Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urea transporter 2

Gene

SLC14A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell adhesion molecule binding Source: MGI
  • urea channel activity Source: GO_Central
  • urea transmembrane transporter activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.28.1.6 the urea transporter (ut) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC14A2
Synonyms:HUT2, UT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132874.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10919 SLC14A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601611 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15849

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei151 – 170HelicalSequence analysisAdd BLAST20
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei272 – 291HelicalSequence analysisAdd BLAST20
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21
Transmembranei832 – 852HelicalSequence analysisAdd BLAST21
Transmembranei854 – 874HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8170

Open Targets

More...
OpenTargetsi
ENSG00000132874

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35811

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03904 Urea

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC14A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495053

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000657391 – 920Urea transporter 2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei477PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15849

PeptideAtlas

More...
PeptideAtlasi
Q15849

PRoteomics IDEntifications database

More...
PRIDEi
Q15849

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60792
60793 [Q15849-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15849

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15849

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132874 Expressed in 45 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC14A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15849 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15849 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SNAPINO952955EBI-1633392,EBI-296723

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113822, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q15849, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255226

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15849

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15849

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the urea transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEWG Eukaryota
COG4413 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018729

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168437

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG073255

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15849

KEGG Orthology (KO)

More...
KOi
K08716

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIQNPWW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G095L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15849

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3430.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR004937 Urea_transporter

The PANTHER Classification System

More...
PANTHERi
PTHR10464 PTHR10464, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03253 UT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15849-1) [UniParc]FASTAAdd to basket
Also known as: UT-A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK
60 70 80 90 100
DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG
110 120 130 140 150
DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP
160 170 180 190 200
WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL
210 220 230 240 250
DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA
260 270 280 290 300
TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW
310 320 330 340 350
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC
360 370 380 390 400
VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW
410 420 430 440 450
AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS
460 470 480 490 500
GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE
510 520 530 540 550
RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG
560 570 580 590 600
KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG
610 620 630 640 650
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL
660 670 680 690 700
VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL
710 720 730 740 750
PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV
760 770 780 790 800
GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF
810 820 830 840 850
DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN
860 870 880 890 900
MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL
910 920
SQERNRRASI ITKYQAYDVS
Length:920
Mass (Da):101,209
Last modified:March 23, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23BF379DC0767619
GO
Isoform 2 (identifier: Q15849-2) [UniParc]FASTAAdd to basket
Also known as: UT-A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-523: Missing.

Show »
Length:397
Mass (Da):43,395
Checksum:i310AD64B1DFA9623
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPU1E7EPU1_HUMAN
Urea transporter 2
SLC14A2
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195V → A in AAL08485 (PubMed:11502588).Curated1
Sequence conflicti515T → I in BAF85111 (PubMed:14702039).Curated1
Sequence conflicti723T → A in AAL08485 (PubMed:11502588).Curated1
Sequence conflicti905N → D in BAF85111 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05701637T → I. Corresponds to variant dbSNP:rs34461862Ensembl.1
Natural variantiVAR_060255132I → V3 PublicationsCorresponds to variant dbSNP:rs1484873Ensembl.1
Natural variantiVAR_057017443G → S. Corresponds to variant dbSNP:rs35245152Ensembl.1
Natural variantiVAR_060256510R → Q3 PublicationsCorresponds to variant dbSNP:rs9960464Ensembl.1
Natural variantiVAR_057018750V → I. Corresponds to variant dbSNP:rs1123617Ensembl.1
Natural variantiVAR_038690880A → T1 PublicationCorresponds to variant dbSNP:rs3745009Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0311711 – 523Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X96969 mRNA Translation: CAA65657.1
AF349446 mRNA Translation: AAL08485.1
AK292422 mRNA Translation: BAF85111.1
AC023421 Genomic DNA No translation available.
BC110446 mRNA Translation: AAI10447.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11924.1 [Q15849-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S71339

NCBI Reference Sequences

More...
RefSeqi
NP_001229621.1, NM_001242692.1 [Q15849-1]
NP_009094.3, NM_007163.3 [Q15849-1]
XP_016881504.1, XM_017026015.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.710927

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255226; ENSP00000255226; ENSG00000132874 [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874 [Q15849-1]
ENST00000642891; ENSP00000494834; ENSG00000285096 [Q15849-1]
ENST00000643366; ENSP00000494573; ENSG00000285096 [Q15849-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8170

UCSC genome browser

More...
UCSCi
uc002lbe.4 human [Q15849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96969 mRNA Translation: CAA65657.1
AF349446 mRNA Translation: AAL08485.1
AK292422 mRNA Translation: BAF85111.1
AC023421 Genomic DNA No translation available.
BC110446 mRNA Translation: AAI10447.1
CCDSiCCDS11924.1 [Q15849-1]
PIRiS71339
RefSeqiNP_001229621.1, NM_001242692.1 [Q15849-1]
NP_009094.3, NM_007163.3 [Q15849-1]
XP_016881504.1, XM_017026015.1
UniGeneiHs.710927

3D structure databases

ProteinModelPortaliQ15849
SMRiQ15849
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113822, 2 interactors
IntActiQ15849, 14 interactors
STRINGi9606.ENSP00000255226

Chemistry databases

DrugBankiDB03904 Urea

Protein family/group databases

TCDBi1.A.28.1.6 the urea transporter (ut) family

PTM databases

iPTMnetiQ15849
PhosphoSitePlusiQ15849

Polymorphism and mutation databases

BioMutaiSLC14A2
DMDMi292495053

Proteomic databases

PaxDbiQ15849
PeptideAtlasiQ15849
PRIDEiQ15849
ProteomicsDBi60792
60793 [Q15849-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255226; ENSP00000255226; ENSG00000132874 [Q15849-1]
ENST00000586448; ENSP00000465953; ENSG00000132874 [Q15849-1]
ENST00000642891; ENSP00000494834; ENSG00000285096 [Q15849-1]
ENST00000643366; ENSP00000494573; ENSG00000285096 [Q15849-1]
GeneIDi8170
KEGGihsa:8170
UCSCiuc002lbe.4 human [Q15849-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8170
DisGeNETi8170
EuPathDBiHostDB:ENSG00000132874.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC14A2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0014422
HGNCiHGNC:10919 SLC14A2
MIMi601611 gene
neXtProtiNX_Q15849
OpenTargetsiENSG00000132874
PharmGKBiPA35811

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEWG Eukaryota
COG4413 LUCA
GeneTreeiENSGT00390000018729
HOGENOMiHOG000168437
HOVERGENiHBG073255
InParanoidiQ15849
KOiK08716
OMAiFIQNPWW
OrthoDBiEOG091G095L
PhylomeDBiQ15849

Enzyme and pathway databases

ReactomeiR-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC14A2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC14A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8170

Protein Ontology

More...
PROi
PR:Q15849

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132874 Expressed in 45 organ(s), highest expression level in kidney
CleanExiHS_SLC14A2
ExpressionAtlasiQ15849 baseline and differential
GenevisibleiQ15849 HS

Family and domain databases

Gene3Di1.10.3430.10, 2 hits
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR004937 Urea_transporter
PANTHERiPTHR10464 PTHR10464, 1 hit
PfamiView protein in Pfam
PF03253 UT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15849
Secondary accession number(s): A8K8Q7, Q2TBD6, Q96PH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: December 5, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again