ITSN1

Functionⁱ

Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688).By similarity4 Publications

Isoform 1: Plays a role in synaptic vesicle endocytosis in brain neurons.By similarity

Caution

Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2, and a Dab2 mutant with impaired binding to EH domain-containing proteins EPS15 and ITSN1 suggesting a partially overlapping role of the EH domain-containing proteins.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	66 – 77	1PROSITE-ProRule annotationAdd BLAST		12
Calcium bindingⁱ	267 – 278	2PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: Ensembl
cellular protein localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- Ref.30
  "A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits."
  Almeida-Souza L., Frank R.A.W., Garcia-Nafria J., Colussi A., Gunawardana N., Johnson C.M., Yu M., Howard G., Andrews B., Vallis Y., McMahon H.T.
  Cell 174:325-337(2018) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (3.44 ANGSTROMS) OF 1074-1138 IN COMPLEX WITH FCHSD2, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ILE-1078 AND ARG-1119.
ephrin receptor signaling pathway Source: Reactome
exocytosis Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
membrane organization Source: Reactome
negative regulation of neuron apoptotic process Source: Ensembl
positive regulation of apoptotic process Source: Reactome
positive regulation of caveolin-mediated endocytosis Source: Ensembl
positive regulation of dendritic spine development Source: Ensembl
positive regulation of growth hormone secretion Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
protein transport Source: UniProtKB-KW
regulation of modification of postsynaptic actin cytoskeleton Source: Ensembl
regulation of Rho protein signal transduction Source: InterPro
regulation of small GTPase mediated signal transduction Source: Reactome
small GTPase mediated signal transduction Source: Ensembl
synaptic vesicle endocytosis Source: Ensembl
viral process Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis, Exocytosis, Host-virus interaction, Protein transport, Transport
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-193648 NRAGE signals death through JNK R-HSA-194840 Rho GTPase cycle R-HSA-3928662 EPHB-mediated forward signaling R-HSA-416482 G alpha (12/13) signalling events R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	Q15811
SIGNORⁱ	Q15811

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Intersectin-1 Alternative name(s): SH3 domain-containing protein 1A1 Publication SH3P17
Gene namesⁱ	Name:ITSN1 Synonyms:ITSN2 Publications, SH3D1A1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6183 ITSN1
MIMⁱ	602442 gene
neXtProtⁱ	NX_Q15811

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Synapse, Synaptosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1078	I → K or S: Abolishes interaction with FCHSD2. 1 Publication	1
Mutagenesisⁱ	1119	R → A or E: Abolishes interaction with FCHSD2. 1 Publication	1
Mutagenesisⁱ	1369	M → L: Decreases specificity for CDC42; when associated with I-1376. 1 Publication	1
Mutagenesisⁱ	1376	L → I: Decreases specificity for CDC42; when associated with L-1369. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6453
Open Targets More...OpenTargetsⁱ	ENSG00000205726
PharmGKBⁱ	PA29981

Miscellaneous databases

Pharosⁱ	Q15811

Pharosⁱ

Q15811

Polymorphism and mutation databases

BioMutaⁱ	ITSN1
DMDMⁱ	116242596

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080957	1 – 1721	Intersectin-1Add BLAST		1721

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	203	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphoserineBy similarity	1
Modified residueⁱ	687	PhosphoserineBy similarity	1
Modified residueⁱ	897	PhosphothreonineBy similarity	1
Modified residueⁱ	901	PhosphoserineCombined sources	1
Modified residueⁱ	902	PhosphoserineCombined sources	1
Modified residueⁱ	904	PhosphoserineCombined sources	1
Modified residueⁱ	978	PhosphoserineBy similarity	1
Modified residueⁱ	986	PhosphoserineCombined sources	1
Modified residueⁱ	995	PhosphoserineCombined sources	1
Modified residueⁱ	1137	PhosphoserineCombined sources	1
Modified residueⁱ	1144	PhosphothreonineCombined sources	1
Modified residueⁱ	1645	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15811
jPOSTⁱ	Q15811
MassIVEⁱ	Q15811
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15811
PaxDbⁱ	Q15811
PeptideAtlas More...PeptideAtlasⁱ	Q15811
PRIDEⁱ	Q15811
ProteomicsDBⁱ	17792 1818 1824 1825 1827 5114 60768 [Q15811-1] 60769 [Q15811-2] 60770 [Q15811-3] 60771 [Q15811-4]

PTM databases

iPTMnetⁱ	Q15811
PhosphoSitePlusⁱ	Q15811

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed almost exclusively in the brain. Isoform 2 is detected in brain, spleen, lung, liver, heart, skeletal muscle and kidney. Isoform 5 is primarily expressed in brain, spleen, lung and kidney (at protein level) (PubMed:21712076). Isoform 1 and isoform 2 are detected in brain (PubMed:10482960). Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord (PubMed:9799604, PubMed:21712076, PubMed:11690630).4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000205726 Expressed in 238 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasⁱ	Q15811 baseline and differential
Genevisibleⁱ	Q15811 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018007

HPAⁱ

HPA018007

Interactionⁱ

Subunit structureⁱ

Interacts (via DH domain) with CDC42 (PubMed:11584276, PubMed:12006984).

Interacts (via SH3 domain 1) with WASL (PubMed:11584276).

Interacts with dynamin, SNAP25 and SNAP23 (By similarity).

Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2 (PubMed:20448150, PubMed:22484487, PubMed:22648170).

Interacts (via SH3 domains) with REPS1 and SGIP1 (PubMed:20946875).

Interacts with ARHGAP31 (PubMed:11744688).

Interacts with ADAM15 (PubMed:19718658).

Interacts with PRRT2 (By similarity).

Interacts (via SH3 domain 4) with FCHSD2 (via SH3 domain 2) (PubMed:29887380).

Interacts (via SH3 domain 1) with ST5 (PubMed:29030480).

Interacts (via SH3 domains) with CBL (By similarity). Isoform 2:

Interacts with CBL and DNM1 (PubMed:21712076). Isoform 2:

Interacts with LMNA (PubMed:29599122). Isoform 2:

Interacts with importin subunit KPNA1; this is likely to mediate its import into the nucleus (PubMed:29599122).

By similarity12 Publications

(Microbial infection) Interacts with vaccinia virus protein A36 (PubMed:27670116).

1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CBL	P22681	12	EBI-602041,EBI-518228
CDC42	P60953-1	2	EBI-602041,EBI-3625591
DISC1	Q9NRI5	4	EBI-602041,EBI-529989
DNM2	P50570	2	EBI-602041,EBI-346547
EPS15	P42566	2	EBI-602041,EBI-396684
Fcho2	Q3UQN2	3	EBI-602041,EBI-6094986	From Mus musculus.
INPPL1	O15357	9	EBI-8052395,EBI-1384248
Sh3kbp1	Q925Q9	4	EBI-8052395,EBI-8020091	From Rattus norvegicus.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112351, 140 interactors
Database of interacting proteins More...DIPⁱ	DIP-33609N
IntActⁱ	Q15811, 60 interactors
Molecular INTeraction database More...MINTⁱ	Q15811
STRINGⁱ	9606.ENSP00000370719

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	12 – 14	Combined sources	3
Helixⁱ	19 – 31	Combined sources	13
Beta strandⁱ	35 – 37	Combined sources	3
Beta strandⁱ	38 – 40	Combined sources	3
Helixⁱ	41 – 48	Combined sources	8
Helixⁱ	49 – 51	Combined sources	3
Helixⁱ	55 – 65	Combined sources	11
Beta strandⁱ	70 – 73	Combined sources	4
Helixⁱ	75 – 89	Combined sources	15
Helixⁱ	100 – 102	Combined sources	3
Beta strandⁱ	215 – 217	Combined sources	3
Helixⁱ	219 – 230	Combined sources	12
Beta strandⁱ	239 – 241	Combined sources	3
Helixⁱ	242 – 250	Combined sources	9
Helixⁱ	256 – 266	Combined sources	11
Beta strandⁱ	272 – 275	Combined sources	4
Helixⁱ	276 – 290	Combined sources	15
Helixⁱ	301 – 303	Combined sources	3
Turnⁱ	306 – 309	Combined sources	4
Beta strandⁱ	741 – 747	Combined sources	7
Beta strandⁱ	766 – 769	Combined sources	4
Beta strandⁱ	775 – 778	Combined sources	4
Beta strandⁱ	780 – 782	Combined sources	3
Beta strandⁱ	784 – 789	Combined sources	6
Beta strandⁱ	792 – 797	Combined sources	6
Helixⁱ	798 – 800	Combined sources	3
Beta strandⁱ	801 – 803	Combined sources	3
Beta strandⁱ	916 – 922	Combined sources	7
Beta strandⁱ	939 – 945	Combined sources	7
Beta strandⁱ	947 – 954	Combined sources	8
Beta strandⁱ	957 – 962	Combined sources	6
Helixⁱ	963 – 965	Combined sources	3
Beta strandⁱ	966 – 969	Combined sources	4
Beta strandⁱ	1078 – 1081	Combined sources	4
Beta strandⁱ	1100 – 1106	Combined sources	7
Beta strandⁱ	1110 – 1117	Combined sources	8
Beta strandⁱ	1119 – 1121	Combined sources	3
Beta strandⁱ	1125 – 1129	Combined sources	5
Helixⁱ	1130 – 1132	Combined sources	3
Beta strandⁱ	1133 – 1136	Combined sources	4
Helixⁱ	1233 – 1262	Combined sources	30
Helixⁱ	1264 – 1269	Combined sources	6
Beta strandⁱ	1271 – 1273	Combined sources	3
Helixⁱ	1275 – 1282	Combined sources	8
Helixⁱ	1285 – 1306	Combined sources	22
Beta strandⁱ	1308 – 1310	Combined sources	3
Helixⁱ	1316 – 1322	Combined sources	7
Helixⁱ	1323 – 1327	Combined sources	5
Helixⁱ	1328 – 1349	Combined sources	22
Helixⁱ	1351 – 1361	Combined sources	11
Helixⁱ	1364 – 1366	Combined sources	3
Helixⁱ	1371 – 1374	Combined sources	4
Helixⁱ	1377 – 1393	Combined sources	17
Helixⁱ	1403 – 1437	Combined sources	35
Beta strandⁱ	1444 – 1447	Combined sources	4
Beta strandⁱ	1451 – 1454	Combined sources	4
Beta strandⁱ	1456 – 1460	Combined sources	5
Beta strandⁱ	1463 – 1466	Combined sources	4
Beta strandⁱ	1472 – 1474	Combined sources	3
Beta strandⁱ	1479 – 1493	Combined sources	15
Beta strandⁱ	1511 – 1513	Combined sources	3
Helixⁱ	1522 – 1524	Combined sources	3
Beta strandⁱ	1525 – 1528	Combined sources	4
Beta strandⁱ	1531 – 1533	Combined sources	3
Beta strandⁱ	1541 – 1544	Combined sources	4
Beta strandⁱ	1547 – 1550	Combined sources	4
Helixⁱ	1556 – 1577	Combined sources	22

Show more details

3D structure databases

SMRⁱ	Q15811
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15811

EvolutionaryTraceⁱ

Q15811

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 109	EH 1PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	53 – 88	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	221 – 310	EH 2PROSITE-ProRule annotationAdd BLAST	90
Domainⁱ	254 – 289	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	740 – 806	SH3 1PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	913 – 971	SH3 2PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	1002 – 1060	SH3 3PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	1074 – 1138	SH3 4PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	1155 – 1214	SH3 5PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	1237 – 1423	DHPROSITE-ProRule annotationAdd BLAST	187
Domainⁱ	1462 – 1571	PHPROSITE-ProRule annotationAdd BLAST	110
Domainⁱ	1583 – 1679	C2PROSITE-ProRule annotationAdd BLAST	97

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	326 – 702	KLERQAdd BLAST		377
Regionⁱ	1074 – 1138	Required for interaction with FCHSD21 PublicationAdd BLAST		65

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	355 – 659	Sequence analysisAdd BLAST		305

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1104 – 1127	Bipartite nuclear localization signal; in isoform 21 PublicationAdd BLAST		24

Domainⁱ

SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.By similarity

The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity

In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.By similarity

Keywords - Domainⁱ

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG1029 Eukaryota KOG4305 Eukaryota COG5422 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157065
HOGENOMⁱ	HOG000010175
InParanoidⁱ	Q15811
KEGG Orthology (KO) More...KOⁱ	K20045
OMAⁱ	HDEISIA
Database of Orthologous Groups More...OrthoDBⁱ	807060at2759
PhylomeDBⁱ	Q15811
TreeFamⁱ	TF324293

