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UniProtKB - Q15788 (NCOA1_HUMAN)

Entry version 197 (02 Dec 2020)
Sequence version 3 (11 Sep 2007)
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Protein

Nuclear receptor coactivator 1

Gene

NCOA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15788

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418, Recycling of bile acids and salts
R-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-3214847, HATs acetylate histones
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15788

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15788

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 1 (EC:2.3.1.48)
Short name:
NCoA-1
Alternative name(s):
Class E basic helix-loop-helix protein 74
Short name:
bHLHe74
Protein Hin-2
RIP160
Renal carcinoma antigen NY-REN-52
Steroid receptor coactivator 1
Short name:
SRC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA1
Synonyms:BHLHE74, SRC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000084676.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:7668, NCOA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602691, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15788

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi636 – 637LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-693; A-694; A-752 and A-753. 1 Publication2
Mutagenesisi693 – 694LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-752 and A-753. 1 Publication2
Mutagenesisi732K → R: Abolishes sumoylation; when associated with R-774. 1 Publication1
Mutagenesisi752 – 753LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-693 and A-694. 1 Publication2
Mutagenesisi774K → R: Abolishes sumoylation; when associated with R-732. 1 Publication1
Mutagenesisi800K → R: Does not affect sumoylation of the protein. 1 Publication1
Mutagenesisi846K → R: Does not affect sumoylation of the protein. 1 Publication1
Mutagenesisi1378K → R: Does not affect sumoylation of the protein. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei867 – 868Breakpoint for translocation to form PAX3-NCOA1 oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		8648

Open Targets

More...OpenTargetsi		ENSG00000084676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31470

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15788, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1615387

Drug and drug target database

More...DrugBanki		DB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol
DB06908, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
DB08220, (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
DB07557, 3,20-Pregnanedione
DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
DB08915, Aleglitazar
DB04652, Corticosterone
DB06875, ERB-196
DB01645, Genistein
DB07215, GW-590735
DB07724, Indeglitazar
DB08231, Myristic acid
DB06832, Prinaberel
DB07080, TO-901317

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2693

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCOA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		158518533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944002 – 1441Nuclear receptor coactivator 1Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1 Publication1
Modified residuei395PhosphoserineCombined sources1 Publication1
Modified residuei517Phosphoserine1 Publication1
Modified residuei558PhosphoserineBy similarity1
Modified residuei569Phosphoserine1 Publication1
Modified residuei698PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1033Phosphoserine1 Publication1
Modified residuei1073Asymmetric dimethylarginineBy similarity1
Modified residuei1091Asymmetric dimethylarginineBy similarity1
Modified residuei1124Asymmetric dimethylarginineBy similarity1
Modified residuei1131Asymmetric dimethylarginineBy similarity1
Modified residuei1179Phosphothreonine1 Publication1
Modified residuei1185Phosphoserine1 Publication1
Modified residuei1372PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.1 Publication
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1255

Encyclopedia of Proteome Dynamics

More...EPDi		Q15788

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15788

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15788

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15788

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15788

PeptideAtlas

More...PeptideAtlasi		Q15788

PRoteomics IDEntifications database

More...PRIDEi		Q15788

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60761 [Q15788-1]
60762 [Q15788-2]
60763 [Q15788-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15788

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15788

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000084676, Expressed in forebrain and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15788, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15788, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000084676, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the methyltransferase CARM1 (By similarity).

Interacts with NCOA6 and NCOA2.

Interacts with the FDL motif of STAT5A and STAT5B.

Interacts with the LXXLL motif of STAT6.

Interacts with STAT3 following IL-6 stimulation.

Interacts with the basal transcription factor GTF2B.

Interacts with the histone acetyltransferases EP300 and CREBBP.

Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP.

Interacts with PSMB9.

Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity.

Interacts with PRMT2 and DDX5.

Interacts with ASXL1.

Interacts with PRMT6.

Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif).

Interacts in a ligand-dependent fashion with RXRA.

Interacts with TRIP4.

Interacts with NR4A3 (By similarity).

Interacts with VDR.

