UniProtKB - Q15916 (ZBTB6_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 6
Gene
ZBTB6
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 301 – 323 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 405 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15916 |
SignaLinki | Q15916 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 6Alternative name(s): Zinc finger protein 482 Zinc finger protein with interaction domain |
Gene namesi | Name:ZBTB6 Synonyms:ZID, ZNF482 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186130.4 |
HGNCi | HGNC:16764, ZBTB6 |
MIMi | 605976, gene |
neXtProti | NX_Q15916 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: ProtInc
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000186130 |
PharmGKBi | PA134939601 |
Miscellaneous databases
Pharosi | Q15916, Tbio |
Polymorphism and mutation databases
BioMutai | ZBTB6 |
DMDMi | 46577664 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047608 | 1 – 424 | Zinc finger and BTB domain-containing protein 6Add BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 202 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15916 |
jPOSTi | Q15916 |
MassIVEi | Q15916 |
MaxQBi | Q15916 |
PaxDbi | Q15916 |
PeptideAtlasi | Q15916 |
PRIDEi | Q15916 |
ProteomicsDBi | 60817 |
PTM databases
iPTMneti | Q15916 |
PhosphoSitePlusi | Q15916 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in brain.1 Publication
Gene expression databases
Bgeei | ENSG00000186130, Expressed in cortical plate and 154 other tissues |
Genevisiblei | Q15916, HS |
Organism-specific databases
HPAi | ENSG00000186130, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ15916
Protein-protein interaction databases
BioGRIDi | 115991, 12 interactors |
DIPi | DIP-2653N |
IntActi | Q15916, 10 interactors |
MINTi | Q15916 |
STRINGi | 9606.ENSP00000362763 |
Miscellaneous databases
RNActi | Q15916, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 97 | BTBPROSITE-ProRule annotationAdd BLAST | 65 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 301 – 323 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 405 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161459 |
HOGENOMi | CLU_037856_1_0_1 |
InParanoidi | Q15916 |
OMAi | EVLHFQF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15916 |
TreeFami | TF333162 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q15916-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNNQHT DLCQSSDPDV
160 170 180 190 200
KNEDENSDKD CEIIEISEDS PVNIDFHVKE EESNALQSTV ESLTSERKEM
210 220 230 240 250
KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT SSKASMYFSE
260 270 280 290 300
TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
310 320 330 340 350
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG
360 370 380 390 400
IRPFQCTVCL KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH
410 420
LTSVHGRSSG EKLSRPDLKR QSLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82018 mRNA Translation: CAA57543.1 AK292401 mRNA Translation: BAF85090.1 CH471090 Genomic DNA Translation: EAW87552.1 BC037282 mRNA Translation: AAH37282.1 |
CCDSi | CCDS6846.1 |
PIRi | I39310 |
RefSeqi | NP_006617.1, NM_006626.5 |
Genome annotation databases
Ensembli | ENST00000373659; ENSP00000362763; ENSG00000186130 |
GeneIDi | 10773 |
KEGGi | hsa:10773 |
UCSCi | uc004bnh.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82018 mRNA Translation: CAA57543.1 AK292401 mRNA Translation: BAF85090.1 CH471090 Genomic DNA Translation: EAW87552.1 BC037282 mRNA Translation: AAH37282.1 |
CCDSi | CCDS6846.1 |
PIRi | I39310 |
RefSeqi | NP_006617.1, NM_006626.5 |
3D structure databases
SMRi | Q15916 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115991, 12 interactors |
DIPi | DIP-2653N |
IntActi | Q15916, 10 interactors |
MINTi | Q15916 |
STRINGi | 9606.ENSP00000362763 |
PTM databases
iPTMneti | Q15916 |
PhosphoSitePlusi | Q15916 |
Polymorphism and mutation databases
BioMutai | ZBTB6 |
DMDMi | 46577664 |
Proteomic databases
EPDi | Q15916 |
jPOSTi | Q15916 |
MassIVEi | Q15916 |
MaxQBi | Q15916 |
PaxDbi | Q15916 |
PeptideAtlasi | Q15916 |
PRIDEi | Q15916 |
ProteomicsDBi | 60817 |
Protocols and materials databases
Antibodypediai | 30390, 219 antibodies |
DNASUi | 10773 |
Genome annotation databases
Ensembli | ENST00000373659; ENSP00000362763; ENSG00000186130 |
GeneIDi | 10773 |
KEGGi | hsa:10773 |
UCSCi | uc004bnh.5, human |
Organism-specific databases
CTDi | 10773 |
EuPathDBi | HostDB:ENSG00000186130.4 |
GeneCardsi | ZBTB6 |
HGNCi | HGNC:16764, ZBTB6 |
HPAi | ENSG00000186130, Low tissue specificity |
MIMi | 605976, gene |
neXtProti | NX_Q15916 |
OpenTargetsi | ENSG00000186130 |
PharmGKBi | PA134939601 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161459 |
HOGENOMi | CLU_037856_1_0_1 |
InParanoidi | Q15916 |
OMAi | EVLHFQF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15916 |
TreeFami | TF333162 |
Enzyme and pathway databases
PathwayCommonsi | Q15916 |
SignaLinki | Q15916 |
Miscellaneous databases
BioGRID-ORCSi | 10773, 3 hits in 867 CRISPR screens |
GenomeRNAii | 10773 |
Pharosi | Q15916, Tbio |
PROi | PR:Q15916 |
RNActi | Q15916, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186130, Expressed in cortical plate and 154 other tissues |
Genevisiblei | Q15916, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBTB6_HUMAN | |
Accessioni | Q15916Primary (citable) accession number: Q15916 Secondary accession number(s): A8K8N6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot