CLUL1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Clusterin-like protein 1 Alternative name(s): Retinal-specific clusterin-like protein
Gene namesⁱ	Name:CLUL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000079101.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2096 CLUL1
MIMⁱ	616990 gene
neXtProtⁱ	NX_Q15846

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27098
Open Targets More...OpenTargetsⁱ	ENSG00000079101
PharmGKBⁱ	PA26621

Polymorphism and mutation databases

BioMutaⁱ	CLUL1
DMDMⁱ	78099959

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000005552	21 – 466	Clusterin-like protein 1Add BLAST		446

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	105 ↔ 333	By similarity
Disulfide bondⁱ	116 ↔ 325	By similarity
Disulfide bondⁱ	119 ↔ 322	By similarity
Disulfide bondⁱ	124 ↔ 315	By similarity
Disulfide bondⁱ	131 ↔ 305	By similarity
Glycosylationⁱ	196	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	257	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	311	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	351	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	412	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	431	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q15846
PaxDbⁱ	Q15846
PeptideAtlas More...PeptideAtlasⁱ	Q15846
PRIDEⁱ	Q15846
ProteomicsDBⁱ	60789

PTM databases

iPTMnetⁱ	Q15846
PhosphoSitePlusⁱ	Q15846

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000079101
CleanExⁱ	HS_CLUL1
ExpressionAtlasⁱ	Q15846 baseline and differential
Genevisibleⁱ	Q15846 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025264 HPA075240

HPAⁱ

CAB025264
HPA075240

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000341128

STRINGⁱ

9606.ENSP00000341128

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15846
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	57 – 111	Sequence analysisAdd BLAST		55

Sequence similaritiesⁱ

Belongs to the clusterin family.Curated

Keywords - Domainⁱ

Coiled coil, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIR2 Eukaryota ENOG410YW4X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063668
HOVERGENⁱ	HBG050998
InParanoidⁱ	Q15846
PhylomeDBⁱ	Q15846
TreeFamⁱ	TF333030

Family and domain databases

InterProⁱ	View protein in InterPro IPR000753 Clusterin-like IPR016015 Clusterin_C IPR016014 Clusterin_N
PANTHERⁱ	PTHR10970 PTHR10970, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01093 Clusterin, 1 hit
SMARTⁱ	View protein in SMART SM00035 CLa, 1 hit SM00030 CLb, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q15846-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK 
        60         70         80         90        100
KALTGIKQMK IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE 
       110        120        130        140        150
EERLCRESLA DSWGECRSCL ENNCMRIYTT CQPSWSSVKN KIERFFRKIY 
       160        170        180        190        200
QFLFPFHEDN EKDLPISEKL IEEDAQLTQM EDVFSQLTVD VNSLFNRSFN 
       210        220        230        240        250
VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA DLEQCWDIPN 
       260        270        280        290        300
FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ 
       310        320        330        340        350
DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV 
       360        370        380        390        400
NVSNQQYGQI LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN 
       410        420        430        440        450
SIQVVPRIHE GNISKQDETM MTDLSILPSS NFTLKIPLEE SAESSNFIGY 
       460 
VVAKALQHFK EHFKTW

Length:466

Mass (Da):54,215

Last modified:November 1, 1996 - v1

Checksum:ⁱ41A603D0FD6439C4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF395889 mRNA Translation: AAM73723.1 D63813 mRNA Translation: BAA09882.1 BC025381 mRNA Translation: AAH25381.1 DQ980621 mRNA Translation: ABJ97142.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42405.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305451.1, NM_001318522.1 NP_055225.1, NM_014410.4 NP_954636.1, NM_199167.1 XP_011523954.1, XM_011525652.1 XP_011523955.1, XM_011525653.2
UniGeneⁱ	Hs.732341

Genome annotation databases

Ensemblⁱ	ENST00000338387; ENSP00000341128; ENSG00000079101 ENST00000400606; ENSP00000383449; ENSG00000079101 ENST00000579494; ENSP00000464642; ENSG00000079101
GeneIDⁱ	27098
KEGGⁱ	hsa:27098
UCSC genome browser More...UCSCⁱ	uc002kkp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q15846	Clusterin		HUMAN		518
Clusterin like 1		GORGO		526
Clusterin		PANTR		524
Clusterin		PANPA		524
Clusterin		RHIRO		520
+55

Protein	Similar proteins		Species	Score	Length
Q15846	Clusterin-like protein 1		CANLF		465
clusterin-like protein 1 isoform X1		ODORO		483
UPI000BB4BD6F		Enhydra lutris kenyoni		465
Clusterin-like protein 1		RAT		464
Clusterin-like protein 1		MOUSE		464
+178

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF395889 mRNA Translation: AAM73723.1 D63813 mRNA Translation: BAA09882.1 BC025381 mRNA Translation: AAH25381.1 DQ980621 mRNA Translation: ABJ97142.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42405.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305451.1, NM_001318522.1 NP_055225.1, NM_014410.4 NP_954636.1, NM_199167.1 XP_011523954.1, XM_011525652.1 XP_011523955.1, XM_011525653.2
UniGeneⁱ	Hs.732341

3D structure databases

ProteinModelPortalⁱ	Q15846
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000341128

STRINGⁱ

9606.ENSP00000341128

PTM databases

iPTMnetⁱ	Q15846
PhosphoSitePlusⁱ	Q15846

Polymorphism and mutation databases

BioMutaⁱ	CLUL1
DMDMⁱ	78099959

Proteomic databases

EPDⁱ	Q15846
PaxDbⁱ	Q15846
PeptideAtlas More...PeptideAtlasⁱ	Q15846
PRIDEⁱ	Q15846
ProteomicsDBⁱ	60789

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27098
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000338387; ENSP00000341128; ENSG00000079101 ENST00000400606; ENSP00000383449; ENSG00000079101 ENST00000579494; ENSP00000464642; ENSG00000079101
GeneIDⁱ	27098
KEGGⁱ	hsa:27098
UCSC genome browser More...UCSCⁱ	uc002kkp.4 human

Organism-specific databases

CTDⁱ	27098
DisGeNET More...DisGeNETⁱ	27098
EuPathDBⁱ	HostDB:ENSG00000079101.16
GeneCardsⁱ	CLUL1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2096 CLUL1
Human Protein Atlas More...HPAⁱ	CAB025264 HPA075240
MIMⁱ	616990 gene
neXtProtⁱ	NX_Q15846
Open Targets More...OpenTargetsⁱ	ENSG00000079101
PharmGKBⁱ	PA26621
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIR2 Eukaryota ENOG410YW4X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063668
HOVERGENⁱ	HBG050998
InParanoidⁱ	Q15846
PhylomeDBⁱ	Q15846
TreeFamⁱ	TF333030

Miscellaneous databases

ChiTaRSⁱ	CLUL1 human
GenomeRNAiⁱ	27098
Protein Ontology More...PROⁱ	PR:Q15846
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079101
CleanExⁱ	HS_CLUL1
ExpressionAtlasⁱ	Q15846 baseline and differential
Genevisibleⁱ	Q15846 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000753 Clusterin-like IPR016015 Clusterin_C IPR016014 Clusterin_N
PANTHERⁱ	PTHR10970 PTHR10970, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01093 Clusterin, 1 hit
SMARTⁱ	View protein in SMART SM00035 CLa, 1 hit SM00030 CLb, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLUL1_HUMAN
Accessionⁱ	Q15846Primary (citable) accession number: Q15846 Secondary accession number(s): A0FDN7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q15846 (CLUL1_HUMAN)

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Clusterin-like protein 1

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