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00052 EH, 2 hits cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR035899 DBL_dom_sf IPR000219 DH-domain IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000261 EH_dom IPR001331 GDS_CDC24_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF12763 EF-hand_4, 2 hits PF16652 PH_13, 1 hit PF00621 RhoGEF, 1 hit PF00018 SH3_1, 3 hits PF14604 SH3_9, 2 hits
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00027 EH, 2 hits SM00233 PH, 1 hit SM00325 RhoGEF, 1 hit SM00326 SH3, 5 hits
SUPFAMⁱ	SSF47473 SSF47473, 2 hits SSF48065 SSF48065, 1 hit SSF50044 SSF50044, 5 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00741 DH_1, 1 hit PS50010 DH_2, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS50031 EH, 2 hits PS50003 PH_DOMAIN, 1 hit PS50002 SH3, 5 hits

Sequences (13+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 13 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist. Alternative splicing affects domains involved in protein recognition and thus may play a role in selecting specific interactions.2 Publications

This entry has 13 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15811-1) [UniParc]FASTA Add to basket

Also known as: Long, ITSN-l

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY 
       810        820        830        840        850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW 
       860        870        880        890        900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
       910        920        930        940        950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW 
       960        970        980        990       1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP 
      1010       1020       1030       1040       1050
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF 
      1060       1070       1080       1090       1100
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL 
      1110       1120       1130       1140       1150
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK 
      1160       1170       1180       1190       1200
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ 
      1210       1220       1230       1240       1250
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE 
      1260       1270       1280       1290       1300
NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR 
      1310       1320       1330       1340       1350
VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA 
      1360       1370       1380       1390       1400
PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH 
      1410       1420       1430       1440       1450
PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV 
      1460       1470       1480       1490       1500
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG 
      1510       1520       1530       1540       1550
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT 
      1560       1570       1580       1590       1600
LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV 
      1610       1620       1630       1640       1650
NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF 
      1660       1670       1680       1690       1700
IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL 
      1710       1720 
LHEVPTGEIV VRLDLQLFDE P

Length:1,721

Mass (Da):195,422

Last modified:October 17, 2006 - v3

Checksum:ⁱFC4DE644D8BEA2BE

GO

Isoform 2 (identifier: Q15811-2) [UniParc]FASTA Add to basket

Also known as: Short, ITSN-s1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY 
       810        820        830        840        850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW 
       860        870        880        890        900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
       910        920        930        940        950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW 
       960        970        980        990       1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP 
      1010       1020       1030       1040       1050
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF 
      1060       1070       1080       1090       1100
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL 
      1110       1120       1130       1140       1150
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK 
      1160       1170       1180       1190       1200
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ 
      1210       1220
VGLFPSNYVK LTTDMDPSQQ

Show »

Length:1,220

Mass (Da):137,649

Checksum:ⁱB09FDBEF1C06F487

GO

Isoform 3 (identifier: Q15811-3) [UniParc]FASTA Add to basket

Also known as: Short 2, SH3P17

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ 
       960        970        980        990       1000
GQKGWFPKSY VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE 
      1010       1020       1030       1040       1050
EIAQVIASYT ATGPEQLTLA PGQLILIRKK NPGGWWEGEL QARGKKRQIG 
      1060       1070       1080       1090       1100
WFPANYVKLL SPGTSKITPT EPPKSTALAA VCQVIGMYDY TAQNDDELAF 
      1110       1120       1130       1140 
NKGQIINVLN KEDPDWWKGE VNGQVGLFPS NYVKLTTDMD PSQQ

Show »

Length:1,144

Mass (Da):129,416

Checksum:ⁱ8EEE8BE230C2F8C7

GO

Isoform 4 (identifier: Q15811-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1006-1076: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY 
       810        820        830        840        850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW 
       860        870        880        890        900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
       910        920        930        940        950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW 
       960        970        980        990       1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP 
      1010       1020       1030       1040       1050
VVSGEEIAQV IASYTATGPE QLTLAPGQLI LIRKKNPGGW WEGELQARGK 
      1060       1070       1080       1090       1100
KRQIGWFPAN YVKLLSPGTS KITPTEPPKS TALAAVCQVI GMYDYTAQND 
      1110       1120       1130       1140       1150
DELAFNKGQI INVLNKEDPD WWKGEVNGQV GLFPSNYVKL TTDMDPSQQW 
      1160       1170       1180       1190       1200
CSDLHLLDML TPTERKRQGY IHELIVTEEN YVNDLQLVTE IFQKPLMESE 
      1210       1220       1230       1240       1250
LLTEKEVAMI FVNWKELIMC NIKLLKALRV RKKMSGEKMP VKMIGDILSA 
      1260       1270       1280       1290       1300
QLPHMQPYIR FCSRQLNGAA LIQQKTDEAP DFKEFVKRLA MDPRCKGMPL 
      1310       1320       1330       1340       1350
SSFILKPMQR VTRYPLIIKN ILENTPENHP DHSHLKHALE KAEELCSQVN 
      1360       1370       1380       1390       1400
EGVREKENSD RLEWIQAHVQ CEGLSEQLVF NSVTNCLGPR KFLHSGKLYK 
      1410       1420       1430       1440       1450
AKSNKELYGF LFNDFLLLTQ ITKPLGSSGT DKVFSPKSNL QYKMYKTPIF 
      1460       1470       1480       1490       1500
LNEVLVKLPT DPSGDEPIFH ISHIDRVYTL RAESINERTA WVQKIKAASE 
      1510       1520       1530       1540       1550
LYIETEKKKR EKAYLVRSQR ATGIGRLMVN VVEGIELKPC RSHGKSNPYC 
      1560       1570       1580       1590       1600
EVTMGSQCHI TKTIQDTLNP KWNSNCQFFI RDLEQEVLCI TVFERDQFSP 
      1610       1620       1630       1640       1650
DDFLGRTEIR VADIKKDQGS KGPVTKCLLL HEVPTGEIVV RLDLQLFDEP

Show »

Length:1,650

Mass (Da):187,788

Checksum:ⁱ584F3A7AD02E4434

GO

Isoform 5 (identifier: Q15811-5) [UniParc]FASTA Add to basket

Also known as: ITSN1-22a

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-1025: GEKVEGLQAQ...SEQGDLTFQQ → PDFLLHPSMR...CFYLCLPHYL
     1026-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQPDFLLH PSMRLGHMQP RIVLLFPDPL QCSTSRLLPM LRPRPGVPFL 
       960        970        980        990       1000
RSPSCQSPSH PSRPISDAAP SVKFTLMPPG RIHPCFLFIP AVNSRNSFLV 
      1010       1020
YFILPGGTLG CFYLCLPHYL

Show »

Length:1,020

Mass (Da):115,873

Checksum:ⁱ53D58238CDB49BB4

GO

Isoform 6 (identifier: Q15811-6) [UniParc]FASTA Add to basket

Also known as: Long form variant 4, Short form variant 11

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1020: EFIAMYTYESSEQGD → GLWNCWENREFRKKT
     1021-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ 
       960        970        980        990       1000
GQKGWFPKSY VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE 
      1010 
GLWNCWENRE FRKKT

Note: Contains a premature stop codon, potentially subjected to NMD.

Show »

Length:1,015

Mass (Da):115,477

Checksum:ⁱ7FAD870DF7E4D42E

GO

Isoform 7 (identifier: Q15811-7) [UniParc]FASTA Add to basket

Also known as: Short form variant 5

The sequence of this isoform differs from the canonical sequence as follows:
770-774: Missing.
1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ 
       960        970        980        990       1000
GQKGWFPKSY VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE 
      1010       1020       1030       1040       1050
EFIAMYTYES SEQGDLTFQQ GDVILVTKKD GDWWTGTVGD KAGVFPSNYV 
      1060       1070       1080       1090       1100
RLKDSEGSGT AGKTGSLGKK PEIAQVIASY TATGPEQLTL APGQLILIRK 
      1110       1120       1130       1140       1150
KNPGGWWEGE LQARGKKRQI GWFPANYVKL LSPGTSKITP TEPPKSTALA 
      1160       1170       1180       1190       1200
AVCQVIGMYD YTAQNDDELA FNKGQIINVL NKEDPDWWKG EVNGQVGLFP 
      1210 
SNYVKLTTDM DPSQQ

Show »

Length:1,215

Mass (Da):137,049

Checksum:ⁱ9610DEBFC4781CED

GO

Isoform 8 (identifier: Q15811-8) [UniParc]FASTA Add to basket

Also known as: Long form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
770-774: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ 
       960        970        980        990       1000
GQKGWFPKSY VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE 
      1010       1020       1030       1040       1050
EFIAMYTYES SEQGDLTFQQ GDVILVTKKD GDWWTGTVGD KAGVFPSNYV 
      1060       1070       1080       1090       1100
RLKDSEGSGT AGKTGSLGKK PEIAQVIASY TATGPEQLTL APGQLILIRK 
      1110       1120       1130       1140       1150
KNPGGWWEGE LQARGKKRQI GWFPANYVKL LSPGTSKITP TEPPKSTALA 
      1160       1170       1180       1190       1200
AVCQVIGMYD YTAQNDDELA FNKGQIINVL NKEDPDWWKG EVNGQVGLFP 
      1210       1220       1230       1240       1250
SNYVKLTTDM DPSQQWCSDL HLLDMLTPTE RKRQGYIHEL IVTEENYVND 
      1260       1270       1280       1290       1300
LQLVTEIFQK PLMESELLTE KEVAMIFVNW KELIMCNIKL LKALRVRKKM 
      1310       1320       1330       1340       1350
SGEKMPVKMI GDILSAQLPH MQPYIRFCSR QLNGAALIQQ KTDEAPDFKE 
      1360       1370       1380       1390       1400
FVKRLAMDPR CKGMPLSSFI LKPMQRVTRY PLIIKNILEN TPENHPDHSH 
      1410       1420       1430       1440       1450
LKHALEKAEE LCSQVNEGVR EKENSDRLEW IQAHVQCEGL SEQLVFNSVT 
      1460       1470       1480       1490       1500
NCLGPRKFLH SGKLYKAKSN KELYGFLFND FLLLTQITKP LGSSGTDKVF 
      1510       1520       1530       1540       1550
SPKSNLQYKM YKTPIFLNEV LVKLPTDPSG DEPIFHISHI DRVYTLRAES 
      1560       1570       1580       1590       1600
INERTAWVQK IKAASELYIE TEKKKREKAY LVRSQRATGI GRLMVNVVEG 
      1610       1620       1630       1640       1650
IELKPCRSHG KSNPYCEVTM GSQCHITKTI QDTLNPKWNS NCQFFIRDLE 
      1660       1670       1680       1690       1700
QEVLCITVFE RDQFSPDDFL GRTEIRVADI KKDQGSKGPV TKCLLLHEVP 
      1710 
TGEIVVRLDL QLFDEP

Show »

Length:1,716

Mass (Da):194,822

Checksum:ⁱA129042F01C34A47

GO

Isoform 9 (identifier: Q15811-9) [UniParc]FASTA Add to basket

Also known as: Long form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
770-774: Missing.
1392-1447: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910        920        930        940        950
VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ 
       960        970        980        990       1000
GQKGWFPKSY VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE 
      1010       1020       1030       1040       1050
EFIAMYTYES SEQGDLTFQQ GDVILVTKKD GDWWTGTVGD KAGVFPSNYV 
      1060       1070       1080       1090       1100
RLKDSEGSGT AGKTGSLGKK PEIAQVIASY TATGPEQLTL APGQLILIRK 
      1110       1120       1130       1140       1150
KNPGGWWEGE LQARGKKRQI GWFPANYVKL LSPGTSKITP TEPPKSTALA 
      1160       1170       1180       1190       1200
AVCQVIGMYD YTAQNDDELA FNKGQIINVL NKEDPDWWKG EVNGQVGLFP 
      1210       1220       1230       1240       1250
SNYVKLTTDM DPSQQWCSDL HLLDMLTPTE RKRQGYIHEL IVTEENYVND 
      1260       1270       1280       1290       1300
LQLVTEIFQK PLMESELLTE KEVAMIFVNW KELIMCNIKL LKALRVRKKM 
      1310       1320       1330       1340       1350
SGEKMPVKMI GDILSAQLPH MQPYIRFCSR QLNGAALIQQ KTDEAPDFKE 
      1360       1370       1380       1390       1400
FVKRLAMDPR CKGMPLSSFI LKPMQRVTRY PLIIKNQLVF NSVTNCLGPR 
      1410       1420       1430       1440       1450
KFLHSGKLYK AKSNKELYGF LFNDFLLLTQ ITKPLGSSGT DKVFSPKSNL 
      1460       1470       1480       1490       1500
QYKMYKTPIF LNEVLVKLPT DPSGDEPIFH ISHIDRVYTL RAESINERTA 
      1510       1520       1530       1540       1550
WVQKIKAASE LYIETEKKKR EKAYLVRSQR ATGIGRLMVN VVEGIELKPC 
      1560       1570       1580       1590       1600
RSHGKSNPYC EVTMGSQCHI TKTIQDTLNP KWNSNCQFFI RDLEQEVLCI 
      1610       1620       1630       1640       1650
TVFERDQFSP DDFLGRTEIR VADIKKDQGS KGPVTKCLLL HEVPTGEIVV 
      1660
RLDLQLFDEP

Show »

Length:1,660

Mass (Da):188,382

Checksum:ⁱ715F81F741A346E4

GO

Isoform 10 (identifier: Q15811-10) [UniParc]FASTA Add to basket

Also known as: Short form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFAAVPP LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR 
       160        170        180        190        200
SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV PQSSRLKYRQ LFNSHDKTMS 
       210        220        230        240        250
GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE EFILAMHLID 
       260        270        280        290        300
VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 
       310        320        330        340        350
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE 
       360        370        380        390        400
RAEQERKERE RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA 
       410        420        430        440        450
KRELERQRQL EWERNRRQEL LNQRNKEQED IVVLKAKKKT LEFELEALND 
       460        470        480        490        500
KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR ELRIAEITHL QQQLQESQQM 
       510        520        530        540        550
LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL ARQHLRDQLD 
       560        570        580        590        600
EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 
       610        620        630        640        650
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES 
       660        670        680        690        700
VKKKDGEEKG KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ 
       710        720        730        740        750
ENVKVVYYRA LYPFESRSHD EITIQPGDIV MVDESQTGEP GWLGGELKGK 
       760        770        780        790        800
TGWFPANYAE KIPENEVPAP VKPVTDSTSA PAPKLALRET PAPLAVTSSE 
       810        820        830        840        850
PSTTPNNWAD FSSTWPTSTN EKPETDNWDA WAAQPSLTVP SAGQLRQRSA 
       860        870        880        890        900
FTPATATGSS PSPVLGQGEK VEGLQAQALY PWRAKKDNHL NFNKNDVITV 
       910        920        930        940        950
LEQQDMWWFG EVQGQKGWFP KSYVKLISGP IRKSTSMDSG SSESPASLKR 
       960        970        980        990       1000
VASPAAKPVV SGEEFIAMYT YESSEQGDLT FQQGDVILVT KKDGDWWTGT 
      1010       1020       1030       1040       1050
VGDKAGVFPS NYVRLKDSEG SGTAGKTGSL GKKPEIAQVI ASYTATGPEQ 
      1060       1070       1080       1090       1100
LTLAPGQLIL IRKKNPGGWW EGELQARGKK RQIGWFPANY VKLLSPGTSK 
      1110       1120       1130       1140       1150
ITPTEPPKST ALAAVCQVIG MYDYTAQNDD ELAFNKGQII NVLNKEDPDW 
      1160       1170 
WKGEVNGQVG LFPSNYVKLT TDMDPSQQ

Show »

Length:1,178

Mass (Da):133,560

Checksum:ⁱA344C5964504BDB1

GO

Isoform 11 (identifier: Q15811-11) [UniParc]FASTA Add to basket

Also known as: Short form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFAAVPP LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR 
       160        170        180        190        200
SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV PQSSRLKYRQ LFNSHDKTMS 
       210        220        230        240        250
GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE EFILAMHLID 
       260        270        280        290        300
VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 
       310        320        330        340        350
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE 
       360        370        380        390        400
RAEQERKERE RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA 
       410        420        430        440        450
KRELERQRQL EWERNRRQEL LNQRNKEQED IVVLKAKKKT LEFELEALND 
       460        470        480        490        500
KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR ELRIAEITHL QQQLQESQQM 
       510        520        530        540        550
LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL ARQHLRDQLD 
       560        570        580        590        600
EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 
       610        620        630        640        650
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES 
       660        670        680        690        700
VKKKDGEEKG KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ 
       710        720        730        740        750
ENVKVVYYRA LYPFESRSHD EITIQPGDIV MVKGEWVDES QTGEPGWLGG 
       760        770        780        790        800
ELKGKTGWFP ANYAEKIPEN EVPAPVKPVT DSTSAPAPKL ALRETPAPLA 
       810        820        830        840        850
VTSSEPSTTP NNWADFSSTW PTSTNEKPET DNWDAWAAQP SLTVPSAGQL 
       860        870        880        890        900
RQRSAFTPAT ATGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN 
       910        920        930        940        950
DVITVLEQQD MWWFGEVQGQ KGWFPKSYVK LISGPIRKST SMDSGSSESP 
       960        970        980        990       1000
ASLKRVASPA AKPVVSGEEI AQVIASYTAT GPEQLTLAPG QLILIRKKNP 
      1010       1020       1030       1040       1050
GGWWEGELQA RGKKRQIGWF PANYVKLLSP GTSKITPTEP PKSTALAAVC 
      1060       1070       1080       1090       1100
QVIGMYDYTA QNDDELAFNK GQIINVLNKE DPDWWKGEVN GQVGLFPSNY 
      1110 
VKLTTDMDPS QQ

Show »

Length:1,112

Mass (Da):126,526

Checksum:ⁱAB25F8723B3FD22A

GO

Isoform 12 (identifier: Q15811-12) [UniParc]FASTA Add to basket

Also known as: Short form variant 10

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFAAVPP LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR 
       160        170        180        190        200
SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV PQSSRLKYRQ LFNSHDKTMS 
       210        220        230        240        250
GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE EFILAMHLID 
       260        270        280        290        300
VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 
       310        320        330        340        350
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE 
       360        370        380        390        400
RAEQERKERE RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA 
       410        420        430        440        450
KRELERQRQL EWERNRRQEL LNQRNKEQED IVVLKAKKKT LEFELEALND 
       460        470        480        490        500
KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR ELRIAEITHL QQQLQESQQM 
       510        520        530        540        550
LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL ARQHLRDQLD 
       560        570        580        590        600
EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 
       610        620        630        640        650
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES 
       660        670        680        690        700
VKKKDGEEKG KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ 
       710        720        730        740        750
ENVKVVYYRA LYPFESRSHD EITIQPGDIV MVDESQTGEP GWLGGELKGK 
       760        770        780        790        800
TGWFPANYAE KIPENEVPAP VKPVTDSTSA PAPKLALRET PAPLAVTSSE 
       810        820        830        840        850
PSTTPNNWAD FSSTWPTSTN EKPETDNWDA WAAQPSLTVP SAGQLRQRSA 
       860        870        880        890        900
FTPATATGSS PSPVLGQGEK VEGLQAQALY PWRAKKDNHL NFNKNDVITV 
       910        920        930        940        950
LEQQDMWWFG EVQGQKGWFP KSYVKLISGP IRKSTSMDSG SSESPASLKR 
       960        970        980        990       1000
VASPAAKPVV SGEEIAQVIA SYTATGPEQL TLAPGQLILI RKKNPGGWWE 
      1010       1020       1030       1040       1050
GELQARGKKR QIGWFPANYV KLLSPGTSKI TPTEPPKSTA LAAVCQVIGM 
      1060       1070       1080       1090       1100
YDYTAQNDDE LAFNKGQIIN VLNKEDPDWW KGEVNGQVGL FPSNYVKLTT 

DMDPSQQ

Show »

Length:1,107

Mass (Da):125,926

Checksum:ⁱ7724CCE4FA98098A

GO

Isoform 13 (identifier: Q15811-13) [UniParc]FASTA Add to basket

Also known as: Short form variant 14

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-919: GEKVEGLQAQ → HGFWFFRESC
     920-1721: Missing.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVD ESQTGEPGWL GGELKGKTGW FPANYAEKIP 
       810        820        830        840        850
ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST TPNNWADFSS 
       860        870        880        890        900
TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 
       910 
VLGQHGFWFF RESC

Note: Contains a premature stop codon, potentially subjected to NMD.

Show »

Length:914

Mass (Da):104,194

Checksum:ⁱ3788E745D07FE820

GO

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	F8W7U0	F8W7U0_HUMAN	Intersectin-1 Intersectin-1	ITSN1	1,149	Annotation score:
	A8CTZ0	A8CTZ0_HUMAN	Intersectin 1 short form variant 13 Intersectin 1 short form variant 13 (Intersectin-1)	ITSN1	877	Annotation score:
	C9JQZ7	C9JQZ7_HUMAN	Intersectin-1 Intersectin-1	ITSN1	361	Annotation score:
	H0Y523	H0Y523_HUMAN	Intersectin-1 Intersectin-1	ITSN1	260	Annotation score:
	C9J1A4	C9J1A4_HUMAN	Intersectin-1 Intersectin-1	ITSN1	115	Annotation score:
	D6PAW0	D6PAW0_HUMAN	Intersectin 1 short form A variant ... Intersectin 1 short form A variant 3 (Intersectin-1)	ITSN1	237	Annotation score:
	C9JXS9	C9JXS9_HUMAN	Intersectin-1 Intersectin-1	ITSN1	78	Annotation score:
	H0Y3G5	H0Y3G5_HUMAN	Intersectin-1 Intersectin-1	ITSN1	317	Annotation score:
	H0Y6W3	H0Y6W3_HUMAN	Intersectin-1 Intersectin-1	ITSN1	66	Annotation score:
	Q6J334	Q6J334_HUMAN	Intersectin 1 isoform 10 Intersectin 1 isoform 10 (Intersectin-1)	ITSN1	173	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAC50592 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114	A → P in AAC78610 (PubMed:9799604).Curated	1
Sequence conflictⁱ	114	A → P in AAC78611 (PubMed:9799604).Curated	1
Sequence conflictⁱ	114	A → P in ABG74695 (PubMed:19777371).Curated	1
Sequence conflictⁱ	114	A → P in ABG74697 (PubMed:19777371).Curated	1
Sequence conflictⁱ	114	A → P in ABG74698 (PubMed:19777371).Curated	1
Sequence conflictⁱ	863	E → G in ABD72328 (PubMed:21712076).Curated	1
Sequence conflictⁱ	1088	T → A in AAD53183 (Ref. 9) Curated	1
Sequence conflictⁱ	1109	G → R in AAD53183 (Ref. 9) Curated	1
Sequence conflictⁱ	1361	A → E in AAC78611 (PubMed:9799604).Curated	1
Sequence conflictⁱ	1361	A → E in AAC50592 (PubMed:9630982).Curated	1
Sequence conflictⁱ	1367	K → R in AAI16187 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1474	S → N in AAC78611 (PubMed:9799604).Curated	1
Sequence conflictⁱ	1474	S → N in AAC50592 (PubMed:9630982).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070011	1137	S → N2 PublicationsCorresponds to variant dbSNP:rs187895245Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053317	116 – 152	Missing in isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST	37
Alternative sequenceⁱVSP_004293	770 – 774	Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 12 and isoform 13. 6 Publications	5
Alternative sequenceⁱVSP_047460	910 – 1025	GEKVE…LTFQQ → PDFLLHPSMRLGHMQPRIVL LFPDPLQCSTSRLLPMLRPR PGVPFLRSPSCQSPSHPSRP ISDAAPSVKFTLMPPGRIHP CFLFIPAVNSRNSFLVYFIL PGGTLGCFYLCLPHYL in isoform 5. 1 PublicationAdd BLAST	116
Alternative sequenceⁱVSP_053318	910 – 919	GEKVEGLQAQ → HGFWFFRESC in isoform 13. Curated	10
Alternative sequenceⁱVSP_053319	920 – 1721	Missing in isoform 13. CuratedAdd BLAST	802
Alternative sequenceⁱVSP_004294	1006 – 1076	Missing in isoform 3, isoform 4, isoform 11 and isoform 12. 4 PublicationsAdd BLAST	71
Alternative sequenceⁱVSP_053320	1006 – 1020	EFIAM…SEQGD → GLWNCWENREFRKKT in isoform 6. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_053321	1021 – 1721	Missing in isoform 6. 1 PublicationAdd BLAST	701
Alternative sequenceⁱVSP_047461	1026 – 1721	Missing in isoform 5. 1 PublicationAdd BLAST	696
Alternative sequenceⁱVSP_004295	1221 – 1721	Missing in isoform 2, isoform 3, isoform 7, isoform 10, isoform 11 and isoform 12. 7 PublicationsAdd BLAST	501
Alternative sequenceⁱVSP_053322	1392 – 1447	Missing in isoform 9. 1 PublicationAdd BLAST	56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064244 mRNA Translation: AAC78611.1 AF064247, AF064245, AF064246 Genomic DNA Translation: AAC80437.1 AF064243 mRNA Translation: AAC78610.1 AF114488 mRNA Translation: AAD29953.1 AF114487 mRNA Translation: AAD29952.1 DQ679754 mRNA Translation: ABG74695.1 DQ679756 mRNA Translation: ABG74697.1 DQ679757 mRNA Translation: ABG74698.1 EU117382 mRNA Translation: ABV21755.1 EU140799 mRNA Translation: ABV58335.1 EU140800 mRNA Translation: ABV58336.1 EU120733 mRNA Translation: ABV24866.1 EU120734 mRNA Translation: ABV24867.1 EU120735 mRNA Translation: ABV24868.1 EU152331 mRNA Translation: ABV69555.1 DQ386455 mRNA Translation: ABD72328.1 AK300274 mRNA Translation: BAG62034.1 AP000308 Genomic DNA No translation available. AP000309 Genomic DNA No translation available. AP000310 Genomic DNA No translation available. AP000311 Genomic DNA No translation available. AP000312 Genomic DNA No translation available. AP000313 Genomic DNA No translation available. BC117560 mRNA Translation: AAI17561.1 BC116186 mRNA Translation: AAI16187.1 U61166 mRNA Translation: AAC50592.1 Different initiation. AF180522 mRNA Translation: AAD53183.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33545.1 [Q15811-1] CCDS33546.1 [Q15811-2] CCDS82663.1 [Q15811-7] CCDS82664.1 [Q15811-8] CCDS82665.1 [Q15811-3] CCDS82666.1 [Q15811-10]
NCBI Reference Sequences More...RefSeqⁱ	NP_001001132.1, NM_001001132.1 [Q15811-2] NP_001317938.1, NM_001331009.1 [Q15811-7] NP_001317939.1, NM_001331010.1 [Q15811-8] NP_001317940.1, NM_001331011.1 [Q15811-3] NP_001317941.1, NM_001331012.1 [Q15811-10] NP_003015.2, NM_003024.2 [Q15811-1] XP_011527994.1, XM_011529692.1 [Q15811-12] XP_011527995.1, XM_011529693.2 [Q15811-5] XP_016883917.1, XM_017028428.1 [Q15811-1] XP_016883921.1, XM_017028432.1 [Q15811-9] XP_016883922.1, XM_017028433.1 [Q15811-4] XP_016883929.1, XM_017028440.1 [Q15811-11]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15811	Isoform 2 of Intersectin-1		HUMAN		1220	UniRef100_Q15811
UPI0007DC77CE		HUMAN		1185
Q15811-3	Intersectin 1 short form A variant 2		HUMAN		1028	UniRef100_D6PAV9
UPI0007DC79B8		HUMAN		1645
Q15811-4	Intersectin-1		HUMAN		1149	UniRef100_F8W7U0
Q15811-6	Intersectin isoform 3 (Fragment)		HUMAN		49	UniRef100_Q15811-6

Protein	Similar proteins		Species	Score	Length	Source
Q15811	Intersectin-1	)	MOUSE		1714	UniRef90_Q15811
Intersectin-1	)	RAT		1713
Isoform 2 of Intersectin-1		HUMAN		1220
Uncharacterized protein		CERAT		1723
intersectin-1 isoform X2		VULVU		1722
+355
Q15811-3	Isoform 11 of Intersectin-1		HUMAN		1112	UniRef90_Q15811-11
Uncharacterized protein		CHLSB		1649
ITSN1 isoform 10		PANTR		1149
Uncharacterized protein		MACMU		1148
Uncharacterized protein		MACFA		1148
+29
Q15811-5	ITSN1 isoform 15		PONAB		1020	UniRef90_Q15811-5
Uncharacterized protein		Cebus capucinus imitator		1020
Intersectin 1		CALJA		1020
ITSN1 isoform 14		PANTR		1020
Uncharacterized protein		RHIBE		1019
+13
Q15811-6	Intersectin isoform 3 (Fragment)		HUMAN		49	UniRef90_Q15811-6
Intersectin 1 isoform ITSN-l (Predicted), 5 prime (Fragment)		RABIT		1216
ITSN1 isoform 1		PONAB		1178
Intersectin 1 long form variant 4		LYNPA		1015
UPI000C879FE8		PTEVA		1216
+2
Q15811-13	intersectin-1 isoform X3		TURTR		1062	UniRef90_Q15811-13
Intersectin-1 isoform X7		PIG		964
Uncharacterized protein		NOMLE		892
UPI000F445EE9		LAGOL		1014
intersectin-1 isoform X4		TURTR		1014
+1

Protein	Similar proteins		Species	Score	Length	Source
Q15811	Intersectin-1	)	MOUSE		1714	UniRef50_Q15811
Intersectin-1	)	RAT		1713
Intersectin-1		XENLA		1705
Isoform 2 of Intersectin-1		HUMAN		1220
Uncharacterized protein		CERAT		1723
+856
Q15811-5	ITSN1 isoform 14		PANTR		1020	UniRef50_Q15811-5
Uncharacterized protein		Cebus capucinus imitator		1020
Intersectin 1		CALJA		1020
ITSN1 isoform 15		PONAB		1020
Uncharacterized protein		CERAT		1019
+58
Q15811-6	Intersectin isoform 3 (Fragment)		HUMAN		49	UniRef50_Q15811-6
Intersectin 1 isoform ITSN-l (Predicted), 5 prime (Fragment)		RABIT		1216
ITSN1 isoform 1		PONAB		1178
Intersectin 1 long form variant 4		LYNPA		1015
Intersectin 1		ANAPP		1151
+69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064244 mRNA Translation: AAC78611.1 AF064247, AF064245, AF064246 Genomic DNA Translation: AAC80437.1 AF064243 mRNA Translation: AAC78610.1 AF114488 mRNA Translation: AAD29953.1 AF114487 mRNA Translation: AAD29952.1 DQ679754 mRNA Translation: ABG74695.1 DQ679756 mRNA Translation: ABG74697.1 DQ679757 mRNA Translation: ABG74698.1 EU117382 mRNA Translation: ABV21755.1 EU140799 mRNA Translation: ABV58335.1 EU140800 mRNA Translation: ABV58336.1 EU120733 mRNA Translation: ABV24866.1 EU120734 mRNA Translation: ABV24867.1 EU120735 mRNA Translation: ABV24868.1 EU152331 mRNA Translation: ABV69555.1 DQ386455 mRNA Translation: ABD72328.1 AK300274 mRNA Translation: BAG62034.1 AP000308 Genomic DNA No translation available. AP000309 Genomic DNA No translation available. AP000310 Genomic DNA No translation available. AP000311 Genomic DNA No translation available. AP000312 Genomic DNA No translation available. AP000313 Genomic DNA No translation available. BC117560 mRNA Translation: AAI17561.1 BC116186 mRNA Translation: AAI16187.1 U61166 mRNA Translation: AAC50592.1 Different initiation. AF180522 mRNA Translation: AAD53183.1
CCDSⁱ	CCDS33545.1 [Q15811-1] CCDS33546.1 [Q15811-2] CCDS82663.1 [Q15811-7] CCDS82664.1 [Q15811-8] CCDS82665.1 [Q15811-3] CCDS82666.1 [Q15811-10]
RefSeqⁱ	NP_001001132.1, NM_001001132.1 [Q15811-2] NP_001317938.1, NM_001331009.1 [Q15811-7] NP_001317939.1, NM_001331010.1 [Q15811-8] NP_001317940.1, NM_001331011.1 [Q15811-3] NP_001317941.1, NM_001331012.1 [Q15811-10] NP_003015.2, NM_003024.2 [Q15811-1] XP_011527994.1, XM_011529692.1 [Q15811-12] XP_011527995.1, XM_011529693.2 [Q15811-5] XP_016883917.1, XM_017028428.1 [Q15811-1] XP_016883921.1, XM_017028432.1 [Q15811-9] XP_016883922.1, XM_017028433.1 [Q15811-4] XP_016883929.1, XM_017028440.1 [Q15811-11]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KI1	X-ray	2.30	B/D	1229-1581	[»]
	2KGR	NMR	-	A	210-312	[»]
	2KHN	NMR	-	A	1-111	[»]
	3FIA	X-ray	1.45	A	1-111	[»]
	3QBV	X-ray	2.65	B/D	1229-1579	[»]
	4IIM	X-ray	1.80	A/B	916-970	[»]
	5HZI	X-ray	2.60	A/B	1230-1580	[»]
	5HZJ	X-ray	2.60	A/B	1230-1580	[»]
	5HZK	X-ray	3.30	B/D	1230-1580	[»]
	6GBU	X-ray	3.44	B/D/F/H	1074-1138	[»]
	6H5T	X-ray	1.69	A/B	741-840	[»]
SMRⁱ	Q15811
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112351, 140 interactors
DIPⁱ	DIP-33609N
IntActⁱ	Q15811, 60 interactors
MINTⁱ	Q15811
STRINGⁱ	9606.ENSP00000370719

