UniProtKB - Q15811 (ITSN1_HUMAN)
Intersectin-1
ITSN1
Functioni
Caution
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1667 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 1670 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 1673 | CalciumPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 66 – 77 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 267 – 278 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- kinase activator activity Source: Ensembl
- molecular adaptor activity Source: UniProtKB
- proline-rich region binding Source: UniProtKB
GO - Biological processi
- brain development Source: Ensembl
- cellular protein localization Source: UniProtKB
- clathrin-dependent synaptic vesicle endocytosis Source: GO_Central
- endocytosis Source: GO_Central
- endosomal transport Source: GO_Central
- ephrin receptor signaling pathway Source: Reactome
- exocytosis Source: UniProtKB-KW
- G protein-coupled receptor signaling pathway Source: Reactome
- membrane organization Source: Reactome
- negative regulation of neuron apoptotic process Source: Ensembl
- positive regulation of apoptotic process Source: Reactome
- positive regulation of caveolin-mediated endocytosis Source: Ensembl
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of growth hormone secretion Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- protein transport Source: UniProtKB-KW
- regulation of modification of postsynaptic actin cytoskeleton Source: Ensembl
- regulation of small GTPase mediated signal transduction Source: Reactome
- small GTPase mediated signal transduction Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Endocytosis, Exocytosis, Host-virus interaction, Protein transport, Transport |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q15811 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-194840, Rho GTPase cycle R-HSA-3928662, EPHB-mediated forward signaling R-HSA-416482, G alpha (12/13) signalling events R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q15811 |
SIGNORi | Q15811 |
Names & Taxonomyi
Protein namesi | Recommended name: Intersectin-1Alternative name(s): SH3 domain-containing protein 1A1 Publication SH3P17 |
Gene namesi | Name:ITSN1 Synonyms:ITSN2 Publications, SH3D1A1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000205726.13 |
HGNCi | HGNC:6183, ITSN1 |
MIMi | 602442, gene |
neXtProti | NX_Q15811 |
Subcellular locationi
Endosome
- Recycling endosome 1 Publication
- Endosome By similarity
Plasma membrane
- Cell membrane 2 Publications
Other locations
- Endomembrane system 1 Publication
- synaptosome By similarity
- lamellipodium 1 Publication
- clathrin-coated pit 2 Publications
- Cytoplasmic vesicle By similarity
Note: Colocalizes with SGIP1 at the plasma membrane in structures corresponding most probably to clathrin-coated pits (PubMed:20946875). Colocalizes with RAB13 on cytoplasmic vesicles that are most likely recycling endosomes (PubMed:29030480).2 Publications
Nucleus
- Nucleus envelope 1 Publication
Other locations
- Cytoplasm 1 Publication
- Endomembrane system 1 Publication
Note: Shuttles between the cytoplasm and nucleus in an XPO1/CRM1-dependent manner.1 Publication
Other locations
- Endomembrane system 1 Publication
Cytosol
- cytosol Source: Reactome
Endosome
- recycling endosome Source: UniProtKB-SubCell
Nucleus
- nuclear envelope Source: UniProtKB
Plasma Membrane
- clathrin-coated pit Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- apical dendrite Source: Ensembl
- calyx of Held Source: Ensembl
- cytoplasm Source: UniProtKB
- dendritic spine Source: Ensembl
- endocytic vesicle Source: Ensembl
- glutamatergic synapse Source: Ensembl
- lamellipodium Source: UniProtKB-SubCell
- neuronal cell body Source: Ensembl
- presynaptic endocytic zone Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Synapse, SynaptosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1078 | I → K or S: Abolishes interaction with FCHSD2. 1 Publication | 1 | |
Mutagenesisi | 1119 | R → A or E: Abolishes interaction with FCHSD2. 1 Publication | 1 | |
Mutagenesisi | 1369 | M → L: Decreases specificity for CDC42; when associated with I-1376. 1 Publication | 1 | |
Mutagenesisi | 1376 | L → I: Decreases specificity for CDC42; when associated with L-1369. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6453 |
OpenTargetsi | ENSG00000205726 |
PharmGKBi | PA29981 |
Miscellaneous databases
Pharosi | Q15811, Tbio |
Polymorphism and mutation databases
BioMutai | ITSN1 |
DMDMi | 116242596 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080957 | 1 – 1721 | Intersectin-1Add BLAST | 1721 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | PhosphoserineBy similarity | 1 | |
Modified residuei | 687 | PhosphoserineBy similarity | 1 | |
Modified residuei | 897 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 901 | PhosphoserineCombined sources | 1 | |
Modified residuei | 902 | PhosphoserineCombined sources | 1 | |
Modified residuei | 904 | PhosphoserineCombined sources | 1 | |
Modified residuei | 978 | PhosphoserineBy similarity | 1 | |
Modified residuei | 986 | PhosphoserineCombined sources | 1 | |
Modified residuei | 995 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1137 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1144 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1645 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15811 |
jPOSTi | Q15811 |
MassIVEi | Q15811 |
MaxQBi | Q15811 |
PaxDbi | Q15811 |
PeptideAtlasi | Q15811 |
PRIDEi | Q15811 |
ProteomicsDBi | 17792 1818 1824 1825 1827 5114 60768 [Q15811-1] 60769 [Q15811-2] 60770 [Q15811-3] 60771 [Q15811-4] |
PTM databases
iPTMneti | Q15811 |
PhosphoSitePlusi | Q15811 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000205726, Expressed in adipose tissue of abdominal region and 247 other tissues |
ExpressionAtlasi | Q15811, baseline and differential |
Genevisiblei | Q15811, HS |
Organism-specific databases
HPAi | ENSG00000205726, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via DH domain) with CDC42 (PubMed:11584276, PubMed:12006984).
Interacts (via SH3 domain 1) with WASL (PubMed:11584276).
Interacts with dynamin, SNAP25 and SNAP23 (By similarity).
Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2 (PubMed:20448150, PubMed:22484487, PubMed:22648170).
Interacts (via SH3 domains) with REPS1 and SGIP1 (PubMed:20946875).
Interacts with ARHGAP31 (PubMed:11744688).
Interacts with ADAM15 (PubMed:19718658).
Interacts with PRRT2 (By similarity).
Interacts (via SH3 domain 4) with FCHSD2 (via SH3 domain 2) (PubMed:29887380).
Interacts (via SH3 domain 1) with DENND2B (PubMed:29030480).
Interacts (via SH3 domains) with CBL (By similarity). Isoform 2:
Interacts with CBL and DNM1 (PubMed:21712076). Isoform 2:
Interacts with LMNA (PubMed:29599122). Isoform 2:
Interacts with importin subunit KPNA1; this is likely to mediate its import into the nucleus (PubMed:29599122).
By similarity12 Publications(Microbial infection) Interacts with vaccinia virus protein A36 (PubMed:27670116).
1 PublicationBinary interactionsi
Hide detailsQ15811
Isoform 2 [Q15811-2]
With | #Exp. | IntAct |
---|---|---|
INPPL1 [O15357] | 9 | EBI-8052395,EBI-1384248 |
Sh3kbp1 [Q925Q9] from Rattus norvegicus. | 4 | EBI-8052395,EBI-8020091 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB
- proline-rich region binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112351, 146 interactors |
DIPi | DIP-33609N |
IntActi | Q15811, 74 interactors |
MINTi | Q15811 |
STRINGi | 9606.ENSP00000370719 |
Miscellaneous databases
RNActi | Q15811, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15811 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15811 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 109 | EH 1PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 53 – 88 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 221 – 310 | EH 2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 254 – 289 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 740 – 806 | SH3 1PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 913 – 971 | SH3 2PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1002 – 1060 | SH3 3PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1074 – 1138 | SH3 4PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 1155 – 1214 | SH3 5PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 1237 – 1423 | DHPROSITE-ProRule annotationAdd BLAST | 187 | |
Domaini | 1462 – 1571 | PHPROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 1579 – 1695 | C2PROSITE-ProRule annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 326 – 702 | KLERQAdd BLAST | 377 | |
Regioni | 1074 – 1138 | Required for interaction with FCHSD21 PublicationAdd BLAST | 65 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 355 – 659 | Sequence analysisAdd BLAST | 305 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1104 – 1127 | Bipartite nuclear localization signal; in isoform 21 PublicationAdd BLAST | 24 |
Domaini
Keywords - Domaini
Coiled coil, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG1029, Eukaryota KOG4305, Eukaryota |
GeneTreei | ENSGT00940000157065 |
HOGENOMi | CLU_002819_0_0_1 |
InParanoidi | Q15811 |
OMAi | RAVYEFN |
OrthoDBi | 807060at2759 |
PhylomeDBi | Q15811 |
TreeFami | TF324293 |
Family and domain databases
CDDi | cd00052, EH, 2 hits cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR001331, GDS_CDC24_CS IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF12763, EF-hand_4, 2 hits PF16652, PH_13, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits PF07653, SH3_2, 2 hits PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00027, EH, 2 hits SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 5 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50031, EH, 2 hits PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 5 hits |
s (13+)i Sequence
Sequence statusi: Complete.
This entry describes 13 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 13 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP
110 120 130 140 150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV
160 170 180 190 200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
210 220 230 240 250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
260 270 280 290 300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF
360 370 380 390 400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE
410 420 430 440 450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE
460 470 480 490 500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR
510 520 530 540 550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND
560 570 580 590 600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI
610 620 630 640 650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ
660 670 680 690 700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE
710 720 730 740 750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP
760 770 780 790 800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY
810 820 830 840 850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW
860 870 880 890 900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG
910 920 930 940 950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW
960 970 980 990 1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP
1010 1020 1030 1040 1050
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF
1060 1070 1080 1090 1100
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL
1110 1120 1130 1140 1150
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK
1160 1170 1180 1190 1200
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ
1210 1220 1230 1240 1250
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE
1260 1270 1280 1290 1300
NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR
1310 1320 1330 1340 1350
VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA
1360 1370 1380 1390 1400
PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH
1410 1420 1430 1440 1450
PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV
1460 1470 1480 1490 1500
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG
1510 1520 1530 1540 1550
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT
1560 1570 1580 1590 1600
LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV
1610 1620 1630 1640 1650
NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF
1660 1670 1680 1690 1700
IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL
1710 1720
LHEVPTGEIV VRLDLQLFDE P
The sequence of this isoform differs from the canonical sequence as follows:
770-774: Missing.
1006-1020: EFIAMYTYESSEQGD → GLWNCWENREFRKKT
1021-1721: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
116-152: Missing.
770-774: Missing.
1221-1721: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
116-152: Missing.
1006-1076: Missing.
1221-1721: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
116-152: Missing.
770-774: Missing.
1006-1076: Missing.
1221-1721: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
770-774: Missing.
910-919: GEKVEGLQAQ → HGFWFFRESC
920-1721: Missing.
