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Entry version 194 (26 Feb 2020)
Sequence version 2 (13 Jun 2006)
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Protein

Zinc finger homeobox protein 3

Gene

ZFHX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).By similarity5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri79 – 101C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri640 – 663C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri671 – 694C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri726 – 750C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri804 – 828C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri945 – 968C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri984 – 1008C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1040 – 1064C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1088 – 1112C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1223 – 1246C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1252 – 1275C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1360 – 1385C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1401 – 1423C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1429 – 1452C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1545 – 1569C2H2-type 16PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1596 – 1620C2H2-type 17PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1983 – 2006C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2145 – 2204Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi2242 – 2301Homeobox 2PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2328 – 2351C2H2-type 19; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2530 – 2552C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
DNA bindingi2641 – 2700Homeobox 3PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2711 – 2734C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
DNA bindingi2944 – 3003Homeobox 4PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri3024 – 3048C2H2-type 22PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3529 – 3553C2H2-type 23PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processMyogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8941855 RUNX3 regulates CDKN1A transcription

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15911

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name:
ZFH-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFHX3
Synonyms:ATBF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:777 ZFHX3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
104155 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15911

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2349K → A: Loss of sumoylation. 1 Publication1
Mutagenesisi2615 – 2617KRK → AAA: Loss of nuclear localization. 1 Publication3
Mutagenesisi2806K → A: Loss of sumoylation. 1 Publication1
Mutagenesisi3258K → A: Loss of sumoylation. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
463

MalaCards human disease database

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MalaCardsi
ZFHX3

Open Targets

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OpenTargetsi
ENSG00000140836

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162409676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q15911 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZFHX3

Domain mapping of disease mutations (DMDM)

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DMDMi
108935822

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469301 – 3703Zinc finger homeobox protein 3Add BLAST3703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei426PhosphoserineCombined sources1
Modified residuei428PhosphothreonineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei1197PhosphoserineCombined sources1
Modified residuei1204PhosphoserineCombined sources1
Modified residuei1590PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei2625PhosphoserineBy similarity1
Modified residuei2786PhosphoserineBy similarity1
Modified residuei2795PhosphoserineCombined sources1
Cross-linki2806Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki2806Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2892PhosphoserineBy similarity1
Modified residuei2896PhosphoserineCombined sources1
Cross-linki3258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei3409PhosphoserineBy similarity1
Modified residuei3418PhosphoserineBy similarity1
Modified residuei3432PhosphoserineCombined sources1
Modified residuei3593PhosphoserineBy similarity1
Modified residuei3677PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation decreases its sensitivity to calpain-mediated proteolysis.By similarity
Adult brain-derived ZFHX3 is sensitive, but embryonic brain-derived ZFHX3 is resistant to calpain 1-mediated proteolysis.By similarity
Ubiquitinated, leading to its proteasomal degradation.1 Publication
Nuclear localization is essential for its sumoylation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15911

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15911

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15911

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15911

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15911

PeptideAtlas

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PeptideAtlasi
Q15911

PRoteomics IDEntifications database

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PRIDEi
Q15911

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60814 [Q15911-1]
60815 [Q15911-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15911

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140836 Expressed in forebrain and 212 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15911 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA059353

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FNBP3 (By similarity).

Interacts with ALKBH4 and PIAS3.

Interacts with ESR1.

Interacts with RUNX3.

Interacts with TRIM25.

Interacts with SMAD2 and SMAD3.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q6A1623EBI-10237226,EBI-10171697

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106954, 19 interactors

Protein interaction database and analysis system

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IntActi
Q15911, 33 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000268489

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15911 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13703
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15911

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q15911

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2615 – 2617Nuclear localization signal1 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 107Poly-Pro4
Compositional biasi460 – 489Poly-GluAdd BLAST30
Compositional biasi770 – 784Poly-AlaAdd BLAST15
Compositional biasi1723 – 1743Poly-GlnAdd BLAST21
Compositional biasi1789 – 1794Poly-Gln6
Compositional biasi1852 – 1857Poly-Gln6
Compositional biasi2037 – 2052Poly-ProAdd BLAST16
Compositional biasi3197 – 3209Poly-GlnAdd BLAST13
Compositional biasi3210 – 3214Poly-Pro5
Compositional biasi3227 – 3231Poly-Gln5
Compositional biasi3376 – 3389Poly-GlnAdd BLAST14
Compositional biasi3392 – 3395Poly-Gln4
Compositional biasi3507 – 3527Poly-GlyAdd BLAST21
Compositional biasi3597 – 3600Poly-Pro4
Compositional biasi3636 – 3639Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 101C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri640 – 663C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri671 – 694C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri726 – 750C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri804 – 828C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri945 – 968C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri984 – 1008C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1040 – 1064C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1088 – 1112C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1223 – 1246C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1252 – 1275C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1360 – 1385C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1401 – 1423C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1429 – 1452C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1545 – 1569C2H2-type 16PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1596 – 1620C2H2-type 17PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1983 – 2006C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2328 – 2351C2H2-type 19; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2530 – 2552C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2711 – 2734C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri3024 – 3048C2H2-type 22PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3529 – 3553C2H2-type 23PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1146 Eukaryota
ENOG410XYHC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000245_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15911

KEGG Orthology (KO)

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KOi
K09378

Identification of Orthologs from Complete Genome Data

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OMAi
GMFDNTP

Database of Orthologous Groups

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OrthoDBi
15351at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15911

TreeFam database of animal gene trees

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TreeFami
TF323288

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF00046 Homeodomain, 4 hits
PF00096 zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 23 hits
SM00451 ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 4 hits
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 2 hits
PS50071 HOMEOBOX_2, 4 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q15911-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGCDSPVVS GKDNGCGIPQ HQQWTELNST HLPDKPSSME QSTGESHGPL
60 70 80 90 100
DSLRAPFNER LAESTASAGP PSEPASKEVT CNECSASFAS LQTYMEHHCP
110 120 130 140 150
SARPPPPLRE ESASDTGEEG DEESDVENLA GEIVYQPDGS AYIVESLSQL
160 170 180 190 200
TQGGGACGSG SGSGPLPSLF LNSLPGAGGK QGDPSCAAPV YPQIINTFHI
210 220 230 240 250
ASSFGKWFEG PDQAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS
260 270 280 290 300
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH
310 320 330 340 350
AVHDHRMTLS EDERKILSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP
360 370 380 390 400
LVSTANLIGP GHSFYGKFSG IRMEGEEALP AGSAAGPEQP QAGLLTPSTL
410 420 430 440 450
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GEKQEVGDGD
460 470 480 490 500
CFSEKVEPAE EEAEEEEEEE EAEEEEEEEE EEEEEEEDEG CKGLFPSELD
510 520 530 540 550
EELEDRPHEE PGAAAGSSSK KDLALSNQSI SNSPLMPNVL QTLSRGTAST
560 570 580 590 600
SSNSASSFVV FDGANRRNRL SFNSEGVRAN VAEGGRRLDF ADESANKDNA
610 620 630 640 650
TAPEPNESTE GDDGGFVPHH QHAGSLCELG VGECPSGSGV ECPKCDTVLG
660 670 680 690 700
SSRSLGGHMT MMHSRNSCKT LKCPKCNWHY KYQQTLEAHM KEKHPEPGGS
710 720 730 740 750
CVYCKSGQPH PRLARGESYT CGYKPFRCEV CNYSTTTKGN LSIHMQSDKH
760 770 780 790 800
LNNMQNLQNG GGEQVFSHTA GAAAAAVAAA AAAANISSSC GAPSPTKPKT
810 820 830 840 850
KPTWRCEVCD YETNVARNLR IHMTSEKHMH NMMLLQQNMT QIQHNRHLGL
860 870 880 890 900
GSLPSPAEAE LYQYYLAQNM NLPNLKMDSA ASDAQFMMSG FQLDPAGPMA
910 920 930 940 950
AMTPALVGGE IPLDMRLGGG QLVSEELMNL GESFIQTNDP SLKLFQCAVC
960 970 980 990 1000
NKFTTDNLDM LGLHMNVERS LSEDEWKAVM GDSYQCKLCR YNTQLKANFQ
1010 1020 1030 1040 1050
LHCKTDKHVQ KYQLVAHIKE GGKANEWRLK CVAIGNPVHL KCNACDYYTN
1060 1070 1080 1090 1100
SLEKLRLHTV NSRHEASLKL YKHLQQHESG VEGESCYYHC VLCNYSTKAK
1110 1120 1130 1140 1150
LNLIQHVRSM KHQRSESLRK LQRLQKGLPE EDEDLGQIFT IRRCPSTDPE
1160 1170 1180 1190 1200
EAIEDVEGPS ETAADPEELA KDQEGGASSS QAEKELTDSP ATSKRISFPG
1210 1220 1230 1240 1250
SSESPLSSKR PKTAEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP
1260 1270 1280 1290 1300
MLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT TPEMVMPSSM
1310 1320 1330 1340 1350
FLPAAVPDRD GNSNLEEAGK QPETSEDLGK NILPSASTEQ SGDLKPSPAD
1360 1370 1380 1390 1400
PGSVREDSGF ICWKKGCNQV FKTSAALQTH FNEVHAKRPQ LPVSDRHVYK
1410 1420 1430 1440 1450
YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT FQALKKHLET
1460 1470 1480 1490 1500
SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE EDKEEESDLE
1510 1520 1530 1540 1550
DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC
1560 1570 1580 1590 1600
KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT
1610 1620 1630 1640 1650
CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGSSNGTG NSSSISLSSS
1660 1670 1680 1690 1700
TPSPVSTSGS NTFTTSNPSS AGIAPSSNLL SQVPTESVGM PPLGNPIGAN
1710 1720 1730 1740 1750
IASPSEPKEA NRKKLADMIA SRQQQQQQQQ QQQQQQQQQQ QAQTLAQAQA
1760 1770 1780 1790 1800
QVQAHLQQEL QQQAALIQSQ LFNPTLLPHF PMTTETLLQL QQQQHLLFPF
1810 1820 1830 1840 1850
YIPSAEFQLN PEVSLPVTSG ALTLTGTGPG LLEDLKAQVQ VPQQSHQQIL
1860 1870 1880 1890 1900
PQQQQNQLSI AQSHSALLQP SQHPEKKNKL VIKEKEKESQ RERDSAEGGE
1910 1920 1930 1940 1950
GNTGPKETLP DALKAKEKKE LAPGGGSEPS MLPPRIASDA RGNATKALLE
1960 1970 1980 1990 2000
NFGFELVIQY NENKQKVQKK NGKTDQGENL EKLECDSCGK LFSNILILKS
2010 2020 2030 2040 2050
HQEHVHQNYF PFKQLERFAK QYRDHYDKLY PLRPQTPEPP PPPPPPPPPP
2060 2070 2080 2090 2100
LPAAPPQPAS TPAIPASAPP ITSPTIAPAQ PSVPLTQLSM PMELPIFSPL
2110 2120 2130 2140 2150
MMQTMPLQTL PAQLPPQLGP VEPLPADLAQ LYQHQLNPTL LQQQNKRPRT
2160 2170 2180 2190 2200
RITDDQLRVL RQYFDINNSP SEEQIKEMAD KSGLPQKVIK HWFRNTLFKE
2210 2220 2230 2240 2250
RQRNKDSPYN FSNPPITSLE ELKIDSRPPS PEPPKQEYWG SKRSSRTRFT
2260 2270 2280 2290 2300
DYQLRVLQDF FDANAYPKDD EFEQLSNLLN LPTRVIVVWF QNARQKARKN
2310 2320 2330 2340 2350
YENQGEGKDG ERRELTNDRY IRTSNLNYQC KKCSLVFQRI FDLIKHQKKL
2360 2370 2380 2390 2400
CYKDEDEEGQ DDSQNEDSMD AMEILTPTSS SCSTPMPSQA YSAPAPSANN
2410 2420 2430 2440 2450
TASSAFLQLT AEAEELATFN SKTEAGDEKP KLAEAPSAQP NQTQEKQGQP
2460 2470 2480 2490 2500
KPELQQQEQP EQKTNTPQQK LPQLVSLPSL PQPPPQAPPP QCPLPQSSPS
2510 2520 2530 2540 2550
PSQLSHLPLK PLHTSTPQQL ANLPPQLIPY QCDQCKLAFP SFEHWQEHQQ
2560 2570 2580 2590 2600
LHFLSAQNQF IHPQFLDRSL DMPFMLFDPS NPLLASQLLS GAIPQIPASS
2610 2620 2630 2640 2650
ATSPSTPTST MNTLKRKLEE KASASPGEND SGTGGEEPQR DKRLRTTITP
2660 2670 2680 2690 2700
EQLEILYQKY LLDSNPTRKM LDHIAHEVGL KKRVVQVWFQ NTRARERKGQ
2710 2720 2730 2740 2750
FRAVGPAQAH RRCPFCRALF KAKTALEAHI RSRHWHEAKR AGYNLTLSAM
2760 2770 2780 2790 2800
LLDCDGGLQM KGDIFDGTSF SHLPPSSSDG QGVPLSPVSK TMELSPRTLL
2810 2820 2830 2840 2850
SPSSIKVEGI EDFESPSMSS VNLNFDQTKL DNDDCSSVNT AITDTTTGDE
2860 2870 2880 2890 2900
GNADNDSATG IATETKSSSA PNEGLTKAAM MAMSEYEDRL SSGLVSPAPS
2910 2920 2930 2940 2950
FYSKEYDNEG TVDYSETSSL ADPCSPSPGA SGSAGKSGDS GDRPGQKRFR
2960 2970 2980 2990 3000
TQMTNLQLKV LKSCFNDYRT PTMLECEVLG NDIGLPKRVV QVWFQNARAK
3010 3020 3030 3040 3050
EKKSKLSMAK HFGINQTSYE GPKTECTLCG IKYSARLSVR DHIFSQQHIS
3060 3070 3080 3090 3100
KVKDTIGSQL DKEKEYFDPA TVRQLMAQQE LDRIKKANEV LGLAAQQQGM
3110 3120 3130 3140 3150
FDNTPLQALN LPTAYPALQG IPPVLLPGLN SPSLPGFTPS NTALTSPKPN
3160 3170 3180 3190 3200
LMGLPSTTVP SPGLPTSGLP NKPSSASLSS PTPAQATMAM GPQQPPQQQQ
3210 3220 3230 3240 3250
QQQQPQVQQP PPPPAAQPPP TPQLPLQQQQ QRKDKDSEKV KEKEKAHKGK
3260 3270 3280 3290 3300
GEPLPVPKKE KGEAPTATAA TISAPLPTME YAVDPAQLQA LQAALTSDPT
3310 3320 3330 3340 3350
ALLTSQFLPY FVPGFSPYYA PQIPGALQSG YLQPMYGMEG LFPYSPALSQ
3360 3370 3380 3390 3400
ALMGLSPGSL LQQYQQYQQS LQEAIQQQQQ RQLQQQQQQK VQQQQPKASQ
3410 3420 3430 3440 3450
TPVPPGAPSP DKDPAKESPK PEEQKNTPRE VSPLLPKLPE EPEAESKSAD
3460 3470 3480 3490 3500
SLYDPFIVPK VQYKLVCRKC QAGFSDEEAA RSHLKSLCFF GQSVVNLQEM
3510 3520 3530 3540 3550
VLHVPTGGGG GGSGGGGGGG GGGGGGGSYH CLACESALCG EEALSQHLES
3560 3570 3580 3590 3600
ALHKHRTITR AARNAKEHPS LLPHSACFPD PSTASTSQSA AHSNDSPPPP
3610 3620 3630 3640 3650
SAAAPSSASP HASRKSWPQV VSRASAAKPP SFPPLSSSST VTSSSCSTSG
3660 3670 3680 3690 3700
VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT

FRL
Length:3,703
Mass (Da):404,419
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i395F5D14A08112CB
GO
Isoform B (identifier: Q15911-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-914: Missing.

Show »
Length:2,789
Mass (Da):306,664
Checksum:i457BA84E550E9AA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti422P → A in AAC14462 (PubMed:7592926).Curated1
Sequence conflicti579A → T in AAC14462 (PubMed:7592926).Curated1
Sequence conflicti767S → I in AAC14462 (PubMed:7592926).Curated1
Sequence conflicti846 – 849RHLG → HHRV in AAC14462 (PubMed:7592926).Curated4
Sequence conflicti1150 – 1190EEAIE…LTDSP → GEWSHRHGRPRLGLGVHLLE TSRGLLFEGDVTDPAGPHVP Y in AAC31674 (PubMed:10493829).CuratedAdd BLAST41

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02666372S → A1 PublicationCorresponds to variant dbSNP:rs7193297Ensembl.1
Natural variantiVAR_061927146S → G. Corresponds to variant dbSNP:rs58480263Ensembl.1
Natural variantiVAR_026664428T → P. Corresponds to variant dbSNP:rs16971436Ensembl.1
Natural variantiVAR_019968460E → Q. Corresponds to variant dbSNP:rs2073852Ensembl.1
Natural variantiVAR_026665777V → A1 PublicationCorresponds to variant dbSNP:rs4788682Ensembl.1
Natural variantiVAR_052733997A → S1 PublicationCorresponds to variant dbSNP:rs2213978Ensembl.1
Natural variantiVAR_0116943374A → V. 1
Natural variantiVAR_0116953377 – 3384Missing . 8
Natural variantiVAR_0266663421P → A. Corresponds to variant dbSNP:rs8044440Ensembl.1
Natural variantiVAR_0116963527G → GGG. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0068251 – 914Missing in isoform B. 1 PublicationAdd BLAST914

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L32832 mRNA Translation: AAC14462.1
D10250 mRNA Translation: BAA01095.1
AC004943 Genomic DNA Translation: AAC79153.1
AC132068 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59168.1
CH471166 Genomic DNA Translation: EAW59170.1
AC002044 Genomic DNA Translation: AAC31674.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10908.1 [Q15911-1]
CCDS54035.1 [Q15911-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A41948

NCBI Reference Sequences

More...
RefSeqi
NP_001158238.1, NM_001164766.1 [Q15911-2]
NP_008816.3, NM_006885.3 [Q15911-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268489; ENSP00000268489; ENSG00000140836 [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836 [Q15911-2]
ENST00000641206; ENSP00000493252; ENSG00000140836 [Q15911-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:463

UCSC genome browser

More...
UCSCi
uc002fck.4 human [Q15911-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32832 mRNA Translation: AAC14462.1
D10250 mRNA Translation: BAA01095.1
AC004943 Genomic DNA Translation: AAC79153.1
AC132068 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59168.1
CH471166 Genomic DNA Translation: EAW59170.1
AC002044 Genomic DNA Translation: AAC31674.1
CCDSiCCDS10908.1 [Q15911-1]
CCDS54035.1 [Q15911-2]
PIRiA41948
RefSeqiNP_001158238.1, NM_001164766.1 [Q15911-2]
NP_008816.3, NM_006885.3 [Q15911-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DA1NMR-A2146-2202[»]
2DA2NMR-A2243-2299[»]
2DA3NMR-A2632-2698[»]
SMRiQ15911
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106954, 19 interactors
IntActiQ15911, 33 interactors
STRINGi9606.ENSP00000268489

PTM databases

iPTMnetiQ15911
PhosphoSitePlusiQ15911

Polymorphism and mutation databases

BioMutaiZFHX3
DMDMi108935822

Proteomic databases

EPDiQ15911
jPOSTiQ15911
MassIVEiQ15911
MaxQBiQ15911
PaxDbiQ15911
PeptideAtlasiQ15911
PRIDEiQ15911
ProteomicsDBi60814 [Q15911-1]
60815 [Q15911-2]

Genome annotation databases

EnsembliENST00000268489; ENSP00000268489; ENSG00000140836 [Q15911-1]
ENST00000397992; ENSP00000438926; ENSG00000140836 [Q15911-2]
ENST00000641206; ENSP00000493252; ENSG00000140836 [Q15911-1]
GeneIDi463
KEGGihsa:463
UCSCiuc002fck.4 human [Q15911-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
463
DisGeNETi463

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZFHX3
HGNCiHGNC:777 ZFHX3
HPAiHPA059353
MalaCardsiZFHX3
MIMi104155 gene
neXtProtiNX_Q15911
OpenTargetsiENSG00000140836
PharmGKBiPA162409676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1146 Eukaryota
ENOG410XYHC LUCA
GeneTreeiENSGT00940000156149
HOGENOMiCLU_000245_0_0_1
InParanoidiQ15911
KOiK09378
OMAiGMFDNTP
OrthoDBi15351at2759
PhylomeDBiQ15911
TreeFamiTF323288

Enzyme and pathway databases

ReactomeiR-HSA-8941855 RUNX3 regulates CDKN1A transcription
SIGNORiQ15911

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFHX3 human
EvolutionaryTraceiQ15911

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATBF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
463
PharosiQ15911 Tbio

Protein Ontology

More...
PROi
PR:Q15911
RNActiQ15911 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140836 Expressed in forebrain and 212 other tissues
GenevisibleiQ15911 HS

Family and domain databases

CDDicd00086 homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeodomain, 4 hits
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 23 hits
SM00451 ZnF_U1, 7 hits
SUPFAMiSSF46689 SSF46689, 4 hits
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 2 hits
PS50071 HOMEOBOX_2, 4 hits
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFHX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15911
Secondary accession number(s): D3DWS8, O15101, Q13719
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 13, 2006
Last modified: February 26, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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