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UniProtKB - Q15878 (CAC1E_HUMAN)

Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

CACNA1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei309Calcium ion selectivity and permeabilityBy similarity1
Sitei657Calcium ion selectivity and permeabilityBy similarity1
Sitei1372Calcium ion selectivity and permeabilityBy similarity1
Sitei1663Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi426 – 437PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1752 – 1763PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
Gene namesi
Name:CACNA1E
Synonyms:CACH6, CACNL1A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198216.10
HGNCiHGNC:1392 CACNA1E
MIMi601013 gene
neXtProtiNX_Q15878

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
Transmembranei90 – 108Helical; Name=S1 of repeat IAdd BLAST19
Topological domaini109 – 127ExtracellularSequence analysisAdd BLAST19
Transmembranei128 – 146Helical; Name=S2 of repeat IAdd BLAST19
Topological domaini147 – 158CytoplasmicSequence analysisAdd BLAST12
Transmembranei159 – 173Helical; Name=S3 of repeat IAdd BLAST15
Topological domaini174 – 185ExtracellularSequence analysisAdd BLAST12
Transmembranei186 – 205Helical; Name=S4 of repeat IAdd BLAST20
Topological domaini206 – 223CytoplasmicSequence analysisAdd BLAST18
Transmembranei224 – 244Helical; Name=S5 of repeat IAdd BLAST21
Topological domaini245 – 326ExtracellularSequence analysisAdd BLAST82
Transmembranei327 – 350Helical; Name=S6 of repeat IAdd BLAST24
Topological domaini351 – 476CytoplasmicSequence analysisAdd BLAST126
Transmembranei477 – 496Helical; Name=S1 of repeat IIAdd BLAST20
Topological domaini497 – 509ExtracellularSequence analysisAdd BLAST13
Transmembranei510 – 529Helical; Name=S2 of repeat IIAdd BLAST20
Topological domaini530 – 538CytoplasmicSequence analysis9
Transmembranei539 – 557Helical; Name=S3 of repeat IIAdd BLAST19
Topological domaini558 – 567ExtracellularSequence analysis10
Transmembranei568 – 586Helical; Name=S4 of repeat IIAdd BLAST19
Topological domaini587 – 605CytoplasmicSequence analysisAdd BLAST19
Transmembranei606 – 625Helical; Name=S5 of repeat IIAdd BLAST20
Topological domaini626 – 678ExtracellularSequence analysisAdd BLAST53
Transmembranei679 – 703Helical; Name=S6 of repeat IIAdd BLAST25
Topological domaini704 – 1148CytoplasmicSequence analysisAdd BLAST445
Transmembranei1149 – 1165Helical; Name=S1 of repeat IIIAdd BLAST17
Topological domaini1166 – 1189ExtracellularSequence analysisAdd BLAST24
Transmembranei1190 – 1209Helical; Name=S2 of repeat IIIAdd BLAST20
Topological domaini1210 – 1217CytoplasmicSequence analysis8
Transmembranei1218 – 1240Helical; Name=S3 of repeat IIIAdd BLAST23
Topological domaini1241 – 1254ExtracellularSequence analysisAdd BLAST14
Transmembranei1255 – 1272Helical; Name=S4 of repeat IIIAdd BLAST18
Topological domaini1273 – 1291CytoplasmicSequence analysisAdd BLAST19
Transmembranei1292 – 1311Helical; Name=S5 of repeat IIIAdd BLAST20
Topological domaini1312 – 1398ExtracellularSequence analysisAdd BLAST87
Transmembranei1399 – 1422Helical; Name=S6 of repeat IIIAdd BLAST24
Topological domaini1423 – 1479CytoplasmicSequence analysisAdd BLAST57
Transmembranei1480 – 1498Helical; Name=S1 of repeat IVAdd BLAST19
Topological domaini1499 – 1513ExtracellularSequence analysisAdd BLAST15
Transmembranei1514 – 1533Helical; Name=S2 of repeat IVAdd BLAST20
Topological domaini1534 – 1541CytoplasmicSequence analysis8
Transmembranei1542 – 1560Helical; Name=S3 of repeat IVAdd BLAST19
Topological domaini1561 – 1571ExtracellularSequence analysisAdd BLAST11
Transmembranei1572 – 1590Helical; Name=S4 of repeat IVAdd BLAST19
Topological domaini1591 – 1609CytoplasmicSequence analysisAdd BLAST19
Transmembranei1610 – 1629Helical; Name=S5 of repeat IVAdd BLAST20
Topological domaini1630 – 1698ExtracellularSequence analysisAdd BLAST69
Transmembranei1699 – 1724Helical; Name=S6 of repeat IVAdd BLAST26
Topological domaini1725 – 2313CytoplasmicSequence analysisAdd BLAST589

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi777
OpenTargetsiENSG00000198216
PharmGKBiPA26009

Chemistry databases

ChEMBLiCHEMBL1687682
GuidetoPHARMACOLOGYi534

Polymorphism and mutation databases

BioMutaiCACNA1E
DMDMi209572758

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539381 – 2313Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei427PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei745PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1
Modified residuei855PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei1097PhosphoserineBy similarity1
Glycosylationi1566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1571N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1734Phosphoserine; by PKASequence analysis1
Modified residuei2094PhosphoserineBy similarity1
Modified residuei2113PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15878
MaxQBiQ15878
PaxDbiQ15878
PeptideAtlasiQ15878
PRIDEiQ15878
ProteomicsDBi60800
60801 [Q15878-2]
60802 [Q15878-3]

PTM databases

iPTMnetiQ15878
PhosphoSitePlusiQ15878

Expressioni

Tissue specificityi

Expressed in neuronal tissues and in kidney.

Gene expression databases

BgeeiENSG00000198216 Expressed in 70 organ(s), highest expression level in caudate nucleus
CleanExiHS_CACNA1E
ExpressionAtlasiQ15878 baseline and differential
GenevisibleiQ15878 HS

Organism-specific databases

HPAiCAB079032
HPA042515

Interactioni

Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.1 Publication

Protein-protein interaction databases

BioGridi107231, 2 interactors
STRINGi9606.ENSP00000356545

Chemistry databases

BindingDBiQ15878

Structurei

Secondary structure

12313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15878
SMRiQ15878
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15878

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 354IAdd BLAST279
Repeati462 – 706IIAdd BLAST245
Repeati1140 – 1426IIIAdd BLAST287
Repeati1463 – 1726IVAdd BLAST264
Domaini1739 – 1774EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 391Binding to the beta subunitBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi716 – 721Poly-Glu6
Compositional biasi748 – 753Poly-Arg6
Compositional biasi767 – 772Poly-Arg6
Compositional biasi1228 – 1231Poly-Val4
Compositional biasi2284 – 2288Poly-Arg5

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INF5 Eukaryota
ENOG410YD06 LUCA
GeneTreeiENSGT00830000128247
HOGENOMiHOG000231530
HOVERGENiHBG050763
InParanoidiQ15878
KOiK04852
OMAiISVRHMV
OrthoDBiEOG091G0TKO
PhylomeDBiQ15878
TreeFamiTF312805

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF57 PTHR10037:SF57, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01633 RVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15878-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM 
        60         70         80         90        100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII 
       110        120        130        140        150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF 
       160        170        180        190        200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL 
       210        220        230        240        250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA 
       260        270        280        290        300
CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL 
       310        320        330        340        350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL 
       360        370        380        390        400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK 
       410        420        430        440        450
NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA 
       460        470        480        490        500
KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ 
       510        520        530        540        550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG 
       560        570        580        590        600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM 
       610        620        630        640        650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV 
       660        670        680        690        700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA 
       710        720        730        740        750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERDR 
       760        770        780        790        800
RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRKHMQ MSSQEALNRE 
       810        820        830        840        850
EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL ALEKFEEERI 
       860        870        880        890        900
SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG 
       910        920        930        940        950
GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE 
       960        970        980        990       1000
AMPTEGEKDH ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD 
      1010       1020       1030       1040       1050
EADTPLVLPH PELEVGKHVV LTEQEPEGSS EQALLGNVQL DMGRVISQSE 
      1060       1070       1080       1090       1100
PDLSCITANT DKATTESTSV TVAIPDVDPL VDSTVVHISN KTDGEASPLK 
      1110       1120       1130       1140       1150
EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN PIRRACHYIV 
      1160       1170       1180       1190       1200
NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE 
      1210       1220       1230       1240       1250
MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD 
      1260       1270       1280       1290       1300
IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM 
      1310       1320       1330       1340       1350
FIFAVIAVQL FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR 
      1360       1370       1380       1390       1400
HEFHYDNIIW ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS 
      1410       1420       1430       1440       1450
IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA 
      1460       1470       1480       1490       1500
ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY 
      1510       1520       1530       1540       1550
SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV 
      1560       1570       1580       1590       1600
IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF 
      1610       1620       1630       1640       1650
VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF 
      1660       1670       1680       1690       1700
GSLMLLFRSA TGEAWQEIML SCLGEKGCEP DTTAPSGQNE NERCGTDLAY 
      1710       1720       1730       1740       1750
VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE 
      1760       1770       1780       1790       1800
YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED 
      1810       1820       1830       1840       1850
MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM 
      1860       1870       1880       1890       1900
LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ 
      1910       1920       1930       1940       1950
RMEPSSLPQE IIANAKALPY LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA 
      1960       1970       1980       1990       2000
CMDPADDGQF QERQSLEPEV SELKSVQPSN HGIYLPSDTQ EHAGSGRASS 
      2010       2020       2030       2040       2050
MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME RSSENTYKSR 
      2060       2070       2080       2090       2100
RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC 
      2110       2120       2130       2140       2150
NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS 
      2160       2170       2180       2190       2200
TPRRSRRQLP PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL 
      2210       2220       2230       2240       2250
ESNNACLTES SNSPHPQQSQ HASPQRYISE PYLALHEDSH ASDCGEEETL 
      2260       2270       2280       2290       2300
TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRRGG PGPGMMCGAV 
      2310 
NNLLSDTEED DKC
Length:2,313
Mass (Da):261,731
Last modified:October 14, 2008 - v3
Checksum:iCCC7F309C27C42F1
GO
Isoform 2 (identifier: Q15878-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-1

The sequence of this isoform differs from the canonical sequence as follows:
     748-766: Missing.
     1967-2009: Missing.

Show »
Length:2,251
Mass (Da):254,604
Checksum:i73640AD59C386BB2
GO
Isoform 3 (identifier: Q15878-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E-3

The sequence of this isoform differs from the canonical sequence as follows:
     1967-2009: Missing.

Show »
Length:2,270
Mass (Da):257,116
Checksum:iD424C3592C9BD5F5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9Z1F8W9Z1_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
2,294Annotation score:
J3KP11J3KP11_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
2,312Annotation score:
E9PIE8E9PIE8_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
583Annotation score:
A0A2R8Y7W1A0A2R8Y7W1_HUMAN
Voltage-dependent R-type calcium ch...
CACNA1E
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti648M → I in AAA72125 (PubMed:7536609).Curated1
Sequence conflicti836 – 838LAL → WP in AAA72125 (PubMed:7536609).Curated3
Sequence conflicti2077R → P in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2077R → P in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2084G → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2206C → W in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2219S → R in AAA59205 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59204 (PubMed:8071363).Curated1
Sequence conflicti2245G → V in AAA59205 (PubMed:8071363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031912859D → E. Corresponds to variant dbSNP:rs35737760Ensembl.1
Natural variantiVAR_0469961955A → T1 PublicationCorresponds to variant dbSNP:rs704326Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000937748 – 766Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0248171967 – 2009Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27745 mRNA Translation: AAA72125.1
L29384 mRNA Translation: AAA59204.1
L29385 mRNA Translation: AAA59205.1
AL161734 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL160059 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
CCDSiCCDS53443.1 [Q15878-3]
CCDS55664.1 [Q15878-1]
CCDS55665.1 [Q15878-2]
PIRiA54972
B54972
RefSeqiNP_000712.2, NM_000721.3 [Q15878-3]
NP_001192222.1, NM_001205293.1 [Q15878-1]
NP_001192223.1, NM_001205294.1 [Q15878-2]
UniGeneiHs.437444
Hs.611396

Genome annotation databases

EnsembliENST00000358338; ENSP00000351101; ENSG00000198216 [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216 [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216 [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216 [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216 [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216 [Q15878-2]
GeneIDi777
KEGGihsa:777
UCSCiuc001gow.5 human [Q15878-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27745 mRNA Translation: AAA72125.1
L29384 mRNA Translation: AAA59204.1
L29385 mRNA Translation: AAA59205.1
AL161734 Genomic DNA No translation available.
AL359270 Genomic DNA No translation available.
AL160059 Genomic DNA No translation available.
AL590998 Genomic DNA No translation available.
CCDSiCCDS53443.1 [Q15878-3]
CCDS55664.1 [Q15878-1]
CCDS55665.1 [Q15878-2]
PIRiA54972
B54972
RefSeqiNP_000712.2, NM_000721.3 [Q15878-3]
NP_001192222.1, NM_001205293.1 [Q15878-1]
NP_001192223.1, NM_001205294.1 [Q15878-2]
UniGeneiHs.437444
Hs.611396

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BXLX-ray2.30B1867-1887[»]
ProteinModelPortaliQ15878
SMRiQ15878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107231, 2 interactors
STRINGi9606.ENSP00000356545

Chemistry databases

BindingDBiQ15878
ChEMBLiCHEMBL1687682
GuidetoPHARMACOLOGYi534

PTM databases

iPTMnetiQ15878
PhosphoSitePlusiQ15878

Polymorphism and mutation databases

BioMutaiCACNA1E
DMDMi209572758

Proteomic databases

EPDiQ15878
MaxQBiQ15878
PaxDbiQ15878
PeptideAtlasiQ15878
PRIDEiQ15878
ProteomicsDBi60800
60801 [Q15878-2]
60802 [Q15878-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358338; ENSP00000351101; ENSG00000198216 [Q15878-2]
ENST00000367567; ENSP00000356539; ENSG00000198216 [Q15878-3]
ENST00000367570; ENSP00000356542; ENSG00000198216 [Q15878-3]
ENST00000367573; ENSP00000356545; ENSG00000198216 [Q15878-1]
ENST00000621551; ENSP00000483914; ENSG00000198216 [Q15878-1]
ENST00000621791; ENSP00000481619; ENSG00000198216 [Q15878-2]
GeneIDi777
KEGGihsa:777
UCSCiuc001gow.5 human [Q15878-1]

Organism-specific databases

CTDi777
DisGeNETi777
EuPathDBiHostDB:ENSG00000198216.10
GeneCardsiCACNA1E
HGNCiHGNC:1392 CACNA1E
HPAiCAB079032
HPA042515
MIMi601013 gene
neXtProtiNX_Q15878
OpenTargetsiENSG00000198216
PharmGKBiPA26009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INF5 Eukaryota
ENOG410YD06 LUCA
GeneTreeiENSGT00830000128247
HOGENOMiHOG000231530
HOVERGENiHBG050763
InParanoidiQ15878
KOiK04852
OMAiISVRHMV
OrthoDBiEOG091G0TKO
PhylomeDBiQ15878
TreeFamiTF312805

Enzyme and pathway databases

ReactomeiR-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRSiCACNA1E human
EvolutionaryTraceiQ15878
GeneWikiiR-type_calcium_channel
GenomeRNAii777
PROiPR:Q15878
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198216 Expressed in 70 organ(s), highest expression level in caudate nucleus
CleanExiHS_CACNA1E
ExpressionAtlasiQ15878 baseline and differential
GenevisibleiQ15878 HS

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF57 PTHR10037:SF57, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01633 RVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1E_HUMAN
AccessioniPrimary (citable) accession number: Q15878
Secondary accession number(s): B1AM12
, B1AM13, B1AM14, Q14580, Q14581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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