Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q15853 (USF2_HUMAN)

Entry version 190 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Upstream stimulatory factor 2

Gene

USF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15853

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15853

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15853

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Upstream stimulatory factor 2
Alternative name(s):
Class B basic helix-loop-helix protein 12
Short name:
bHLHb12
FOS-interacting protein
Short name:
FIP
Major late transcription factor 2
Upstream transcription factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USF2
Synonyms:BHLHB12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12594, USF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600390, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15853

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105698

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7392

Open Targets

More...OpenTargetsi		ENSG00000105698

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37224

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15853, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		USF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		2833271

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275001 – 346Upstream stimulatory factor 2Add BLAST346

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15853

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15853

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15853

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15853

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15853

PeptideAtlas

More...PeptideAtlasi		Q15853

PRoteomics IDEntifications database

More...PRIDEi		Q15853

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60794 [Q15853-1]
60795 [Q15853-2]
60796 [Q15853-3]
67853

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15853, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15853

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q15853

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15853

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105698, Expressed in frontal cortex and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15853, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15853, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105698, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The USF1/USF2B heterodimer accounted for almost 15% in some cell.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113238, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3079, USF1-USF2 upstream stimulatory factor complex
CPX-3083, USF2 upstream stimulatory factor complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15853

Protein interaction database and analysis system

More...IntActi		Q15853, 19 interactors

Molecular INTeraction database

More...MINTi		Q15853

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222305

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15853, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15853

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 290bHLHPROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni215 – 244DisorderedSequence analysisAdd BLAST30
Regioni307 – 328Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 244Basic and acidic residuesSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1318, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160704

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070485_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15853

Identification of Orthologs from Complete Genome Data

More...OMAi		CAQDHTK

Database of Orthologous Groups

More...OrthoDBi		1345445at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15853

TreeFam database of animal gene trees

More...TreeFami		TF323338

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform USF2A (identifier: Q15853-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMLDPGLDP AASATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA 
        60         70         80         90        100
ITSVQQAAFG DHNIQYQFRT ETNGGQVTYR VVQVTDGQLD GQGDTAGAVS 
       110        120        130        140        150
VVSTAAFAGG QQAVTQVGVD GAAQRPGPAA ASVPPGPAAP FPLAVIQNPF 
       160        170        180        190        200
SNGGSPAAEA VSGEARFAYF PASSVGDTTA VSVQTTDQSL QAGGQFYVMM 
       210        220        230        240        250
TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH NEVERRRRDK 
       260        270        280        290        300
INNWIVQLSK IIPDCNADNS KTGASKGGIL SKACDYIREL RQTNQRMQET 
       310        320        330        340 
FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GEGTRQ
Length:346
Mass (Da):36,955
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78CEFE97AC4C10CF
GO
Isoform USF2A-delta-H (identifier: Q15853-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-282: Missing.

Show »
Length:338
Mass (Da):36,184
Checksum:i681B0AE58A84042B
GO
Isoform USF2B (identifier: Q15853-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-143: Missing.

Show »
Length:279
Mass (Da):30,570
Checksum:i15C53A2CC946CEA7
GO
Isoform USF2c (identifier: Q15853-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-206: Missing.

Note: Can bind as a homodimer to the E-box of the cathepsin B (CTSB) promoter.Curated
Show »
Length:215
Mass (Da):23,988
Checksum:iE10CB131E46B58D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DLJ1B4DLJ1_HUMAN
Upstream stimulatory factor 2
USF2
349Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXT0M0QXT0_HUMAN
Upstream stimulatory factor 2
USF2
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1C6M0R1C6_HUMAN
Upstream stimulatory factor 2
USF2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY46M0QY46_HUMAN
Upstream stimulatory factor 2
USF2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYU7M0QYU7_HUMAN
Upstream stimulatory factor 2
USF2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYR5V9GYR5_HUMAN
Upstream stimulatory factor 2
USF2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ39M0QZ39_HUMAN
Upstream stimulatory factor 2
USF2
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46 – 64QTAVA…GDHNI → GGGTSGGRGSGIQTRVQHV (PubMed:1450663).CuratedAdd BLAST19
Sequence conflicti93 – 100GDTAGAVS → EFHSWRRH in M77476 (PubMed:1589769).Curated8
Sequence conflicti122A → V in M77476 (PubMed:1589769).Curated1
Sequence conflicti308Q → R in CAG38742 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04780476 – 206Missing in isoform USF2c. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_00216477 – 143Missing in isoform USF2B. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_002165275 – 282Missing in isoform USF2A-delta-H. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X90824 mRNA Translation: CAA62339.1
X90825 mRNA Translation: CAA62340.1
X90826 mRNA Translation: CAA62341.1
Y07661 Genomic DNA Translation: CAA68942.1
AY147880 mRNA Translation: AAN63092.1
CR536504 mRNA Translation: CAG38742.1
AD000684 Genomic DNA Translation: AAB51179.1
BC049821 mRNA Translation: AAH49821.1
S50537 mRNA Translation: AAB24368.1
M77476 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12452.1 [Q15853-1]
CCDS12453.1 [Q15853-3]
CCDS82329.1 [Q15853-4]

Protein sequence database of the Protein Information Resource

More...PIRi		I54074

NCBI Reference Sequences

More...RefSeqi		NP_001308079.1, NM_001321150.1 [Q15853-4]
NP_003358.1, NM_003367.3 [Q15853-1]
NP_997174.1, NM_207291.2 [Q15853-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222305; ENSP00000222305; ENSG00000105698
ENST00000343550; ENSP00000340633; ENSG00000105698 [Q15853-3]
ENST00000379134; ENSP00000368429; ENSG00000105698 [Q15853-4]
ENST00000595068; ENSP00000471099; ENSG00000105698 [Q15853-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7392

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000222305.8; ENSP00000222305.2; NM_003367.4; NP_003358.1

UCSC genome browser

More...UCSCi		uc002nyq.2, human [Q15853-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90824 mRNA Translation: CAA62339.1
X90825 mRNA Translation: CAA62340.1
X90826 mRNA Translation: CAA62341.1
Y07661 Genomic DNA Translation: CAA68942.1
AY147880 mRNA Translation: AAN63092.1
CR536504 mRNA Translation: CAG38742.1
AD000684 Genomic DNA Translation: AAB51179.1
BC049821 mRNA Translation: AAH49821.1
S50537 mRNA Translation: AAB24368.1
M77476 mRNA No translation available.
CCDSiCCDS12452.1 [Q15853-1]
CCDS12453.1 [Q15853-3]
CCDS82329.1 [Q15853-4]
PIRiI54074
RefSeqiNP_001308079.1, NM_001321150.1 [Q15853-4]
NP_003358.1, NM_003367.3 [Q15853-1]
NP_997174.1, NM_207291.2 [Q15853-3]

3D structure databases

SMRiQ15853
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113238, 37 interactors
ComplexPortaliCPX-3079, USF1-USF2 upstream stimulatory factor complex
CPX-3083, USF2 upstream stimulatory factor complex
CORUMiQ15853
IntActiQ15853, 19 interactors
MINTiQ15853
STRINGi9606.ENSP00000222305

PTM databases

GlyGeniQ15853, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ15853
MetOSiteiQ15853
PhosphoSitePlusiQ15853

Genetic variation databases

BioMutaiUSF2
DMDMi2833271

Proteomic databases

EPDiQ15853
jPOSTiQ15853
MassIVEiQ15853
MaxQBiQ15853
PaxDbiQ15853
PeptideAtlasiQ15853
PRIDEiQ15853
ProteomicsDBi60794 [Q15853-1]
60795 [Q15853-2]
60796 [Q15853-3]
67853

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15859, 378 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		7392

Genome annotation databases

EnsembliENST00000222305; ENSP00000222305; ENSG00000105698
ENST00000343550; ENSP00000340633; ENSG00000105698 [Q15853-3]
ENST00000379134; ENSP00000368429; ENSG00000105698 [Q15853-4]
ENST00000595068; ENSP00000471099; ENSG00000105698 [Q15853-2]
GeneIDi7392
KEGGihsa:7392
MANE-SelectiENST00000222305.8; ENSP00000222305.2; NM_003367.4; NP_003358.1
UCSCiuc002nyq.2, human [Q15853-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7392
DisGeNETi7392

GeneCards: human genes, protein and diseases

More...GeneCardsi		USF2
HGNCiHGNC:12594, USF2
HPAiENSG00000105698, Low tissue specificity
MIMi600390, gene
neXtProtiNX_Q15853
OpenTargetsiENSG00000105698
PharmGKBiPA37224
VEuPathDBiHostDB:ENSG00000105698

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1318, Eukaryota
GeneTreeiENSGT00940000160704
HOGENOMiCLU_070485_2_0_1
InParanoidiQ15853
OMAiCAQDHTK
OrthoDBi1345445at2759
PhylomeDBiQ15853
TreeFamiTF323338

Enzyme and pathway databases

PathwayCommonsiQ15853
ReactomeiR-HSA-9018519, Estrogen-dependent gene expression
SignaLinkiQ15853
SIGNORiQ15853

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7392, 182 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USF2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		USF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7392
PharosiQ15853, Tbio

Protein Ontology

More...PROi		PR:Q15853
RNActiQ15853, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105698, Expressed in frontal cortex and 248 other tissues
ExpressionAtlasiQ15853, baseline and differential
GenevisibleiQ15853, HS

Family and domain databases

Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15853
Secondary accession number(s): O00671
, O00709, Q05750, Q07952, Q15851, Q15852, Q6FI33, Q6YI47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again