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Protein

Clusterin-like protein 1

Gene

CLUL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Clusterin-like protein 1
Alternative name(s):
Retinal-specific clusterin-like protein
Gene namesi
Name:CLUL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000079101.16
HGNCiHGNC:2096 CLUL1
MIMi616990 gene
neXtProtiNX_Q15846

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27098
OpenTargetsiENSG00000079101
PharmGKBiPA26621

Polymorphism and mutation databases

BioMutaiCLUL1
DMDMi78099959

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000555221 – 466Clusterin-like protein 1Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 333By similarity
Disulfide bondi116 ↔ 325By similarity
Disulfide bondi119 ↔ 322By similarity
Disulfide bondi124 ↔ 315By similarity
Disulfide bondi131 ↔ 305By similarity
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15846
PaxDbiQ15846
PeptideAtlasiQ15846
PRIDEiQ15846
ProteomicsDBi60789

PTM databases

iPTMnetiQ15846
PhosphoSitePlusiQ15846

Expressioni

Gene expression databases

BgeeiENSG00000079101
CleanExiHS_CLUL1
ExpressionAtlasiQ15846 baseline and differential
GenevisibleiQ15846 HS

Organism-specific databases

HPAiCAB025264
HPA075240

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341128

Structurei

3D structure databases

ProteinModelPortaliQ15846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 111Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the clusterin family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IIR2 Eukaryota
ENOG410YW4X LUCA
GeneTreeiENSGT00530000063668
HOVERGENiHBG050998
InParanoidiQ15846
PhylomeDBiQ15846
TreeFamiTF333030

Family and domain databases

InterProiView protein in InterPro
IPR000753 Clusterin-like
IPR016015 Clusterin_C
IPR016014 Clusterin_N
PANTHERiPTHR10970 PTHR10970, 1 hit
PfamiView protein in Pfam
PF01093 Clusterin, 1 hit
SMARTiView protein in SMART
SM00035 CLa, 1 hit
SM00030 CLb, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK
60 70 80 90 100
KALTGIKQMK IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE
110 120 130 140 150
EERLCRESLA DSWGECRSCL ENNCMRIYTT CQPSWSSVKN KIERFFRKIY
160 170 180 190 200
QFLFPFHEDN EKDLPISEKL IEEDAQLTQM EDVFSQLTVD VNSLFNRSFN
210 220 230 240 250
VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA DLEQCWDIPN
260 270 280 290 300
FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ
310 320 330 340 350
DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV
360 370 380 390 400
NVSNQQYGQI LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN
410 420 430 440 450
SIQVVPRIHE GNISKQDETM MTDLSILPSS NFTLKIPLEE SAESSNFIGY
460
VVAKALQHFK EHFKTW
Length:466
Mass (Da):54,215
Last modified:November 1, 1996 - v1
Checksum:i41A603D0FD6439C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395889 mRNA Translation: AAM73723.1
D63813 mRNA Translation: BAA09882.1
BC025381 mRNA Translation: AAH25381.1
DQ980621 mRNA Translation: ABJ97142.1
CCDSiCCDS42405.1
RefSeqiNP_001305451.1, NM_001318522.1
NP_055225.1, NM_014410.4
NP_954636.1, NM_199167.1
XP_011523954.1, XM_011525652.1
XP_011523955.1, XM_011525653.2
UniGeneiHs.732341

Genome annotation databases

EnsembliENST00000338387; ENSP00000341128; ENSG00000079101
ENST00000400606; ENSP00000383449; ENSG00000079101
ENST00000579494; ENSP00000464642; ENSG00000079101
GeneIDi27098
KEGGihsa:27098
UCSCiuc002kkp.4 human

Similar proteinsi

Entry informationi

Entry nameiCLUL1_HUMAN
AccessioniPrimary (citable) accession number: Q15846
Secondary accession number(s): A0FDN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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