ENSG00000186130.4
GeneCardsiZBTB6
HGNCiHGNC:16764 ZBTB6
HPAiHPA054111
HPA076894
MIMi605976 gene
neXtProtiNX_Q15916
OpenTargetsiENSG00000186130
PharmGKBiPA134939601
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ15916
KOiK10493
OMAiGQGLFCE
OrthoDBiEOG091G04SQ
PhylomeDBiQ15916
TreeFamiTF333162

Enzyme and pathway databases

SignaLinkiQ15916

Miscellaneous databases

GenomeRNAii10773
PROiPR:Q15916
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186130 Expressed in 135 organ(s), highest expression level in leukocyte
CleanExiHS_ZBTB6
GenevisibleiQ15916 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB6_HUMAN
AccessioniPrimary (citable) accession number: Q15916
Secondary accession number(s): A8K8N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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