VAMP3

Functionⁱ

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	41 – 42	(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)1 Publication	2
Siteⁱ	42 – 43	(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)1 Publication	2
Siteⁱ	58 – 59	(Microbial infection) Cleavage; by C.botulinum neurotoxin type B (BoNT/B, botB)1 Publication	2

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
SNARE binding Source: GO_Central
syntaxin-1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
calcium ion regulated exocytosis Source: Ensembl
cellular response to interferon-gamma Source: Ensembl
exocytosis
Source: ProtInc
Traceable author statementⁱ
- 9885218
Golgi to plasma membrane protein transport Source: Ensembl
membrane fusion
Source: ProtInc
Traceable author statementⁱ
- 9885218
membrane organization Source: Reactome
negative regulation of secretion by cell
Source: UniProtKB
Inferred from direct assayⁱ
- 12130530
positive regulation of receptor recycling Source: UniProtKB
protein-containing complex assembly
Source: ProtInc
Traceable author statementⁱ
- 9885218
retrograde transport, endosome to Golgi
Source: UniProtKB
Inferred from direct assayⁱ
- 18195106
SNARE complex assembly Source: Ensembl
substrate adhesion-dependent cell spreading Source: UniProtKB
vesicle docking involved in exocytosis
Source: ProtInc
Traceable author statementⁱ
- 9885218
vesicle fusion Source: GO_Central
vesicle-mediated transport Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORⁱ	Q15836

Protein family/group databases

TCDBⁱ	1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vesicle-associated membrane protein 3 Short name: VAMP-3 Alternative name(s): Cellubrevin Short name: CEB Synaptobrevin-3
Gene namesⁱ	Name:VAMP3 Synonyms:SYB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000049245.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12644 VAMP3
MIMⁱ	603657 gene
neXtProtⁱ	NX_Q15836

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 77	CytoplasmicSequence analysisAdd BLAST	76
Transmembraneⁱ	78 – 98	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	99 – 100	VesicularSequence analysis	2

Keywords - Cellular componentⁱ

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9341
Open Targets More...OpenTargetsⁱ	ENSG00000049245
PharmGKBⁱ	PA37268

Polymorphism and mutation databases

BioMutaⁱ	VAMP3
DMDMⁱ	2501082

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000206728	2 – 100	Vesicle-associated membrane protein 3Add BLAST		99

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Post-translational modificationⁱ

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.Curated1 Publication

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q15836
PaxDbⁱ	Q15836
PeptideAtlas More...PeptideAtlasⁱ	Q15836
PRIDEⁱ	Q15836
ProteomicsDBⁱ	60786
TopDownProteomicsⁱ	Q15836

PTM databases

iPTMnetⁱ	Q15836
PhosphoSitePlusⁱ	Q15836
SwissPalmⁱ	Q15836

Miscellaneous databases

PMAP-CutDBⁱ	Q15836

PMAP-CutDBⁱ

Q15836

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000049245
CleanExⁱ	HS_VAMP3
ExpressionAtlasⁱ	Q15836 baseline and differential
Genevisibleⁱ	Q15836 HS

Interactionⁱ

Subunit structureⁱ

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BCL2L13	Q9BXK5	3	EBI-722343,EBI-747430
Picalm	O55012	2	EBI-722343,EBI-915601	From Rattus norvegicus.
SNAP23	O00161	2	EBI-722343,EBI-745000
STX4	Q12846	8	EBI-722343,EBI-744942
VEGFD	O43915	4	EBI-722343,EBI-11750035

Show more details

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
SNARE binding Source: GO_Central
syntaxin-1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114747, 79 interactors
CORUMⁱ	Q15836
Database of interacting proteins More...DIPⁱ	DIP-56422N
IntActⁱ	Q15836, 72 interactors
Molecular INTeraction database More...MINTⁱ	Q15836
STRINGⁱ	9606.ENSP00000054666

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15836
SMRⁱ	Q15836
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 74	v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the synaptobrevin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074449
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	Q15836
KEGG Orthology (KO) More...KOⁱ	K13505
OMAⁱ	IIIWACS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MPE
PhylomeDBⁱ	Q15836
TreeFamⁱ	TF313666

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q15836-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA 
        60         70         80         90        100
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS

Length:100

Mass (Da):11,309

Last modified:January 23, 2007 - v3

Checksum:ⁱ347E9163157AFF42

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	77	K → E in AAH05941 (PubMed:16710414).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U64520 mRNA Translation: AAB05814.1 BT007327 mRNA Translation: AAP35991.1 Z98884 Genomic DNA No translation available. BC003570 mRNA Translation: AAH03570.1 BC005941 mRNA Translation: AAH05941.1 BC007050 mRNA Translation: AAH07050.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS88.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004772.1, NM_004781.3
UniGeneⁱ	Hs.66708

Genome annotation databases

Ensemblⁱ	ENST00000054666; ENSP00000054666; ENSG00000049245
GeneIDⁱ	9341
KEGGⁱ	hsa:9341

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q15836	VAMP3 protein		HUMAN		100
VAMP3 isoform 1		PANTR		100
VAMP3 isoform 1		PONAB		100
Vesicle associated membrane protein 3		GORGO		100

Protein	Similar proteins		Species	Score	Length
Q15836	VAMP3 protein		HUMAN		100
VAMP3 isoform 1		PANTR		100
VAMP3 isoform 1		PONAB		100
Vesicle associated membrane protein 3		GORGO		100
Vesicle associated membrane protein 3		SAIBB		122
+24

Protein	Similar proteins		Species	Score	Length
Q15836	VAMP3 protein		HUMAN		100
VAMP3 isoform 1		PANTR		100
VAMP3 isoform 1		PONAB		100
Vesicle associated membrane protein 3		GORGO		100
Vesicle associated membrane protein 3		Cebus capucinus imitator		122
+98

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U64520 mRNA Translation: AAB05814.1 BT007327 mRNA Translation: AAP35991.1 Z98884 Genomic DNA No translation available. BC003570 mRNA Translation: AAH03570.1 BC005941 mRNA Translation: AAH05941.1 BC007050 mRNA Translation: AAH07050.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS88.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004772.1, NM_004781.3
UniGeneⁱ	Hs.66708

3D structure databases

ProteinModelPortalⁱ	Q15836
SMRⁱ	Q15836
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114747, 79 interactors
CORUMⁱ	Q15836
Database of interacting proteins More...DIPⁱ	DIP-56422N
IntActⁱ	Q15836, 72 interactors
Molecular INTeraction database More...MINTⁱ	Q15836
STRINGⁱ	9606.ENSP00000054666

Protein family/group databases

TCDBⁱ	1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetⁱ	Q15836
PhosphoSitePlusⁱ	Q15836
SwissPalmⁱ	Q15836

Polymorphism and mutation databases

BioMutaⁱ	VAMP3
DMDMⁱ	2501082

Proteomic databases

EPDⁱ	Q15836
PaxDbⁱ	Q15836
PeptideAtlas More...PeptideAtlasⁱ	Q15836
PRIDEⁱ	Q15836
ProteomicsDBⁱ	60786
TopDownProteomicsⁱ	Q15836

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9341
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000054666; ENSP00000054666; ENSG00000049245
GeneIDⁱ	9341
KEGGⁱ	hsa:9341

Organism-specific databases

CTDⁱ	9341
DisGeNET More...DisGeNETⁱ	9341
EuPathDBⁱ	HostDB:ENSG00000049245.12
GeneCardsⁱ	VAMP3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12644 VAMP3
MIMⁱ	603657 gene
neXtProtⁱ	NX_Q15836
Open Targets More...OpenTargetsⁱ	ENSG00000049245
PharmGKBⁱ	PA37268
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074449
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	Q15836
KEGG Orthology (KO) More...KOⁱ	K13505
OMAⁱ	IIIWACS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MPE
PhylomeDBⁱ	Q15836
TreeFamⁱ	TF313666

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORⁱ	Q15836

Miscellaneous databases

ChiTaRSⁱ	VAMP3 human
GeneWikiⁱ	VAMP3
GenomeRNAiⁱ	9341
PMAP-CutDBⁱ	Q15836
Protein Ontology More...PROⁱ	PR:Q15836
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000049245
CleanExⁱ	HS_VAMP3
ExpressionAtlasⁱ	Q15836 baseline and differential
Genevisibleⁱ	Q15836 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VAMP3_HUMAN
Accessionⁱ	Q15836Primary (citable) accession number: Q15836 Secondary accession number(s): Q9BRV4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	July 18, 2018
	This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q15836 (VAMP3_HUMAN)

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Vesicle-associated membrane protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