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Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

UBE2V2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ15819

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Alternative name(s):
DDVit 1
Enterocyte differentiation-associated factor 1
Short name:
EDAF-1
Enterocyte differentiation-promoting factor 1
Short name:
EDPF-1
MMS2 homolog
Vitamin D3-inducible protein
Gene namesi
Name:UBE2V2
Synonyms:MMS2, UEV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169139.11
HGNCiHGNC:12495 UBE2V2
MIMi603001 gene
neXtProtiNX_Q15819

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169139
PharmGKBiPA37143

Polymorphism and mutation databases

BioMutaiUBE2V2
DMDMi51701935

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000826022 – 145Ubiquitin-conjugating enzyme E2 variant 2Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15819
MaxQBiQ15819
PaxDbiQ15819
PeptideAtlasiQ15819
PRIDEiQ15819
ProteomicsDBi60775
TopDownProteomicsiQ15819

PTM databases

iPTMnetiQ15819
PhosphoSitePlusiQ15819

Expressioni

Tissue specificityi

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.2 Publications

Inductioni

Up-regulated in cultured fresh blood cells upon treatment with vitamin D3.1 Publication

Gene expression databases

BgeeiENSG00000169139 Expressed in 235 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_UBE2V2
ExpressionAtlasiQ15819 baseline and differential
GenevisibleiQ15819 HS

Organism-specific databases

HPAiHPA052535
HPA053186

Interactioni

Subunit structurei

Heterodimer with UBE2N. Binds CHFR.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113184, 59 interactors
ComplexPortaliCPX-530 UBC13-MMS2 ubiquitin-conjugating enzyme E2 complex
CORUMiQ15819
DIPiDIP-29830N
IntActiQ15819, 26 interactors
STRINGi9606.ENSP00000428209

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15819
SMRiQ15819
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15819

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0896 Eukaryota
ENOG4111MDW LUCA
GeneTreeiENSGT00740000115534
HOVERGENiHBG054552
InParanoidiQ15819
KOiK10704
OMAiGPARTNY
OrthoDBiEOG091G0SMT
PhylomeDBiQ15819
TreeFamiTF316971

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q15819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI
60 70 80 90 100
IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA
110 120 130 140
RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN
Length:145
Mass (Da):16,363
Last modified:January 23, 2007 - v4
Checksum:i98D632A1AEC0AADE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBX6H0YBX6_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UBE2V2
154Annotation score:
G3V113G3V113_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UBE2V2 hCG_1640505
105Annotation score:
H0YBP9H0YBP9_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UBE2V2
109Annotation score:
E5RIF1E5RIF1_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UBE2V2
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05243136E → G. Corresponds to variant dbSNP:rs11557776Ensembl.1
Natural variantiVAR_05243378P → Q. Corresponds to variant dbSNP:rs11557786Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98091 mRNA Translation: CAA66717.1
AF049140 mRNA Translation: AAC05381.1
U62136 mRNA Translation: AAB04758.2
BT006744 mRNA Translation: AAP35390.1
CR407628 mRNA Translation: CAG28556.1
BC007051 mRNA Translation: AAH07051.1
BC016332 mRNA Translation: AAH16332.1
BC016710 mRNA Translation: AAH16710.1
BC028673 mRNA Translation: AAH28673.1
BC062418 mRNA Translation: AAH62418.1
CCDSiCCDS43738.1
PIRiJC5525
RefSeqiNP_003341.1, NM_003350.2
UniGeneiHs.491695
Hs.595400

Genome annotation databases

EnsembliENST00000523111; ENSP00000428209; ENSG00000169139
GeneIDi7336
KEGGihsa:7336
UCSCiuc003xqm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUB2V2_HUMAN
AccessioniPrimary (citable) accession number: Q15819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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