By similarity24 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114200, 120 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-517, PXR-NCOA1 activated nuclear receptor complex
CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex
CPX-5342, RXRalpha-NCOA1 activated retinoic acid receptor complex
CPX-711, PPARgamma-NCOA1 activated nuclear receptor complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15788

Database of interacting proteins

More...DIPi		DIP-30877N

Protein interaction database and analysis system

More...IntActi		Q15788, 46 interactors

Molecular INTeraction database

More...MINTi		Q15788

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385216

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15788

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15788, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15788

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15788

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 80bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini109 – 180PASPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni361 – 567Interaction with STAT31 PublicationAdd BLAST207
Regioni781 – 988Interaction with CREBBPAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi46 – 50LXXLL motif 15
Motifi112 – 116LXXLL motif 25
Motifi633 – 637LXXLL motif 35
Motifi690 – 694LXXLL motif 45
Motifi749 – 753LXXLL motif 55
Motifi913 – 917LXXLL motif 65
Motifi1435 – 1439LXXLL motif 75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi389 – 682Ser-richAdd BLAST294
Compositional biasi1053 – 1138Gln-richAdd BLAST86

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3561, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001988_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15788

Identification of Orthologs from Complete Genome Data

More...OMAi		TPNRTNC

Database of Orthologous Groups

More...OrthoDBi		59971at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15788

TreeFam database of animal gene trees

More...TreeFami		TF332652

Family and domain databases

Conserved Domains Database

More...CDDi		cd00083, HLH, 1 hit
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00083

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR010011, DUF1518
IPR036638, HLH_DNA-bd_sf
IPR028819, NCOA1
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL

The PANTHER Classification System

More...PANTHERi		PTHR10684, PTHR10684, 1 hit
PTHR10684:SF1, PTHR10684:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07469, DUF1518, 2 hits
PF00010, HLH, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038181, Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01151, DUF1518, 2 hits
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15788-1) [UniParc]FASTAAdd to basket
Also known as: SRC-1A, SRC1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL 
        60         70         80         90        100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS 
       110        120        130        140        150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 
       160        170        180        190        200
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML 
       210        220        230        240        250
IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL 
       260        270        280        290        300
PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF 
       310        320        330        340        350
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ 
       360        370        380        390        400
SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPSV NPSISPAHGV 
       410        420        430        440        450
ARSSTLPPSN SNMVSTRINR QQSSDLHSSS HSNSSNSQGS FGCSPGSQIV 
       460        470        480        490        500
ANVALNQGQA SSQSSNPSLN LNNSPMEGTG ISLAQFMSPR RQVTSGLATR 
       510        520        530        540        550
PRMPNNSFPP NISTLSSPVG MTSSACNNNN RSYSNIPVTS LQGMNEGPNN 
       560        570        580        590        600
SVGFSASSPV LRQMSSQNSP SRLNIQPAKA ESKDNKEIAS ILNEMIQSDN 
       610        620        630        640        650
SSSDGKPLDS GLLHNNDRLS DGDSKYSQTS HKLVQLLTTT AEQQLRHADI 
       660        670        680        690        700
DTSCKDVLSC TGTSNSASAN SSGGSCPSSH SSLTERHKIL HRLLQEGSPS 
       710        720        730        740        750
DITTLSVEPD KKDSASTSVS VTGQVQGNSS IKLELDASKK KESKDHQLLR 
       760        770        780        790        800
YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPTPEEIK 
       810        820        830        840        850
LEAQSQFTAD LDQFDQLLPT LEKAAQLPGL CETDRMDGAV TSVTIKSEIL 
       860        870        880        890        900
PASLQSATAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WTNNTVTAIN 
       910        920        930        940        950
QSKSEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE 
       960        970        980        990       1000
LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLIMEERPNL YSQPYSSPSP 
      1010       1020       1030       1040       1050
TANLPSPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA 
      1060       1070       1080       1090       1100
PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AATAPVGINM RSGMQQQITP 
      1110       1120       1130       1140       1150
QPPLNAQMLA QRQRELYSQQ HRQRQLIQQQ RAMLMRQQSF GNNLPPSSGL 
      1160       1170       1180       1190       1200
PVQMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AANPEASLAN 
      1210       1220       1230       1240       1250
RNSMVSRGMT GNIGGQFGTG INPQMQQNVF QYPGAGMVPQ GEANFAPSLS 
      1260       1270       1280       1290       1300
PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAI GNNNVFSQAV 
      1310       1320       1330       1340       1350
QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMAQMQM SSLQMPGMNT 
      1360       1370       1380       1390       1400
VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQQVQQV QVFADVQCTV 
      1410       1420       1430       1440 
NLVGGDPYLN QPGPLGTQKP TSGPQTPQAQ QKSLLQQLLT E
Length:1,441
Mass (Da):156,757
Last modified:September 11, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25EF6F389489121E
GO
Isoform 2 (identifier: Q15788-2) [UniParc]FASTAAdd to basket
Also known as: SRC-1E, SRC1e

The sequence of this isoform differs from the canonical sequence as follows:
     1386-1441: QVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE → DKKTEEFFSVVTTD

Note: Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation.Curated
Show »
Length:1,399
Mass (Da):152,385
Checksum:iDACE967B31AC6B69
GO
Isoform 3 (identifier: Q15788-3) [UniParc]FASTAAdd to basket
Also known as: SRC-1 (-Q)

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1385: Missing.

Show »
Length:1,440
Mass (Da):156,628
Checksum:i4E3FFED7088CDBF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCN7B5MCN7_HUMAN
Nuclear receptor coactivator 1
NCOA1
1,248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA64187 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAC50305 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1035Missing in AAT47737 (PubMed:15313887).Curated1
Sequence conflicti1370Q → H in AAA64187 (PubMed:11831720).Curated1
Sequence conflicti1382D → G in AAT47737 (PubMed:15313887).Curated1
Sequence conflicti1435L → R in AAB50242 (PubMed:9575154).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019768457Q → K3 PublicationsCorresponds to variant dbSNP:rs1049015Ensembl.1
Natural variantiVAR_019769466N → K3 PublicationsCorresponds to variant dbSNP:rs1049016Ensembl.1
Natural variantiVAR_019770474S → P3 PublicationsCorresponds to variant dbSNP:rs1049018Ensembl.1
Natural variantiVAR_019771591I → T3 PublicationsCorresponds to variant dbSNP:rs1049020Ensembl.1
Natural variantiVAR_019772685E → A3 PublicationsCorresponds to variant dbSNP:rs1049021Ensembl.1
Natural variantiVAR_019773794P → A1 PublicationCorresponds to variant dbSNP:rs1049025Ensembl.1
Natural variantiVAR_019774999S → F3 PublicationsCorresponds to variant dbSNP:rs1049032Ensembl.1
Natural variantiVAR_0197751154M → T3 PublicationsCorresponds to variant dbSNP:rs1049038Ensembl.1
Natural variantiVAR_0388321238V → I1 PublicationCorresponds to variant dbSNP:rs56099330Ensembl.1
Natural variantiVAR_0348821272P → S1 PublicationCorresponds to variant dbSNP:rs1804645Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0117381385Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_0117391386 – 1441QVQQV…QLLTE → DKKTEEFFSVVTTD in isoform 2. 4 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U59302 mRNA Translation: AAC50631.1
AJ000881 mRNA Translation: CAA04371.1
AJ000882 mRNA Translation: CAA04372.1
U90661 mRNA Translation: AAB50242.1
EF660499 Genomic DNA Translation: ABS29266.1
AC013459 Genomic DNA Translation: AAX93184.1
AC093798 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00746.1
BC111533 mRNA Translation: AAI11534.1
BC111534 mRNA Translation: AAI11535.1
U40396 mRNA Translation: AAC50305.1 Different initiation.
U19179 mRNA Translation: AAA64187.1 Different initiation.
AY633656 mRNA Translation: AAT47737.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1712.1 [Q15788-1]
CCDS1713.1 [Q15788-2]
CCDS42660.1 [Q15788-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A57620
PC4363
PC4364

NCBI Reference Sequences

More...RefSeqi		NP_003734.3, NM_003743.4 [Q15788-1]
NP_671756.1, NM_147223.2 [Q15788-2]
NP_671766.1, NM_147233.2 [Q15788-3]
XP_005264682.1, XM_005264625.1 [Q15788-1]
XP_005264683.1, XM_005264626.1 [Q15788-3]
XP_005264685.1, XM_005264628.1
XP_016860657.1, XM_017005168.1
XP_016860658.1, XM_017005169.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2]
ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1]
ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3]
ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2]
ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8648

UCSC genome browser

More...UCSCi		uc002rfj.4, human [Q15788-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59302 mRNA Translation: AAC50631.1
AJ000881 mRNA Translation: CAA04371.1
AJ000882 mRNA Translation: CAA04372.1
U90661 mRNA Translation: AAB50242.1
EF660499 Genomic DNA Translation: ABS29266.1
AC013459 Genomic DNA Translation: AAX93184.1
AC093798 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00746.1
BC111533 mRNA Translation: AAI11534.1
BC111534 mRNA Translation: AAI11535.1
U40396 mRNA Translation: AAC50305.1 Different initiation.
U19179 mRNA Translation: AAA64187.1 Different initiation.
AY633656 mRNA Translation: AAT47737.1
CCDSiCCDS1712.1 [Q15788-1]
CCDS1713.1 [Q15788-2]
CCDS42660.1 [Q15788-3]
PIRiA57620
PC4363
PC4364
RefSeqiNP_003734.3, NM_003743.4 [Q15788-1]
NP_671756.1, NM_147223.2 [Q15788-2]
NP_671766.1, NM_147233.2 [Q15788-3]
XP_005264682.1, XM_005264625.1 [Q15788-1]
XP_005264683.1, XM_005264626.1 [Q15788-3]
XP_005264685.1, XM_005264628.1
XP_016860657.1, XM_017005168.1
XP_016860658.1, XM_017005169.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM6X-ray2.10B/E/V/Y676-700[»]
1FM9X-ray2.10B/E676-700[»]
1K4WX-ray1.90B686-700[»]
1K74X-ray2.30B/E676-700[»]
1K7LX-ray2.50B/D/F/H680-700[»]
1KV6X-ray2.70C/D686-700[»]
1N4HX-ray2.10B686-700[»]
1NQ7X-ray1.50B687-696[»]
1NRLX-ray2.00C/D676-700[»]
1P8DX-ray2.80C/D676-700[»]
1PZLX-ray2.10B687-700[»]
1RDTX-ray2.40B676-700[»]
1TFCX-ray2.40C/D686-700[»]
1U3RX-ray2.21C/D630-640[»]
1U3SX-ray2.50C/D630-640[»]
1X76X-ray2.20C/D630-640[»]
1X78X-ray2.30C/D630-640[»]
1X7BX-ray2.30C/D630-640[»]
1X7JX-ray2.30C/D630-640[»]
1XIUX-ray2.50E/F686-700[»]
1XV9X-ray2.70E/F/G/H685-697[»]
1XVPX-ray2.60E/F/G/H685-697[»]
1YY4X-ray2.70C/D630-640[»]
1YYEX-ray2.03C/D630-640[»]
1ZAFX-ray2.20C/D630-640[»]
2A3IX-ray1.95B1430-1441[»]
2C52NMR-B920-970[»]
2FVJX-ray1.99B628-640[»]
2GTKX-ray2.10B631-640[»]
2HBHX-ray2.65B686-700[»]
2HC4X-ray2.20B686-700[»]
2HCDX-ray2.60B686-700[»]
2HFPX-ray2.00B680-700[»]
2NPAX-ray2.30B/D683-697[»]
2NV7X-ray2.10C/D631-640[»]
2P54X-ray1.79B686-696[»]
2PRGX-ray2.30C623-710[»]
3BEJX-ray1.90E/F676-700[»]
3BQDX-ray2.50B1429-1441[»]
3CTBX-ray2.00A/B678-700[»]
3CWDX-ray2.40C/D685-700[»]
3DCTX-ray2.50B741-761[»]
3DCUX-ray2.95B741-761[»]
3DR1X-ray2.70B686-700[»]
3ET1X-ray2.50P/Q681-696[»]
3ET3X-ray1.95P680-695[»]
3FEIX-ray2.40Z744-756[»]
3FEJX-ray2.01B628-640[»]
3FURX-ray2.30H629-640[»]
3FXVX-ray2.26B744-756[»]
3G8IX-ray2.20Z744-756[»]
3G9EX-ray2.30B628-640[»]
3GYTX-ray2.40B1429-1441[»]
3GYUX-ray2.40B1429-1441[»]
3H0AX-ray2.10B/E629-640[»]
3HC5X-ray2.60B741-761[»]
3HC6X-ray3.20B741-761[»]
3HVLX-ray2.10A/B678-700[»]
3IPQX-ray2.00B676-700[»]
3IPSX-ray2.26C/D676-700[»]
3IPUX-ray2.40C/D676-700[»]
3KMRX-ray1.80C686-698[»]
3LMPX-ray1.90C686-700[»]
3OKHX-ray2.50B744-757[»]
3OKIX-ray2.00B/D744-757[»]
3OLFX-ray1.90B/D744-757[»]
3OLLX-ray1.50C/D683-701[»]
3OLSX-ray2.20C/D683-701[»]
3OMKX-ray1.90B/D744-757[»]
3OMMX-ray2.10B/D744-757[»]
3OMOX-ray2.21C/D683-701[»]
3OMPX-ray2.05C/D683-701[»]
3OMQX-ray1.97C/D683-701[»]
3OOFX-ray2.29B/D744-757[»]
3OOKX-ray2.29B/D744-757[»]
3P88X-ray2.95B745-755[»]
3P89X-ray2.30B745-755[»]
3QT0X-ray2.50C685-700[»]
3RUTX-ray3.00B745-755[»]
3RUUX-ray2.50B745-755[»]
3RVFX-ray3.10B741-761[»]
3S9SX-ray2.55B685-697[»]
3T03X-ray2.10C/D683-700[»]
3UU7X-ray2.20F/G686-698[»]
3UUAX-ray2.05F/G686-698[»]
3UUDX-ray1.60C/D686-698[»]
3V9YX-ray2.10B686-700[»]
3VN2X-ray2.18C685-700[»]
4DK7X-ray2.45B/D745-756[»]
4DK8X-ray2.75B/D745-756[»]
4DM6X-ray1.90E/F676-700[»]
4DM8X-ray2.30C/D676-700[»]
4DQMX-ray2.75B/D1432-1441[»]
4F9MX-ray1.90C686-700[»]
4FGYX-ray2.84B686-696[»]
4G1DX-ray2.90B686-700[»]
4G1YX-ray2.85B686-700[»]
4G1ZX-ray2.50B686-700[»]
4G20X-ray2.90B686-700[»]
4G21X-ray2.90B686-700[»]
4G2HX-ray2.50B686-700[»]
4HEEX-ray2.50Y676-700[»]
4J5XX-ray2.80A/B/C/D678-700[»]
4JYGX-ray2.35F/G686-698[»]
4JYHX-ray2.60C/G686-698[»]
4JYIX-ray1.90F/G686-698[»]
4MG5X-ray2.05C/D686-698[»]
4MG6X-ray2.10C/D686-698[»]
4MG7X-ray2.15C/D686-698[»]
4MG8X-ray1.85C/D686-698[»]
4MG9X-ray2.00F/G686-698[»]
4MGAX-ray1.80C/D686-698[»]
4MGBX-ray1.85C/D686-698[»]
4MGCX-ray2.15F/G686-698[»]
4MGDX-ray1.90F/G686-698[»]
4RUJX-ray2.35B686-700[»]
4RUPX-ray2.75B686-700[»]
4TUZX-ray1.90F/G686-698[»]
4TV1X-ray1.85C/D686-698[»]
4UDAX-ray2.03B1427-1441[»]
4UDBX-ray2.36B1427-1441[»]
4Y29X-ray1.98B1432-1441[»]
5A86X-ray2.25C/D682-698[»]
5AVIX-ray2.70B/D676-700[»]
5AVLX-ray2.80B676-700[»]
5AZTX-ray3.45C683-697[»]
5DSHX-ray2.95B685-700[»]
5DV3X-ray2.75B685-700[»]
5DV6X-ray2.80B685-700[»]
5DV8X-ray2.75B685-700[»]
5DVCX-ray2.30B685-700[»]
5DWLX-ray2.20B685-700[»]
5E7VX-ray2.40B686-700[»]
5GTNX-ray1.85B685-700[»]
5GTOX-ray2.10B685-700[»]
5GTPX-ray2.35B685-700[»]
5HJSX-ray1.72C/D676-700[»]
5JI0X-ray1.98E/F676-700[»]
5JMMX-ray2.10F/G686-698[»]
5L7EX-ray1.86B1432-1441[»]
5L7GX-ray2.01B1432-1441[»]
5L7HX-ray1.84B1432-1441[»]
5MWPX-ray1.82B1427-1441[»]
5MWYX-ray1.75B1427-1441[»]
5MX7X-ray1.98B1686-700[»]
5NKYX-ray2.10B686-700[»]
5NMAX-ray2.80B686-700[»]
5NMBX-ray2.50B2686-700[»]
5NWMNMR-A257-385[»]
5OW7X-ray2.10B686-700[»]
5OW9X-ray2.40B686-700[»]
5OWDX-ray2.15B686-700[»]
5Q0JX-ray2.00B/D744-757[»]
5Q0KX-ray1.80B744-757[»]
5Q0LX-ray2.50B/D744-757[»]
5Q0MX-ray2.20B744-757[»]
5Q0NX-ray2.40B/D744-757[»]
5Q0OX-ray1.90B/D744-757[»]
5Q0PX-ray1.80B/D744-757[»]
5Q0QX-ray2.60B/D744-757[»]
5Q0RX-ray1.91B744-757[»]
5Q0SX-ray2.50B/D744-757[»]
5Q0TX-ray2.14B744-757[»]
5Q0UX-ray1.90B/D744-757[»]
5Q0VX-ray1.87B/D744-757[»]
5Q0WX-ray1.90B744-757[»]
5Q0XX-ray2.26B744-757[»]
5Q0YX-ray2.20B/D744-757[»]
5Q0ZX-ray2.26B/D744-757[»]
5Q10X-ray2.20B744-757[»]
5Q11X-ray2.20B744-757[»]
5Q12X-ray2.00B744-757[»]
5Q13X-ray1.90B/D744-757[»]
5Q14X-ray1.85B/D744-757[»]
5Q15X-ray1.90B/D744-757[»]
5Q16X-ray2.00B/D744-757[»]
5Q18X-ray1.90B/D744-757[»]
5Q19X-ray1.98B/D744-757[»]
5Q1AX-ray2.00B/D744-757[»]
5Q1BX-ray2.30B/D744-757[»]
5Q1CX-ray2.30B/D744-757[»]
5Q1DX-ray1.89B/D744-757[»]
5Q1EX-ray1.85B744-757[»]
5Q1FX-ray2.30B/D744-757[»]
5Q1GX-ray2.00B744-757[»]
5Q1HX-ray2.20B/D/F/H744-757[»]
5Q1IX-ray1.95B744-757[»]
5X0RX-ray2.67C/D676-700[»]
5X8UX-ray2.00B686-700[»]
5X8WX-ray2.30B686-700[»]
5Y44X-ray2.35B745-755[»]
5YCNX-ray2.15B685-700[»]
5YCPX-ray2.00B685-700[»]
5YP6X-ray2.20B688-695[»]
6A5WX-ray2.88B/D745-756[»]
6A5XX-ray2.60B745-755[»]
6A5YX-ray2.10B/F685-700[»]
6A5ZX-ray2.95E/F/G/I685-700[»]
6A60X-ray3.05B/F685-700[»]
6BNSX-ray2.56A/B678-710[»]
6E3GX-ray2.10C/D688-695[»]
6FO7X-ray2.59B686-700[»]
6FO8X-ray2.30B686-700[»]
6FO9X-ray2.70B686-700[»]
6FOBX-ray2.75B686-700[»]
6FODX-ray2.50B686-700[»]
6GEVX-ray1.54B1427-1441[»]
6GG8X-ray1.80B1427-1441[»]
6HTYX-ray2.22A/B678-700[»]
6ICJX-ray2.48B676-700[»]
6IJRX-ray2.85B/D685-700[»]
6IJSX-ray2.15B685-700[»]
6ILQX-ray2.41B676-700[»]
6ITMX-ray2.50B/D744-757[»]
6JNRX-ray2.30C/D687-698[»]
6JQ7X-ray2.55B685-700[»]
6KTMX-ray2.70B685-700[»]
6KTNX-ray2.75B685-700[»]
6L96X-ray3.20C686-698[»]
6NX1X-ray2.27A/B678-710[»]
6P9FX-ray2.80A/B683-696[»]
6SSQX-ray2.30F/G686-698[»]
6T2MX-ray3.00B686-700[»]
6U25X-ray2.61A683-696[»]
6W9HX-ray2.00A683-696[»]
6W9IX-ray1.61A683-696[»]
SMRiQ15788
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114200, 120 interactors
ComplexPortaliCPX-517, PXR-NCOA1 activated nuclear receptor complex
CPX-525, RARalpha-NCOA1 activated retinoic acid receptor complex
CPX-5342, RXRalpha-NCOA1 activated retinoic acid receptor complex
CPX-711, PPARgamma-NCOA1 activated nuclear receptor complex
CORUMiQ15788
DIPiDIP-30877N
IntActiQ15788, 46 interactors
MINTiQ15788
STRINGi9606.ENSP00000385216

Chemistry databases

BindingDBiQ15788
ChEMBLiCHEMBL1615387
DrugBankiDB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol
DB06908, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
DB08220, (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
DB07557, 3,20-Pregnanedione
DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
DB08915, Aleglitazar
DB04652, Corticosterone
DB06875, ERB-196
DB01645, Genistein
DB07215, GW-590735
DB07724, Indeglitazar
DB08231, Myristic acid
DB06832, Prinaberel
DB07080, TO-901317
GuidetoPHARMACOLOGYi2693

PTM databases

iPTMnetiQ15788
PhosphoSitePlusiQ15788

Polymorphism and mutation databases

BioMutaiNCOA1
DMDMi158518533

Proteomic databases

CPTACiCPTAC-1255
EPDiQ15788
jPOSTiQ15788
MassIVEiQ15788
MaxQBiQ15788
PaxDbiQ15788
PeptideAtlasiQ15788
PRIDEiQ15788
ProteomicsDBi60761 [Q15788-1]
60762 [Q15788-2]
60763 [Q15788-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27525, 403 antibodies

Genome annotation databases

EnsembliENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2]
ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1]
ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3]
ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2]
ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1]
GeneIDi8648
KEGGihsa:8648
UCSCiuc002rfj.4, human [Q15788-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8648
DisGeNETi8648
EuPathDBiHostDB:ENSG00000084676.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCOA1
HGNCiHGNC:7668, NCOA1
HPAiENSG00000084676, Low tissue specificity
MIMi602691, gene
neXtProtiNX_Q15788
OpenTargetsiENSG00000084676
PharmGKBiPA31470

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3561, Eukaryota
GeneTreeiENSGT00950000183021
HOGENOMiCLU_001988_0_0_1
InParanoidiQ15788
OMAiTPNRTNC
OrthoDBi59971at2759
PhylomeDBiQ15788
TreeFamiTF332652

Enzyme and pathway databases

PathwayCommonsiQ15788
ReactomeiR-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418, Recycling of bile acids and salts
R-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-3214847, HATs acetylate histones
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
SignaLinkiQ15788
SIGNORiQ15788

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8648, 9 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCOA1, human
EvolutionaryTraceiQ15788

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Nuclear_receptor_coactivator_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8648
PharosiQ15788, Tchem

Protein Ontology

More...PROi		PR:Q15788
RNActiQ15788, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000084676, Expressed in forebrain and 250 other tissues
ExpressionAtlasiQ15788, baseline and differential
GenevisibleiQ15788, HS

Family and domain databases

CDDicd00083, HLH, 1 hit
cd00130, PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
IDEALiIID00083
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR010011, DUF1518
IPR036638, HLH_DNA-bd_sf
IPR028819, NCOA1
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL
PANTHERiPTHR10684, PTHR10684, 1 hit
PTHR10684:SF1, PTHR10684:SF1, 1 hit
PfamiView protein in Pfam
PF07469, DUF1518, 2 hits
PF00010, HLH, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit
PIRSFiPIRSF038181, Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151, DUF1518, 2 hits
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15788
Secondary accession number(s): O00150
, O43792, O43793, Q13071, Q13420, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 11, 2007
Last modified: December 2, 2020
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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