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Protein

Vesicle-associated membrane protein 3

Gene

VAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)1 Publication2
Sitei42 – 43(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)1 Publication2
Sitei58 – 59(Microbial infection) Cleavage; by C.botulinum neurotoxin type B (BoNT/B, botB)1 Publication2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiQ15836

Protein family/group databases

TCDBi1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:VAMP3
Synonyms:SYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000049245.12
HGNCiHGNC:12644 VAMP3
MIMi603657 gene
neXtProtiNX_Q15836

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
Transmembranei78 – 98Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini99 – 100VesicularSequence analysis2

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9341
OpenTargetsiENSG00000049245
PharmGKBiPA37268

Polymorphism and mutation databases

BioMutaiVAMP3
DMDMi2501082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067282 – 100Vesicle-associated membrane protein 3Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.Curated1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15836
PaxDbiQ15836
PeptideAtlasiQ15836
PRIDEiQ15836
ProteomicsDBi60786
TopDownProteomicsiQ15836

PTM databases

iPTMnetiQ15836
PhosphoSitePlusiQ15836
SwissPalmiQ15836

Miscellaneous databases

PMAP-CutDBiQ15836

Expressioni

Gene expression databases

BgeeiENSG00000049245 Expressed in 241 organ(s), highest expression level in inferior olivary complex
CleanExiHS_VAMP3
ExpressionAtlasiQ15836 baseline and differential
GenevisibleiQ15836 HS

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114747, 79 interactors
CORUMiQ15836
DIPiDIP-56422N
IntActiQ15836, 72 interactors
MINTiQ15836
STRINGi9606.ENSP00000054666

Structurei

3D structure databases

ProteinModelPortaliQ15836
SMRiQ15836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 74v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiQ15836
KOiK13505
OMAiHANDFRK
OrthoDBiEOG091G0MPE
PhylomeDBiQ15836
TreeFamiTF313666

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA
60 70 80 90 100
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS
Length:100
Mass (Da):11,309
Last modified:January 23, 2007 - v3
Checksum:i347E9163157AFF42
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKX0K7EKX0_HUMAN
Vesicle-associated membrane protein...
VAMP3
72Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → E in AAH05941 (PubMed:16710414).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64520 mRNA Translation: AAB05814.1
BT007327 mRNA Translation: AAP35991.1
Z98884 Genomic DNA No translation available.
BC003570 mRNA Translation: AAH03570.1
BC005941 mRNA Translation: AAH05941.1
BC007050 mRNA Translation: AAH07050.1
CCDSiCCDS88.1
RefSeqiNP_004772.1, NM_004781.3
UniGeneiHs.66708

Genome annotation databases

EnsembliENST00000054666; ENSP00000054666; ENSG00000049245
GeneIDi9341
KEGGihsa:9341

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64520 mRNA Translation: AAB05814.1
BT007327 mRNA Translation: AAP35991.1
Z98884 Genomic DNA No translation available.
BC003570 mRNA Translation: AAH03570.1
BC005941 mRNA Translation: AAH05941.1
BC007050 mRNA Translation: AAH07050.1
CCDSiCCDS88.1
RefSeqiNP_004772.1, NM_004781.3
UniGeneiHs.66708

3D structure databases

ProteinModelPortaliQ15836
SMRiQ15836
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114747, 79 interactors
CORUMiQ15836
DIPiDIP-56422N
IntActiQ15836, 72 interactors
MINTiQ15836
STRINGi9606.ENSP00000054666

Protein family/group databases

TCDBi1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiQ15836
PhosphoSitePlusiQ15836
SwissPalmiQ15836

Polymorphism and mutation databases

BioMutaiVAMP3
DMDMi2501082

Proteomic databases

EPDiQ15836
PaxDbiQ15836
PeptideAtlasiQ15836
PRIDEiQ15836
ProteomicsDBi60786
TopDownProteomicsiQ15836

Protocols and materials databases

DNASUi9341
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000054666; ENSP00000054666; ENSG00000049245
GeneIDi9341
KEGGihsa:9341

Organism-specific databases

CTDi9341
DisGeNETi9341
EuPathDBiHostDB:ENSG00000049245.12
GeneCardsiVAMP3
HGNCiHGNC:12644 VAMP3
MIMi603657 gene
neXtProtiNX_Q15836
OpenTargetsiENSG00000049245
PharmGKBiPA37268
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiQ15836
KOiK13505
OMAiHANDFRK
OrthoDBiEOG091G0MPE
PhylomeDBiQ15836
TreeFamiTF313666

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiQ15836

Miscellaneous databases

ChiTaRSiVAMP3 human
GeneWikiiVAMP3
GenomeRNAii9341
PMAP-CutDBiQ15836
PROiPR:Q15836
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049245 Expressed in 241 organ(s), highest expression level in inferior olivary complex
CleanExiHS_VAMP3
ExpressionAtlasiQ15836 baseline and differential
GenevisibleiQ15836 HS

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q15836
Secondary accession number(s): Q9BRV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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