Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal pentraxin-1

Gene

NPTX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2PROSITE-ProRule annotation1
Metal bindingi370Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: GO_Central
  • central nervous system development Source: ProtInc
  • chemical synaptic transmission Source: ProtInc
  • regulation of postsynaptic neurotransmitter receptor activity Source: SynGO

Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

TCDBi1.C.92.1.3 the pentraxin (pentraxin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:NPTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171246.5
HGNCiHGNC:7952 NPTX1
MIMi602367 gene
neXtProtiNX_Q15818

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi4884
OpenTargetsiENSG00000171246
PharmGKBiPA31738

Polymorphism and mutation databases

BioMutaiNPTX1
DMDMi77416871

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354723 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 316PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15818
MaxQBiQ15818
PaxDbiQ15818
PeptideAtlasiQ15818
PRIDEiQ15818
ProteomicsDBi60774

PTM databases

iPTMnetiQ15818
PhosphoSitePlusiQ15818

Expressioni

Gene expression databases

BgeeiENSG00000171246 Expressed in 181 organ(s), highest expression level in cerebellum
CleanExiHS_NPTX1
GenevisibleiQ15818 HS

Organism-specific databases

HPAiHPA077062

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

BioGridi110944, 47 interactors
IntActiQ15818, 4 interactors
STRINGi9606.ENSP00000307549

Structurei

3D structure databases

ProteinModelPortaliQ15818
SMRiQ15818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 428Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiQ15818
OMAiGASKWTF
OrthoDBiEOG091G0AHP
PhylomeDBiQ15818
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15818-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG
110 120 130 140 150
EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK
210 220 230 240 250
IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK
410 420 430
ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,122
Last modified:October 11, 2005 - v2
Checksum:iB881AC19F7C8F74A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Missing in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti20 – 22AGA → P in AAC50727 (PubMed:8884281).Curated3
Sequence conflicti57S → SN in AAC50727 (PubMed:8884281).Curated1
Sequence conflicti192R → K in AAC50727 (PubMed:8884281).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA Translation: AAC50727.1
AK127335 mRNA Translation: BAG54485.1
BC089441 mRNA Translation: AAH89441.1
CCDSiCCDS32762.1
RefSeqiNP_002513.2, NM_002522.3
UniGeneiHs.514556
Hs.715784

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246
GeneIDi4884
KEGGihsa:4884
UCSCiuc002jyp.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61849 mRNA Translation: AAC50727.1
AK127335 mRNA Translation: BAG54485.1
BC089441 mRNA Translation: AAH89441.1
CCDSiCCDS32762.1
RefSeqiNP_002513.2, NM_002522.3
UniGeneiHs.514556
Hs.715784

3D structure databases

ProteinModelPortaliQ15818
SMRiQ15818
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110944, 47 interactors
IntActiQ15818, 4 interactors
STRINGi9606.ENSP00000307549

Protein family/group databases

TCDBi1.C.92.1.3 the pentraxin (pentraxin) family

PTM databases

iPTMnetiQ15818
PhosphoSitePlusiQ15818

Polymorphism and mutation databases

BioMutaiNPTX1
DMDMi77416871

Proteomic databases

EPDiQ15818
MaxQBiQ15818
PaxDbiQ15818
PeptideAtlasiQ15818
PRIDEiQ15818
ProteomicsDBi60774

Protocols and materials databases

DNASUi4884
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306773; ENSP00000307549; ENSG00000171246
GeneIDi4884
KEGGihsa:4884
UCSCiuc002jyp.2 human

Organism-specific databases

CTDi4884
DisGeNETi4884
EuPathDBiHostDB:ENSG00000171246.5
GeneCardsiNPTX1
HGNCiHGNC:7952 NPTX1
HPAiHPA077062
MIMi602367 gene
neXtProtiNX_Q15818
OpenTargetsiENSG00000171246
PharmGKBiPA31738
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiQ15818
OMAiGASKWTF
OrthoDBiEOG091G0AHP
PhylomeDBiQ15818
TreeFamiTF330208

Miscellaneous databases

ChiTaRSiNPTX1 human
GeneWikiiNPTX1
GenomeRNAii4884
PROiPR:Q15818
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171246 Expressed in 181 organ(s), highest expression level in cerebellum
CleanExiHS_NPTX1
GenevisibleiQ15818 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX1_HUMAN
AccessioniPrimary (citable) accession number: Q15818
Secondary accession number(s): B3KXH3, Q5FWE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again