UniProtKB - Q15848 (ADIPO_HUMAN)
Adiponectin
ADIPOQ
Functioni
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
1 PublicationMiscellaneous
Caution
Activity regulationi
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- hormone activity Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- sialic acid binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- brown fat cell differentiation Source: UniProtKB
- cellular response to cAMP Source: Ensembl
- cellular response to epinephrine stimulus Source: Ensembl
- cellular response to insulin stimulus Source: UniProtKB
- cellular response to xenobiotic stimulus Source: UniProtKB
- circadian rhythm Source: Ensembl
- detection of oxidative stress Source: UniProtKB
- fatty acid beta-oxidation Source: UniProtKB
- fatty acid oxidation Source: UniProtKB
- gene expression Source: Ensembl
- generation of precursor metabolites and energy Source: ProtInc
- glucose homeostasis Source: UniProtKB
- glucose metabolic process Source: UniProtKB
- low-density lipoprotein particle clearance Source: BHF-UCL
- negative regulation of blood pressure Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of DNA biosynthetic process Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of fat cell differentiation Source: BHF-UCL
- negative regulation of gluconeogenesis Source: BHF-UCL
- negative regulation of granulocyte differentiation Source: BHF-UCL
- negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- negative regulation of hormone secretion Source: Ensembl
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
- negative regulation of inflammatory response Source: UniProtKB
- negative regulation of intracellular protein transport Source: UniProtKB
- negative regulation of low-density lipoprotein receptor activity Source: BHF-UCL
- negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
- negative regulation of macrophage differentiation Source: BHF-UCL
- negative regulation of MAP kinase activity Source: UniProtKB
- negative regulation of metanephric mesenchymal cell migration Source: UniProtKB
- negative regulation of phagocytosis Source: BHF-UCL
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
- negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
- negative regulation of protein autophosphorylation Source: UniProtKB
- negative regulation of receptor binding Source: UniProtKB
- negative regulation of synaptic transmission Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
- negative regulation of tumor necrosis factor production Source: BHF-UCL
- negative regulation of vascular associated smooth muscle cell migration Source: UniProtKB
- negative regulation of vascular associated smooth muscle cell proliferation Source: UniProtKB
- positive regulation of cAMP-dependent protein kinase activity Source: UniProtKB
- positive regulation of cholesterol efflux Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of fatty acid metabolic process Source: BHF-UCL
- positive regulation of glucose import Source: BHF-UCL
- positive regulation of glycogen (starch) synthase activity Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of lipid transporter activity Source: ARUK-UCL
- positive regulation of metanephric glomerular visceral epithelial cell development Source: UniProtKB
- positive regulation of monocyte chemotactic protein-1 production Source: UniProtKB
- positive regulation of myeloid cell apoptotic process Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of protein kinase A signaling Source: BHF-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of renal albumin absorption Source: UniProtKB
- positive regulation of signal transduction Source: BHF-UCL
- protein localization to plasma membrane Source: UniProtKB
- regulation of glucose metabolic process Source: UniProtKB
- response to activity Source: Ensembl
- response to bacterium Source: Ensembl
- response to ethanol Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to glucose Source: BHF-UCL
- response to hypoxia Source: Ensembl
- response to linoleic acid Source: Ensembl
- response to nutrient Source: Ensembl
- response to sucrose Source: Ensembl
- response to tumor necrosis factor Source: BHF-UCL
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | Q15848 |
Reactomei | R-HSA-163680, AMPK inhibits chREBP transcriptional activation activity R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | Q15848 |
SIGNORi | Q15848 |
Protein family/group databases
TCDBi | 8.A.94.1.1, the adiponectin (adiponectin) family |
Names & Taxonomyi
