UniProtKB - Q15788 (NCOA1_HUMAN)
Nuclear receptor coactivator 1
NCOA1
Functioni
Catalytic activityi
- EC:2.3.1.48
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: CAFA
- chromatin binding Source: Ensembl
- enzyme binding Source: UniProtKB
- estrogen receptor binding Source: ParkinsonsUK-UCL
- histone acetyltransferase activity Source: UniProtKB-EC
- nuclear hormone receptor binding Source: UniProtKB
- nuclear receptor binding Source: UniProtKB
- nuclear receptor transcription coactivator activity Source: UniProtKB
- progesterone receptor binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: UniProtKB
- retinoid X receptor binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- bile acid and bile salt transport Source: Reactome
- cellular response to hormone stimulus Source: GO_Central
- cellular response to Thyroglobulin triiodothyronine Source: Ensembl
- cerebellum development Source: Ensembl
- cerebral cortex development Source: Ensembl
- estrous cycle Source: Ensembl
- hippocampus development Source: Ensembl
- histone H4 acetylation Source: Ensembl
- hypothalamus development Source: Ensembl
- labyrinthine layer morphogenesis Source: Ensembl
- lactation Source: Ensembl
- male gonad development Source: Ensembl
- male mating behavior Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of female receptivity Source: Ensembl
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription from RNA polymerase II promoter by galactose Source: UniProtKB
- regulation of cellular response to drug Source: Ensembl
- regulation of lipid metabolic process Source: Reactome
- regulation of thyroid hormone mediated signaling pathway Source: Ensembl
- response to estradiol Source: Ensembl
- response to progesterone Source: Ensembl
- response to retinoic acid Source: Ensembl
Keywordsi
Molecular function | Activator, Acyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q15788 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-159418, Recycling of bile acids and salts R-HSA-192105, Synthesis of bile acids and bile salts R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-1989781, PPARA activates gene expression R-HSA-211976, Endogenous sterols R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214847, HATs acetylate histones R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SignaLinki | Q15788 |
SIGNORi | Q15788 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 1 (EC:2.3.1.48)Short name: NCoA-1 Alternative name(s): Class E basic helix-loop-helix protein 74 Short name: bHLHe74 Protein Hin-2 RIP160 Renal carcinoma antigen NY-REN-52 Steroid receptor coactivator 1 Short name: SRC-1 |
Gene namesi | Name:NCOA1 Synonyms:BHLHE74, SRC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000084676.15 |
HGNCi | HGNC:7668, NCOA1 |
MIMi | 602691, gene |
neXtProti | NX_Q15788 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- neuron projection Source: Ensembl
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 636 – 637 | LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-693; A-694; A-752 and A-753. 1 Publication | 2 | |
Mutagenesisi | 693 – 694 | LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-752 and A-753. 1 Publication | 2 | |
Mutagenesisi | 732 | K → R: Abolishes sumoylation; when associated with R-774. 1 Publication | 1 | |
Mutagenesisi | 752 – 753 | LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-693 and A-694. 1 Publication | 2 | |
Mutagenesisi | 774 | K → R: Abolishes sumoylation; when associated with R-732. 1 Publication | 1 | |
Mutagenesisi | 800 | K → R: Does not affect sumoylation of the protein. 1 Publication | 1 | |
Mutagenesisi | 846 | K → R: Does not affect sumoylation of the protein. 1 Publication | 1 | |
Mutagenesisi | 1378 | K → R: Does not affect sumoylation of the protein. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 867 – 868 | Breakpoint for translocation to form PAX3-NCOA1 oncogene | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8648 |
OpenTargetsi | ENSG00000084676 |
PharmGKBi | PA31470 |
Miscellaneous databases
Pharosi | Q15788, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1615387 |
DrugBanki | DB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol DB06908, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID DB08220, (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL DB07557, 3,20-Pregnanedione DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB08915, Aleglitazar DB04652, Corticosterone DB06875, ERB-196 DB01645, Genistein DB07215, GW-590735 DB07724, Indeglitazar DB08231, Myristic acid DB06832, Prinaberel DB07080, TO-901317 |
GuidetoPHARMACOLOGYi | 2693 |
Polymorphism and mutation databases
BioMutai | NCOA1 |
DMDMi | 158518533 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000094400 | 2 – 1441 | Nuclear receptor coactivator 1Add BLAST | 1440 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 22 | PhosphoserineCombined sources | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 517 | Phosphoserine1 Publication | 1 | |
Modified residuei | 558 | PhosphoserineBy similarity | 1 | |
Modified residuei | 569 | Phosphoserine1 Publication | 1 | |
Modified residuei | 698 | PhosphoserineCombined sources | 1 | |
Cross-linki | 732 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 774 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 846 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1033 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1073 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1091 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1124 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1131 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1179 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1185 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1372 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1255 |
EPDi | Q15788 |
jPOSTi | Q15788 |
MassIVEi | Q15788 |
MaxQBi | Q15788 |
PaxDbi | Q15788 |
PeptideAtlasi | Q15788 |
PRIDEi | Q15788 |
ProteomicsDBi | 60761 [Q15788-1] 60762 [Q15788-2] 60763 [Q15788-3] |
PTM databases
iPTMneti | Q15788 |
PhosphoSitePlusi | Q15788 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000084676, Expressed in forebrain and 250 other tissues |
ExpressionAtlasi | Q15788, baseline and differential |
Genevisiblei | Q15788, HS |
Organism-specific databases
HPAi | ENSG00000084676, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the methyltransferase CARM1 (By similarity).
