VPS72

Functionⁱ

Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	156 – 206	Sequence analysisAdd BLAST		51

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26974126

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone exchange
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26974126
negative regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 7702631
somatic stem cell population maintenance Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 72 homolog Alternative name(s): Protein YL-1 Transcription factor-like 1
Gene namesⁱ	Name:VPS72 Synonyms:TCFL1, YL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163159.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11644 VPS72
MIMⁱ	600607 gene
neXtProtⁱ	NX_Q15906

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	29 – 37	FYQTTYGGF → AAQTTAGGA: Highly decreases interaction with H2AFZ and HIST1H2BJ. Abolishes interaction with H2AFZ and HIST1H2BJ and exchange of H2A for H2AFZ in nucleosomes; when associated with A-43--46-A. 1 Publication		9
Mutagenesisⁱ	43 – 46	DDEY → ADAA: Almost abolishes interation with H2AFZ and HIST1H2BJ. Abolishes interaction with H2AFZ and HIST1H2BJ and exchange of H2A for H2AFZ in nucleosomes; when associated with A-29--37-A. 1 Publication		4

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6944
Open Targets More...OpenTargetsⁱ	ENSG00000163159
PharmGKBⁱ	PA36396

Polymorphism and mutation databases

DMDMⁱ	2499159

DMDMⁱ

2499159

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066283	1 – 364	Vacuolar protein sorting-associated protein 72 homologAdd BLAST		364

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	115	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	127	PhosphoserineCombined sources	1
Modified residueⁱ	129	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15906
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15906
PaxDbⁱ	Q15906
PeptideAtlas More...PeptideAtlasⁱ	Q15906
PRIDEⁱ	Q15906
ProteomicsDBⁱ	60807

PTM databases

iPTMnetⁱ	Q15906
PhosphoSitePlusⁱ	Q15906

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163159 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_VPS72
ExpressionAtlasⁱ	Q15906 baseline and differential
Genevisibleⁱ	Q15906 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065709

HPAⁱ

HPA065709

Interactionⁱ

Subunit structureⁱ

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ. Interacts (via N-terminal domain) with heterodimer HIST1H2BJ and H2AFZ (PubMed:26974126).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HMBOX1	Q6NT76	3	EBI-399189,EBI-2549423
MDFI	Q99750	4	EBI-399189,EBI-724076
RUVBL1	Q9Y265	6	EBI-399189,EBI-353675

GO - Molecular functionⁱ

histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26974126

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112804, 77 interactors
ComplexPortalⁱ	CPX-974 SRCAP histone exchanging complex CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	Q15906
Database of interacting proteins More...DIPⁱ	DIP-31767N
IntActⁱ	Q15906, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q15906
STRINGⁱ	9606.ENSP00000357887

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	11 – 16	Combined sources	6
Helixⁱ	17 – 22	Combined sources	6
Helixⁱ	29 – 32	Combined sources	4
Helixⁱ	33 – 35	Combined sources	3
Beta strandⁱ	54 – 57	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15906
SMRⁱ	Q15906
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	22 – 77	Asp/Glu-rich (acidic)Add BLAST	56
Compositional biasⁱ	333 – 354	Pro-richAdd BLAST	22
Compositional biasⁱ	341 – 350	Poly-Pro	10

Sequence similaritiesⁱ

Belongs to the VPS72/YL1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2897 Eukaryota ENOG41119RU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017503
HOGENOMⁱ	HOG000033695
HOVERGENⁱ	HBG083244
InParanoidⁱ	Q15906
KEGG Orthology (KO) More...KOⁱ	K11664
OMAⁱ	CERTFVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQW
PhylomeDBⁱ	Q15906
TreeFamⁱ	TF314532

Family and domain databases

InterProⁱ	View protein in InterPro IPR008895 Vps72/YL1 IPR013272 Vps72/YL1_C
PANTHERⁱ	PTHR13275 PTHR13275, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05764 YL1, 1 hit PF08265 YL1_C, 1 hit
SMARTⁱ	View protein in SMART SM00993 YL1_C, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q15906-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ 
        60         70         80         90        100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK 
       110        120        130        140        150
VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE 
       160        170        180        190        200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ 
       210        220        230        240        250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA PSVSALTPHA 
       260        270        280        290        300
GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL 
       310        320        330        340        350
YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP 
       360 
GSGPRALRQK IVIK

Length:364

Mass (Da):40,594

Last modified:November 1, 1996 - v1

Checksum:ⁱ0AEB90B62B2BCA4A

GO

Isoform 2 (identifier: Q15906-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
236-236: G → GSLCFSLSFVLR

« Hide

        10         20         30         40         50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ 
        60         70         80         90        100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK 
       110        120        130        140        150
VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE 
       160        170        180        190        200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ 
       210        220        230        240        250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGSLCF SLSFVLRLDP 
       260        270        280        290        300
APSVSALTPH AGTGPVNPPA RCSRTFITFS DDATFEEWFP QGRPPKVPVR 
       310        320        330        340        350
EVCPVTHRPA LYRDPVTDIP YATARAFKII REAYKKYITA HGLPPTASAL 
       360        370 
GPGPPPPEPL PGSGPRALRQ KIVIK

Note: No experimental confirmation available.

Show »

Length:375

Mass (Da):41,848

Checksum:ⁱDB81322C6CAECD8D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1W2PPT2	A0A1W2PPT2_HUMAN		Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 72 homolog	VPS72	199	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	Y → H in BAD96655 (Ref. 3) Curated	1
Sequence conflictⁱ	30	Y → H in BAD96659 (Ref. 3) Curated	1
Sequence conflictⁱ	53	T → I in BAD96655 (Ref. 3) Curated	1
Sequence conflictⁱ	53	T → I in BAD96659 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035803	318	I → V in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047566	236	G → GSLCFSLSFVLR in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43642 mRNA Translation: BAA07757.1 BT019356 mRNA Translation: AAV38163.1 BT019357 mRNA Translation: AAV38164.1 AK222935 mRNA Translation: BAD96655.1 AK222939 mRNA Translation: BAD96659.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53462.1 BC003151 mRNA Translation: AAH03151.1 CX163016 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59201.1 [Q15906-2] CCDS989.1 [Q15906-1]
PIRⁱ	JC4140
NCBI Reference Sequences More...RefSeqⁱ	NP_001258016.1, NM_001271087.1 [Q15906-2] NP_005988.1, NM_005997.2 [Q15906-1]
UniGeneⁱ	Hs.2430

Genome annotation databases

Ensemblⁱ	ENST00000354473; ENSP00000346464; ENSG00000163159 [Q15906-2] ENST00000368892; ENSP00000357887; ENSG00000163159 [Q15906-1]
GeneIDⁱ	6944
KEGGⁱ	hsa:6944
UCSC genome browser More...UCSCⁱ	uc001exe.3 human [Q15906-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15906	Vacuolar protein sorting-associated protein 72 homolog		MOUSE		368	UniRef90_Q15906
Vacuolar protein sorting-associated protein 72 homolog		PONAB		364
Vacuolar protein sorting-associated protein 72 homolog		BOVIN		364
Vacuolar protein sorting-associated protein 72 like protein		FUKDA		411
vacuolar protein sorting-associated protein 72 homolog isoform X1		LEPWE		376
+131

Protein	Similar proteins		Species	Score	Length	Source
Q15906	Vacuolar protein sorting-associated protein 72 homolog		MOUSE		368	UniRef50_Q15906
Vacuolar protein sorting-associated protein 72 homolog		PONAB		364
Vacuolar protein sorting-associated protein 72 homolog		BOVIN		364
Vacuolar protein sorting-associated protein 72 like protein		FUKDA		411
vacuolar protein sorting-associated protein 72 homolog isoform X1		LEPWE		376
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43642 mRNA Translation: BAA07757.1 BT019356 mRNA Translation: AAV38163.1 BT019357 mRNA Translation: AAV38164.1 AK222935 mRNA Translation: BAD96655.1 AK222939 mRNA Translation: BAD96659.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53462.1 BC003151 mRNA Translation: AAH03151.1 CX163016 mRNA No translation available.
CCDSⁱ	CCDS59201.1 [Q15906-2] CCDS989.1 [Q15906-1]
PIRⁱ	JC4140
RefSeqⁱ	NP_001258016.1, NM_001271087.1 [Q15906-2] NP_005988.1, NM_005997.2 [Q15906-1]
UniGeneⁱ	Hs.2430

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5FUG	X-ray	2.70	C/F/I/L	6-69	[»]
ProteinModelPortalⁱ	Q15906
SMRⁱ	Q15906
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112804, 77 interactors
ComplexPortalⁱ	CPX-974 SRCAP histone exchanging complex CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	Q15906
DIPⁱ	DIP-31767N
IntActⁱ	Q15906, 33 interactors
MINTⁱ	Q15906
STRINGⁱ	9606.ENSP00000357887

PTM databases

iPTMnetⁱ	Q15906
PhosphoSitePlusⁱ	Q15906

Polymorphism and mutation databases

DMDMⁱ	2499159

DMDMⁱ

2499159

Proteomic databases

EPDⁱ	Q15906
MaxQBⁱ	Q15906
PaxDbⁱ	Q15906
PeptideAtlasⁱ	Q15906
PRIDEⁱ	Q15906
ProteomicsDBⁱ	60807

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6944
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354473; ENSP00000346464; ENSG00000163159 [Q15906-2] ENST00000368892; ENSP00000357887; ENSG00000163159 [Q15906-1]
GeneIDⁱ	6944
KEGGⁱ	hsa:6944
UCSCⁱ	uc001exe.3 human [Q15906-1]

Organism-specific databases

CTDⁱ	6944
DisGeNETⁱ	6944
EuPathDBⁱ	HostDB:ENSG00000163159.11
GeneCardsⁱ	VPS72
HGNCⁱ	HGNC:11644 VPS72
HPAⁱ	HPA065709
MIMⁱ	600607 gene
neXtProtⁱ	NX_Q15906
OpenTargetsⁱ	ENSG00000163159
PharmGKBⁱ	PA36396
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2897 Eukaryota ENOG41119RU LUCA
GeneTreeⁱ	ENSGT00390000017503
HOGENOMⁱ	HOG000033695
HOVERGENⁱ	HBG083244
InParanoidⁱ	Q15906
KOⁱ	K11664
OMAⁱ	CERTFVT
OrthoDBⁱ	EOG091G0BQW
PhylomeDBⁱ	Q15906
TreeFamⁱ	TF314532

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSⁱ	VPS72 human
GeneWikiⁱ	VPS72
GenomeRNAiⁱ	6944
Protein Ontology More...PROⁱ	PR:Q15906
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163159 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_VPS72
ExpressionAtlasⁱ	Q15906 baseline and differential
Genevisibleⁱ	Q15906 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008895 Vps72/YL1 IPR013272 Vps72/YL1_C
PANTHERⁱ	PTHR13275 PTHR13275, 1 hit
Pfamⁱ	View protein in Pfam PF05764 YL1, 1 hit PF08265 YL1_C, 1 hit
SMARTⁱ	View protein in SMART SM00993 YL1_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS72_HUMAN
Accessionⁱ	Q15906Primary (citable) accession number: Q15906 Secondary accession number(s): A6NLK9 , A6PW55, Q53GJ2, Q5U0R4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q15906 (VPS72_HUMAN)

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Vacuolar protein sorting-associated protein 72 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