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Entry version 182 (08 May 2019)
Sequence version 3 (14 Oct 2008)
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Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

CACNA1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei309Calcium ion selectivity and permeabilityBy similarity1
Sitei657Calcium ion selectivity and permeabilityBy similarity1
Sitei1372Calcium ion selectivity and permeabilityBy similarity1
Sitei1663Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi426 – 437PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1752 – 1763PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-422356 Regulation of insulin secretion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1E
Synonyms:CACH6, CACNL1A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1392 CACNA1E

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601013 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei90 – 108Helical; Name=S1 of repeat IAdd BLAST19
Topological domaini109 – 127ExtracellularSequence analysisAdd BLAST19
Transmembranei128 – 146Helical; Name=S2 of repeat IAdd BLAST19
Topological domaini147 – 158CytoplasmicSequence analysisAdd BLAST12
Transmembranei159 – 173Helical; Name=S3 of repeat IAdd BLAST15
Topological domaini174 – 185ExtracellularSequence analysisAdd BLAST12
Transmembranei186 – 205Helical; Name=S4 of repeat IAdd BLAST20
Topological domaini206 – 223CytoplasmicSequence analysisAdd BLAST18
Transmembranei224 – 244Helical; Name=S5 of repeat IAdd BLAST21
Topological domaini245 – 326ExtracellularSequence analysisAdd BLAST82
Transmembranei327 – 350Helical; Name=S6 of repeat IAdd BLAST24
Topological domaini351 – 476CytoplasmicSequence analysisAdd BLAST126
Transmembranei477 – 496Helical; Name=S1 of repeat IIAdd BLAST20
Topological domaini497 – 509ExtracellularSequence analysisAdd BLAST13
Transmembranei510 – 529Helical; Name=S2 of repeat IIAdd BLAST20
Topological domaini530 – 538CytoplasmicSequence analysis9
Transmembranei539 – 557Helical; Name=S3 of repeat IIAdd BLAST19
Topological domaini558 – 567ExtracellularSequence analysis10
Transmembranei568 – 586Helical; Name=S4 of repeat IIAdd BLAST19
Topological domaini587 – 605CytoplasmicSequence analysisAdd BLAST19
Transmembranei606 – 625Helical; Name=S5 of repeat IIAdd BLAST20
Topological domaini626 – 678ExtracellularSequence analysisAdd BLAST53
Transmembranei679 – 703Helical; Name=S6 of repeat IIAdd BLAST25
Topological domaini704 – 1148CytoplasmicSequence analysisAdd BLAST445
Transmembranei1149 – 1165Helical; Name=S1 of repeat IIIAdd BLAST17
Topological domaini1166 – 1189ExtracellularSequence analysisAdd BLAST24
Transmembranei1190 – 1209Helical; Name=S2 of repeat IIIAdd BLAST20
Topological domaini1210 – 1217CytoplasmicSequence analysis8
Transmembranei1218 – 1240Helical; Name=S3 of repeat IIIAdd BLAST23
Topological domaini1241 – 1254ExtracellularSequence analysisAdd BLAST14
Transmembranei1255 – 1272Helical; Name=S4 of repeat IIIAdd BLAST18
Topological domaini1273 – 1291CytoplasmicSequence analysisAdd BLAST19
Transmembranei1292 – 1311Helical; Name=S5 of repeat IIIAdd BLAST20
Topological domaini1312 – 1398ExtracellularSequence analysisAdd BLAST87
Transmembranei1399 – 1422Helical; Name=S6 of repeat IIIAdd BLAST24
Topological domaini1423 – 1479CytoplasmicSequence analysisAdd BLAST57
Transmembranei1480 – 1498Helical; Name=S1 of repeat IVAdd BLAST19
Topological domaini1499 – 1513ExtracellularSequence analysisAdd BLAST15
Transmembranei1514 – 1533Helical; Name=S2 of repeat IVAdd BLAST20
Topological domaini1534 – 1541CytoplasmicSequence analysis8
Transmembranei1542 – 1560Helical; Name=S3 of repeat IVAdd BLAST19
Topological domaini1561 – 1571ExtracellularSequence analysisAdd BLAST11
Transmembranei1572 – 1590Helical; Name=S4 of repeat IVAdd BLAST19
Topological domaini1591 – 1609CytoplasmicSequence analysisAdd BLAST19
Transmembranei1610 – 1629Helical; Name=S5 of repeat IVAdd BLAST20
Topological domaini1630 – 1698ExtracellularSequence analysisAdd BLAST69
Transmembranei1699 – 1724Helical; Name=S6 of repeat IVAdd BLAST26
Topological domaini1725 – 2313CytoplasmicSequence analysisAdd BLAST589

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
777

Open Targets

More...
OpenTargetsi
ENSG00000198216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26009

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1687682

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
534

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CACNA1E

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572758

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539381 – 2313Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei427PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei745PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei1097PhosphoserineBy similarity1
Glycosylationi1566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1571N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1734Phosphoserine; by PKASequence analysis1
Modified residuei2094PhosphoserineBy similarity1
Modified residuei2113PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15878

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15878

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15878

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15878

PeptideAtlas

More...
PeptideAtlasi
Q15878

PRoteomics IDEntifications database

More...
PRIDEi
Q15878

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60800
60801 [Q15878-2]
60802 [Q15878-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15878

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neuronal tissues and in kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198216 Expressed in 70 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15878 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15878 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB079032
HPA042515

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107231, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q15878, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356545

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15878

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15878

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15878

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati76 – 354IAdd BLAST279
Repeati462 – 706IIAdd BLAST245
Repeati1140 – 1426IIIAdd BLAST287
Repeati1463 – 1726IVAdd BLAST264
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1739 – 1774EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni374 – 391Binding to the beta subunitBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi716 – 721Poly-Glu6
Compositional biasi748 – 753Poly-Arg6
Compositional biasi767 – 772Poly-Arg6
Compositional biasi1228 – 1231Poly-Val4
Compositional biasi2284 – 2288Poly-Arg5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF5 Eukaryota
ENOG410YD06 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231530

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15878

KEGG Orthology (KO)

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KOi
K04852

Identification of Orthologs from Complete Genome Data

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OMAi
ISVRHMV

Database of Orthologous Groups

More...
OrthoDBi
1566576at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15878

TreeFam database of animal gene trees

More...
TreeFami
TF312805

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45628:SF5 PTHR45628:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01633 RVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15878-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM
60 70 80 90 100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII
110 120 130 140 150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF
160 170 180 190 200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL
210 220 230 240 250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA
260 270 280 290 300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
310 320 330 340 350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK
410 420 430 440 450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA
460 470 480 490 500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ
510 520 530 540 550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG
560 570 580 590 600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
610 620 630 640 650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV
660 670 680 690 700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA
710 720 730 740 750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERDR
760 770 780 790 800
RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRKHMQ MSSQEALNRE
810 820 830 840 850
EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL ALEKFEEERI
860 870 880 890 900
SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG
910 920 930 940 950
GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE
960 970 980 990 1000
AMPTEGEKDH ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD
1010 1020 1030 1040 1050
EADTPLVLPH PELEVGKHVV LTEQEPEGSS EQALLGNVQL DMGRVISQSE
1060 1070 1080 1090 1100
PDLSCITANT DKATTESTSV TVAIPDVDPL VDSTVVHISN KTDGEASPLK
1110 1120 1130 1140 1150
EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN PIRRACHYIV
1160 1170 1180 1190 1200
NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE
1210 1220 1230 1240 1250
MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD
1260 1270 1280 1290 1300
IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM
1310 1320 1330 1340 1350
FIFAVIAVQL FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR
1360 1370 1380 1390 1400
HEFHYDNIIW ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS
1410 1420 1430 1440 1450
IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA
1460 1470 1480 1490 1500
ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY
1510 1520 1530 1540 1550
SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV
1560 1570 1580 1590 1600
IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF
1610 1620 1630 1640 1650
VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF
1660 1670 1680 1690 1700
GSLMLLFRSA TGEAWQEIML SCLGEKGCEP DTTAPSGQNE NERCGTDLAY
1710 1720 1730 1740 1750
VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE
1760 1770 1780 1790 1800
YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED
1810 1820 1830 1840 1850
MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM
1860 1870 1880 1890 1900
LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ
1910 1920 1930 1940 1950
RMEPSSLPQE IIANAKALPY LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA
1960 1970 1980 1990 2000
CMDPADDGQF QERQSLEPEV SELKSVQPSN HGIYLPSDTQ EHAGSGRASS
2010 2020 2030 2040 2050
MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME RSSENTYKSR
2060 2070 2080 2090 2100
RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC
2110 2120 2130 2140 2150
NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS
2160 2170 2180 2190 2200
TPRRSRRQLP PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL
2210 2220 2230 2240 2250
ESNNACLTES SNSPHPQQSQ HASPQRYISE PYLALHEDSH ASDCGEEETL
2260 2270 2280 2290 2300
TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRRGG PGPGMMCGAV
2310
NNLLSDTEED DKC
Length:2,313
Mass (Da):261,731
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCC7F309C27C42F1
GO
Isoform 2 (identifier: Q15878-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-1

The sequence of this isoform differs from the canonical sequence as follows:
     748-766: Missing.
     1967-2009: Missing.

Show »
Length:2,251
Mass (Da):254,604
Checksum:i73640AD59C386BB2
GO
Isoform 3 (identifier: Q15878-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-3

The sequence of this isoform differs from the canonical sequence as follows:
     1967-2009: Missing.

Show »
Length:2,270
Mass (Da):257,116
Checksum:iD424C3592C9BD5F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9Z1F8W9Z1_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
2,294Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP11J3KP11_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
2,312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIE8E9PIE8_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
583Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7W1A0A2R8Y7W1_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti648M → I in AAA72125 (PubMed:7536609).Curated1
Sequence conflicti836 – 838LAL → WP in AAA72125 (PubMed:7536609).Curated3
Sequence conflicti2077R → P in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2077R → P in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59205 (PubMed:8071363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031912859D → E. Corresponds to variant dbSNP:rs35737760Ensembl.1
Natural variantiVAR_0469961955A → T1 PublicationCorresponds to variant dbSNP:rs704326Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000937748 – 766Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0248171967 – 2009Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L27745 mRNA Translation: AAA72125.1
L29384 mRNA Translation: AAA59204.1
L29385 mRNA Translation: AAA59205.1
AL161734 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL160059 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53443.1 [Q15878-3]
CCDS55664.1 [Q15878-1]
CCDS55665.1 [Q15878-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54972
B54972

NCBI Reference Sequences

More...
RefSeqi
NP_000712.2, NM_000721.3 [Q15878-3]
NP_001192222.1, NM_001205293.1 [Q15878-1]
NP_001192223.1, NM_001205294.1 [Q15878-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358338; ENSP00000351101; ENSG00000198216 [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216 [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216 [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216 [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216 [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216 [Q15878-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:777

UCSC genome browser

More...
UCSCi
uc001gow.5 human [Q15878-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27745 mRNA Translation: AAA72125.1
L29384 mRNA Translation: AAA59204.1
L29385 mRNA Translation: AAA59205.1
AL161734 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL160059 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
CCDSiCCDS53443.1 [Q15878-3]
CCDS55664.1 [Q15878-1]
CCDS55665.1 [Q15878-2]
PIRiA54972
B54972
RefSeqiNP_000712.2, NM_000721.3 [Q15878-3]
NP_001192222.1, NM_001205293.1 [Q15878-1]
NP_001192223.1, NM_001205294.1 [Q15878-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]
SMRiQ15878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107231, 2 interactors
IntActiQ15878, 1 interactor
STRINGi9606.ENSP00000356545

Chemistry databases

BindingDBiQ15878
ChEMBLiCHEMBL1687682
GuidetoPHARMACOLOGYi534

PTM databases

iPTMnetiQ15878
PhosphoSitePlusiQ15878

Polymorphism and mutation databases

BioMutaiCACNA1E
DMDMi209572758

Proteomic databases

EPDiQ15878
jPOSTiQ15878
MaxQBiQ15878
PaxDbiQ15878
PeptideAtlasiQ15878
PRIDEiQ15878
ProteomicsDBi60800
60801 [Q15878-2]
60802 [Q15878-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358338; ENSP00000351101; ENSG00000198216 [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216 [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216 [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216 [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216 [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216 [Q15878-2]
GeneIDi777
KEGGihsa:777
UCSCiuc001gow.5 human [Q15878-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
777
DisGeNETi777

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CACNA1E
HGNCiHGNC:1392 CACNA1E
HPAiCAB079032
HPA042515
MIMi601013 gene
neXtProtiNX_Q15878
OpenTargetsiENSG00000198216
PharmGKBiPA26009

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INF5 Eukaryota
ENOG410YD06 LUCA
GeneTreeiENSGT00940000155601
HOGENOMiHOG000231530
InParanoidiQ15878
KOiK04852
OMAiISVRHMV
OrthoDBi1566576at2759
PhylomeDBiQ15878
TreeFamiTF312805

Enzyme and pathway databases

ReactomeiR-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CACNA1E human
EvolutionaryTraceiQ15878

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
R-type_calcium_channel

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
777

Protein Ontology

More...
PROi
PR:Q15878

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198216 Expressed in 70 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ15878 baseline and differential
GenevisibleiQ15878 HS

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR45628:SF5 PTHR45628:SF5, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01633 RVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15878
Secondary accession number(s): B1AM12
, B1AM13, B1AM14, Q14580, Q14581
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 14, 2008
Last modified: May 8, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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