PTM databases

iPTMnetⁱ	Q15811
PhosphoSitePlusⁱ	Q15811

Polymorphism and mutation databases

BioMutaⁱ	ITSN1
DMDMⁱ	116242596

Proteomic databases

EPDⁱ	Q15811
jPOSTⁱ	Q15811
MassIVEⁱ	Q15811
MaxQBⁱ	Q15811
PaxDbⁱ	Q15811
PeptideAtlasⁱ	Q15811
PRIDEⁱ	Q15811
ProteomicsDBⁱ	17792 1818 1824 1825 1827 5114 60768 [Q15811-1] 60769 [Q15811-2] 60770 [Q15811-3] 60771 [Q15811-4]

Genome annotation databases

Ensemblⁱ	ENST00000381291; ENSP00000370691; ENSG00000205726 [Q15811-2] ENST00000381318; ENSP00000370719; ENSG00000205726 [Q15811-1] ENST00000399338; ENSP00000382275; ENSG00000205726 [Q15811-5] ENST00000399349; ENSP00000382286; ENSG00000205726 [Q15811-3] ENST00000399352; ENSP00000382289; ENSG00000205726 [Q15811-7] ENST00000399353; ENSP00000382290; ENSG00000205726 [Q15811-10] ENST00000399367; ENSP00000382301; ENSG00000205726 [Q15811-8]
GeneIDⁱ	6453
KEGGⁱ	hsa:6453
UCSCⁱ	uc002ysw.4 human [Q15811-1]

Organism-specific databases

CTDⁱ	6453
DisGeNETⁱ	6453
GeneCardsⁱ	ITSN1
HGNCⁱ	HGNC:6183 ITSN1
HPAⁱ	HPA018007
MIMⁱ	602442 gene
neXtProtⁱ	NX_Q15811
OpenTargetsⁱ	ENSG00000205726
PharmGKBⁱ	PA29981
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1029 Eukaryota KOG4305 Eukaryota COG5422 LUCA
GeneTreeⁱ	ENSGT00940000157065
HOGENOMⁱ	HOG000010175
InParanoidⁱ	Q15811
KOⁱ	K20045
OMAⁱ	HDEISIA
OrthoDBⁱ	807060at2759
PhylomeDBⁱ	Q15811
TreeFamⁱ	TF324293

Enzyme and pathway databases

Reactomeⁱ	R-HSA-193648 NRAGE signals death through JNK R-HSA-194840 Rho GTPase cycle R-HSA-3928662 EPHB-mediated forward signaling R-HSA-416482 G alpha (12/13) signalling events R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	Q15811
SIGNORⁱ	Q15811

Miscellaneous databases

ChiTaRSⁱ	ITSN1 human
EvolutionaryTraceⁱ	Q15811
GeneWikiⁱ	ITSN1
GenomeRNAiⁱ	6453
Pharosⁱ	Q15811
Protein Ontology More...PROⁱ	PR:Q15811
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000205726 Expressed in 238 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasⁱ	Q15811 baseline and differential
Genevisibleⁱ	Q15811 HS

Family and domain databases

CDDⁱ	cd00052 EH, 2 hits cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR035899 DBL_dom_sf IPR000219 DH-domain IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000261 EH_dom IPR001331 GDS_CDC24_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF12763 EF-hand_4, 2 hits PF16652 PH_13, 1 hit PF00621 RhoGEF, 1 hit PF00018 SH3_1, 3 hits PF14604 SH3_9, 2 hits
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00027 EH, 2 hits SM00233 PH, 1 hit SM00325 RhoGEF, 1 hit SM00326 SH3, 5 hits
SUPFAMⁱ	SSF47473 SSF47473, 2 hits SSF48065 SSF48065, 1 hit SSF50044 SSF50044, 5 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00741 DH_1, 1 hit PS50010 DH_2, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS50031 EH, 2 hits PS50003 PH_DOMAIN, 1 hit PS50002 SH3, 5 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITSN1_HUMAN
Accessionⁱ	Q15811Primary (citable) accession number: Q15811 Secondary accession number(s): A7Y322 Q9UQ92
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	October 17, 2006
	Last modified:	October 16, 2019
	This is version 209 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

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Help

UniRef

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Supporting data

UniProtKB - Q15811 (ITSN1_HUMAN)

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Intersectin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Other locations

Nucleus

Other locations

Other locations

Cytoskeleton

Cytosol

Endosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