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Protein

Coiled-coil domain-containing protein 85B

Gene

CCDC85B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity).By similarity2 Publications
(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.1 Publication

Miscellaneous

May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processDifferentiation, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85B
Alternative name(s):
Hepatitis delta antigen-interacting protein A
Short name:
Delta-interacting protein A
Gene namesi
Name:CCDC85B
Synonyms:DIPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175602.3
HGNCiHGNC:24926 CCDC85B
MIMi605360 gene
neXtProtiNX_Q15834

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131L → A: Loss of interaction with TCF7L2 and loss of suppression of CTNNB1 activity. Loss of cell growth inhibition. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000175602
PharmGKBiPA144596453

Polymorphism and mutation databases

BioMutaiCCDC85B
DMDMi92090801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799081 – 202Coiled-coil domain-containing protein 85BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15834
MaxQBiQ15834
PaxDbiQ15834
PeptideAtlasiQ15834
PRIDEiQ15834
ProteomicsDBi60784

PTM databases

iPTMnetiQ15834
PhosphoSitePlusiQ15834

Expressioni

Tissue specificityi

Widely expressed including liver.

Inductioni

Up-regulated by doxorubicin.1 Publication

Gene expression databases

BgeeiENSG00000175602 Expressed in 224 organ(s), highest expression level in substantia nigra
CleanExiHS_CCDC85B
GenevisibleiQ15834 HS

Organism-specific databases

HPAiHPA054415

Interactioni

Subunit structurei

Interacts with CEBPB (By similarity). Interacts with EURL (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1 (PubMed:17014843). Interacts with TCF7L2; competes with CTNNB1 (PubMed:17873903). Interacts with ANKRD26 (PubMed:22666460).By similarity3 Publications
(Microbial infection) Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG); this interaction affects hepatitis delta virus (HDV) genomic replication in intact cells.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116198, 151 interactors
CORUMiQ15834
IntActiQ15834, 138 interactors
STRINGi9606.ENSP00000311695

Structurei

3D structure databases

ProteinModelPortaliQ15834
SMRiQ15834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 90Sequence analysisAdd BLAST48
Coiled coili118 – 147Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3819 Eukaryota
ENOG410YXPD LUCA
GeneTreeiENSGT00390000003531
HOGENOMiHOG000234335
HOVERGENiHBG107255
InParanoidiQ15834
KOiK16758
OMAiGHHAAKV
OrthoDBiEOG091G0MA4
PhylomeDBiQ15834
TreeFamiTF320243

Family and domain databases

InterProiView protein in InterPro
IPR019359 CCDC85
PANTHERiPTHR13546 PTHR13546, 1 hit
PfamiView protein in Pfam
PF10226 CCDC85, 1 hit

Sequencei

Sequence statusi: Complete.

Q15834-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN
60 70 80 90 100
RQLQGHLGEI RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL
110 120 130 140 150
FGTQASRAVR EDLGGCWQKL AELEGRQEEL LRENLALKEL CLALGEEWGP
160 170 180 190 200
RGGPSGAGGS GAGPAPELAL PPCGPRDLGD GSSSTGSVGS PDQLPLACSP

DD
Length:202
Mass (Da):22,091
Last modified:March 7, 2006 - v2
Checksum:iEA92D1B712A54047
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in AAB05928 (PubMed:8810253).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63825 mRNA Translation: AAB05928.1
AK312109 mRNA Translation: BAG35045.1
CH471076 Genomic DNA Translation: EAW74468.1
BC008796 mRNA Translation: AAH08796.1
CCDSiCCDS8120.1
RefSeqiNP_006839.2, NM_006848.2
UniGeneiHs.66713

Genome annotation databases

EnsembliENST00000312579; ENSP00000311695; ENSG00000175602
GeneIDi11007
KEGGihsa:11007
UCSCiuc001ogf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63825 mRNA Translation: AAB05928.1
AK312109 mRNA Translation: BAG35045.1
CH471076 Genomic DNA Translation: EAW74468.1
BC008796 mRNA Translation: AAH08796.1
CCDSiCCDS8120.1
RefSeqiNP_006839.2, NM_006848.2
UniGeneiHs.66713

3D structure databases

ProteinModelPortaliQ15834
SMRiQ15834
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116198, 151 interactors
CORUMiQ15834
IntActiQ15834, 138 interactors
STRINGi9606.ENSP00000311695

PTM databases

iPTMnetiQ15834
PhosphoSitePlusiQ15834

Polymorphism and mutation databases

BioMutaiCCDC85B
DMDMi92090801

Proteomic databases

EPDiQ15834
MaxQBiQ15834
PaxDbiQ15834
PeptideAtlasiQ15834
PRIDEiQ15834
ProteomicsDBi60784

Protocols and materials databases

DNASUi11007
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312579; ENSP00000311695; ENSG00000175602
GeneIDi11007
KEGGihsa:11007
UCSCiuc001ogf.4 human

Organism-specific databases

CTDi11007
EuPathDBiHostDB:ENSG00000175602.3
GeneCardsiCCDC85B
HGNCiHGNC:24926 CCDC85B
HPAiHPA054415
MIMi605360 gene
neXtProtiNX_Q15834
OpenTargetsiENSG00000175602
PharmGKBiPA144596453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3819 Eukaryota
ENOG410YXPD LUCA
GeneTreeiENSGT00390000003531
HOGENOMiHOG000234335
HOVERGENiHBG107255
InParanoidiQ15834
KOiK16758
OMAiGHHAAKV
OrthoDBiEOG091G0MA4
PhylomeDBiQ15834
TreeFamiTF320243

Miscellaneous databases

GeneWikiiCCDC85B
GenomeRNAii11007
PROiPR:Q15834
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175602 Expressed in 224 organ(s), highest expression level in substantia nigra
CleanExiHS_CCDC85B
GenevisibleiQ15834 HS

Family and domain databases

InterProiView protein in InterPro
IPR019359 CCDC85
PANTHERiPTHR13546 PTHR13546, 1 hit
PfamiView protein in Pfam
PF10226 CCDC85, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC85B_HUMAN
AccessioniPrimary (citable) accession number: Q15834
Secondary accession number(s): B2R598, Q96HA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 7, 2006
Last modified: October 10, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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