ADIPOQ

Functionⁱ

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.1 Publication

Miscellaneous

Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.

HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.By similarity

Caution

The expected hydroxylation of Lys-33 was not identified, probably due to poor representation of the N-terminal peptide in mass fingerprinting.1 Publication

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 12611609
extracellular matrix structural constituent
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 28675934
hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11222466
identical protein binding
Source: BHF-UCL
Traceable author statementⁱ
- 10961870
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12021245
sialic acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19855092
signaling receptor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brown fat cell differentiation Source: UniProtKB
cellular response to cAMP Source: Ensembl
cellular response to drug Source: UniProtKB
cellular response to epinephrine stimulus Source: Ensembl
cellular response to insulin stimulus Source: UniProtKB
circadian rhythm Source: Ensembl
detection of oxidative stress Source: UniProtKB
fatty acid beta-oxidation Source: UniProtKB
fatty acid oxidation Source: UniProtKB
generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 10095105
glucose homeostasis Source: UniProtKB
glucose metabolic process Source: UniProtKB
low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 11222466
negative regulation of blood pressure
Source: UniProtKB
Inferred from direct assayⁱ
- 17327472
negative regulation of cell migration Source: UniProtKB
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 24531262
- 26166748
negative regulation of DNA biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of fat cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 12021245
negative regulation of gluconeogenesis
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12368907
negative regulation of granulocyte differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
negative regulation of heterotypic cell-cell adhesion
Source: BHF-UCL
Inferred from direct assayⁱ
- 10604883
negative regulation of hormone secretion Source: Ensembl
negative regulation of I-kappaB kinase/NF-kappaB signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 10982546
negative regulation of inflammatory response Source: UniProtKB
negative regulation of intracellular protein transport
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
negative regulation of low-density lipoprotein particle receptor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11222466
negative regulation of macrophage derived foam cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 11222466
negative regulation of macrophage differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
negative regulation of MAP kinase activity Source: UniProtKB
negative regulation of metanephric mesenchymal cell migration Source: UniProtKB
negative regulation of phagocytosis
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
negative regulation of platelet-derived growth factor receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of synaptic transmission
Source: UniProtKB
Inferred from direct assayⁱ
- 17327472
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
negative regulation of tumor necrosis factor-mediated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10604883
negative regulation of tumor necrosis factor production
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
negative regulation of vascular associated smooth muscle cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
negative regulation of vascular smooth muscle cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12070119
positive regulation of cAMP-dependent protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
- 19524870
positive regulation of cellular protein metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18703020
positive regulation of cholesterol efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 18703020
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 24531262
- 26166748
positive regulation of fatty acid metabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12368907
positive regulation of glucose import
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12368907
positive regulation of glycogen (starch) synthase activity Source: UniProtKB
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
positive regulation of interleukin-8 production
Source: UniProtKB
Inferred from direct assayⁱ
- 19524870
positive regulation of metanephric glomerular visceral epithelial cell development Source: UniProtKB
positive regulation of monocyte chemotactic protein-1 production
Source: UniProtKB
Inferred from direct assayⁱ
- 19524870
positive regulation of myeloid cell apoptotic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of protein kinase A signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 10982546
positive regulation of protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
positive regulation of renal albumin absorption
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
positive regulation of signal transduction
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12368907
protein heterotrimerization Source: Ensembl
protein homooligomerization Source: UniProtKB
protein localization to plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 18431508
regulation of fatty acid biosynthetic process Source: Reactome
regulation of glucose metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17327472
response to activity Source: Ensembl
response to bacterium Source: Ensembl
response to ethanol Source: Ensembl
response to glucocorticoid Source: Ensembl
response to glucose
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12368907
response to hypoxia Source: Ensembl
response to linoleic acid Source: Ensembl
response to nutrient Source: Ensembl
response to sucrose Source: Ensembl
response to tumor necrosis factor
Source: BHF-UCL
Inferred from direct assayⁱ
- 10604883

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORⁱ	Q15848

Protein family/group databases

TCDBⁱ	8.A.94.1.1 the adiponectin (adiponectin) family

TCDBⁱ

8.A.94.1.1 the adiponectin (adiponectin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adiponectin Alternative name(s): 30 kDa adipocyte complement-related protein Adipocyte complement-related 30 kDa protein Short name: ACRP30 Adipocyte, C1q and collagen domain-containing protein Adipose most abundant gene transcript 1 protein1 Publication Short name: apM-11 Publication Gelatin-binding protein
Gene namesⁱ	Name:ADIPOQ Synonyms:ACDC, ACRP30, APM1, GBP282 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181092.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13633 ADIPOQ
MIMⁱ	605441 gene
neXtProtⁱ	NX_Q15848

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Adiponectin deficiency (ADPND)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition that results in very low concentrations of plasma adiponectin.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013274	112	R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs121917815EnsemblClinVar.		1

Diabetes mellitus, non-insulin-dependent (NIDDM)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Pharmaceutical useⁱ

Adiponectin might be used in the treatment of diabetes type 2 and insulin resistance.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	20	T → A: No change in sialylated isoforms. 1 Publication	1
Mutagenesisⁱ	21	T → A: Some loss of sialylated isoforms. 1 Publication	1
Mutagenesisⁱ	22	T → A: Abolishes sialylated isoforms. 1 Publication	1
Mutagenesisⁱ	33	K → R: No effect on formation of HMW multimers. 1 Publication	1
Mutagenesisⁱ	36	C → S: Impaired formation of MMW and HMW multimers. 2 Publications	1
Mutagenesisⁱ	65	K → R: Impaired formation of HMW multimers; when associated with R-68. 1 Publication	1
Mutagenesisⁱ	68	K → R: Impaired formation of HMW multimers; when associated with R-65. 1 Publication	1
Mutagenesisⁱ	77	K → R: Impaired formation of HMW multimers; when associated with R-101. 1 Publication	1
Mutagenesisⁱ	101	K → R: Impaired formation of HMW multimers; when associated with R-77. 1 Publication	1

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9370
MalaCards human disease database More...MalaCardsⁱ	ADIPOQ
MIMⁱ	125853 phenotype 612556 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000181092
PharmGKBⁱ	PA134933118

Polymorphism and mutation databases

BioMutaⁱ	ADIPOQ
DMDMⁱ	2493789

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	2 PublicationsAdd BLAST		18
ChainⁱPRO_0000003543	19 – 244	AdiponectinAdd BLAST		226

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	22	O-linked (GalNAc...) threonine1 Publication	1
Modified residueⁱ	33	5-hydroxylysineBy similarity	1
Disulfide bondⁱ	36	Interchain; in form MMW and form HMW2 Publications
Modified residueⁱ	44	4-hydroxyproline1 Publication	1
Modified residueⁱ	47	4-hydroxyproline1 Publication	1
Modified residueⁱ	53	4-hydroxyproline1 Publication	1
Modified residueⁱ	65	5-hydroxylysine1 Publication	1
Glycosylationⁱ	65	O-linked (Gal...) hydroxylysine; partial1 Publication	1
Modified residueⁱ	68	5-hydroxylysine1 Publication	1
Glycosylationⁱ	68	O-linked (Gal...) hydroxylysine; partial1 Publication	1
Modified residueⁱ	71	4-hydroxyproline; partial1 Publication	1
Modified residueⁱ	76	4-hydroxyproline; partial1 Publication	1
Modified residueⁱ	77	5-hydroxylysine1 Publication	1
Glycosylationⁱ	77	O-linked (Gal...) hydroxylysine; partial1 Publication	1
Modified residueⁱ	91	4-hydroxyproline1 Publication	1
Modified residueⁱ	95	4-hydroxyproline; partial1 Publication	1
Modified residueⁱ	101	5-hydroxylysine1 Publication	1
Glycosylationⁱ	101	O-linked (Gal...) hydroxylysine; partial1 Publication	1

Post-translational modificationⁱ

HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagen-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes.By similarity

O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	62	Not hydroxylated1 Publication	1
Siteⁱ	86	Not hydroxylated1 Publication	1
Siteⁱ	104	Not hydroxylated1 Publication	1
Siteⁱ	230	Not glycosylated1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

EPDⁱ	Q15848
jPOSTⁱ	Q15848
PaxDbⁱ	Q15848
PeptideAtlas More...PeptideAtlasⁱ	Q15848
PRIDEⁱ	Q15848
ProteomicsDBⁱ	60791

PTM databases

iPTMnetⁱ	Q15848
PhosphoSitePlusⁱ	Q15848

Expressionⁱ

Tissue specificityⁱ

Synthesized exclusively by adipocytes and secreted into plasma.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000181092 Expressed in 120 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasⁱ	Q15848 baseline and differential
Genevisibleⁱ	Q15848 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB046467 HPA051767

HPAⁱ

CAB046467
HPA051767

Interactionⁱ

Subunit structureⁱ

Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly is also modulated by the degree of lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9 via the C1q domain (heterotrimeric complex).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BNIP3L	O60238	3	EBI-10827839,EBI-849893
CCDC155	Q8N6L0	3	EBI-10827839,EBI-749265
SGTA	O43765	5	EBI-10827839,EBI-347996
SYNE4	Q8N205-2	5	EBI-10827839,EBI-12099160

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 12611609
hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11222466
identical protein binding
Source: BHF-UCL
Traceable author statementⁱ
- 10961870
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12021245
signaling receptor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114771, 22 interactors
CORUMⁱ	Q15848
IntActⁱ	Q15848, 55 interactors
STRINGⁱ	9606.ENSP00000320709

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	114 – 118	Combined sources	5
Beta strandⁱ	134 – 137	Combined sources	4
Turnⁱ	145 – 147	Combined sources	3
Beta strandⁱ	156 – 177	Combined sources	22
Beta strandⁱ	180 – 187	Combined sources	8
Beta strandⁱ	195 – 205	Combined sources	11
Beta strandⁱ	210 – 215	Combined sources	6
Beta strandⁱ	219 – 225	Combined sources	7
Beta strandⁱ	233 – 241	Combined sources	9

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DOU	X-ray	2.00	A	104-244	[»]
ProteinModelPortalⁱ	Q15848
SMRⁱ	Q15848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 107	Collagen-likeAdd BLAST		66
Domainⁱ	108 – 244	C1qPROSITE-ProRule annotationAdd BLAST		137

Domainⁱ

The C1q domain is commonly called the globular domain.

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IHSJ Eukaryota ENOG4111F5K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159828
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	Q15848
KEGG Orthology (KO) More...KOⁱ	K07296
OMAⁱ	QQNHYDG
Database of Orthologous Groups More...OrthoDBⁱ	1110472at2759
PhylomeDBⁱ	Q15848
TreeFamⁱ	TF329591

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR008983 Tumour_necrosis_fac-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q15848-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN 
        60         70         80         90        100
GAPGRDGRDG TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR 
       110        120        130        140        150
KGEPGEGAYV YRSAFSVGLE TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF 
       160        170        180        190        200
HCNIPGLYYF AYHITVYMKD VKVSLFKKDK AMLFTYDQYQ ENNVDQASGS 
       210        220        230        240 
VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY HDTN

Length:244

Mass (Da):26,414

Last modified:November 1, 1996 - v1

Checksum:ⁱ64D8C6C1204B1018

GO

Polymorphismⁱ

Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIMⁱ:612556].

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013273	84	G → R Does not form high molecular weight multimers. 3 PublicationsCorresponds to variant dbSNP:rs199646033Ensembl.	1
Natural variantⁱVAR_027395	90	G → S Does not form high molecular weight multimers. 2 PublicationsCorresponds to variant dbSNP:rs62625753Ensembl.	1
Natural variantⁱVAR_027396	111	Y → H1 PublicationCorresponds to variant dbSNP:rs17366743Ensembl.	1
Natural variantⁱVAR_013274	112	R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs121917815EnsemblClinVar.	1
Natural variantⁱVAR_013275	117	V → M1 PublicationCorresponds to variant dbSNP:rs747223144Ensembl.	1
Natural variantⁱVAR_013276	164	I → T Associated with low plasma adiponectin concentration and diabetes mellitus type 2; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs185847354Ensembl.	1
Natural variantⁱVAR_013277	221	R → S2 PublicationsCorresponds to variant dbSNP:rs138773406Ensembl.	1
Natural variantⁱVAR_013278	241	H → P2 PublicationsCorresponds to variant dbSNP:rs141205818Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45371 mRNA Translation: BAA08227.1 AB012165 Genomic DNA Translation: BAA86716.1 AJ131460, AJ131461 Genomic DNA Translation: CAB52413.1 BC054496 mRNA Translation: AAH54496.1 BC096308 mRNA Translation: AAH96308.1 BC096309 mRNA Translation: AAH96309.1 BC096310 mRNA Translation: AAH96310.1 BC096311 mRNA Translation: AAH96311.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3284.1
PIRⁱ	JC4708
NCBI Reference Sequences More...RefSeqⁱ	NP_001171271.1, NM_001177800.1 NP_004788.1, NM_004797.3
UniGeneⁱ	Hs.80485

Genome annotation databases

Ensemblⁱ	ENST00000320741; ENSP00000320709; ENSG00000181092 ENST00000444204; ENSP00000389814; ENSG00000181092
GeneIDⁱ	9370
KEGGⁱ	hsa:9370
UCSC genome browser More...UCSCⁱ	uc003fra.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15848	Adiponectin D		HUMAN		275	UniRef100_Q15848
Adiponectin		HUMAN		244

Protein	Similar proteins		Species	Score	Length	Source
Q15848	Adiponectin D		HUMAN		275	UniRef90_Q15848
Adiponectin, C1Q and collagen domain containing		PANPA		286
ADIPOQ isoform 1		PANTR		244
Adiponectin, C1Q and collagen domain containing		PAPAN		275
Adiponectin, C1Q and collagen domain containing		CHLSB		275
+30

Protein	Similar proteins		Species	Score	Length	Source
Q15848	Adiponectin D		HUMAN		275	UniRef50_Q15848
Adiponectin, C1Q and collagen domain containing		PANPA		286
ADIPOQ isoform 1		PANTR		244
Adiponectin, C1Q and collagen domain containing		PAPAN		275
Adiponectin, C1Q and collagen domain containing		RHIBE		275
+176

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Adiponectin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45371 mRNA Translation: BAA08227.1 AB012165 Genomic DNA Translation: BAA86716.1 AJ131460, AJ131461 Genomic DNA Translation: CAB52413.1 BC054496 mRNA Translation: AAH54496.1 BC096308 mRNA Translation: AAH96308.1 BC096309 mRNA Translation: AAH96309.1 BC096310 mRNA Translation: AAH96310.1 BC096311 mRNA Translation: AAH96311.1
CCDSⁱ	CCDS3284.1
PIRⁱ	JC4708
RefSeqⁱ	NP_001171271.1, NM_001177800.1 NP_004788.1, NM_004797.3
UniGeneⁱ	Hs.80485

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DOU	X-ray	2.00	A	104-244	[»]
ProteinModelPortalⁱ	Q15848
SMRⁱ	Q15848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114771, 22 interactors
CORUMⁱ	Q15848
IntActⁱ	Q15848, 55 interactors
STRINGⁱ	9606.ENSP00000320709

Protein family/group databases

TCDBⁱ	8.A.94.1.1 the adiponectin (adiponectin) family

TCDBⁱ

8.A.94.1.1 the adiponectin (adiponectin) family

PTM databases

iPTMnetⁱ	Q15848
PhosphoSitePlusⁱ	Q15848

Polymorphism and mutation databases

BioMutaⁱ	ADIPOQ
DMDMⁱ	2493789

Proteomic databases

EPDⁱ	Q15848
jPOSTⁱ	Q15848
PaxDbⁱ	Q15848
PeptideAtlasⁱ	Q15848
PRIDEⁱ	Q15848
ProteomicsDBⁱ	60791

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000320741; ENSP00000320709; ENSG00000181092 ENST00000444204; ENSP00000389814; ENSG00000181092
GeneIDⁱ	9370
KEGGⁱ	hsa:9370
UCSCⁱ	uc003fra.4 human

Organism-specific databases

CTDⁱ	9370
DisGeNETⁱ	9370
EuPathDBⁱ	HostDB:ENSG00000181092.9
GeneCardsⁱ	ADIPOQ
HGNCⁱ	HGNC:13633 ADIPOQ
HPAⁱ	CAB046467 HPA051767
MalaCardsⁱ	ADIPOQ
MIMⁱ	125853 phenotype 605441 gene 612556 phenotype
neXtProtⁱ	NX_Q15848
OpenTargetsⁱ	ENSG00000181092
PharmGKBⁱ	PA134933118
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHSJ Eukaryota ENOG4111F5K LUCA
GeneTreeⁱ	ENSGT00940000159828
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	Q15848
KOⁱ	K07296
OMAⁱ	QQNHYDG
OrthoDBⁱ	1110472at2759
PhylomeDBⁱ	Q15848
TreeFamⁱ	TF329591

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORⁱ	Q15848

Miscellaneous databases

ChiTaRSⁱ	ADIPOQ human
GeneWikiⁱ	Adiponectin
GenomeRNAiⁱ	9370
Protein Ontology More...PROⁱ	PR:Q15848
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181092 Expressed in 120 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasⁱ	Q15848 baseline and differential
Genevisibleⁱ	Q15848 HS

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR008983 Tumour_necrosis_fac-like_dom
Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADIPO_HUMAN
Accessionⁱ	Q15848Primary (citable) accession number: Q15848 Secondary accession number(s): Q58EX9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	February 13, 2019
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q15848 (ADIPO_HUMAN)

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Adiponectin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Diabetes mellitus, non-insulin-dependent (NIDDM)

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