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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

CHRNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-gated cation-selective channel activity Source: ProtInc
  • acetylcholine receptor activity Source: ProtInc
  • ligand-gated ion channel activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:CHRNA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147434.8
HGNCiHGNC:15963 CHRNA6
MIMi606888 gene
neXtProtiNX_Q15825

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 239ExtracellularAdd BLAST214
Transmembranei240 – 264HelicalSequence analysisAdd BLAST25
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 465CytoplasmicAdd BLAST138
Transmembranei466 – 484HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi8973
OpenTargetsiENSG00000147434
PharmGKBiPA26492

Chemistry databases

ChEMBLiCHEMBL3137285
DrugBankiDB09028 Cytisine
DB00898 Ethanol
DB00674 Galantamine
DB00184 Nicotine
DB01273 Varenicline
GuidetoPHARMACOLOGYi467

Polymorphism and mutation databases

BioMutaiCHRNA6
DMDMi2492620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000036026 – 494Neuronal acetylcholine receptor subunit alpha-6Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15825
PRIDEiQ15825
ProteomicsDBi60777
60778 [Q15825-2]

PTM databases

iPTMnetiQ15825
PhosphoSitePlusiQ15825

Expressioni

Gene expression databases

BgeeiENSG00000147434
CleanExiHS_CHRNA6
ExpressionAtlasiQ15825 baseline and differential
GenevisibleiQ15825 HS

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6 (PubMed:27344019).1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-213 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4
CPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
IntActiQ15825, 2 interactors
STRINGi9606.ENSP00000276410

Chemistry databases

BindingDBiQ15825

Structurei

3D structure databases

ProteinModelPortaliQ15825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ15825
KOiK04808
OMAiVHFEVAI
OrthoDBiEOG091G0R20
PhylomeDBiQ15825
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTSKGQGFL HGGLCLWLCV FTPFFKGCVG CATEERLFHK LFSHYNQFIR
60 70 80 90 100
PVENVSDPVT VHFEVAITQL ANVDEVNQIM ETNLWLRHIW NDYKLRWDPM
110 120 130 140 150
EYDGIETLRV PADKIWKPDI VLYNNAVGDF QVEGKTKALL KYNGMITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIID ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVV
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPTTHTMPRW VKTVFLKLLP
360 370 380 390 400
QVLLMRWPLD KTRGTGSDAV PRGLARRPAK GKLASHGEPR HLKECFHCHK
410 420 430 440 450
SNELATSKRR LSHQPLQWVV ENSEHSPEVE DVINSVQFIA ENMKSHNETK
460 470 480 490
EVEDDWKYVA MVVDRVFLWV FIIVCVFGTA GLFLQPLLGN TGKS
Length:494
Mass (Da):56,898
Last modified:November 1, 1997 - v1
Checksum:i1A437E6DEE02ABFE
GO
Isoform 2 (identifier: Q15825-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):55,018
Checksum:i87749CBC64674D70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048171447N → S. Corresponds to variant dbSNP:rs16891583Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04271374 – 88Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62435 mRNA Translation: AAB40113.1
Y16282 mRNA Translation: CAA76155.1
AB079251 Genomic DNA Translation: BAC06855.1
AK298798 mRNA Translation: BAG60933.1
AK313521 mRNA Translation: BAG36301.1
AC087533 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63207.1
BC014456 mRNA Translation: AAH14456.1
CCDSiCCDS56536.1 [Q15825-2]
CCDS6135.1 [Q15825-1]
RefSeqiNP_001186208.1, NM_001199279.1 [Q15825-2]
NP_004189.1, NM_004198.3 [Q15825-1]
UniGeneiHs.103128

Genome annotation databases

EnsembliENST00000276410; ENSP00000276410; ENSG00000147434 [Q15825-1]
ENST00000534622; ENSP00000433871; ENSG00000147434 [Q15825-2]
GeneIDi8973
KEGGihsa:8973
UCSCiuc003xpj.5 human [Q15825-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACHA6_HUMAN
AccessioniPrimary (citable) accession number: Q15825
Secondary accession number(s): B2R8V4, B4DQH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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