Interacts with NCOA6 and NCOA2.
Interacts with the FDL motif of STAT5A and STAT5B.
Interacts with the LXXLL motif of STAT6.
Interacts with STAT3 following IL-6 stimulation.
Interacts with the basal transcription factor GTF2B.
Interacts with the histone acetyltransferases EP300 and CREBBP.
Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP.
Interacts with PSMB9.
Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity.
Interacts with PRMT2 and DDX5.
Interacts with ASXL1.
Interacts with PRMT6.
Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif).
Interacts in a ligand-dependent fashion with RXRA.
Interacts with TRIP4.
Interacts with NR4A3 (By similarity).
Interacts with VDR.
By similarity24 PublicationsBinary interactionsi
Hide detailsQ15788
Isoform 2 [Q15788-2]
With | #Exp. | IntAct |
---|---|---|
TDG [Q13569] | 2 | EBI-5327712,EBI-348333 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: CAFA
- enzyme binding Source: UniProtKB
- estrogen receptor binding Source: ParkinsonsUK-UCL
- nuclear hormone receptor binding Source: UniProtKB
- nuclear receptor binding Source: UniProtKB
- progesterone receptor binding Source: Ensembl
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: UniProtKB
- retinoid X receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114200, 120 interactors |
ComplexPortali | CPX-517, PXR-NCOA1 activated nuclear receptor complex CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-5342, RXRalpha-NCOA1 activated retinoic acid receptor complex CPX-711, PPARgamma-NCOA1 activated nuclear receptor complex |
CORUMi | Q15788 |
DIPi | DIP-30877N |
IntActi | Q15788, 46 interactors |
MINTi | Q15788 |
STRINGi | 9606.ENSP00000385216 |
Chemistry databases
BindingDBi | Q15788 |
Miscellaneous databases
RNActi | Q15788, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15788 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15788 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 80 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 109 – 180 | PASPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 361 – 567 | Interaction with STAT31 PublicationAdd BLAST | 207 | |
Regioni | 781 – 988 | Interaction with CREBBPAdd BLAST | 208 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 46 – 50 | LXXLL motif 1 | 5 | |
Motifi | 112 – 116 | LXXLL motif 2 | 5 | |
Motifi | 633 – 637 | LXXLL motif 3 | 5 | |
Motifi | 690 – 694 | LXXLL motif 4 | 5 | |
Motifi | 749 – 753 | LXXLL motif 5 | 5 | |
Motifi | 913 – 917 | LXXLL motif 6 | 5 | |
Motifi | 1435 – 1439 | LXXLL motif 7 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 389 – 682 | Ser-richAdd BLAST | 294 | |
Compositional biasi | 1053 – 1138 | Gln-richAdd BLAST | 86 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | Q15788 |
OMAi | TPNRTNC |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q15788 |
TreeFami | TF332652 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 1.10.287.1070, 1 hit 4.10.280.10, 1 hit |
IDEALi | IID00083 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR010011, DUF1518 IPR036638, HLH_DNA-bd_sf IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF1, PTHR10684:SF1, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL
60 70 80 90 100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS
110 120 130 140 150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE
160 170 180 190 200
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML
210 220 230 240 250
IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL
260 270 280 290 300
PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF
310 320 330 340 350
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ
360 370 380 390 400
SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPSV NPSISPAHGV
410 420 430 440 450
ARSSTLPPSN SNMVSTRINR QQSSDLHSSS HSNSSNSQGS FGCSPGSQIV
460 470 480 490 500
ANVALNQGQA SSQSSNPSLN LNNSPMEGTG ISLAQFMSPR RQVTSGLATR
510 520 530 540 550
PRMPNNSFPP NISTLSSPVG MTSSACNNNN RSYSNIPVTS LQGMNEGPNN
560 570 580 590 600
SVGFSASSPV LRQMSSQNSP SRLNIQPAKA ESKDNKEIAS ILNEMIQSDN
610 620 630 640 650
SSSDGKPLDS GLLHNNDRLS DGDSKYSQTS HKLVQLLTTT AEQQLRHADI
660 670 680 690 700
DTSCKDVLSC TGTSNSASAN SSGGSCPSSH SSLTERHKIL HRLLQEGSPS
710 720 730 740 750
DITTLSVEPD KKDSASTSVS VTGQVQGNSS IKLELDASKK KESKDHQLLR
760 770 780 790 800
YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPTPEEIK
810 820 830 840 850
LEAQSQFTAD LDQFDQLLPT LEKAAQLPGL CETDRMDGAV TSVTIKSEIL
860 870 880 890 900
PASLQSATAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WTNNTVTAIN
910 920 930 940 950
QSKSEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE
960 970 980 990 1000
LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLIMEERPNL YSQPYSSPSP
1010 1020 1030 1040 1050
TANLPSPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA
1060 1070 1080 1090 1100
PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AATAPVGINM RSGMQQQITP
1110 1120 1130 1140 1150
QPPLNAQMLA QRQRELYSQQ HRQRQLIQQQ RAMLMRQQSF GNNLPPSSGL
1160 1170 1180 1190 1200
PVQMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AANPEASLAN
1210 1220 1230 1240 1250
RNSMVSRGMT GNIGGQFGTG INPQMQQNVF QYPGAGMVPQ GEANFAPSLS
1260 1270 1280 1290 1300
PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAI GNNNVFSQAV
1310 1320 1330 1340 1350
QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMAQMQM SSLQMPGMNT
1360 1370 1380 1390 1400
VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQQVQQV QVFADVQCTV
1410 1420 1430 1440
NLVGGDPYLN QPGPLGTQKP TSGPQTPQAQ QKSLLQQLLT E
The sequence of this isoform differs from the canonical sequence as follows:
1386-1441: QVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE → DKKTEEFFSVVTTD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB5MCN7 | B5MCN7_HUMAN | Nuclear receptor coactivator 1 | NCOA1 | 1,248 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1035 | Missing in AAT47737 (PubMed:15313887).Curated | 1 | |
Sequence conflicti | 1370 | Q → H in AAA64187 (PubMed:11831720).Curated | 1 | |
Sequence conflicti | 1382 | D → G in AAT47737 (PubMed:15313887).Curated | 1 | |
Sequence conflicti | 1435 | L → R in AAB50242 (PubMed:9575154).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019768 | 457 | Q → K3 PublicationsCorresponds to variant dbSNP:rs1049015Ensembl. | 1 | |
Natural variantiVAR_019769 | 466 | N → K3 PublicationsCorresponds to variant dbSNP:rs1049016Ensembl. | 1 | |
Natural variantiVAR_019770 | 474 | S → P3 PublicationsCorresponds to variant dbSNP:rs1049018Ensembl. | 1 | |
Natural variantiVAR_019771 | 591 | I → T3 PublicationsCorresponds to variant dbSNP:rs1049020Ensembl. | 1 | |
Natural variantiVAR_019772 | 685 | E → A3 PublicationsCorresponds to variant dbSNP:rs1049021Ensembl. | 1 | |
Natural variantiVAR_019773 | 794 | P → A1 PublicationCorresponds to variant dbSNP:rs1049025Ensembl. | 1 | |
Natural variantiVAR_019774 | 999 | S → F3 PublicationsCorresponds to variant dbSNP:rs1049032Ensembl. | 1 | |
Natural variantiVAR_019775 | 1154 | M → T3 PublicationsCorresponds to variant dbSNP:rs1049038Ensembl. | 1 | |
Natural variantiVAR_038832 | 1238 | V → I1 PublicationCorresponds to variant dbSNP:rs56099330Ensembl. | 1 | |
Natural variantiVAR_034882 | 1272 | P → S1 PublicationCorresponds to variant dbSNP:rs1804645Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011738 | 1385 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_011739 | 1386 – 1441 | QVQQV…QLLTE → DKKTEEFFSVVTTD in isoform 2. 4 PublicationsAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59302 mRNA Translation: AAC50631.1 AJ000881 mRNA Translation: CAA04371.1 AJ000882 mRNA Translation: CAA04372.1 U90661 mRNA Translation: AAB50242.1 EF660499 Genomic DNA Translation: ABS29266.1 AC013459 Genomic DNA Translation: AAX93184.1 AC093798 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00746.1 BC111533 mRNA Translation: AAI11534.1 BC111534 mRNA Translation: AAI11535.1 U40396 mRNA Translation: AAC50305.1 Different initiation. U19179 mRNA Translation: AAA64187.1 Different initiation. AY633656 mRNA Translation: AAT47737.1 |
CCDSi | CCDS1712.1 [Q15788-1] CCDS1713.1 [Q15788-2] CCDS42660.1 [Q15788-3] |
PIRi | A57620 PC4363 PC4364 |
RefSeqi | NP_003734.3, NM_003743.4 [Q15788-1] NP_671756.1, NM_147223.2 [Q15788-2] NP_671766.1, NM_147233.2 [Q15788-3] XP_005264682.1, XM_005264625.1 [Q15788-1] XP_005264683.1, XM_005264626.1 [Q15788-3] XP_005264685.1, XM_005264628.1 XP_016860657.1, XM_017005168.1 XP_016860658.1, XM_017005169.1 |
Genome annotation databases
Ensembli | ENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2] ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1] ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3] ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2] ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1] |
GeneIDi | 8648 |
KEGGi | hsa:8648 |
UCSCi | uc002rfj.4, human [Q15788-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59302 mRNA Translation: AAC50631.1 AJ000881 mRNA Translation: CAA04371.1 AJ000882 mRNA Translation: CAA04372.1 U90661 mRNA Translation: AAB50242.1 EF660499 Genomic DNA Translation: ABS29266.1 AC013459 Genomic DNA Translation: AAX93184.1 AC093798 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00746.1 BC111533 mRNA Translation: AAI11534.1 BC111534 mRNA Translation: AAI11535.1 U40396 mRNA Translation: AAC50305.1 Different initiation. U19179 mRNA Translation: AAA64187.1 Different initiation. AY633656 mRNA Translation: AAT47737.1 |
CCDSi | CCDS1712.1 [Q15788-1] CCDS1713.1 [Q15788-2] CCDS42660.1 [Q15788-3] |
PIRi | A57620 PC4363 PC4364 |
RefSeqi | NP_003734.3, NM_003743.4 [Q15788-1] NP_671756.1, NM_147223.2 [Q15788-2] NP_671766.1, NM_147233.2 [Q15788-3] XP_005264682.1, XM_005264625.1 [Q15788-1] XP_005264683.1, XM_005264626.1 [Q15788-3] XP_005264685.1, XM_005264628.1 XP_016860657.1, XM_017005168.1 XP_016860658.1, XM_017005169.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FM6 | X-ray | 2.10 | B/E/V/Y | 676-700 | [»] | |
1FM9 | X-ray | 2.10 | B/E | 676-700 | [»] | |
1K4W | X-ray | 1.90 | B | 686-700 | [»] | |
1K74 | X-ray | 2.30 | B/E | 676-700 | [»] | |
1K7L | X-ray | 2.50 | B/D/F/H | 680-700 | [»] | |
1KV6 | X-ray | 2.70 | C/D | 686-700 | [»] | |
1N4H | X-ray | 2.10 | B | 686-700 | [»] | |
1NQ7 | X-ray | 1.50 | B | 687-696 | [»] | |
1NRL | X-ray | 2.00 | C/D | 676-700 | [»] | |
1P8D | X-ray | 2.80 | C/D | 676-700 | [»] | |
