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UniProtKB - Q15811 (ITSN1_HUMAN)

Entry version 219 (02 Jun 2021)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Intersectin-1

Gene

ITSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380).

Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276).

Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity).

Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380).

Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity).

Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170).

Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity).

Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688).

By similarity4 Publications

Plays a role in synaptic vesicle endocytosis in brain neurons.

By similarity

Caution

Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2, and a Dab2 mutant with impaired binding to EH domain-containing proteins EPS15 and ITSN1 suggesting a partially overlapping role of the EH domain-containing proteins.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1667CalciumPROSITE-ProRule annotation1
Metal bindingi1670CalciumPROSITE-ProRule annotation1
Metal bindingi1673CalciumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi66 – 771PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi267 – 2782PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Exocytosis, Host-virus interaction, Protein transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15811

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15811

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15811

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intersectin-1
Alternative name(s):
SH3 domain-containing protein 1A1 Publication
SH3P17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITSN1
Synonyms:ITSN2 Publications, SH3D1A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6183, ITSN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602442, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15811

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000205726.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1078I → K or S: Abolishes interaction with FCHSD2. 1 Publication1
Mutagenesisi1119R → A or E: Abolishes interaction with FCHSD2. 1 Publication1
Mutagenesisi1369M → L: Decreases specificity for CDC42; when associated with I-1376. 1 Publication1
Mutagenesisi1376L → I: Decreases specificity for CDC42; when associated with L-1369. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6453

Open Targets

More...OpenTargetsi		ENSG00000205726

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29981

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15811, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523302

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ITSN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809571 – 1721Intersectin-1Add BLAST1721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphoserineCombined sources1
Modified residuei318PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei897PhosphothreonineBy similarity1
Modified residuei901PhosphoserineCombined sources1
Modified residuei902PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Modified residuei978PhosphoserineBy similarity1
Modified residuei986PhosphoserineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1137PhosphoserineCombined sources1
Modified residuei1144PhosphothreonineCombined sources1
Modified residuei1645PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15811

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15811

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15811

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15811

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15811

PeptideAtlas

More...PeptideAtlasi		Q15811

PRoteomics IDEntifications database

More...PRIDEi		Q15811

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17792
1818
1824
1825
1827
5114
60768 [Q15811-1]
60769 [Q15811-2]
60770 [Q15811-3]
60771 [Q15811-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15811

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15811

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed almost exclusively in the brain. Isoform 2 is detected in brain, spleen, lung, liver, heart, skeletal muscle and kidney. Isoform 5 is primarily expressed in brain, spleen, lung and kidney (at protein level) (PubMed:21712076). Isoform 1 and isoform 2 are detected in brain (PubMed:10482960). Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord (PubMed:9799604, PubMed:21712076, PubMed:11690630).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205726, Expressed in adipose tissue of abdominal region and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15811, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15811, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000205726, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via DH domain) with CDC42 (PubMed:11584276, PubMed:12006984).

Interacts (via SH3 domain 1) with WASL (PubMed:11584276).

Interacts with dynamin, SNAP25 and SNAP23 (By similarity).

Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2 (PubMed:20448150, PubMed:22484487, PubMed:22648170).

Interacts (via SH3 domains) with REPS1 and SGIP1 (PubMed:20946875).

Interacts with ARHGAP31 (PubMed:11744688).

Interacts with ADAM15 (PubMed:19718658).

Interacts with PRRT2 (By similarity).

Interacts (via SH3 domain 4) with FCHSD2 (via SH3 domain 2) (PubMed:29887380).

Interacts (via SH3 domain 1) with DENND2B (PubMed:29030480).

Interacts (via SH3 domains) with CBL (By similarity). Isoform 2:

Interacts with CBL and DNM1 (PubMed:21712076). Isoform 2:

Interacts with LMNA (PubMed:29599122). Isoform 2:

Interacts with importin subunit KPNA1; this is likely to mediate its import into the nucleus (PubMed:29599122).

By similarity12 Publications

(Microbial infection) Interacts with vaccinia virus protein A36 (PubMed:27670116).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112351, 175 interactors

Database of interacting proteins

More...DIPi		DIP-33609N

Protein interaction database and analysis system

More...IntActi		Q15811, 75 interactors

Molecular INTeraction database

More...MINTi		Q15811

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370719

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15811, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15811

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15811

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 109EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini53 – 88EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini221 – 310EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini254 – 289EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini740 – 806SH3 1PROSITE-ProRule annotationAdd BLAST67
Domaini913 – 971SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini1002 – 1060SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1074 – 1138SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1155 – 1214SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1237 – 1423DHPROSITE-ProRule annotationAdd BLAST187
Domaini1462 – 1571PHPROSITE-ProRule annotationAdd BLAST110
Domaini1579 – 1695C2PROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni322 – 348DisorderedSequence analysisAdd BLAST27
Regioni326 – 702KLERQAdd BLAST377
Regioni650 – 701DisorderedSequence analysisAdd BLAST52
Regioni836 – 868DisorderedSequence analysisAdd BLAST33
Regioni1074 – 1138Required for interaction with FCHSD21 PublicationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili355 – 659Sequence analysisAdd BLAST305

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1104 – 1127Bipartite nuclear localization signal; in isoform 21 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi330 – 348Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi837 – 868Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.By similarity
The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.By similarity

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1029, Eukaryota
KOG4305, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002819_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15811

Identification of Orthologs from Complete Genome Data

More...OMAi		RAVYEFN

Database of Orthologous Groups

More...OrthoDBi		807060at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15811

TreeFam database of animal gene trees

More...TreeFami		TF324293

Family and domain databases

Conserved Domains Database

More...CDDi		cd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Alternative splicing affects domains involved in protein recognition and thus may play a role in selecting specific interactions.2 Publications

This entry has 13 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15811-1) [UniParc]FASTAAdd to basket
Also known as: Long, ITSN-l

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ 
        60         70         80         90        100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP 
       110        120        130        140        150
VMKQQPVAIS SAPAFGMGGI ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV 
       160        170        180        190        200
PTAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 
       210        220        230        240        250
AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 
       260        270        280        290        300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
       310        320        330        340        350
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF 
       360        370        380        390        400
EDKKRENFER GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE 
       410        420        430        440        450
QERKRQLELE KQLEKQRELE RQREEERRKE IERREAAKRE LERQRQLEWE 
       460        470        480        490        500
RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF ELEALNDKKH QLEGKLQDIR 
       510        520        530        540        550
CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR LIPEKQILND 
       560        570        580        590        600
QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
       610        620        630        640        650
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ 
       660        670        680        690        700
RRAQERDKQW LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE 
       710        720        730        740        750
AQDKLGRLFH QHQEPAKPAV QAPWSTAEKG PLTISAQENV KVVYYRALYP 
       760        770        780        790        800
FESRSHDEIT IQPGDIVMVK GEWVDESQTG EPGWLGGELK GKTGWFPANY 
       810        820        830        840        850
AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS SEPSTTPNNW 
       860        870        880        890        900
ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
       910        920        930        940        950
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW 
       960        970        980        990       1000
FGEVQGQKGW FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP 
      1010       1020       1030       1040       1050
VVSGEEFIAM YTYESSEQGD LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF 
      1060       1070       1080       1090       1100
PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ VIASYTATGP EQLTLAPGQL 
      1110       1120       1130       1140       1150
ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT SKITPTEPPK 
      1160       1170       1180       1190       1200
STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ 
      1210       1220       1230       1240       1250
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE 
      1260       1270       1280       1290       1300
NYVNDLQLVT EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR 
      1310       1320       1330       1340       1350
VRKKMSGEKM PVKMIGDILS AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA 
      1360       1370       1380       1390       1400
PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ RVTRYPLIIK NILENTPENH 
      1410       1420       1430       1440       1450
PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV 
      1460       1470       1480       1490       1500
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG 
      1510       1520       1530       1540       1550
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT 
      1560       1570       1580       1590       1600
LRAESINERT AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV 
      1610       1620       1630       1640       1650
NVVEGIELKP CRSHGKSNPY CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF 
      1660       1670       1680       1690       1700
IRDLEQEVLC ITVFERDQFS PDDFLGRTEI RVADIKKDQG SKGPVTKCLL 
      1710       1720 
LHEVPTGEIV VRLDLQLFDE P
Length:1,721
Mass (Da):195,422
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC4DE644D8BEA2BE
GO
Isoform 2 (identifier: Q15811-2) [UniParc]FASTAAdd to basket
Also known as: Short, ITSN-s1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1721: Missing.

Show »
Length:1,220
Mass (Da):137,649
Checksum:iB09FDBEF1C06F487
GO
Isoform 3 (identifier: Q15811-3) [UniParc]FASTAAdd to basket
Also known as: Short 2, SH3P17

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,144
Mass (Da):129,416
Checksum:i8EEE8BE230C2F8C7
GO
Isoform 4 (identifier: Q15811-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1076: Missing.

Show »
Length:1,650
Mass (Da):187,788
Checksum:i584F3A7AD02E4434
GO
Isoform 5 (identifier: Q15811-5) [UniParc]FASTAAdd to basket
Also known as: ITSN1-22a

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-1025: GEKVEGLQAQ...SEQGDLTFQQ → PDFLLHPSMR...CFYLCLPHYL
     1026-1721: Missing.

Show »
Length:1,020
Mass (Da):115,873
Checksum:i53D58238CDB49BB4
GO
Isoform 6 (identifier: Q15811-6) [UniParc]FASTAAdd to basket
Also known as: Long form variant 4, Short form variant 11

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1006-1020: EFIAMYTYESSEQGD → GLWNCWENREFRKKT
     1021-1721: Missing.

Note: Contains a premature stop codon, potentially subjected to NMD.Curated
Show »
Length:1,015
Mass (Da):115,477
Checksum:i7FAD870DF7E4D42E
GO
Isoform 7 (identifier: Q15811-7) [UniParc]FASTAAdd to basket
Also known as: Short form variant 5

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1221-1721: Missing.

Show »
Length:1,215
Mass (Da):137,049
Checksum:i9610DEBFC4781CED
GO
Isoform 8 (identifier: Q15811-8) [UniParc]FASTAAdd to basket
Also known as: Long form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.

Show »
Length:1,716
Mass (Da):194,822
Checksum:iA129042F01C34A47
GO
Isoform 9 (identifier: Q15811-9) [UniParc]FASTAAdd to basket
Also known as: Long form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     1392-1447: Missing.

Show »
Length:1,660
Mass (Da):188,382
Checksum:i715F81F741A346E4
GO
Isoform 10 (identifier: Q15811-10) [UniParc]FASTAAdd to basket
Also known as: Short form variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1221-1721: Missing.

Show »
Length:1,178
Mass (Da):133,560
Checksum:iA344C5964504BDB1
GO
Isoform 11 (identifier: Q15811-11) [UniParc]FASTAAdd to basket
Also known as: Short form variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,112
Mass (Da):126,526
Checksum:iAB25F8723B3FD22A
GO
Isoform 12 (identifier: Q15811-12) [UniParc]FASTAAdd to basket
Also known as: Short form variant 10

The sequence of this isoform differs from the canonical sequence as follows:
     116-152: Missing.
     770-774: Missing.
     1006-1076: Missing.
     1221-1721: Missing.

Show »
Length:1,107
Mass (Da):125,926
Checksum:i7724CCE4FA98098A
GO
Isoform 13 (identifier: Q15811-13) [UniParc]FASTAAdd to basket
Also known as: Short form variant 14

The sequence of this isoform differs from the canonical sequence as follows:
     770-774: Missing.
     910-919: GEKVEGLQAQ → HGFWFFRESC
     920-1721: Missing.

Note: Contains a premature stop codon, potentially subjected to NMD.Curated
Show »
Length:914
Mass (Da):104,194
Checksum:i3788E745D07FE820
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7U0F8W7U0_HUMAN
Intersectin-1
ITSN1
1,149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8CTZ0A8CTZ0_HUMAN
Intersectin 1 short form variant 13
ITSN1
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQZ7C9JQZ7_HUMAN
Intersectin-1
ITSN1
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y523H0Y523_HUMAN
Intersectin-1
ITSN1
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6PAW0D6PAW0_HUMAN
Intersectin 1 short form A variant ...
ITSN1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1A4C9J1A4_HUMAN
Intersectin-1
ITSN1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXS9C9JXS9_HUMAN
Intersectin-1
ITSN1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6J334Q6J334_HUMAN
Intersectin 1 isoform 10
ITSN1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3G5H0Y3G5_HUMAN
Intersectin-1
ITSN1
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3F1H7C3F1_HUMAN
Intersectin-1
ITSN1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50592 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114A → P in AAC78610 (PubMed:9799604).Curated1
Sequence conflicti114A → P in AAC78611 (PubMed:9799604).Curated1
Sequence conflicti114A → P in ABG74695 (PubMed:19777371).Curated1
Sequence conflicti114A → P in ABG74697 (PubMed:19777371).Curated1
Sequence conflicti114A → P in ABG74698 (PubMed:19777371).Curated1
Sequence conflicti863E → G in ABD72328 (PubMed:21712076).Curated1
Sequence conflicti1088T → A in AAD53183 (Ref. 9) Curated1
Sequence conflicti1109G → R in AAD53183 (Ref. 9) Curated1
Sequence conflicti1361A → E in AAC78611 (PubMed:9799604).Curated1
Sequence conflicti1361A → E in AAC50592 (PubMed:9630982).Curated1
Sequence conflicti1367K → R in AAI16187 (PubMed:15489334).Curated1
Sequence conflicti1474S → N in AAC78611 (PubMed:9799604).Curated1
Sequence conflicti1474S → N in AAC50592 (PubMed:9630982).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0700111137S → N2 PublicationsCorresponds to variant dbSNP:rs187895245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053317116 – 152Missing in isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_004293770 – 774Missing in isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 12 and isoform 13. 6 Publications5
Alternative sequenceiVSP_047460910 – 1025GEKVE…LTFQQ → PDFLLHPSMRLGHMQPRIVL LFPDPLQCSTSRLLPMLRPR PGVPFLRSPSCQSPSHPSRP ISDAAPSVKFTLMPPGRIHP CFLFIPAVNSRNSFLVYFIL PGGTLGCFYLCLPHYL in isoform 5. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_053318910 – 919GEKVEGLQAQ → HGFWFFRESC in isoform 13. Curated10
Alternative sequenceiVSP_053319920 – 1721Missing in isoform 13. CuratedAdd BLAST802
Alternative sequenceiVSP_0042941006 – 1076Missing in isoform 3, isoform 4, isoform 11 and isoform 12. 4 PublicationsAdd BLAST71
Alternative sequenceiVSP_0533201006 – 1020EFIAM…SEQGD → GLWNCWENREFRKKT in isoform 6. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0533211021 – 1721Missing in isoform 6. 1 PublicationAdd BLAST701
Alternative sequenceiVSP_0474611026 – 1721Missing in isoform 5. 1 PublicationAdd BLAST696
Alternative sequenceiVSP_0042951221 – 1721Missing in isoform 2, isoform 3, isoform 7, isoform 10, isoform 11 and isoform 12. 7 PublicationsAdd BLAST501
Alternative sequenceiVSP_0533221392 – 1447Missing in isoform 9. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF064244 mRNA Translation: AAC78611.1
AF064247, AF064245, AF064246 Genomic DNA Translation: AAC80437.1
AF064243 mRNA Translation: AAC78610.1
AF114488 mRNA Translation: AAD29953.1
AF114487 mRNA Translation: AAD29952.1
DQ679754 mRNA Translation: ABG74695.1
DQ679756 mRNA Translation: ABG74697.1
DQ679757 mRNA Translation: ABG74698.1
EU117382 mRNA Translation: ABV21755.1
EU140799 mRNA Translation: ABV58335.1
EU140800 mRNA Translation: ABV58336.1
EU120733 mRNA Translation: ABV24866.1
EU120734 mRNA Translation: ABV24867.1
EU120735 mRNA Translation: ABV24868.1
EU152331 mRNA Translation: ABV69555.1
DQ386455 mRNA Translation: ABD72328.1
AK300274 mRNA Translation: BAG62034.1
AP000308 Genomic DNA No translation available.
AP000309 Genomic DNA No translation available.
AP000310 Genomic DNA No translation available.
AP000311 Genomic DNA No translation available.
AP000312 Genomic DNA No translation available.
AP000313 Genomic DNA No translation available.
BC117560 mRNA Translation: AAI17561.1
BC116186 mRNA Translation: AAI16187.1
U61166 mRNA Translation: AAC50592.1 Different initiation.
AF180522 mRNA Translation: AAD53183.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33545.1 [Q15811-1]
CCDS33546.1 [Q15811-2]
CCDS82663.1 [Q15811-7]
CCDS82664.1 [Q15811-8]
CCDS82665.1 [Q15811-3]
CCDS82666.1 [Q15811-10]

NCBI Reference Sequences

More...RefSeqi		NP_001001132.1, NM_001001132.1 [Q15811-2]
NP_001317938.1, NM_001331009.1 [Q15811-7]
NP_001317939.1, NM_001331010.1 [Q15811-8]
NP_001317940.1, NM_001331011.1 [Q15811-3]
NP_001317941.1, NM_001331012.1 [Q15811-10]
NP_003015.2, NM_003024.2 [Q15811-1]
XP_011527994.1, XM_011529692.1 [Q15811-12]
XP_011527995.1, XM_011529693.2 [Q15811-5]
XP_016883917.1, XM_017028428.1 [Q15811-1]
XP_016883921.1, XM_017028432.1 [Q15811-9]
XP_016883922.1, XM_017028433.1 [Q15811-4]
XP_016883929.1, XM_017028440.1 [Q15811-11]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381291; ENSP00000370691; ENSG00000205726 [Q15811-2]
ENST00000381318; ENSP00000370719; ENSG00000205726 [Q15811-1]
ENST00000399338; ENSP00000382275; ENSG00000205726 [Q15811-5]
ENST00000399349; ENSP00000382286; ENSG00000205726 [Q15811-3]
ENST00000399352; ENSP00000382289; ENSG00000205726 [Q15811-7]
ENST00000399353; ENSP00000382290; ENSG00000205726 [Q15811-10]
ENST00000399367; ENSP00000382301; ENSG00000205726 [Q15811-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6453

UCSC genome browser

More...UCSCi		uc002ysw.4, human [Q15811-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064244 mRNA Translation: AAC78611.1
AF064247, AF064245, AF064246 Genomic DNA Translation: AAC80437.1
AF064243 mRNA Translation: AAC78610.1
AF114488 mRNA Translation: AAD29953.1
AF114487 mRNA Translation: AAD29952.1
DQ679754 mRNA Translation: ABG74695.1
DQ679756 mRNA Translation: ABG74697.1
DQ679757 mRNA Translation: ABG74698.1
EU117382 mRNA Translation: ABV21755.1
EU140799 mRNA Translation: ABV58335.1
EU140800 mRNA Translation: ABV58336.1
EU120733 mRNA Translation: ABV24866.1
EU120734 mRNA Translation: ABV24867.1
EU120735 mRNA Translation: ABV24868.1
EU152331 mRNA Translation: ABV69555.1
DQ386455 mRNA Translation: ABD72328.1
AK300274 mRNA Translation: BAG62034.1
AP000308 Genomic DNA No translation available.
AP000309 Genomic DNA No translation available.
AP000310 Genomic DNA No translation available.
AP000311 Genomic DNA No translation available.
AP000312 Genomic DNA No translation available.
AP000313 Genomic DNA No translation available.
BC117560 mRNA Translation: AAI17561.1
BC116186 mRNA Translation: AAI16187.1
U61166 mRNA Translation: AAC50592.1 Different initiation.
AF180522 mRNA Translation: AAD53183.1
CCDSiCCDS33545.1 [Q15811-1]
CCDS33546.1 [Q15811-2]
CCDS82663.1 [Q15811-7]
CCDS82664.1 [Q15811-8]
CCDS82665.1 [Q15811-3]
CCDS82666.1 [Q15811-10]
RefSeqiNP_001001132.1, NM_001001132.1 [Q15811-2]
NP_001317938.1, NM_001331009.1 [Q15811-7]
NP_001317939.1, NM_001331010.1 [Q15811-8]
NP_001317940.1, NM_001331011.1 [Q15811-3]
NP_001317941.1, NM_001331012.1 [Q15811-10]
NP_003015.2, NM_003024.2 [Q15811-1]
XP_011527994.1, XM_011529692.1 [Q15811-12]
XP_011527995.1, XM_011529693.2 [Q15811-5]
XP_016883917.1, XM_017028428.1 [Q15811-1]
XP_016883921.1, XM_017028432.1 [Q15811-9]
XP_016883922.1, XM_017028433.1 [Q15811-4]
XP_016883929.1, XM_017028440.1 [Q15811-11]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KI1X-ray2.30B/D1229-1581[»]
2KGRNMR-A210-312[»]
2KHNNMR-A1-111[»]
3FIAX-ray1.45A1-111[»]
3QBVX-ray2.65B/D1229-1579[»]
4IIMX-ray1.80A/B916-970[»]
5HZIX-ray2.60A/B1230-1580[»]
5HZJX-ray2.60A/B1230-1580[»]
5HZKX-ray3.30B/D1230-1580[»]
6GBUX-ray3.44B/D/F/H1074-1138[»]
6H5TX-ray1.69A/B741-840[»]
SMRiQ15811
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112351, 175 interactors
DIPiDIP-33609N
IntActiQ15811, 75 interactors
MINTiQ15811
STRINGi9606.ENSP00000370719

Chemistry databases

ChEMBLiCHEMBL4523302

PTM databases

iPTMnetiQ15811
PhosphoSitePlusiQ15811

Genetic variation databases

BioMutaiITSN1
DMDMi116242596

Proteomic databases

EPDiQ15811
jPOSTiQ15811
MassIVEiQ15811
MaxQBiQ15811
PaxDbiQ15811
PeptideAtlasiQ15811
PRIDEiQ15811
ProteomicsDBi17792
1818
1824
1825
1827
5114
60768 [Q15811-1]
60769 [Q15811-2]
60770 [Q15811-3]
60771 [Q15811-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q15811, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7532, 81 antibodies

The DNASU plasmid repository

More...DNASUi		6453

Genome annotation databases

EnsembliENST00000381291; ENSP00000370691; ENSG00000205726 [Q15811-2]
ENST00000381318; ENSP00000370719; ENSG00000205726 [Q15811-1]
ENST00000399338; ENSP00000382275; ENSG00000205726 [Q15811-5]
ENST00000399349; ENSP00000382286; ENSG00000205726 [Q15811-3]
ENST00000399352; ENSP00000382289; ENSG00000205726 [Q15811-7]
ENST00000399353; ENSP00000382290; ENSG00000205726 [Q15811-10]
ENST00000399367; ENSP00000382301; ENSG00000205726 [Q15811-8]
GeneIDi6453
KEGGihsa:6453
UCSCiuc002ysw.4, human [Q15811-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6453
DisGeNETi6453

GeneCards: human genes, protein and diseases

More...GeneCardsi		ITSN1
HGNCiHGNC:6183, ITSN1
HPAiENSG00000205726, Low tissue specificity
MIMi602442, gene
neXtProtiNX_Q15811
OpenTargetsiENSG00000205726
PharmGKBiPA29981
VEuPathDBiHostDB:ENSG00000205726.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1029, Eukaryota
KOG4305, Eukaryota
GeneTreeiENSGT00940000157065
HOGENOMiCLU_002819_0_0_1
InParanoidiQ15811
OMAiRAVYEFN
OrthoDBi807060at2759
PhylomeDBiQ15811
TreeFamiTF324293

Enzyme and pathway databases

PathwayCommonsiQ15811
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiQ15811
SIGNORiQ15811

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6453, 7 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITSN1, human
EvolutionaryTraceiQ15811

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ITSN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6453
PharosiQ15811, Tbio

Protein Ontology

More...PROi		PR:Q15811
RNActiQ15811, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000205726, Expressed in adipose tissue of abdominal region and 248 other tissues
ExpressionAtlasiQ15811, baseline and differential
GenevisibleiQ15811, HS

Family and domain databases

CDDicd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits
SUPFAMiSSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITSN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15811
Secondary accession number(s): A7Y322
, A8CTX8, A8CTY3, A8CTY7, A8D7D0, A8DCP3, B4DTM2, E7ERJ1, E9PE44, E9PG01, E9PHV2, O95216, Q0PW94, Q0PW95, Q0PW97, Q14BD3, Q1ED40, Q20BK3, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 219 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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