Adiponectin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "The role of the novel adipocyte-derived hormone adiponectin in human disease."
    Diez J.J., Iglesias P.
    Eur. J. Endocrinol. 148:293-300(2003) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix structural constituent Source: BHF-UCLInferred from high throughput direct assayⁱ
  • "Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics."
    Naba A., Pearce O.M.T., Del Rosario A., Ma D., Ding H., Rajeeve V., Cutillas P.R., Balkwill F.R., Hynes R.O.
    J. Proteome Res. 16:3083-3091(2017) [PubMed] [Europe PMC] [Abstract]
• hormone activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."
    Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 103:1057-1063(2001) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• protein homodimerization activity Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins."
    Yokota T., Meka C.S., Medina K.L., Igarashi H., Comp P.C., Takahashi M., Nishida M., Oritani K., Miyagawa J., Funahashi T., Tomiyama Y., Matsuzawa Y., Kincade P.W.
    J. Clin. Invest. 109:1303-1310(2002) [PubMed] [Europe PMC] [Abstract]
• sialic acid binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation."
    Richards A.A., Colgrave M.L., Zhang J., Webster J., Simpson F., Preston E., Wilks D., Hoehn K.L., Stephenson M., Macdonald G.A., Prins J.B., Cooney G.J., Xu A., Whitehead J.P.
    Mol. Endocrinol. 24:229-239(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: GLYCOSYLATION AT THR-21 AND THR-22, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF THR-20; THR-21 AND THR-22.
• signaling receptor binding Source: UniProtKB

GO - Biological processⁱ

• brown fat cell differentiation Source: UniProtKB
• cellular response to cAMP Source: Ensembl
• cellular response to drug Source: UniProtKB
• cellular response to epinephrine stimulus Source: Ensembl
• cellular response to insulin stimulus Source: UniProtKB
• circadian rhythm Source: Ensembl
• detection of oxidative stress Source: UniProtKB
• fatty acid beta-oxidation Source: UniProtKB
• fatty acid oxidation Source: UniProtKB
• generation of precursor metabolites and energy Source: ProtIncTraceable author statementⁱ
  • Ref.2

    "Organization of the gene for gelatin-binding protein (GBP28)."
    Saito K., Tobe T., Minoshima S., Asakawa S., Sumiya J., Yoda M., Nakano Y., Shimizu N., Tomita M.
    Gene 229:67-73(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• glucose homeostasis Source: UniProtKB
• glucose metabolic process Source: UniProtKB
• low-density lipoprotein particle clearance Source: BHF-UCLInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."
    Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 103:1057-1063(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood pressure Source: UniProtKBInferred from direct assayⁱ
  • "Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats."
    Tanida M., Shen J., Horii Y., Matsuda M., Kihara S., Funahashi T., Shimomura I., Sawai H., Fukuda Y., Matsuzawa Y., Nagai K.
    Exp. Biol. Med. (Maywood) 232:390-397(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: UniProtKB
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice."
    Qiao L., Yoo H.s., Bosco C., Lee B., Feng G.S., Schaack J., Chi N.W., Shao J.
    Diabetologia 57:1027-1036(2014) [PubMed] [Europe PMC] [Abstract]
  • "Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation."
    Hui X., Gu P., Zhang J., Nie T., Pan Y., Wu D., Feng T., Zhong C., Wang Y., Lam K.S., Xu A.
    Cell Metab. 22:279-290(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ERK1 and ERK2 cascade Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins."
    Yokota T., Meka C.S., Medina K.L., Igarashi H., Comp P.C., Takahashi M., Nishida M., Oritani K., Miyagawa J., Funahashi T., Tomiyama Y., Matsuzawa Y., Kincade P.W.
    J. Clin. Invest. 109:1303-1310(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gluconeogenesis Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase."
    Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.
    Nat. Med. 8:1288-1295(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of granulocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• negative regulation of heterotypic cell-cell adhesion Source: BHF-UCLInferred from direct assayⁱ
  • "Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin."
    Ouchi N., Kihara S., Arita Y., Maeda K., Kuriyama H., Okamoto Y., Hotta K., Nishida M., Takahashi M., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 100:2473-2476(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hormone secretion Source: Ensembl
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCLInferred from direct assayⁱ
  • Ref.8