1PZL | X-ray | 2.10 | B | 687-700 | [»] | |
1RDT | X-ray | 2.40 | B | 676-700 | [»] | |
1TFC | X-ray | 2.40 | C/D | 686-700 | [»] | |
1U3R | X-ray | 2.21 | C/D | 630-640 | [»] | |
1U3S | X-ray | 2.50 | C/D | 630-640 | [»] | |
1X76 | X-ray | 2.20 | C/D | 630-640 | [»] | |
1X78 | X-ray | 2.30 | C/D | 630-640 | [»] | |
1X7B | X-ray | 2.30 | C/D | 630-640 | [»] | |
1X7J | X-ray | 2.30 | C/D | 630-640 | [»] | |
1XIU | X-ray | 2.50 | E/F | 686-700 | [»] | |
1XV9 | X-ray | 2.70 | E/F/G/H | 685-697 | [»] | |
1XVP | X-ray | 2.60 | E/F/G/H | 685-697 | [»] | |
1YY4 | X-ray | 2.70 | C/D | 630-640 | [»] | |
1YYE | X-ray | 2.03 | C/D | 630-640 | [»] | |
1ZAF | X-ray | 2.20 | C/D | 630-640 | [»] | |
2A3I | X-ray | 1.95 | B | 1430-1441 | [»] | |
2C52 | NMR | - | B | 920-970 | [»] | |
2FVJ | X-ray | 1.99 | B | 628-640 | [»] | |
2GTK | X-ray | 2.10 | B | 631-640 | [»] | |
2HBH | X-ray | 2.65 | B | 686-700 | [»] | |
2HC4 | X-ray | 2.20 | B | 686-700 | [»] | |
2HCD | X-ray | 2.60 | B | 686-700 | [»] | |
2HFP | X-ray | 2.00 | B | 680-700 | [»] | |
2NPA | X-ray | 2.30 | B/D | 683-697 | [»] | |
2NV7 | X-ray | 2.10 | C/D | 631-640 | [»] | |
2P54 | X-ray | 1.79 | B | 686-696 | [»] | |
2PRG | X-ray | 2.30 | C | 623-710 | [»] | |
3BEJ | X-ray | 1.90 | E/F | 676-700 | [»] | |
3BQD | X-ray | 2.50 | B | 1429-1441 | [»] | |
3CTB | X-ray | 2.00 | A/B | 678-700 | [»] | |
3CWD | X-ray | 2.40 | C/D | 685-700 | [»] | |
3DCT | X-ray | 2.50 | B | 741-761 | [»] | |
3DCU | X-ray | 2.95 | B | 741-761 | [»] | |
3DR1 | X-ray | 2.70 | B | 686-700 | [»] | |
3ET1 | X-ray | 2.50 | P/Q | 681-696 | [»] | |
3ET3 | X-ray | 1.95 | P | 680-695 | [»] | |
3FEI | X-ray | 2.40 | Z | 744-756 | [»] | |
3FEJ | X-ray | 2.01 | B | 628-640 | [»] | |
3FUR | X-ray | 2.30 | H | 629-640 | [»] | |
3FXV | X-ray | 2.26 | B | 744-756 | [»] | |
3G8I | X-ray | 2.20 | Z | 744-756 | [»] | |
3G9E | X-ray | 2.30 | B | 628-640 | [»] | |
3GYT | X-ray | 2.40 | B | 1429-1441 | [»] | |
3GYU | X-ray | 2.40 | B | 1429-1441 | [»] | |
3H0A | X-ray | 2.10 | B/E | 629-640 | [»] | |
3HC5 | X-ray | 2.60 | B | 741-761 | [»] | |
3HC6 | X-ray | 3.20 | B | 741-761 | [»] | |
3HVL | X-ray | 2.10 | A/B | 678-700 | [»] | |
3IPQ | X-ray | 2.00 | B | 676-700 | [»] | |
3IPS | X-ray | 2.26 | C/D | 676-700 | [»] | |
3IPU | X-ray | 2.40 | C/D | 676-700 | [»] | |
3KMR | X-ray | 1.80 | C | 686-698 | [»] | |
3LMP | X-ray | 1.90 | C | 686-700 | [»] | |
3OKH | X-ray | 2.50 | B | 744-757 | [»] | |
3OKI | X-ray | 2.00 | B/D | 744-757 | [»] | |
3OLF | X-ray | 1.90 | B/D | 744-757 | [»] | |
3OLL | X-ray | 1.50 | C/D | 683-701 | [»] | |
3OLS | X-ray | 2.20 | C/D | 683-701 | [»] | |
3OMK | X-ray | 1.90 | B/D | 744-757 | [»] | |
3OMM | X-ray | 2.10 | B/D | 744-757 | [»] | |
3OMO | X-ray | 2.21 | C/D | 683-701 | [»] | |
3OMP | X-ray | 2.05 | C/D | 683-701 | [»] | |
3OMQ | X-ray | 1.97 | C/D | 683-701 | [»] | |
3OOF | X-ray | 2.29 | B/D | 744-757 | [»] | |
3OOK | X-ray | 2.29 | B/D | 744-757 | [»] | |
3P88 | X-ray | 2.95 | B | 745-755 | [»] | |
3P89 | X-ray | 2.30 | B | 745-755 | [»] | |
3QT0 | X-ray | 2.50 | C | 685-700 | [»] | |
3RUT | X-ray | 3.00 | B | 745-755 | [»] | |
3RUU | X-ray | 2.50 | B | 745-755 | [»] | |
3RVF | X-ray | 3.10 | B | 741-761 | [»] | |
3S9S | X-ray | 2.55 | B | 685-697 | [»] | |
3T03 | X-ray | 2.10 | C/D | 683-700 | [»] | |
3UU7 | X-ray | 2.20 | F/G | 686-698 | [»] | |
3UUA | X-ray | 2.05 | F/G | 686-698 | [»] | |
3UUD | X-ray | 1.60 | C/D | 686-698 | [»] | |
3V9Y | X-ray | 2.10 | B | 686-700 | [»] | |
3VN2 | X-ray | 2.18 | C | 685-700 | [»] | |
4DK7 | X-ray | 2.45 | B/D | 745-756 | [»] | |
4DK8 | X-ray | 2.75 | B/D | 745-756 | [»] | |
4DM6 | X-ray | 1.90 | E/F | 676-700 | [»] | |
4DM8 | X-ray | 2.30 | C/D | 676-700 | [»] | |
4DQM | X-ray | 2.75 | B/D | 1432-1441 | [»] | |
4F9M | X-ray | 1.90 | C | 686-700 | [»] | |
4FGY | X-ray | 2.84 | B | 686-696 | [»] | |
4G1D | X-ray | 2.90 | B | 686-700 | [»] | |
4G1Y | X-ray | 2.85 | B | 686-700 | [»] | |
4G1Z | X-ray | 2.50 | B | 686-700 | [»] | |
4G20 | X-ray | 2.90 | B | 686-700 | [»] | |
4G21 | X-ray | 2.90 | B | 686-700 | [»] | |
4G2H | X-ray | 2.50 | B | 686-700 | [»] | |
4HEE | X-ray | 2.50 | Y | 676-700 | [»] | |
4J5X | X-ray | 2.80 | A/B/C/D | 678-700 | [»] | |
4JYG | X-ray | 2.35 | F/G | 686-698 | [»] | |
4JYH | X-ray | 2.60 | C/G | 686-698 | [»] | |
4JYI | X-ray | 1.90 | F/G | 686-698 | [»] | |
4MG5 | X-ray | 2.05 | C/D | 686-698 | [»] | |
4MG6 | X-ray | 2.10 | C/D | 686-698 | [»] | |
4MG7 | X-ray | 2.15 | C/D | 686-698 | [»] | |
4MG8 | X-ray | 1.85 | C/D | 686-698 | [»] | |
4MG9 | X-ray | 2.00 | F/G | 686-698 | [»] | |
4MGA | X-ray | 1.80 | C/D | 686-698 | [»] | |
4MGB | X-ray | 1.85 | C/D | 686-698 | [»] | |
4MGC | X-ray | 2.15 | F/G | 686-698 | [»] | |
4MGD | X-ray | 1.90 | F/G | 686-698 | [»] | |
4RUJ | X-ray | 2.35 | B | 686-700 | [»] | |
4RUP | X-ray | 2.75 | B | 686-700 | [»] | |
4TUZ | X-ray | 1.90 | F/G | 686-698 | [»] | |
4TV1 | X-ray | 1.85 | C/D | 686-698 | [»] | |
4UDA | X-ray | 2.03 | B | 1427-1441 | [»] | |
4UDB | X-ray | 2.36 | B | 1427-1441 | [»] | |
4Y29 | X-ray | 1.98 | B | 1432-1441 | [»] | |
5A86 | X-ray | 2.25 | C/D | 682-698 | [»] | |
5AVI | X-ray | 2.70 | B/D | 676-700 | [»] | |
5AVL | X-ray | 2.80 | B | 676-700 | [»] | |
5AZT | X-ray | 3.45 | C | 683-697 | [»] | |
5DSH | X-ray | 2.95 | B | 685-700 | [»] | |
5DV3 | X-ray | 2.75 | B | 685-700 | [»] | |
5DV6 | X-ray | 2.80 | B | 685-700 | [»] | |
5DV8 | X-ray | 2.75 | B | 685-700 | [»] | |
5DVC | X-ray | 2.30 | B | 685-700 | [»] | |
5DWL | X-ray | 2.20 | B | 685-700 | [»] | |
5E7V | X-ray | 2.40 | B | 686-700 | [»] | |
5GTN | X-ray | 1.85 | B | 685-700 | [»] | |
5GTO | X-ray | 2.10 | B | 685-700 | [»] | |
5GTP | X-ray | 2.35 | B | 685-700 | [»] | |
5HJS | X-ray | 1.72 | C/D | 676-700 | [»] | |
5JI0 | X-ray | 1.98 | E/F | 676-700 | [»] | |
5JMM | X-ray | 2.10 | F/G | 686-698 | [»] | |
5L7E | X-ray | 1.86 | B | 1432-1441 | [»] | |
5L7G | X-ray | 2.01 | B | 1432-1441 | [»] | |
5L7H | X-ray | 1.84 | B | 1432-1441 | [»] | |
5MWP | X-ray | 1.82 | B | 1427-1441 | [»] | |
5MWY | X-ray | 1.75 | B | 1427-1441 | [»] | |
5MX7 | X-ray | 1.98 | B1 | 686-700 | [»] | |
5NKY | X-ray | 2.10 | B | 686-700 | [»] | |
5NMA | X-ray | 2.80 | B | 686-700 | [»] | |
5NMB | X-ray | 2.50 | B2 | 686-700 | [»] | |
5NWM | NMR | - | A | 257-385 | [»] | |
5OW7 | X-ray | 2.10 | B | 686-700 | [»] | |
5OW9 | X-ray | 2.40 | B | 686-700 | [»] | |
5OWD | X-ray | 2.15 | B | 686-700 | [»] | |
5Q0J | X-ray | 2.00 | B/D | 744-757 | [»] | |
5Q0K | X-ray | 1.80 | B | 744-757 | [»] | |
5Q0L | X-ray | 2.50 | B/D | 744-757 | [»] | |
5Q0M | X-ray | 2.20 | B | 744-757 | [»] | |
5Q0N | X-ray | 2.40 | B/D | 744-757 | [»] | |
5Q0O | X-ray | 1.90 | B/D | 744-757 | [»] | |
5Q0P | X-ray | 1.80 | B/D | 744-757 | [»] | |
5Q0Q | X-ray | 2.60 | B/D | 744-757 | [»] | |
5Q0R | X-ray | 1.91 | B | 744-757 | [»] | |
5Q0S | X-ray | 2.50 | B/D | 744-757 | [»] | |
5Q0T | X-ray | 2.14 | B | 744-757 | [»] | |
5Q0U | X-ray | 1.90 | B/D | 744-757 | [»] | |
5Q0V | X-ray | 1.87 | B/D | 744-757 | [»] | |
5Q0W | X-ray | 1.90 | B | 744-757 | [»] | |
5Q0X | X-ray | 2.26 | B | 744-757 | [»] | |
5Q0Y | X-ray | 2.20 | B/D | 744-757 | [»] | |
5Q0Z | X-ray | 2.26 | B/D | 744-757 | [»] | |
5Q10 | X-ray | 2.20 | B | 744-757 | [»] | |
5Q11 | X-ray | 2.20 | B | 744-757 | [»] | |
5Q12 | X-ray | 2.00 | B | 744-757 | [»] | |
5Q13 | X-ray | 1.90 | B/D | 744-757 | [»] | |
5Q14 | X-ray | 1.85 | B/D | 744-757 | [»] | |
5Q15 | X-ray | 1.90 | B/D | 744-757 | [»] | |
5Q16 | X-ray | 2.00 | B/D | 744-757 | [»] | |
5Q18 | X-ray | 1.90 | B/D | 744-757 | [»] | |
5Q19 | X-ray | 1.98 | B/D | 744-757 | [»] | |
5Q1A | X-ray | 2.00 | B/D | 744-757 | [»] | |
5Q1B | X-ray | 2.30 | B/D | 744-757 | [»] | |
5Q1C | X-ray | 2.30 | B/D | 744-757 | [»] | |
5Q1D | X-ray | 1.89 | B/D | 744-757 | [»] | |
5Q1E | X-ray | 1.85 | B | 744-757 | [»] | |
5Q1F | X-ray | 2.30 | B/D | 744-757 | [»] | |
5Q1G | X-ray | 2.00 | B | 744-757 | [»] | |
5Q1H | X-ray | 2.20 | B/D/F/H | 744-757 | [»] | |
5Q1I | X-ray | 1.95 | B | 744-757 | [»] | |
5X0R | X-ray | 2.67 | C/D | 676-700 | [»] | |
5X8U | X-ray | 2.00 | B | 686-700 | [»] | |
5X8W | X-ray | 2.30 | B | 686-700 | [»] | |
5Y44 | X-ray | 2.35 | B | 745-755 | [»] | |
5YCN | X-ray | 2.15 | B | 685-700 | [»] | |
5YCP | X-ray | 2.00 | B | 685-700 | [»] | |
5YP6 | X-ray | 2.20 | B | 688-695 | [»] | |
6A5W | X-ray | 2.88 | B/D | 745-756 | [»] | |
6A5X | X-ray | 2.60 | B | 745-755 | [»] | |
6A5Y | X-ray | 2.10 | B/F | 685-700 | [»] | |
6A5Z | X-ray | 2.95 | E/F/G/I | 685-700 | [»] | |
6A60 | X-ray | 3.05 | B/F | 685-700 | [»] | |
6BNS | X-ray | 2.56 | A/B | 678-710 | [»] | |
6E3G | X-ray | 2.10 | C/D | 688-695 | [»] | |
6FO7 | X-ray | 2.59 | B | 686-700 | [»] | |
6FO8 | X-ray | 2.30 | B | 686-700 | [»] | |
6FO9 | X-ray | 2.70 | B | 686-700 | [»] | |
6FOB | X-ray | 2.75 | B | 686-700 | [»] | |
6FOD | X-ray | 2.50 | B | 686-700 | [»] | |
6GEV | X-ray | 1.54 | B | 1427-1441 | [»] | |
6GG8 | X-ray | 1.80 | B | 1427-1441 | [»] | |
6HTY | X-ray | 2.22 | A/B | 678-700 | [»] | |
6ICJ | X-ray | 2.48 | B | 676-700 | [»] | |
6IJR | X-ray | 2.85 | B/D | 685-700 | [»] | |
6IJS | X-ray | 2.15 | B | 685-700 | [»] | |
6ILQ | X-ray | 2.41 | B | 676-700 | [»] | |
6ITM | X-ray | 2.50 | B/D | 744-757 | [»] | |
6JNR | X-ray | 2.30 | C/D | 687-698 | [»] | |
6JQ7 | X-ray | 2.55 | B | 685-700 | [»] | |
6KTM | X-ray | 2.70 | B | 685-700 | [»] | |
6KTN | X-ray | 2.75 | B | 685-700 | [»] | |
6L96 | X-ray | 3.20 | C | 686-698 | [»] | |
6NX1 | X-ray | 2.27 | A/B | 678-710 | [»] | |
6P9F | X-ray | 2.80 | A/B | 683-696 | [»] | |
6SSQ | X-ray | 2.30 | F/G | 686-698 | [»] | |
6T2M | X-ray | 3.00 | B | 686-700 | [»] | |
6U25 | X-ray | 2.61 | A | 683-696 | [»] | |
6W9H | X-ray | 2.00 | A | 683-696 | [»] | |
6W9I | X-ray | 1.61 | A | 683-696 | [»] | |
SMRi | Q15788 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114200, 120 interactors |
ComplexPortali | CPX-517, PXR-NCOA1 activated nuclear receptor complex CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex CPX-5342, RXRalpha-NCOA1 activated retinoic acid receptor complex CPX-711, PPARgamma-NCOA1 activated nuclear receptor complex |
CORUMi | Q15788 |
DIPi | DIP-30877N |
IntActi | Q15788, 46 interactors |
MINTi | Q15788 |
STRINGi | 9606.ENSP00000385216 |
Chemistry databases
BindingDBi | Q15788 |
ChEMBLi | CHEMBL1615387 |
DrugBanki | DB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol DB06908, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID DB08220, (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL DB07557, 3,20-Pregnanedione DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB08915, Aleglitazar DB04652, Corticosterone DB06875, ERB-196 DB01645, Genistein DB07215, GW-590735 DB07724, Indeglitazar DB08231, Myristic acid DB06832, Prinaberel DB07080, TO-901317 |
GuidetoPHARMACOLOGYi | 2693 |
PTM databases
iPTMneti | Q15788 |
PhosphoSitePlusi | Q15788 |
Polymorphism and mutation databases
BioMutai | NCOA1 |
DMDMi | 158518533 |
Proteomic databases
CPTACi | CPTAC-1255 |
EPDi | Q15788 |
jPOSTi | Q15788 |
MassIVEi | Q15788 |
MaxQBi | Q15788 |
PaxDbi | Q15788 |
PeptideAtlasi | Q15788 |
PRIDEi | Q15788 |
ProteomicsDBi | 60761 [Q15788-1] 60762 [Q15788-2] 60763 [Q15788-3] |
Protocols and materials databases
Antibodypediai | 27525, 403 antibodies |
Genome annotation databases
Ensembli | ENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2] ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1] ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3] ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2] ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1] |
GeneIDi | 8648 |
KEGGi | hsa:8648 |
UCSCi | uc002rfj.4, human [Q15788-1] |
Organism-specific databases
CTDi | 8648 |
DisGeNETi | 8648 |
EuPathDBi | HostDB:ENSG00000084676.15 |
GeneCardsi | NCOA1 |
HGNCi | HGNC:7668, NCOA1 |
HPAi | ENSG00000084676, Low tissue specificity |
MIMi | 602691, gene |
neXtProti | NX_Q15788 |
OpenTargetsi | ENSG00000084676 |
PharmGKBi | PA31470 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
HOGENOMi | CLU_001988_0_0_1 |
InParanoidi | Q15788 |
OMAi | TPNRTNC |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q15788 |
TreeFami | TF332652 |
Enzyme and pathway databases
PathwayCommonsi | Q15788 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-159418, Recycling of bile acids and salts R-HSA-192105, Synthesis of bile acids and bile salts R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-1989781, PPARA activates gene expression R-HSA-211976, Endogenous sterols R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214847, HATs acetylate histones R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SignaLinki | Q15788 |
SIGNORi | Q15788 |
Miscellaneous databases
BioGRID-ORCSi | 8648, 9 hits in 851 CRISPR screens |
ChiTaRSi | NCOA1, human |
EvolutionaryTracei | Q15788 |
GeneWikii | Nuclear_receptor_coactivator_1 |
GenomeRNAii | 8648 |
Pharosi | Q15788, Tchem |
PROi | PR:Q15788 |
RNActi | Q15788, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000084676, Expressed in forebrain and 250 other tissues |
ExpressionAtlasi | Q15788, baseline and differential |
Genevisiblei | Q15788, HS |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 1.10.287.1070, 1 hit 4.10.280.10, 1 hit |
IDEALi | IID00083 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR010011, DUF1518 IPR036638, HLH_DNA-bd_sf IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF1, PTHR10684:SF1, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA1_HUMAN | |
Accessioni | Q15788Primary (citable) accession number: Q15788 Secondary accession number(s): O00150 Q7KYV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | September 11, 2007 | |
Last modified: | December 2, 2020 | |
This is version 197 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations