UniProtKB - Q15836 (VAMP3_HUMAN)
Vesicle-associated membrane protein 3
VAMP3
Functioni
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 41 – 42 | (Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)1 Publication | 2 | |
Sitei | 42 – 43 | (Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)1 Publication | 2 | |
Sitei | 58 – 59 | (Microbial infection) Cleavage; by C.botulinum neurotoxin type B (BoNT/B, botB)1 Publication | 2 |
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- syntaxin-1 binding Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: Ensembl
- cellular response to interferon-gamma Source: Ensembl
- exocytosis Source: ProtInc
- Golgi to plasma membrane protein transport Source: Ensembl
- membrane fusion Source: ProtInc
- negative regulation of secretion by cell Source: UniProtKB
- positive regulation of receptor recycling Source: UniProtKB
- protein-containing complex assembly Source: ProtInc
- retrograde transport, endosome to Golgi Source: UniProtKB
- SNARE complex assembly Source: GO_Central
- substrate adhesion-dependent cell spreading Source: UniProtKB
- vesicle docking involved in exocytosis Source: ProtInc
- vesicle fusion Source: GO_Central
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q15836 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013405, RHOD GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9035034, RHOF GTPase cycle |
SignaLinki | Q15836 |
SIGNORi | Q15836 |
Protein family/group databases
TCDBi | 1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 3Short name: VAMP-3 Alternative name(s): Cellubrevin Short name: CEB Synaptobrevin-3 |
Gene namesi | Name:VAMP3 Synonyms:SYB3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12644, VAMP3 |
MIMi | 603657, gene |
neXtProti | NX_Q15836 |
VEuPathDBi | HostDB:ENSG00000049245 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type IV membrane protein Curated
- synaptosome By similarity
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: Ensembl
- recycling endosome Source: MGI
- recycling endosome membrane Source: Reactome
Golgi apparatus
- trans-Golgi network membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: Ensembl
- clathrin-coated endocytic vesicle membrane Source: Reactome
- clathrin-coated vesicle Source: UniProtKB
- integral component of membrane Source: ProtInc
- intracellular membrane-bounded organelle Source: UniProtKB
- neuron projection Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: Ensembl
- phagocytic vesicle membrane Source: Reactome
- secretory granule Source: Ensembl
- SNARE complex Source: UniProtKB
- synapse Source: UniProtKB-SubCell
- transport vesicle Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 77 | CytoplasmicSequence analysisAdd BLAST | 76 | |
Transmembranei | 78 – 98 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 100 | VesicularSequence analysis | 2 |
Keywords - Cellular componenti
Cell junction, Membrane, Synapse, SynaptosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 9341 |
OpenTargetsi | ENSG00000049245 |
PharmGKBi | PA37268 |
Miscellaneous databases
Pharosi | Q15836, Tbio |
Genetic variation databases
BioMutai | VAMP3 |
DMDMi | 2501082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000206728 | 2 – 100 | Vesicle-associated membrane protein 3Add BLAST | 99 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q15836 |
jPOSTi | Q15836 |
MassIVEi | Q15836 |
PaxDbi | Q15836 |
PeptideAtlasi | Q15836 |
PRIDEi | Q15836 |
ProteomicsDBi | 60786 |
TopDownProteomicsi | Q15836 |
PTM databases
GlyGeni | Q15836, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15836 |
MetOSitei | Q15836 |
PhosphoSitePlusi | Q15836 |
SwissPalmi | Q15836 |
Expressioni
Gene expression databases
Bgeei | ENSG00000049245, Expressed in inferior olivary complex and 252 other tissues |
ExpressionAtlasi | Q15836, baseline and differential |
Genevisiblei | Q15836, HS |
Organism-specific databases
HPAi | ENSG00000049245, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BVES (via the C-terminus cytoplasmic tail).
Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity).
Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).
Interacts with PICALM.