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W7U0 | F8W7U0_HUMAN | Intersectin-1 | ITSN1 | 1,149 | Annotation score: | ||
A8CTZ0 | A8CTZ0_HUMAN | Intersectin 1 short form variant 13 | ITSN1 | 877 | Annotation score: | ||
C9JQZ7 | C9JQZ7_HUMAN | Intersectin-1 | ITSN1 | 361 | Annotation score: | ||
H0Y523 | H0Y523_HUMAN | Intersectin-1 | ITSN1 | 260 | Annotation score: | ||
C9J1A4 | C9J1A4_HUMAN | Intersectin-1 | ITSN1 | 115 | Annotation score: | ||
D6PAW0 | D6PAW0_HUMAN | Intersectin 1 short form A variant ... | ITSN1 | 237 | Annotation score: | ||
C9JXS9 | C9JXS9_HUMAN | Intersectin-1 | ITSN1 | 78 | Annotation score: | ||
H0Y6W3 | H0Y6W3_HUMAN | Intersectin-1 | ITSN1 | 66 | Annotation score: | ||
Q6J334 | Q6J334_HUMAN | Intersectin 1 isoform 10 | ITSN1 | 173 | Annotation score: | ||
H0Y3G5 | H0Y3G5_HUMAN | Intersectin-1 | ITSN1 | 317 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | A → P in AAC78610 (PubMed:9799604).Curated | 1 | |
Sequence conflicti | 114 | A → P in AAC78611 (PubMed:9799604).Curated | 1 | |
Sequence conflicti | 114 | A → P in ABG74695 (PubMed:19777371).Curated | 1 | |
Sequence conflicti | 114 | A → P in ABG74697 (PubMed:19777371).Curated | 1 | |
Sequence conflicti | 114 | A → P in ABG74698 (PubMed:19777371).Curated | 1 | |
Sequence conflicti | 863 | E → G in ABD72328 (PubMed:21712076).Curated | 1 | |
Sequence conflicti | 1088 | T → A in AAD53183 (Ref. 9) Curated | 1 | |
Sequence conflicti | 1109 | G → R in AAD53183 (Ref. 9) Curated | 1 | |
Sequence conflicti | 1361 | A → E in AAC78611 (PubMed:9799604).Curated | 1 | |
Sequence conflicti | 1361 | A → E in AAC50592 (PubMed:9630982).Curated | 1 | |
Sequence conflicti | 1367 | K → R in AAI16187 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1474 | S → N in AAC78611 (PubMed:9799604).Curated | 1 | |
Sequence conflicti | 1474 | S → N in AAC50592 (PubMed:9630982).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070011 | 1137 | S → N2 PublicationsCorresponds to variant dbSNP:rs187895245Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053317 | 116 – 152 | Missing in isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_004293 | 770 – 774 | Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 12 and isoform 13. 6 Publications | 5 | |
Alternative sequenceiVSP_047460 | 910 – 1025 | GEKVE…LTFQQ → PDFLLHPSMRLGHMQPRIVL LFPDPLQCSTSRLLPMLRPR PGVPFLRSPSCQSPSHPSRP ISDAAPSVKFTLMPPGRIHP CFLFIPAVNSRNSFLVYFIL PGGTLGCFYLCLPHYL in isoform 5. 1 PublicationAdd BLAST | 116 | |
Alternative sequenceiVSP_053318 | 910 – 919 | GEKVEGLQAQ → HGFWFFRESC in isoform 13. Curated | 10 | |
Alternative sequenceiVSP_053319 | 920 – 1721 | Missing in isoform 13. CuratedAdd BLAST | 802 | |
Alternative sequenceiVSP_004294 | 1006 – 1076 | Missing in isoform 3, isoform 4, isoform 11 and isoform 12. 4 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_053320 | 1006 – 1020 | EFIAM…SEQGD → GLWNCWENREFRKKT in isoform 6. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_053321 | 1021 – 1721 | Missing in isoform 6. 1 PublicationAdd BLAST | 701 | |
Alternative sequenceiVSP_047461 | 1026 – 1721 | Missing in isoform 5. 1 PublicationAdd BLAST | 696 | |
Alternative sequenceiVSP_004295 | 1221 – 1721 | Missing in isoform 2, isoform 3, isoform 7, isoform 10, isoform 11 and isoform 12. 7 PublicationsAdd BLAST | 501 | |
Alternative sequenceiVSP_053322 | 1392 – 1447 | Missing in isoform 9. 1 PublicationAdd BLAST | 56 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000381291; ENSP00000370691; ENSG00000205726 [Q15811-2] ENST00000381318; ENSP00000370719; ENSG00000205726 [Q15811-1] ENST00000399338; ENSP00000382275; ENSG00000205726 [Q15811-5] ENST00000399349; ENSP00000382286; ENSG00000205726 [Q15811-3] ENST00000399352; ENSP00000382289; ENSG00000205726 [Q15811-7] ENST00000399353; ENSP00000382290; ENSG00000205726 [Q15811-10] ENST00000399367; ENSP00000382301; ENSG00000205726 [Q15811-8] |
GeneIDi | 6453 |
KEGGi | hsa:6453 |
UCSCi | uc002ysw.4, human [Q15811-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KI1 | X-ray | 2.30 | B/D | 1229-1581 | [»] | |
2KGR | NMR | - | A | 210-312 | [»] | |
2KHN | NMR | - | A | 1-111 | [»] | |
3FIA | X-ray | 1.45 | A | 1-111 | [»] | |
3QBV | X-ray | 2.65 | B/D | 1229-1579 | [»] | |
4IIM | X-ray | 1.80 | A/B | 916-970 | [»] | |
5HZI | X-ray | 2.60 | A/B | 1230-1580 | [»] | |
5HZJ | X-ray | 2.60 | A/B | 1230-1580 | [»] | |
5HZK | X-ray | 3.30 | B/D | 1230-1580 | [»] | |
6GBU | X-ray | 3.44 | B/D/F/H | 1074-1138 | [»] | |
6H5T | X-ray | 1.69 | A/B | 741-840 | [»] | |
SMRi | Q15811 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112351, 146 interactors |
DIPi | DIP-33609N |
IntActi | Q15811, 74 interactors |
MINTi | Q15811 |
STRINGi | 9606.ENSP00000370719 |
PTM databases
iPTMneti | Q15811 |
PhosphoSitePlusi | Q15811 |
Polymorphism and mutation databases
BioMutai | ITSN1 |
DMDMi | 116242596 |
Proteomic databases
EPDi | Q15811 |
jPOSTi | Q15811 |
MassIVEi | Q15811 |
MaxQBi | Q15811 |
PaxDbi | Q15811 |
PeptideAtlasi | Q15811 |
PRIDEi | Q15811 |
ProteomicsDBi | 17792 1818 1824 1825 1827 5114 60768 [Q15811-1] 60769 [Q15811-2] 60770 [Q15811-3] 60771 [Q15811-4] |
Protocols and materials databases
ABCDi | Q15811, 2 sequenced antibodies |
Antibodypediai | 7532, 82 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 6453 |
DisGeNETi | 6453 |
EuPathDBi | HostDB:ENSG00000205726.13 |
GeneCardsi | ITSN1 |
HGNCi | HGNC:6183, ITSN1 |
HPAi | ENSG00000205726, Low tissue specificity |
MIMi | 602442, gene |
neXtProti | NX_Q15811 |
OpenTargetsi | ENSG00000205726 |
PharmGKBi | PA29981 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1029, Eukaryota KOG4305, Eukaryota |
GeneTreei | ENSGT00940000157065 |
HOGENOMi | CLU_002819_0_0_1 |
InParanoidi | Q15811 |
OMAi | RAVYEFN |
OrthoDBi | 807060at2759 |
PhylomeDBi | Q15811 |
TreeFami | TF324293 |
Enzyme and pathway databases
PathwayCommonsi | Q15811 |
Reactomei | R-HSA-193648, NRAGE signals death through JNK R-HSA-194840, Rho GTPase cycle R-HSA-3928662, EPHB-mediated forward signaling R-HSA-416482, G alpha (12/13) signalling events R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q15811 |
SIGNORi | Q15811 |
Miscellaneous databases
BioGRID-ORCSi | 6453, 6 hits in 844 CRISPR screens |
ChiTaRSi | ITSN1, human |
EvolutionaryTracei | Q15811 |
GeneWikii | ITSN1 |
GenomeRNAii | 6453 |
Pharosi | Q15811, Tbio |
PROi | PR:Q15811 |
RNActi | Q15811, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205726, Expressed in adipose tissue of abdominal region and 247 other tissues |
ExpressionAtlasi | Q15811, baseline and differential |
Genevisiblei | Q15811, HS |
Family and domain databases
CDDi | cd00052, EH, 2 hits cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR001331, GDS_CDC24_CS IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF12763, EF-hand_4, 2 hits PF16652, PH_13, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits PF07653, SH3_2, 2 hits PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00027, EH, 2 hits SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 5 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50031, EH, 2 hits PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITSN1_HUMAN | |
Accessioni | Q15811Primary (citable) accession number: Q15811 Secondary accession number(s): A7Y322 Q9UQ92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 216 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations