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UniProtKB - Q15818 (NPTX1_HUMAN)
Protein
Neuronal pentraxin-1
Gene
NPTX1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
By similarityCofactori
Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 280 | Calcium 1By similarity | 1 | |
Metal bindingi | 358 | Calcium 1By similarity | 1 | |
Metal bindingi | 358 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 360 | Calcium 1By similarity | 1 | |
Metal bindingi | 360 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 370 | Calcium 2PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- axonogenesis involved in innervation Source: GO_Central
- cellular response to glucose stimulus Source: Ensembl
- cellular response to potassium ion Source: Ensembl
- central nervous system development Source: ProtInc
- chemical synaptic transmission Source: ProtInc
- mitochondrial fragmentation involved in apoptotic process Source: Ensembl
- mitochondrial transport Source: Ensembl
- neurotransmitter receptor localization to postsynaptic specialization membrane Source: Ensembl
- regulation of postsynaptic density assembly Source: Ensembl
- regulation of postsynaptic neurotransmitter receptor activity Source: SynGO
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q15818 |
SignaLinki | Q15818 |
SIGNORi | Q15818 |
Protein family/group databases
TCDBi | 1.C.92.1.3, the pentraxin (pentraxin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal pentraxin-1Short name: NP1 Alternative name(s): Neuronal pentraxin I Short name: NP-I |
Gene namesi | Name:NPTX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7952, NPTX1 |
MIMi | 602367, gene |
neXtProti | NX_Q15818 |
VEuPathDBi | HostDB:ENSG00000171246 |
Subcellular locationi
Other locations
- secretory vesicle Curated
Extracellular region or secreted
- synaptic cleft Source: Ensembl
Mitochondrion
- mitochondrion Source: Ensembl
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- glutamatergic synapse Source: SynGO
- neuron projection Source: GO_Central
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesiclePathology & Biotechi
Organism-specific databases
DisGeNETi | 4884 |
OpenTargetsi | ENSG00000171246 |
PharmGKBi | PA31738 |
Miscellaneous databases
Pharosi | Q15818, Tbio |
Genetic variation databases
BioMutai | NPTX1 |
DMDMi | 77416871 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000023547 | 23 – 432 | Neuronal pentraxin-1Add BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 256 ↔ 316 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q15818 |
jPOSTi | Q15818 |
MassIVEi | Q15818 |
MaxQBi | Q15818 |
PaxDbi | Q15818 |
PeptideAtlasi | Q15818 |
PRIDEi | Q15818 |
ProteomicsDBi | 60774 |
PTM databases
GlyGeni | Q15818, 2 sites |
iPTMneti | Q15818 |
PhosphoSitePlusi | Q15818 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171246, Expressed in cerebellum and 201 other tissues |
Genevisiblei | Q15818, HS |
Organism-specific databases
HPAi | ENSG00000171246, Tissue enriched (brain) |
Interactioni
Subunit structurei
Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).
By similarityProtein-protein interaction databases
BioGRIDi | 110944, 71 interactors |
IntActi | Q15818, 37 interactors |
MINTi | Q15818 |
STRINGi | 9606.ENSP00000307549 |
Miscellaneous databases
RNActi | Q15818, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15818 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 226 – 428 | Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST | 203 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 90 – 122 | DisorderedSequence analysisAdd BLAST | 33 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTID, Eukaryota |
GeneTreei | ENSGT00990000203576 |
HOGENOMi | CLU_032051_0_0_1 |
InParanoidi | Q15818 |
OMAi | VFSWLET |
OrthoDBi | 770812at2759 |
PhylomeDBi | Q15818 |
TreeFami | TF330208 |
Family and domain databases
CDDi | cd00152, PTX, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030476, Pentaxin_CS IPR001759, Pentraxin-related |
Pfami | View protein in Pfam PF00354, Pentaxin, 1 hit |
PRINTSi | PR00895, PENTAXIN |
SMARTi | View protein in SMART SM00159, PTX, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00289, PTX_1, 1 hit PS51828, PTX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q15818-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG
110 120 130 140 150
EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK
210 220 230 240 250
IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK
410 420 430
ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | Missing in AAC50727 (PubMed:8884281).Curated | 1 | |
Sequence conflicti | 20 – 22 | AGA → P in AAC50727 (PubMed:8884281).Curated | 3 | |
Sequence conflicti | 57 | S → SN in AAC50727 (PubMed:8884281).Curated | 1 | |
Sequence conflicti | 192 | R → K in AAC50727 (PubMed:8884281).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61849 mRNA Translation: AAC50727.1 AK127335 mRNA Translation: BAG54485.1 BC089441 mRNA Translation: AAH89441.1 |
CCDSi | CCDS32762.1 |
RefSeqi | NP_002513.2, NM_002522.3 |
Genome annotation databases
Ensembli | ENST00000306773; ENSP00000307549; ENSG00000171246 |
GeneIDi | 4884 |
KEGGi | hsa:4884 |
MANE-Selecti | ENST00000306773.5; ENSP00000307549.4; NM_002522.4; NP_002513.2 |
UCSCi | uc002jyp.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61849 mRNA Translation: AAC50727.1 AK127335 mRNA Translation: BAG54485.1 BC089441 mRNA Translation: AAH89441.1 |
CCDSi | CCDS32762.1 |
RefSeqi | NP_002513.2, NM_002522.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6YPE | X-ray | 1.45 | A/B | 225-429 | [»] | |
SMRi | Q15818 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110944, 71 interactors |
IntActi | Q15818, 37 interactors |
MINTi | Q15818 |
STRINGi | 9606.ENSP00000307549 |
Protein family/group databases
TCDBi | 1.C.92.1.3, the pentraxin (pentraxin) family |
PTM databases
GlyGeni | Q15818, 2 sites |
iPTMneti | Q15818 |
PhosphoSitePlusi | Q15818 |
Genetic variation databases
BioMutai | NPTX1 |
DMDMi | 77416871 |
Proteomic databases
EPDi | Q15818 |
jPOSTi | Q15818 |
MassIVEi | Q15818 |
MaxQBi | Q15818 |
PaxDbi | Q15818 |
PeptideAtlasi | Q15818 |
PRIDEi | Q15818 |
ProteomicsDBi | 60774 |
Protocols and materials databases
Antibodypediai | 32766, 407 antibodies from 32 providers |
DNASUi | 4884 |
Genome annotation databases
Ensembli | ENST00000306773; ENSP00000307549; ENSG00000171246 |
GeneIDi | 4884 |
KEGGi | hsa:4884 |
MANE-Selecti | ENST00000306773.5; ENSP00000307549.4; NM_002522.4; NP_002513.2 |
UCSCi | uc002jyp.2, human |
Organism-specific databases
CTDi | 4884 |
DisGeNETi | 4884 |
GeneCardsi | NPTX1 |
HGNCi | HGNC:7952, NPTX1 |
HPAi | ENSG00000171246, Tissue enriched (brain) |
MIMi | 602367, gene |
neXtProti | NX_Q15818 |
OpenTargetsi | ENSG00000171246 |
PharmGKBi | PA31738 |
VEuPathDBi | HostDB:ENSG00000171246 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTID, Eukaryota |
GeneTreei | ENSGT00990000203576 |
HOGENOMi | CLU_032051_0_0_1 |
InParanoidi | Q15818 |
OMAi | VFSWLET |
OrthoDBi | 770812at2759 |
PhylomeDBi | Q15818 |
TreeFami | TF330208 |
Enzyme and pathway databases
PathwayCommonsi | Q15818 |
SignaLinki | Q15818 |
SIGNORi | Q15818 |
Miscellaneous databases
BioGRID-ORCSi | 4884, 5 hits in 1040 CRISPR screens |
ChiTaRSi | NPTX1, human |
GeneWikii | NPTX1 |
GenomeRNAii | 4884 |
Pharosi | Q15818, Tbio |
PROi | PR:Q15818 |
RNActi | Q15818, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171246, Expressed in cerebellum and 201 other tissues |
Genevisiblei | Q15818, HS |
Family and domain databases
CDDi | cd00152, PTX, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030476, Pentaxin_CS IPR001759, Pentraxin-related |
Pfami | View protein in Pfam PF00354, Pentaxin, 1 hit |
PRINTSi | PR00895, PENTAXIN |
SMARTi | View protein in SMART SM00159, PTX, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS00289, PTX_1, 1 hit PS51828, PTX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NPTX1_HUMAN | |
Accessioni | Q15818Primary (citable) accession number: Q15818 Secondary accession number(s): B3KXH3, Q5FWE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references