Protein namesi | Recommended name: AdiponectinAlternative name(s): 30 kDa adipocyte complement-related protein Adipocyte complement-related 30 kDa protein Short name: ACRP30 Adipocyte, C1q and collagen domain-containing protein Adipose most abundant gene transcript 1 protein1 Publication Short name: apM-11 Publication Gelatin-binding protein |
Gene namesi | Name:ADIPOQ Synonyms:ACDC, ACRP30, APM1, GBP282 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13633, ADIPOQ |
MIMi | 605441, gene |
neXtProti | NX_Q15848 |
VEuPathDBi | HostDB:ENSG00000181092 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Other locations
- cell surface Source: BHF-UCL
- collagen trimer Source: UniProtKB-KW
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Adiponectin deficiency (ADPND)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013274 | 112 | R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs121917815EnsemblClinVar. | 1 |
Diabetes mellitus, non-insulin-dependent (NIDDM)
Pharmaceutical usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 20 | T → A: No change in sialylated isoforms. 1 Publication | 1 | |
Mutagenesisi | 21 | T → A: Some loss of sialylated isoforms. 1 Publication | 1 | |
Mutagenesisi | 22 | T → A: Abolishes sialylated isoforms. 1 Publication | 1 | |
Mutagenesisi | 33 | K → R: No effect on formation of HMW multimers. 1 Publication | 1 | |
Mutagenesisi | 36 | C → S: Impaired formation of MMW and HMW multimers. 2 Publications | 1 | |
Mutagenesisi | 65 | K → R: Impaired formation of HMW multimers; when associated with R-68. 1 Publication | 1 | |
Mutagenesisi | 68 | K → R: Impaired formation of HMW multimers; when associated with R-65. 1 Publication | 1 | |
Mutagenesisi | 77 | K → R: Impaired formation of HMW multimers; when associated with R-101. 1 Publication | 1 | |
Mutagenesisi | 101 | K → R: Impaired formation of HMW multimers; when associated with R-77. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variant, ObesityOrganism-specific databases
DisGeNETi | 9370 |
MalaCardsi | ADIPOQ |
MIMi | 125853, phenotype 612556, phenotype |
OpenTargetsi | ENSG00000181092 |
PharmGKBi | PA134933118 |
Miscellaneous databases
Pharosi | Q15848, Tbio |
Genetic variation databases
BioMutai | ADIPOQ |
DMDMi | 2493789 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 2 PublicationsAdd BLAST | 18 | |
ChainiPRO_0000003543 | 19 – 244 | AdiponectinAdd BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 22 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 33 | 5-hydroxylysineBy similarity | 1 | |
Modified residuei | 36 | S-(2-succinyl)cysteineBy similarity | 1 | |
Disulfide bondi | 36 | Interchain; in form MMW and form HMW2 Publications | ||
Modified residuei | 44 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 47 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 53 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 65 | 5-hydroxylysine1 Publication | 1 | |
Glycosylationi | 65 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 68 | 5-hydroxylysine1 Publication | 1 | |
Glycosylationi | 68 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 71 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 76 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 77 | 5-hydroxylysine1 Publication | 1 | |
Glycosylationi | 77 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 | |
Modified residuei | 91 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 95 | 4-hydroxyproline; partial1 Publication | 1 | |
Modified residuei | 101 | 5-hydroxylysine1 Publication | 1 | |
Glycosylationi | 101 | O-linked (Gal...) hydroxylysine; partial1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 62 | Not hydroxylated1 Publication | 1 | |
Sitei | 86 | Not hydroxylated1 Publication | 1 | |
Sitei | 104 | Not hydroxylated1 Publication | 1 | |
Sitei | 230 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
CPTACi | non-CPTAC-1057 |
EPDi | Q15848 |
jPOSTi | Q15848 |
MassIVEi | Q15848 |
PaxDbi | Q15848 |
PeptideAtlasi | Q15848 |
PRIDEi | Q15848 |
ProteomicsDBi | 60791 |
PTM databases
GlyGeni | Q15848, 6 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q15848 |
PhosphoSitePlusi | Q15848 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000181092, Expressed in adipose tissue of abdominal region and 130 other tissues |
ExpressionAtlasi | Q15848, baseline and differential |
Genevisiblei | Q15848, HS |
Organism-specific databases
HPAi | ENSG00000181092, Group enriched (adipose tissue, breast) |
Interactioni
Subunit structurei
Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly is also modulated by the degree of lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2.
Interacts with CTRP9 via the C1q domain (heterotrimeric complex).
By similarityBinary interactionsi
Q15848
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- hormone activity Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114771, 102 interactors |
CORUMi | Q15848 |
IntActi | Q15848, 61 interactors |
STRINGi | 9606.ENSP00000389814 |
Miscellaneous databases
RNActi | Q15848, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15848 |
SMRi | Q15848 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 107 | Collagen-likeAdd BLAST | 66 | |
Domaini | 108 – 244 | C1qPROSITE-ProRule annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 101 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 58 – 72 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QRY3, Eukaryota |
GeneTreei | ENSGT00940000159828 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | Q15848 |
OMAi | DSTFMGF |
OrthoDBi | 1258047at2759 |
PhylomeDBi | Q15848 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR028572, Adiponectin IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15427:SF20, PTHR15427:SF20, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN
60 70 80 90 100
GAPGRDGRDG TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR
110 120 130 140 150
KGEPGEGAYV YRSAFSVGLE TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF
160 170 180 190 200
HCNIPGLYYF AYHITVYMKD VKVSLFKKDK AMLFTYDQYQ ENNVDQASGS
210 220 230 240
VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY HDTN
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013273 | 84 | G → R Does not form high molecular weight multimers. 3 PublicationsCorresponds to variant dbSNP:rs199646033Ensembl. | 1 | |
Natural variantiVAR_027395 | 90 | G → S Does not form high molecular weight multimers. 2 PublicationsCorresponds to variant dbSNP:rs62625753EnsemblClinVar. | 1 | |
Natural variantiVAR_027396 | 111 | Y → H1 PublicationCorresponds to variant dbSNP:rs17366743Ensembl. | 1 | |
Natural variantiVAR_013274 | 112 | R → C in ADPND; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs121917815EnsemblClinVar. | 1 | |
Natural variantiVAR_013275 | 117 | V → M1 PublicationCorresponds to variant dbSNP:rs747223144Ensembl. | 1 | |
Natural variantiVAR_013276 | 164 | I → T Associated with low plasma adiponectin concentration and diabetes mellitus type 2; does not assemble into trimers resulting in impaired secretion from the cell. 3 PublicationsCorresponds to variant dbSNP:rs185847354Ensembl. | 1 | |
Natural variantiVAR_013277 | 221 | R → S2 PublicationsCorresponds to variant dbSNP:rs138773406Ensembl. | 1 | |
Natural variantiVAR_013278 | 241 | H → P2 PublicationsCorresponds to variant dbSNP:rs141205818Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D45371 mRNA Translation: BAA08227.1 AB012165 Genomic DNA Translation: BAA86716.1 AJ131460, AJ131461 Genomic DNA Translation: CAB52413.1 BC054496 mRNA Translation: AAH54496.1 BC096308 mRNA Translation: AAH96308.1 BC096309 mRNA Translation: AAH96309.1 BC096310 mRNA Translation: AAH96310.1 BC096311 mRNA Translation: AAH96311.1 |
CCDSi | CCDS3284.1 |
PIRi | JC4708 |
RefSeqi | NP_001171271.1, NM_001177800.1 NP_004788.1, NM_004797.3 |
Genome annotation databases
Ensembli | ENST00000320741.7; ENSP00000320709.2; ENSG00000181092.10 ENST00000444204.2; ENSP00000389814.2; ENSG00000181092.10 |
GeneIDi | 9370 |
KEGGi | hsa:9370 |
MANE-Selecti | ENST00000320741.7; ENSP00000320709.2; NM_004797.4; NP_004788.1 |