    "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway."
    Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 102:1296-1301(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• negative regulation of inflammatory response Source: UniProtKB
• negative regulation of intracellular protein transport Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."
    Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 103:1057-1063(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage derived foam cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."
    Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 103:1057-1063(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage differentiation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• negative regulation of MAP kinase activity Source: UniProtKB
• negative regulation of metanephric mesenchymal cell migration Source: UniProtKB
• negative regulation of phagocytosis Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• negative regulation of platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
• negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein autophosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of receptor binding Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission Source: UniProtKBInferred from direct assayⁱ
  • "Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats."
    Tanida M., Shen J., Horii Y., Matsuda M., Kihara S., Funahashi T., Shimomura I., Sawai H., Fukuda Y., Matsuzawa Y., Nagai K.
    Exp. Biol. Med. (Maywood) 232:390-397(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin."
    Ouchi N., Kihara S., Arita Y., Maeda K., Kuriyama H., Okamoto Y., Hotta K., Nishida M., Takahashi M., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 100:2473-2476(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of tumor necrosis factor production Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• negative regulation of vascular associated smooth muscle cell migration Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vascular smooth muscle cell proliferation Source: UniProtKBInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell."
    Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y.
    Circulation 105:2893-2898(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cAMP-dependent protein kinase activity Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
  • "Induction of chemokine expression by adiponectin in vitro is isoform dependent."
    Song H., Chan J., Rovin B.H.
    Transl Res 154:18-26(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular protein metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages."
    Tsubakio-Yamamoto K., Matsuura F., Koseki M., Oku H., Sandoval J.C., Inagaki M., Nakatani K., Nakaoka H., Kawase R., Yuasa-Kawase M., Masuda D., Ohama T., Maeda N., Nakagawa-Toyama Y., Ishigami M., Nishida M., Kihara S., Shimomura I., Yamashita S.
    Biochem. Biophys. Res. Commun. 375:390-394(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol efflux Source: BHF-UCLInferred from direct assayⁱ
  • "Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages."
    Tsubakio-Yamamoto K., Matsuura F., Koseki M., Oku H., Sandoval J.C., Inagaki M., Nakatani K., Nakaoka H., Kawase R., Yuasa-Kawase M., Masuda D., Ohama T., Maeda N., Nakagawa-Toyama Y., Ishigami M., Nishida M., Kihara S., Shimomura I., Yamashita S.
    Biochem. Biophys. Res. Commun. 375:390-394(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from sequence or structural similarityⁱ
  • "Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice."
    Qiao L., Yoo H.s., Bosco C., Lee B., Feng G.S., Schaack J., Chi N.W., Shao J.
    Diabetologia 57:1027-1036(2014) [PubMed] [Europe PMC] [Abstract]
  • "Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation."
    Hui X., Gu P., Zhang J., Nie T., Pan Y., Wu D., Feng T., Zhong C., Wang Y., Lam K.S., Xu A.
    Cell Metab. 22:279-290(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid metabolic process Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase."
    Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.
    Nat. Med. 8:1288-1295(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glucose import Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase."
    Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.
    Nat. Med. 8:1288-1295(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glycogen (starch) synthase activity Source: UniProtKB
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
• positive regulation of interleukin-8 production Source: UniProtKBInferred from direct assayⁱ
  • "Induction of chemokine expression by adiponectin in vitro is isoform dependent."
    Song H., Chan J., Rovin B.H.
    Transl Res 154:18-26(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of metanephric glomerular visceral epithelial cell development Source: UniProtKB
• positive regulation of monocyte chemotactic protein-1 production Source: UniProtKBInferred from direct assayⁱ
  • "Induction of chemokine expression by adiponectin in vitro is isoform dependent."
    Song H., Chan J., Rovin B.H.
    Transl Res 154:18-26(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myeloid cell apoptotic process Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
• positive regulation of protein kinase A signaling Source: BHF-UCLInferred from direct assayⁱ
  • Ref.8

    "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway."
    Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 102:1296-1301(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• positive regulation of protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of renal albumin absorption Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of signal transduction Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase."
    Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.
    Nat. Med. 8:1288-1295(2002) [PubMed] [Europe PMC] [Abstract]
• protein heterotrimerization Source: Ensembl
• protein homooligomerization Source: UniProtKB
• protein localization to plasma membrane Source: UniProtKBInferred from direct assayⁱ
  • "Adiponectin regulates albuminuria and podocyte function in mice."
    Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J.
    J. Clin. Invest. 118:1645-1656(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of fatty acid biosynthetic process Source: Reactome
• regulation of glucose metabolic process Source: UniProtKBInferred from direct assayⁱ
  • "Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats."
    Tanida M., Shen J., Horii Y., Matsuda M., Kihara S., Funahashi T., Shimomura I., Sawai H., Fukuda Y., Matsuzawa Y., Nagai K.
    Exp. Biol. Med. (Maywood) 232:390-397(2007) [PubMed] [Europe PMC] [Abstract]
• response to activity Source: Ensembl
• response to bacterium Source: Ensembl
• response to ethanol Source: Ensembl
• response to glucocorticoid Source: Ensembl
• response to glucose Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase."
    Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.
    Nat. Med. 8:1288-1295(2002) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: Ensembl
• response to linoleic acid Source: Ensembl
• response to nutrient Source: Ensembl
• response to sucrose Source: Ensembl
• response to tumor necrosis factor Source: BHF-UCLInferred from direct assayⁱ
  • "Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin."
    Ouchi N., Kihara S., Arita Y., Maeda K., Kuriyama H., Okamoto Y., Hotta K., Nishida M., Takahashi M., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 100:2473-2476(1999) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical useⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCLNon-traceable author statementⁱ
  • "The role of the novel adipocyte-derived hormone adiponectin in human disease."
    Diez J.J., Iglesias P.
    Eur. J. Endocrinol. 148:293-300(2003) [PubMed] [Europe PMC] [Abstract]
• hormone activity Source: BHF-UCLInferred from direct assayⁱ
  • "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."
    Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., Ishigami M., Kuriyama H., Kishida K., Nishizawa H., Hotta K., Muraguchi M., Ohmoto Y., Yamashita S., Funahashi T., Matsuzawa Y.
    Circulation 103:1057-1063(2001) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: BHF-UCLTraceable author statementⁱ
  • Ref.7

    "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
    Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., Matsuzawa Y.
    Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: CHARACTERIZATION.
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins."
    Yokota T., Meka C.S., Medina K.L., Igarashi H., Comp P.C., Takahashi M., Nishida M., Oritani K., Miyagawa J., Funahashi T., Tomiyama Y., Matsuzawa Y., Kincade P.W.
    J. Clin. Invest. 109:1303-1310(2002) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN 
        60         70         80         90        100
GAPGRDGRDG TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR 
       110        120        130        140        150
KGEPGEGAYV YRSAFSVGLE TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF 
       160        170        180        190        200
HCNIPGLYYF AYHITVYMKD VKVSLFKKDK AMLFTYDQYQ ENNVDQASGS 
       210        220        230        240 
VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY HDTN       

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
5. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations