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UniProtKB - Q15915 (ZIC1_HUMAN)

Entry version 185 (07 Apr 2021)
Sequence version 2 (14 Oct 2008)
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Protein

Zinc finger protein ZIC 1

Gene

ZIC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri225 – 260C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri269 – 296C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri302 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15915

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15915

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15915

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein ZIC 1
Alternative name(s):
Zinc finger protein 201
Zinc finger protein of the cerebellum 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZIC1
Synonyms:ZIC, ZNF201
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12872, ZIC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600470, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15915

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152977.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Craniosynostosis 6 (CRS6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of craniosynostosis, a primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075867400G → R in CRS6. 1 PublicationCorresponds to variant dbSNP:rs1057517670EnsemblClinVar.1
Structural brain anomalies with impaired intellectual development and craniosynostosis (BAIDCS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by microcephaly, agenesis of corpus callosum, abnormal conformation of the ventricles and posterior fossa, hypoplasia of both cerebellar hemispheres, colpocephaly, and partial absence of the cerebellar vermis with fusion of the cerebellar hemispheres. Intellectual development is moderately to severely impaired. Bicoronal synostosis, scoliosis, and tethered cord may be present.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083723388 – 447Missing in BAIDCS. 1 PublicationAdd BLAST60
Natural variantiVAR_083724389 – 447Missing in BAIDCS. 1 PublicationAdd BLAST59
Natural variantiVAR_083725402 – 447Missing in BAIDCS. 1 PublicationAdd BLAST46

Keywords - Diseasei

Craniosynostosis, Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		7545

MalaCards human disease database

More...MalaCardsi		ZIC1
MIMi616602, phenotype
618736, phenotype

Open Targets

More...OpenTargetsi		ENSG00000152977

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		35099, Isolated brachycephaly
269212, Isolated Dandy-Walker malformation with hydrocephalus
269215, Isolated Dandy-Walker malformation without hydrocephalus
63440, Isolated oxycephaly
35098, Isolated plagiocephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37461

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15915, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZIC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472441 – 447Zinc finger protein ZIC 1Add BLAST447

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15915

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15915

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15915

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15915

PeptideAtlas

More...PeptideAtlasi		Q15915

PRoteomics IDEntifications database

More...PRIDEi		Q15915

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60816

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15915

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152977, Expressed in cerebellum and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15915, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15915, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152977, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5).

Interacts with GLI1; the interaction enhances transcription activation.

Interacts with GLI2.

Interacts with GLI3; the interaction enhances transcription activation (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q15915
With#Exp.IntAct
ABHD11 - isoform 4 [Q8NFV4-4]3EBI-11963196,EBI-12318443
AKAP8L [Q9ULX6]3EBI-11963196,EBI-357530
ANKRD10 - isoform 2 [Q9NXR5-2]3EBI-11963196,EBI-12102070
ARID5A [Q03989]3EBI-11963196,EBI-948603
ATP23 [Q9Y6H3]3EBI-11963196,EBI-12811889
BATF3 [Q9NR55]3EBI-11963196,EBI-10312707
BBS4 [Q96RK4]3EBI-11963196,EBI-1805814
BLZF1 [Q9H2G9]3EBI-11963196,EBI-2548012
C11orf1 [Q9H5F2]3EBI-11963196,EBI-718615
CDPF1 [Q6NVV7]3EBI-11963196,EBI-2802782
CRX [O43186]3EBI-11963196,EBI-748171
CYSRT1 [A8MQ03]3EBI-11963196,EBI-3867333
DAPL1 [A0PJW8]3EBI-11963196,EBI-12840152
DDIT4L [Q96D03]3EBI-11963196,EBI-742054
EEF1AKMT3 [Q96AZ1]3EBI-11963196,EBI-12108304
FAM168B - isoform 2 [A1KXE4-2]3EBI-11963196,EBI-12193763
FOXH1 [O75593]3EBI-11963196,EBI-1759806
GAS2L3 [Q86XJ1]3EBI-11963196,EBI-9248152
INTS11 [Q5TA45]3EBI-11963196,EBI-748258
KLHL26 [Q53HC5]3EBI-11963196,EBI-724915
KRT31 [Q15323]3EBI-11963196,EBI-948001
KRT34 [O76011]3EBI-11963196,EBI-1047093
KRTAP10-8 [P60410]3EBI-11963196,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-11963196,EBI-1052037
KRTAP12-1 [P59990]3EBI-11963196,EBI-10210845
KRTAP13-2 [Q52LG2]3EBI-11963196,EBI-11953846
KRTAP15-1 [Q3LI76]3EBI-11963196,EBI-11992140
KRTAP19-1 [Q8IUB9]3EBI-11963196,EBI-12811111
KRTAP19-2 [Q3LHN2]3EBI-11963196,EBI-12196745
KRTAP19-5 [Q3LI72]3EBI-11963196,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-11963196,EBI-10241353
KRTAP21-2 [Q3LI59]3EBI-11963196,EBI-18395721
KRTAP3-2 [Q9BYR7]3EBI-11963196,EBI-751260
KRTAP6-1 [Q3LI64]3EBI-11963196,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-11963196,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-11963196,EBI-18394498
KRTAP8-1 [Q8IUC2]5EBI-11963196,EBI-10261141
LITAF [Q99732]3EBI-11963196,EBI-725647
MAGED1 [Q9Y5V3]3EBI-11963196,EBI-716006
METTL27 [Q8N6F8]3EBI-11963196,EBI-8487781
NFKBID [Q8NI38]3EBI-11963196,EBI-10271199
OIP5 [O43482]5EBI-11963196,EBI-536879
OXER1 [Q8TDS5]3EBI-11963196,EBI-12813389
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-11963196,EBI-11022007
PEF1 [Q9UBV8]3EBI-11963196,EBI-724639
PLAAT1 [Q9HDD0]3EBI-11963196,EBI-12387058
PLSCR3 [Q9NRY6]3EBI-11963196,EBI-750734
RBPMS - isoform C [Q93062-3]3EBI-11963196,EBI-740343
REL - isoform 2 [Q04864-2]3EBI-11963196,EBI-10829018
RFC2 - isoform 2 [P35250-2]3EBI-11963196,EBI-12936957
RUSC1 [Q9BVN2]3EBI-11963196,EBI-6257312
SMAD4 [Q13485]3EBI-11963196,EBI-347263
SMUG1 - isoform 2 [Q53HV7-2]3EBI-11963196,EBI-12275818
SMYD3 [Q9H7B4]3EBI-11963196,EBI-347919
SPAG8 - isoform 2 [Q99932-2]5EBI-11963196,EBI-11959123
SPATS1 [Q496A3]3EBI-11963196,EBI-3923692
SUFU [Q9UMX1]3EBI-11963196,EBI-740595
TBX19 [O60806]3EBI-11963196,EBI-12096770
TEPSIN [Q96N21]3EBI-11963196,EBI-11139477
TLE5 - isoform 2 [Q08117-2]3EBI-11963196,EBI-11741437
TRAF1 [Q13077]3EBI-11963196,EBI-359224
TRIP6 [Q15654]3EBI-11963196,EBI-742327
TSC1 [Q86WV8]3EBI-11963196,EBI-12806590
UBE2I [Q7KZS0]3EBI-11963196,EBI-10180829
UFSP1 [Q6NVU6]3EBI-11963196,EBI-12068150
WWOX - isoform 5 [Q9NZC7-5]3EBI-11963196,EBI-12040603
ZNF474 [Q6S9Z5]3EBI-11963196,EBI-17269964
ZNF620 [Q6ZNG0]3EBI-11963196,EBI-4395669

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113377, 116 interactors

Protein interaction database and analysis system

More...IntActi		Q15915, 109 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15915, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15915

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 76Poly-Ala5
Compositional biasi79 – 82Poly-His4
Compositional biasi110 – 116Poly-Ala7
Compositional biasi386 – 440Ser-richAdd BLAST55

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 260C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri269 – 296C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri302 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 356C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 384C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_37_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15915

Identification of Orthologs from Complete Genome Data

More...OMAi		YGRAEQY

Database of Orthologous Groups

More...OrthoDBi		768287at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15915

TreeFam database of animal gene trees

More...TreeFami		TF351425

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR041643, Znf_ZIC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits
PF18366, zf_ZIC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN 
        60         70         80         90        100
PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF 
       110        120        130        140        150
LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFPGLHEQA 
       160        170        180        190        200
AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM 
       210        220        230        240        250
NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH 
       260        270        280        290        300
ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 
       310        320        330        340        350
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK 
       360        370        380        390        400
KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG 
       410        420        430        440 
YESSTPPTIV SPSTDNPTTS SLSPSSSAVH HTAGHSALSS NFNEWYV
Length:447
Mass (Da):48,309
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DA3E32C99BF1AAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5D8H7C5D8_HUMAN
Zinc finger protein ZIC 1
ZIC1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti377L → V in BAA11179 (PubMed:8542595).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083723388 – 447Missing in BAIDCS. 1 PublicationAdd BLAST60
Natural variantiVAR_083724389 – 447Missing in BAIDCS. 1 PublicationAdd BLAST59
Natural variantiVAR_075867400G → R in CRS6. 1 PublicationCorresponds to variant dbSNP:rs1057517670EnsemblClinVar.1
Natural variantiVAR_083725402 – 447Missing in BAIDCS. 1 PublicationAdd BLAST46
Natural variantiVAR_075868414T → A1 PublicationCorresponds to variant dbSNP:rs143292136EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D76435 mRNA Translation: BAA11179.1
CH471052 Genomic DNA Translation: EAW78915.1
BC104848 mRNA Translation: AAI04849.1
BC104850 mRNA Translation: AAI04851.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3136.1

NCBI Reference Sequences

More...RefSeqi		NP_003403.2, NM_003412.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282928; ENSP00000282928; ENSG00000152977

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7545

UCSC genome browser

More...UCSCi		uc003ewe.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76435 mRNA Translation: BAA11179.1
CH471052 Genomic DNA Translation: EAW78915.1
BC104848 mRNA Translation: AAI04849.1
BC104850 mRNA Translation: AAI04851.1
CCDSiCCDS3136.1
RefSeqiNP_003403.2, NM_003412.3

3D structure databases

SMRiQ15915
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113377, 116 interactors
IntActiQ15915, 109 interactors
STRINGi9606.ENSP00000282928

PTM databases

iPTMnetiQ15915
PhosphoSitePlusiQ15915

Genetic variation databases

BioMutaiZIC1
DMDMi209572702

Proteomic databases

jPOSTiQ15915
MassIVEiQ15915
MaxQBiQ15915
PaxDbiQ15915
PeptideAtlasiQ15915
PRIDEiQ15915
ProteomicsDBi60816

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1317, 406 antibodies

Genome annotation databases

EnsembliENST00000282928; ENSP00000282928; ENSG00000152977
GeneIDi7545
KEGGihsa:7545
UCSCiuc003ewe.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7545
DisGeNETi7545

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZIC1
HGNCiHGNC:12872, ZIC1
HPAiENSG00000152977, Tissue enriched (brain)
MalaCardsiZIC1
MIMi600470, gene
616602, phenotype
618736, phenotype
neXtProtiNX_Q15915
OpenTargetsiENSG00000152977
Orphaneti35099, Isolated brachycephaly
269212, Isolated Dandy-Walker malformation with hydrocephalus
269215, Isolated Dandy-Walker malformation without hydrocephalus
63440, Isolated oxycephaly
35098, Isolated plagiocephaly
PharmGKBiPA37461
VEuPathDBiHostDB:ENSG00000152977.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000160269
HOGENOMiCLU_002678_37_1_1
InParanoidiQ15915
OMAiYGRAEQY
OrthoDBi768287at2759
PhylomeDBiQ15915
TreeFamiTF351425

Enzyme and pathway databases

PathwayCommonsiQ15915
SignaLinkiQ15915
SIGNORiQ15915

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7545, 7 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZIC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZIC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7545
PharosiQ15915, Tbio

Protein Ontology

More...PROi		PR:Q15915
RNActiQ15915, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152977, Expressed in cerebellum and 168 other tissues
ExpressionAtlasiQ15915, baseline and differential
GenevisibleiQ15915, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR041643, Znf_ZIC
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
PF18366, zf_ZIC, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZIC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15915
Secondary accession number(s): Q2M3N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: April 7, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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