UCSCi | uc003fra.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Adiponectin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D45371 mRNA Translation: BAA08227.1 AB012165 Genomic DNA Translation: BAA86716.1 AJ131460, AJ131461 Genomic DNA Translation: CAB52413.1 BC054496 mRNA Translation: AAH54496.1 BC096308 mRNA Translation: AAH96308.1 BC096309 mRNA Translation: AAH96309.1 BC096310 mRNA Translation: AAH96310.1 BC096311 mRNA Translation: AAH96311.1 |
CCDSi | CCDS3284.1 |
PIRi | JC4708 |
RefSeqi | NP_001171271.1, NM_001177800.1 NP_004788.1, NM_004797.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DOU | X-ray | 2.00 | A | 104-244 | [»] | |
6U66 | X-ray | 0.99 | A/B/C | 107-244 | [»] | |
6U6N | X-ray | 2.15 | C | 108-244 | [»] | |
AlphaFoldDBi | Q15848 | |||||
SMRi | Q15848 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114771, 102 interactors |
CORUMi | Q15848 |
IntActi | Q15848, 61 interactors |
STRINGi | 9606.ENSP00000389814 |
Protein family/group databases
TCDBi | 8.A.94.1.1, the adiponectin (adiponectin) family |
PTM databases
GlyGeni | Q15848, 6 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q15848 |
PhosphoSitePlusi | Q15848 |
Genetic variation databases
BioMutai | ADIPOQ |
DMDMi | 2493789 |
Proteomic databases
CPTACi | non-CPTAC-1057 |
EPDi | Q15848 |
jPOSTi | Q15848 |
MassIVEi | Q15848 |
PaxDbi | Q15848 |
PeptideAtlasi | Q15848 |
PRIDEi | Q15848 |
ProteomicsDBi | 60791 |
Protocols and materials databases
ABCDi | Q15848, 5 sequenced antibodies |
Antibodypediai | 19310, 1856 antibodies from 49 providers |
DNASUi | 9370 |
Genome annotation databases
Ensembli | ENST00000320741.7; ENSP00000320709.2; ENSG00000181092.10 ENST00000444204.2; ENSP00000389814.2; ENSG00000181092.10 |
GeneIDi | 9370 |
KEGGi | hsa:9370 |
MANE-Selecti | ENST00000320741.7; ENSP00000320709.2; NM_004797.4; NP_004788.1 |
UCSCi | uc003fra.4, human |
Organism-specific databases
CTDi | 9370 |
DisGeNETi | 9370 |
GeneCardsi | ADIPOQ |
HGNCi | HGNC:13633, ADIPOQ |
HPAi | ENSG00000181092, Group enriched (adipose tissue, breast) |
MalaCardsi | ADIPOQ |
MIMi | 125853, phenotype 605441, gene 612556, phenotype |
neXtProti | NX_Q15848 |
OpenTargetsi | ENSG00000181092 |
PharmGKBi | PA134933118 |
VEuPathDBi | HostDB:ENSG00000181092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRY3, Eukaryota |
GeneTreei | ENSGT00940000159828 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | Q15848 |
OMAi | DSTFMGF |
OrthoDBi | 1258047at2759 |
PhylomeDBi | Q15848 |
TreeFami | TF329591 |
Enzyme and pathway databases
PathwayCommonsi | Q15848 |
Reactomei | R-HSA-163680, AMPK inhibits chREBP transcriptional activation activity R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | Q15848 |
SIGNORi | Q15848 |
Miscellaneous databases
BioGRID-ORCSi | 9370, 6 hits in 1070 CRISPR screens |
GeneWikii | Adiponectin |
GenomeRNAii | 9370 |
Pharosi | Q15848, Tbio |
PROi | PR:Q15848 |
RNActi | Q15848, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181092, Expressed in adipose tissue of abdominal region and 130 other tissues |
ExpressionAtlasi | Q15848, baseline and differential |
Genevisiblei | Q15848, HS |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR028572, Adiponectin IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15427:SF20, PTHR15427:SF20, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADIPO_HUMAN | |
Accessioni | Q15848Primary (citable) accession number: Q15848 Secondary accession number(s): Q58EX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references