By similarity2 PublicationsBinary interactionsi
Q15836
GO - Molecular functioni
- syntaxin-1 binding Source: GO_Central
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114747, 239 interactors |
CORUMi | Q15836 |
DIPi | DIP-56422N |
IntActi | Q15836, 131 interactors |
MINTi | Q15836 |
STRINGi | 9606.ENSP00000054666 |
Miscellaneous databases
RNActi | Q15836, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 74 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0860, Eukaryota |
GeneTreei | ENSGT00940000158192 |
HOGENOMi | CLU_064620_4_1_1 |
InParanoidi | Q15836 |
OMAi | MKMWGIL |
OrthoDBi | 1606985at2759 |
PhylomeDBi | Q15836 |
TreeFami | TF313666 |
Family and domain databases
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR016444, Synaptobrevin/VAMP IPR042855, V_SNARE_CC |
PANTHERi | PTHR45701, PTHR45701, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PIRSFi | PIRSF005409, Synaptobrevin_euk, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA
60 70 80 90 100
DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EKX0 | K7EKX0_HUMAN | Vesicle-associated membrane protein... | VAMP3 | 72 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | K → E in AAH05941 (PubMed:16710414).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64520 mRNA Translation: AAB05814.1 BT007327 mRNA Translation: AAP35991.1 Z98884 Genomic DNA No translation available. BC003570 mRNA Translation: AAH03570.1 BC005941 mRNA Translation: AAH05941.1 BC007050 mRNA Translation: AAH07050.1 |
CCDSi | CCDS88.1 |
RefSeqi | NP_004772.1, NM_004781.3 |
Genome annotation databases
Ensembli | ENST00000054666.11; ENSP00000054666.6; ENSG00000049245.13 |
GeneIDi | 9341 |
KEGGi | hsa:9341 |
MANE-Selecti | ENST00000054666.11; ENSP00000054666.6; NM_004781.4; NP_004772.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64520 mRNA Translation: AAB05814.1 BT007327 mRNA Translation: AAP35991.1 Z98884 Genomic DNA No translation available. BC003570 mRNA Translation: AAH03570.1 BC005941 mRNA Translation: AAH05941.1 BC007050 mRNA Translation: AAH07050.1 |
CCDSi | CCDS88.1 |
RefSeqi | NP_004772.1, NM_004781.3 |
3D structure databases
AlphaFoldDBi | Q15836 |
SMRi | Q15836 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114747, 239 interactors |
CORUMi | Q15836 |
DIPi | DIP-56422N |
IntActi | Q15836, 131 interactors |
MINTi | Q15836 |
STRINGi | 9606.ENSP00000054666 |
Protein family/group databases
TCDBi | 1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family |
PTM databases
GlyGeni | Q15836, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15836 |
MetOSitei | Q15836 |
PhosphoSitePlusi | Q15836 |
SwissPalmi | Q15836 |
Genetic variation databases
BioMutai | VAMP3 |
DMDMi | 2501082 |
Proteomic databases
EPDi | Q15836 |
jPOSTi | Q15836 |
MassIVEi | Q15836 |
PaxDbi | Q15836 |
PeptideAtlasi | Q15836 |
PRIDEi | Q15836 |
ProteomicsDBi | 60786 |
TopDownProteomicsi | Q15836 |
Protocols and materials databases
Antibodypediai | 27516, 267 antibodies from 31 providers |
DNASUi | 9341 |
Genome annotation databases
Ensembli | ENST00000054666.11; ENSP00000054666.6; ENSG00000049245.13 |
GeneIDi | 9341 |
KEGGi | hsa:9341 |
MANE-Selecti | ENST00000054666.11; ENSP00000054666.6; NM_004781.4; NP_004772.1 |
Organism-specific databases
CTDi | 9341 |
DisGeNETi | 9341 |
GeneCardsi | VAMP3 |
HGNCi | HGNC:12644, VAMP3 |
HPAi | ENSG00000049245, Low tissue specificity |
MIMi | 603657, gene |
neXtProti | NX_Q15836 |
OpenTargetsi | ENSG00000049245 |
PharmGKBi | PA37268 |
VEuPathDBi | HostDB:ENSG00000049245 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0860, Eukaryota |
GeneTreei | ENSGT00940000158192 |
HOGENOMi | CLU_064620_4_1_1 |
InParanoidi | Q15836 |
OMAi | MKMWGIL |
OrthoDBi | 1606985at2759 |
PhylomeDBi | Q15836 |
TreeFami | TF313666 |
Enzyme and pathway databases
PathwayCommonsi | Q15836 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8980692, RHOA GTPase cycle R-HSA-9013026, RHOB GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013405, RHOD GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9035034, RHOF GTPase cycle |
SignaLinki | Q15836 |
SIGNORi | Q15836 |
Miscellaneous databases
BioGRID-ORCSi | 9341, 11 hits in 1078 CRISPR screens |
ChiTaRSi | VAMP3, human |
GeneWikii | VAMP3 |
GenomeRNAii | 9341 |
Pharosi | Q15836, Tbio |
PROi | PR:Q15836 |
RNActi | Q15836, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000049245, Expressed in inferior olivary complex and 252 other tissues |
ExpressionAtlasi | Q15836, baseline and differential |
Genevisiblei | Q15836, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR016444, Synaptobrevin/VAMP IPR042855, V_SNARE_CC |
PANTHERi | PTHR45701, PTHR45701, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PIRSFi | PIRSF005409, Synaptobrevin_euk, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VAMP3_HUMAN | |
Accessioni | Q15836Primary (citable) accession number: Q15836 Secondary accession number(s): Q9BRV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 196 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families