UniProtKB - Q15846 (CLUL1_HUMAN)
Protein
Clusterin-like protein 1
Gene
CLUL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q15846 |
Names & Taxonomyi
Protein namesi | Recommended name: Clusterin-like protein 1Alternative name(s): Retinal-specific clusterin-like protein |
Gene namesi | Name:CLUL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2096, CLUL1 |
MIMi | 616990, gene |
neXtProti | NX_Q15846 |
VEuPathDBi | HostDB:ENSG00000079101.16 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 27098 |
OpenTargetsi | ENSG00000079101 |
PharmGKBi | PA26621 |
Miscellaneous databases
Pharosi | Q15846, Tdark |
Genetic variation databases
BioMutai | CLUL1 |
DMDMi | 78099959 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000005552 | 21 – 466 | Clusterin-like protein 1Add BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 105 ↔ 333 | By similarity | ||
Disulfide bondi | 116 ↔ 325 | By similarity | ||
Disulfide bondi | 119 ↔ 322 | By similarity | ||
Disulfide bondi | 124 ↔ 315 | By similarity | ||
Disulfide bondi | 131 ↔ 305 | By similarity | ||
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 257 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 351 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 412 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 431 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q15846 |
jPOSTi | Q15846 |
MassIVEi | Q15846 |
PaxDbi | Q15846 |
PeptideAtlasi | Q15846 |
PRIDEi | Q15846 |
ProteomicsDBi | 60789 |
PTM databases
GlyGeni | Q15846, 6 sites |
iPTMneti | Q15846 |
PhosphoSitePlusi | Q15846 |
Expressioni
Gene expression databases
Bgeei | ENSG00000079101, Expressed in pigmented layer of retina and 146 other tissues |
ExpressionAtlasi | Q15846, baseline and differential |
Genevisiblei | Q15846, HS |
Organism-specific databases
HPAi | ENSG00000079101, Tissue enhanced (retina) |
Interactioni
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9606.ENSP00000441726 |
Miscellaneous databases
RNActi | Q15846, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 57 – 111 | Sequence analysisAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the clusterin family.Curated
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | ENOG502QQ44, Eukaryota |
GeneTreei | ENSGT00530000063668 |
HOGENOMi | CLU_042162_0_0_1 |
InParanoidi | Q15846 |
OMAi | CLESDCM |
PhylomeDBi | Q15846 |
TreeFami | TF333030 |
Family and domain databases
InterProi | View protein in InterPro IPR000753, Clusterin-like IPR016015, Clusterin_C IPR016014, Clusterin_N |
PANTHERi | PTHR10970, PTHR10970, 1 hit |
Pfami | View protein in Pfam PF01093, Clusterin, 1 hit |
SMARTi | View protein in SMART SM00035, CLa, 1 hit SM00030, CLb, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q15846-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK
60 70 80 90 100
KALTGIKQMK IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE
110 120 130 140 150
EERLCRESLA DSWGECRSCL ENNCMRIYTT CQPSWSSVKN KIERFFRKIY
160 170 180 190 200
QFLFPFHEDN EKDLPISEKL IEEDAQLTQM EDVFSQLTVD VNSLFNRSFN
210 220 230 240 250
VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA DLEQCWDIPN
260 270 280 290 300
FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ
310 320 330 340 350
DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV
360 370 380 390 400
NVSNQQYGQI LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN
410 420 430 440 450
SIQVVPRIHE GNISKQDETM MTDLSILPSS NFTLKIPLEE SAESSNFIGY
460
VVAKALQHFK EHFKTW
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GWQ8 | F5GWQ8_HUMAN | Clusterin | CLUL1 | 518 | Annotation score: | ||
J3QKW8 | J3QKW8_HUMAN | Clusterin | CLUL1 | 491 | Annotation score: | ||
R4GN76 | R4GN76_HUMAN | Clusterin-like protein 1 | CLUL1 | 82 | Annotation score: | ||
R4GN95 | R4GN95_HUMAN | Clusterin-like protein 1 | CLUL1 | 34 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395889 mRNA Translation: AAM73723.1 D63813 mRNA Translation: BAA09882.1 BC025381 mRNA Translation: AAH25381.1 DQ980621 mRNA Translation: ABJ97142.1 |
CCDSi | CCDS42405.1 |
RefSeqi | NP_001305451.1, NM_001318522.1 NP_055225.1, NM_014410.4 NP_954636.1, NM_199167.1 XP_011523954.1, XM_011525652.1 XP_011523955.1, XM_011525653.2 |
Genome annotation databases
Ensembli | ENST00000338387; ENSP00000341128; ENSG00000079101 ENST00000400606; ENSP00000383449; ENSG00000079101 ENST00000579494; ENSP00000464642; ENSG00000079101 |
GeneIDi | 27098 |
KEGGi | hsa:27098 |
UCSCi | uc002kkp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395889 mRNA Translation: AAM73723.1 D63813 mRNA Translation: BAA09882.1 BC025381 mRNA Translation: AAH25381.1 DQ980621 mRNA Translation: ABJ97142.1 |
CCDSi | CCDS42405.1 |
RefSeqi | NP_001305451.1, NM_001318522.1 NP_055225.1, NM_014410.4 NP_954636.1, NM_199167.1 XP_011523954.1, XM_011525652.1 XP_011523955.1, XM_011525653.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000441726 |
PTM databases
GlyGeni | Q15846, 6 sites |
iPTMneti | Q15846 |
PhosphoSitePlusi | Q15846 |
Genetic variation databases
BioMutai | CLUL1 |
DMDMi | 78099959 |
Proteomic databases
EPDi | Q15846 |
jPOSTi | Q15846 |
MassIVEi | Q15846 |
PaxDbi | Q15846 |
PeptideAtlasi | Q15846 |
PRIDEi | Q15846 |
ProteomicsDBi | 60789 |
Protocols and materials databases
Antibodypediai | 21905, 95 antibodies |
DNASUi | 27098 |
Genome annotation databases
Ensembli | ENST00000338387; ENSP00000341128; ENSG00000079101 ENST00000400606; ENSP00000383449; ENSG00000079101 ENST00000579494; ENSP00000464642; ENSG00000079101 |
GeneIDi | 27098 |
KEGGi | hsa:27098 |
UCSCi | uc002kkp.4, human |
Organism-specific databases
CTDi | 27098 |
DisGeNETi | 27098 |
GeneCardsi | CLUL1 |
HGNCi | HGNC:2096, CLUL1 |
HPAi | ENSG00000079101, Tissue enhanced (retina) |
MIMi | 616990, gene |
neXtProti | NX_Q15846 |
OpenTargetsi | ENSG00000079101 |
PharmGKBi | PA26621 |
VEuPathDBi | HostDB:ENSG00000079101.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ44, Eukaryota |
GeneTreei | ENSGT00530000063668 |
HOGENOMi | CLU_042162_0_0_1 |
InParanoidi | Q15846 |
OMAi | CLESDCM |
PhylomeDBi | Q15846 |
TreeFami | TF333030 |
Enzyme and pathway databases
PathwayCommonsi | Q15846 |
Miscellaneous databases
BioGRID-ORCSi | 27098, 9 hits in 979 CRISPR screens |
ChiTaRSi | CLUL1, human |
GenomeRNAii | 27098 |
Pharosi | Q15846, Tdark |
PROi | PR:Q15846 |
RNActi | Q15846, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079101, Expressed in pigmented layer of retina and 146 other tissues |
ExpressionAtlasi | Q15846, baseline and differential |
Genevisiblei | Q15846, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000753, Clusterin-like IPR016015, Clusterin_C IPR016014, Clusterin_N |
PANTHERi | PTHR10970, PTHR10970, 1 hit |
Pfami | View protein in Pfam PF01093, Clusterin, 1 hit |
SMARTi | View protein in SMART SM00035, CLa, 1 hit SM00030, CLb, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLUL1_HUMAN | |
Accessioni | Q15846Primary (citable) accession number: Q15846 Secondary accession number(s): A0FDN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families