UniProtKB - Q15906 (VPS72_HUMAN)
Vacuolar protein sorting-associated protein 72 homolog
VPS72
Functioni
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 156 – 206 | Sequence analysisAdd BLAST | 51 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone binding Source: UniProtKB
GO - Biological processi
- histone acetylation Source: ComplexPortal
- histone exchange Source: UniProtKB
- histone H2A acetylation Source: ComplexPortal
- histone H4 acetylation Source: ComplexPortal
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of apoptotic process Source: ComplexPortal
- regulation of cell cycle Source: ComplexPortal
- regulation of double-strand break repair Source: ComplexPortal
- regulation of transcription, DNA-templated Source: ComplexPortal
- somatic stem cell population maintenance Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q15906 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q15906 |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 72 homologAlternative name(s): Protein YL-1 Transcription factor-like 1 |
Gene namesi | Name:VPS72 Synonyms:TCFL1, YL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11644, VPS72 |
MIMi | 600607, gene |
neXtProti | NX_Q15906 |
VEuPathDBi | HostDB:ENSG00000163159 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- NuA4 histone acetyltransferase complex Source: ComplexPortal
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- nucleosome Source: ComplexPortal
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 29 – 37 | FYQTTYGGF → AAQTTAGGA: Highly decreases interaction with H2AZ1 and H2BC11. Abolishes interaction with H2AZ1 and H2BC11 and exchange of H2A for H2AZ1 in nucleosomes; when associated with A-43--46-A. 1 Publication | 9 | |
Mutagenesisi | 43 – 46 | DDEY → ADAA: Almost abolishes interaction with H2AZ1 and H2BC11. Abolishes interaction with H2AZ1 and H2BC11 and exchange of H2A for H2AZ1 in nucleosomes; when associated with A-29--37-A. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 6944 |
OpenTargetsi | ENSG00000163159 |
PharmGKBi | PA36396 |
Miscellaneous databases
Pharosi | Q15906, Tbio |
Genetic variation databases
BioMutai | VPS72 |
DMDMi | 2499159 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066283 | 1 – 364 | Vacuolar protein sorting-associated protein 72 homologAdd BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15906 |
jPOSTi | Q15906 |
MassIVEi | Q15906 |
MaxQBi | Q15906 |
PaxDbi | Q15906 |
PeptideAtlasi | Q15906 |
PRIDEi | Q15906 |
ProteomicsDBi | 1732 60807 [Q15906-1] |
PTM databases
iPTMneti | Q15906 |
PhosphoSitePlusi | Q15906 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163159, Expressed in frontal cortex and 242 other tissues |
ExpressionAtlasi | Q15906, baseline and differential |
Genevisiblei | Q15906, HS |
Organism-specific databases
HPAi | ENSG00000163159, Low tissue specificity |
Interactioni
Subunit structurei
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1.
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ.
Interacts (via N-terminal domain) with heterodimer H2BC11 and H2AZ1 (PubMed:26974126).
3 PublicationsBinary interactionsi
Q15906
With | #Exp. | IntAct |
---|---|---|
HMBOX1 [Q6NT76] | 3 | EBI-399189,EBI-2549423 |
HSF2BP [O75031] | 3 | EBI-399189,EBI-7116203 |
MDFI [Q99750] | 4 | EBI-399189,EBI-724076 |
RUVBL1 [Q9Y265] | 7 | EBI-399189,EBI-353675 |
GO - Molecular functioni
- histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112804, 104 interactors |
ComplexPortali | CPX-974, SRCAP chromatin remodeling complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q15906 |
DIPi | DIP-31767N |
IntActi | Q15906, 72 interactors |
MINTi | Q15906 |
STRINGi | 9606.ENSP00000346464 |
Miscellaneous databases
RNActi | Q15906, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15906 |
SMRi | Q15906 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 165 | DisorderedSequence analysisAdd BLAST | 165 | |
Regioni | 335 – 357 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 72 | Acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 73 – 97 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 114 – 137 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 151 – 165 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 337 – 352 | Pro residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2897, Eukaryota |
GeneTreei | ENSGT00390000017503 |
HOGENOMi | CLU_040862_0_0_1 |
InParanoidi | Q15906 |
OMAi | VNTKAYK |
OrthoDBi | 1468037at2759 |
PhylomeDBi | Q15906 |
TreeFami | TF314532 |
Family and domain databases
InterProi | View protein in InterPro IPR008895, Vps72/YL1 IPR013272, Vps72/YL1_C |
PANTHERi | PTHR13275, PTHR13275, 1 hit |
Pfami | View protein in Pfam PF05764, YL1, 1 hit PF08265, YL1_C, 1 hit |
SMARTi | View protein in SMART SM00993, YL1_C, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ
60 70 80 90 100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK
110 120 130 140 150
VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE
160 170 180 190 200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ
210 220 230 240 250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA PSVSALTPHA
260 270 280 290 300
GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL
310 320 330 340 350
YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP
360
GSGPRALRQK IVIK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | Y → H in BAD96655 (Ref. 3) Curated | 1 | |
Sequence conflicti | 30 | Y → H in BAD96659 (Ref. 3) Curated | 1 | |
Sequence conflicti | 53 | T → I in BAD96655 (Ref. 3) Curated | 1 | |
Sequence conflicti | 53 | T → I in BAD96659 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035803 | 318 | I → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1182821166Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047566 | 236 | G → GSLCFSLSFVLR in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D43642 mRNA Translation: BAA07757.1 BT019356 mRNA Translation: AAV38163.1 BT019357 mRNA Translation: AAV38164.1 AK222935 mRNA Translation: BAD96655.1 AK222939 mRNA Translation: BAD96659.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53462.1 BC003151 mRNA Translation: AAH03151.1 CX163016 mRNA No translation available. |
CCDSi | CCDS59201.1 [Q15906-2] CCDS989.1 [Q15906-1] |
PIRi | JC4140 |
RefSeqi | NP_001258016.1, NM_001271087.1 [Q15906-2] NP_005988.1, NM_005997.2 [Q15906-1] |
Genome annotation databases
Ensembli | ENST00000354473.4; ENSP00000346464.4; ENSG00000163159.15 [Q15906-2] ENST00000368892.9; ENSP00000357887.5; ENSG00000163159.15 |
GeneIDi | 6944 |
KEGGi | hsa:6944 |
MANE-Selecti | ENST00000368892.9; ENSP00000357887.5; NM_005997.3; NP_005988.1 |
UCSCi | uc001exe.3, human [Q15906-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D43642 mRNA Translation: BAA07757.1 BT019356 mRNA Translation: AAV38163.1 BT019357 mRNA Translation: AAV38164.1 AK222935 mRNA Translation: BAD96655.1 AK222939 mRNA Translation: BAD96659.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53462.1 BC003151 mRNA Translation: AAH03151.1 CX163016 mRNA No translation available. |
CCDSi | CCDS59201.1 [Q15906-2] CCDS989.1 [Q15906-1] |
PIRi | JC4140 |
RefSeqi | NP_001258016.1, NM_001271087.1 [Q15906-2] NP_005988.1, NM_005997.2 [Q15906-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5FUG | X-ray | 2.70 | C/F/I/L | 6-69 | [»] | |
AlphaFoldDBi | Q15906 | |||||
SMRi | Q15906 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112804, 104 interactors |
ComplexPortali | CPX-974, SRCAP chromatin remodeling complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q15906 |
DIPi | DIP-31767N |
IntActi | Q15906, 72 interactors |
MINTi | Q15906 |
STRINGi | 9606.ENSP00000346464 |
PTM databases
iPTMneti | Q15906 |
PhosphoSitePlusi | Q15906 |
Genetic variation databases
BioMutai | VPS72 |
DMDMi | 2499159 |
Proteomic databases
EPDi | Q15906 |
jPOSTi | Q15906 |
MassIVEi | Q15906 |
MaxQBi | Q15906 |
PaxDbi | Q15906 |
PeptideAtlasi | Q15906 |
PRIDEi | Q15906 |
ProteomicsDBi | 1732 60807 [Q15906-1] |
Protocols and materials databases
Antibodypediai | 20319, 184 antibodies from 31 providers |
DNASUi | 6944 |
Genome annotation databases
Ensembli | ENST00000354473.4; ENSP00000346464.4; ENSG00000163159.15 [Q15906-2] ENST00000368892.9; ENSP00000357887.5; ENSG00000163159.15 |
GeneIDi | 6944 |
KEGGi | hsa:6944 |
MANE-Selecti | ENST00000368892.9; ENSP00000357887.5; NM_005997.3; NP_005988.1 |
UCSCi | uc001exe.3, human [Q15906-1] |
Organism-specific databases
CTDi | 6944 |
DisGeNETi | 6944 |
GeneCardsi | VPS72 |
HGNCi | HGNC:11644, VPS72 |
HPAi | ENSG00000163159, Low tissue specificity |
MIMi | 600607, gene |
neXtProti | NX_Q15906 |
OpenTargetsi | ENSG00000163159 |
PharmGKBi | PA36396 |
VEuPathDBi | HostDB:ENSG00000163159 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2897, Eukaryota |
GeneTreei | ENSGT00390000017503 |
HOGENOMi | CLU_040862_0_0_1 |
InParanoidi | Q15906 |
OMAi | VNTKAYK |
OrthoDBi | 1468037at2759 |
PhylomeDBi | Q15906 |
TreeFami | TF314532 |
Enzyme and pathway databases
PathwayCommonsi | Q15906 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q15906 |
Miscellaneous databases
BioGRID-ORCSi | 6944, 315 hits in 1090 CRISPR screens |
ChiTaRSi | VPS72, human |
GeneWikii | VPS72 |
GenomeRNAii | 6944 |
Pharosi | Q15906, Tbio |
PROi | PR:Q15906 |
RNActi | Q15906, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163159, Expressed in frontal cortex and 242 other tissues |
ExpressionAtlasi | Q15906, baseline and differential |
Genevisiblei | Q15906, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008895, Vps72/YL1 IPR013272, Vps72/YL1_C |
PANTHERi | PTHR13275, PTHR13275, 1 hit |
Pfami | View protein in Pfam PF05764, YL1, 1 hit PF08265, YL1_C, 1 hit |
SMARTi | View protein in SMART SM00993, YL1_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS72_HUMAN | |
Accessioni | Q15906Primary (citable) accession number: Q15906 Secondary accession number(s): A6NLK9 Q5U0R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families