Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q15836 (VAMP3_HUMAN)

Entry version 196 (25 May 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Vesicle-associated membrane protein 3

Gene

VAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei41 – 42(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)1 Publication2
Sitei42 – 43(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)1 Publication2
Sitei58 – 59(Microbial infection) Cleavage; by C.botulinum neurotoxin type B (BoNT/B, botB)1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15836

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1236974, ER-Phagosome pathway
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013026, RHOB GTPase cycle
R-HSA-9013106, RHOC GTPase cycle
R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013404, RAC2 GTPase cycle
R-HSA-9013405, RHOD GTPase cycle
R-HSA-9013406, RHOQ GTPase cycle
R-HSA-9013407, RHOH GTPase cycle
R-HSA-9013408, RHOG GTPase cycle
R-HSA-9013409, RHOJ GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9035034, RHOF GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15836

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15836

Protein family/group databases

Transport Classification Database

More...TCDBi		1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VAMP3
Synonyms:SYB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12644, VAMP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603657, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15836

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000049245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 98Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini99 – 100VesicularSequence analysis2

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9341

Open Targets

More...OpenTargetsi		ENSG00000049245

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37268

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15836, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VAMP3

Domain mapping of disease mutations (DMDM)

More...DMDMi		2501082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067282 – 100Vesicle-associated membrane protein 3Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.Curated1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15836

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15836

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15836

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15836

PeptideAtlas

More...PeptideAtlasi		Q15836

PRoteomics IDEntifications database

More...PRIDEi		Q15836

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60786

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q15836

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15836, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15836

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q15836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15836

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q15836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000049245, Expressed in inferior olivary complex and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15836, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15836, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000049245, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail).

Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity).

Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).

Interacts with PICALM.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q15836
With#Exp.IntAct
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-722343,EBI-12078468
AIG1 - isoform 1 [Q9NVV5-2]3EBI-722343,EBI-11957045
AQP6 [Q13520]3EBI-722343,EBI-13059134
ARL13B [Q3SXY8]3EBI-722343,EBI-11343438
BCL2L13 [Q9BXK5]3EBI-722343,EBI-747430
BIK [Q13323]3EBI-722343,EBI-700794
BSCL2 [J3KQ12]3EBI-722343,EBI-11532900
BSND [Q8WZ55]3EBI-722343,EBI-7996695
CD79A [P11912]3EBI-722343,EBI-7797864
CIAO2A [Q9H5X1]3EBI-722343,EBI-752069
CLDN7 [O95471]3EBI-722343,EBI-740744
CLEC14A [Q86T13]3EBI-722343,EBI-17710733
COMT [P21964]3EBI-722343,EBI-372265
EBP [Q15125]3EBI-722343,EBI-3915253
ELOVL4 [Q9GZR5]3EBI-722343,EBI-18535450
EMP3 [P54852]3EBI-722343,EBI-3907816
ERGIC3 [Q9Y282]3EBI-722343,EBI-781551
FAM174A [Q8TBP5]3EBI-722343,EBI-18636064
FAM209A [Q5JX71]3EBI-722343,EBI-18304435
FAM210B [Q96KR6]3EBI-722343,EBI-18938272
GORAB [Q5T7V8]3EBI-722343,EBI-3917143
GPX8 [Q8TED1]3EBI-722343,EBI-11721746
KAT5 [Q92993]3EBI-722343,EBI-399080
KCNK5 [O95279]3EBI-722343,EBI-3934936
LHFPL5 [Q8TAF8]3EBI-722343,EBI-2820517
LMO3 - isoform 4 [Q8TAP4-4]3EBI-722343,EBI-11742507
MGST2 [Q99735]3EBI-722343,EBI-11324706
MGST3 [O14880]3EBI-722343,EBI-724754
NEMP1 - isoform 2 [O14524-2]3EBI-722343,EBI-10969203
PDZK1IP1 [Q13113]3EBI-722343,EBI-716063
PLEKHO1 [Q53GL0]3EBI-722343,EBI-949945
PTGES [O14684]3EBI-722343,EBI-11161398
RETREG3 [Q86VR2]3EBI-722343,EBI-10192441
RMDN3 [Q96TC7]3EBI-722343,EBI-1056589
SAR1A [Q9NR31]3EBI-722343,EBI-3920694
SCN3B [Q9NY72]3EBI-722343,EBI-17247926
SETDB1 - isoform 2 [Q15047-2]3EBI-722343,EBI-9090795
SLC10A1 [Q14973]3EBI-722343,EBI-3923031
SNAP23 [O00161]2EBI-722343,EBI-745000
SNAP29 [O95721]3EBI-722343,EBI-490676
STX1A [Q16623]3EBI-722343,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-722343,EBI-11956649
STX4 [Q12846]9EBI-722343,EBI-744942
TM4SF19 [Q96DZ7]3EBI-722343,EBI-6448756
TM4SF20 [Q53R12]3EBI-722343,EBI-1805798
TMEM237 - isoform 2 [Q96Q45-2]3EBI-722343,EBI-10982110
TMEM35A [Q53FP2]3EBI-722343,EBI-11722971
TMEM52B [Q4KMG9]3EBI-722343,EBI-18178701
TMEM86B [Q8N661]3EBI-722343,EBI-2548832
TMPPE [Q6ZT21]3EBI-722343,EBI-11724433
TMX2 [Q9Y320]3EBI-722343,EBI-6447886
VEGFD [O43915]4EBI-722343,EBI-11750035
VSIR [Q9H7M9]3EBI-722343,EBI-744988
YWHAG [P61981]3EBI-722343,EBI-359832
Picalm [O55012] from Rattus norvegicus.2EBI-722343,EBI-915601

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114747, 239 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15836

Database of interacting proteins

More...DIPi		DIP-56422N

Protein interaction database and analysis system

More...IntActi		Q15836, 131 interactors

Molecular INTeraction database

More...MINTi		Q15836

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000054666

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15836, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q15836

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15836

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 74v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0860, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158192

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064620_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15836

Identification of Orthologs from Complete Genome Data

More...OMAi		MKMWGIL

Database of Orthologous Groups

More...OrthoDBi		1606985at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15836

TreeFam database of animal gene trees

More...TreeFami		TF313666

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001388, Synaptobrevin
IPR016444, Synaptobrevin/VAMP
IPR042855, V_SNARE_CC

The PANTHER Classification System

More...PANTHERi		PTHR45701, PTHR45701, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00957, Synaptobrevin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005409, Synaptobrevin_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00219, SYNAPTOBREVN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00417, SYNAPTOBREVIN, 1 hit
PS50892, V_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA 
        60         70         80         90        100
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS
Length:100
Mass (Da):11,309
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i347E9163157AFF42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKX0K7EKX0_HUMAN
Vesicle-associated membrane protein...
VAMP3
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77K → E in AAH05941 (PubMed:16710414).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U64520 mRNA Translation: AAB05814.1
BT007327 mRNA Translation: AAP35991.1
Z98884 Genomic DNA No translation available.
BC003570 mRNA Translation: AAH03570.1
BC005941 mRNA Translation: AAH05941.1
BC007050 mRNA Translation: AAH07050.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS88.1

NCBI Reference Sequences

More...RefSeqi		NP_004772.1, NM_004781.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000054666.11; ENSP00000054666.6; ENSG00000049245.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9341

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000054666.11; ENSP00000054666.6; NM_004781.4; NP_004772.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64520 mRNA Translation: AAB05814.1
BT007327 mRNA Translation: AAP35991.1
Z98884 Genomic DNA No translation available.
BC003570 mRNA Translation: AAH03570.1
BC005941 mRNA Translation: AAH05941.1
BC007050 mRNA Translation: AAH07050.1
CCDSiCCDS88.1
RefSeqiNP_004772.1, NM_004781.3

3D structure databases

AlphaFoldDBiQ15836
SMRiQ15836
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114747, 239 interactors
CORUMiQ15836
DIPiDIP-56422N
IntActiQ15836, 131 interactors
MINTiQ15836
STRINGi9606.ENSP00000054666

Protein family/group databases

TCDBi1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

GlyGeniQ15836, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ15836
MetOSiteiQ15836
PhosphoSitePlusiQ15836
SwissPalmiQ15836

Genetic variation databases

BioMutaiVAMP3
DMDMi2501082

Proteomic databases

EPDiQ15836
jPOSTiQ15836
MassIVEiQ15836
PaxDbiQ15836
PeptideAtlasiQ15836
PRIDEiQ15836
ProteomicsDBi60786
TopDownProteomicsiQ15836

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27516, 267 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		9341

Genome annotation databases

EnsembliENST00000054666.11; ENSP00000054666.6; ENSG00000049245.13
GeneIDi9341
KEGGihsa:9341
MANE-SelectiENST00000054666.11; ENSP00000054666.6; NM_004781.4; NP_004772.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9341
DisGeNETi9341

GeneCards: human genes, protein and diseases

More...GeneCardsi		VAMP3
HGNCiHGNC:12644, VAMP3
HPAiENSG00000049245, Low tissue specificity
MIMi603657, gene
neXtProtiNX_Q15836
OpenTargetsiENSG00000049245
PharmGKBiPA37268
VEuPathDBiHostDB:ENSG00000049245

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0860, Eukaryota
GeneTreeiENSGT00940000158192
HOGENOMiCLU_064620_4_1_1
InParanoidiQ15836
OMAiMKMWGIL
OrthoDBi1606985at2759
PhylomeDBiQ15836
TreeFamiTF313666

Enzyme and pathway databases

PathwayCommonsiQ15836
ReactomeiR-HSA-1236974, ER-Phagosome pathway
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013026, RHOB GTPase cycle
R-HSA-9013106, RHOC GTPase cycle
R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013404, RAC2 GTPase cycle
R-HSA-9013405, RHOD GTPase cycle
R-HSA-9013406, RHOQ GTPase cycle
R-HSA-9013407, RHOH GTPase cycle
R-HSA-9013408, RHOG GTPase cycle
R-HSA-9013409, RHOJ GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9035034, RHOF GTPase cycle
SignaLinkiQ15836
SIGNORiQ15836

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9341, 11 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VAMP3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VAMP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9341
PharosiQ15836, Tbio

Protein Ontology

More...PROi		PR:Q15836
RNActiQ15836, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000049245, Expressed in inferior olivary complex and 252 other tissues
ExpressionAtlasiQ15836, baseline and differential
GenevisibleiQ15836, HS

Family and domain databases

InterProiView protein in InterPro
IPR001388, Synaptobrevin
IPR016444, Synaptobrevin/VAMP
IPR042855, V_SNARE_CC
PANTHERiPTHR45701, PTHR45701, 1 hit
PfamiView protein in Pfam
PF00957, Synaptobrevin, 1 hit
PIRSFiPIRSF005409, Synaptobrevin_euk, 1 hit
PRINTSiPR00219, SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417, SYNAPTOBREVIN, 1 hit
PS50892, V_SNARE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVAMP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15836
Secondary accession number(s): Q9BRV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again