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UniProtKB - Q15788 (NCOA1_HUMAN)

Protein

Nuclear receptor coactivator 1

Gene

NCOA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.7 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418 Recycling of bile acids and salts
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781 PPARA activates gene expression
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214847 HATs acetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ15788
SIGNORiQ15788

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 1 (EC:2.3.1.48)
Short name:
NCoA-1
Alternative name(s):
Class E basic helix-loop-helix protein 74
Short name:
bHLHe74
Protein Hin-2
RIP160
Renal carcinoma antigen NY-REN-52
Steroid receptor coactivator 1
Short name:
SRC-1
Gene namesi
Name:NCOA1
Synonyms:BHLHE74, SRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000084676.15
HGNCiHGNC:7668 NCOA1
MIMi602691 gene
neXtProtiNX_Q15788

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi636 – 637LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-693; A-694; A-752 and A-753. 1 Publication2
Mutagenesisi693 – 694LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-752 and A-753. 1 Publication2
Mutagenesisi732K → R: Abolishes sumoylation; when associated with R-774. 1 Publication1
Mutagenesisi752 – 753LL → AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-693 and A-694. 1 Publication2
Mutagenesisi774K → R: Abolishes sumoylation; when associated with R-732. 1 Publication1
Mutagenesisi800K → R: Does not affect sumoylation of the protein. 1 Publication1
Mutagenesisi846K → R: Does not affect sumoylation of the protein. 1 Publication1
Mutagenesisi1378K → R: Does not affect sumoylation of the protein. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei867 – 868Breakpoint for translocation to form PAX3-NCOA1 oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8648
OpenTargetsiENSG00000084676
PharmGKBiPA31470

Chemistry databases

ChEMBLiCHEMBL1615387
DrugBankiDB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
DB06875 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
DB08915 Aleglitazar
DB01645 Genistein
DB08231 MYRISTIC ACID
GuidetoPHARMACOLOGYi2693

Polymorphism and mutation databases

BioMutaiNCOA1
DMDMi158518533

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000944002 – 1441Nuclear receptor coactivator 1Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1 Publication1
Modified residuei395PhosphoserineCombined sources1 Publication1
Modified residuei517Phosphoserine1 Publication1
Modified residuei558PhosphoserineBy similarity1
Modified residuei569Phosphoserine1 Publication1
Modified residuei698PhosphoserineCombined sources1
Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1033Phosphoserine1 Publication1
Modified residuei1073Asymmetric dimethylarginineBy similarity1
Modified residuei1091Asymmetric dimethylarginineBy similarity1
Modified residuei1124Asymmetric dimethylarginineBy similarity1
Modified residuei1131Asymmetric dimethylarginineBy similarity1
Modified residuei1179Phosphothreonine1 Publication1
Modified residuei1185Phosphoserine1 Publication1
Modified residuei1372PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.1 Publication
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15788
MaxQBiQ15788
PaxDbiQ15788
PeptideAtlasiQ15788
PRIDEiQ15788
ProteomicsDBi60761
60762 [Q15788-2]
60763 [Q15788-3]

PTM databases

iPTMnetiQ15788
PhosphoSitePlusiQ15788

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000084676 Expressed in 240 organ(s), highest expression level in forebrain
ExpressionAtlasiQ15788 baseline and differential
GenevisibleiQ15788 HS

Organism-specific databases

HPAiCAB019402
HPA070213
HPA070520

Interactioni

Subunit structurei

Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA. Interacts with TRIP4. Interacts with NR4A3 (By similarity). Interacts with VDR.By similarity24 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114200, 114 interactors
ComplexPortaliCPX-711 PPARgamma-NCOA1 activated nuclear receptor complex
CORUMiQ15788
DIPiDIP-30877N
IntActiQ15788, 36 interactors
MINTiQ15788
STRINGi9606.ENSP00000320940

Chemistry databases

BindingDBiQ15788

Structurei

Secondary structure

11441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15788
SMRiQ15788
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15788

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 80bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini109 – 180PASPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni361 – 567Interaction with STAT31 PublicationAdd BLAST207
Regioni781 – 988Interaction with CREBBPAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50LXXLL motif 15
Motifi112 – 116LXXLL motif 25
Motifi633 – 637LXXLL motif 35
Motifi690 – 694LXXLL motif 45
Motifi749 – 753LXXLL motif 55
Motifi913 – 917LXXLL motif 65
Motifi1435 – 1439LXXLL motif 75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi389 – 682Ser-richAdd BLAST294
Compositional biasi1053 – 1138Gln-richAdd BLAST86

Domaini

The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.

Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
HOVERGENiHBG052583
InParanoidiQ15788
KOiK09101
OMAiQSMNEGP
OrthoDBiEOG091G00US
PhylomeDBiQ15788
TreeFamiTF332652

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR036638 HLH_DNA-bd_sf
IPR028819 NCOA1
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF1 PTHR10684:SF1, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 2 hits
PF00010 HLH, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 2 hits
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15788-1) [UniParc]FASTAAdd to basket
Also known as: SRC-1A, SRC1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL 
        60         70         80         90        100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS 
       110        120        130        140        150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 
       160        170        180        190        200
LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG VPWPQEATRR NSHTFNCRML 
       210        220        230        240        250
IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ SCLICIARRL 
       260        270        280        290        300
PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF 
       310        320        330        340        350
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ 
       360        370        380        390        400
SPDMQPFIMG IHIIDREHSG LSPQDDTNSG MSIPRVNPSV NPSISPAHGV 
       410        420        430        440        450
ARSSTLPPSN SNMVSTRINR QQSSDLHSSS HSNSSNSQGS FGCSPGSQIV 
       460        470        480        490        500
ANVALNQGQA SSQSSNPSLN LNNSPMEGTG ISLAQFMSPR RQVTSGLATR 
       510        520        530        540        550
PRMPNNSFPP NISTLSSPVG MTSSACNNNN RSYSNIPVTS LQGMNEGPNN 
       560        570        580        590        600
SVGFSASSPV LRQMSSQNSP SRLNIQPAKA ESKDNKEIAS ILNEMIQSDN 
       610        620        630        640        650
SSSDGKPLDS GLLHNNDRLS DGDSKYSQTS HKLVQLLTTT AEQQLRHADI 
       660        670        680        690        700
DTSCKDVLSC TGTSNSASAN SSGGSCPSSH SSLTERHKIL HRLLQEGSPS 
       710        720        730        740        750
DITTLSVEPD KKDSASTSVS VTGQVQGNSS IKLELDASKK KESKDHQLLR 
       760        770        780        790        800
YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ MDPCNTNPTP MTKPTPEEIK 
       810        820        830        840        850
LEAQSQFTAD LDQFDQLLPT LEKAAQLPGL CETDRMDGAV TSVTIKSEIL 
       860        870        880        890        900
PASLQSATAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WTNNTVTAIN 
       910        920        930        940        950
QSKSEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE 
       960        970        980        990       1000
LDRALGIDKL VQGGGLDVLS ERFPPQQATP PLIMEERPNL YSQPYSSPSP 
      1010       1020       1030       1040       1050
TANLPSPFQG MVRQKPSLGT MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA 
      1060       1070       1080       1090       1100
PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF AATAPVGINM RSGMQQQITP 
      1110       1120       1130       1140       1150
QPPLNAQMLA QRQRELYSQQ HRQRQLIQQQ RAMLMRQQSF GNNLPPSSGL 
      1160       1170       1180       1190       1200
PVQMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AANPEASLAN 
      1210       1220       1230       1240       1250
RNSMVSRGMT GNIGGQFGTG INPQMQQNVF QYPGAGMVPQ GEANFAPSLS 
      1260       1270       1280       1290       1300
PGSSMVPMPI PPPQSSLLQQ TPPASGYQSP DMKAWQQGAI GNNNVFSQAV 
      1310       1320       1330       1340       1350
QNQPTPAQPG VYNNMSITVS MAGGNTNVQN MNPMMAQMQM SSLQMPGMNT 
      1360       1370       1380       1390       1400
VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE ADGTQQVQQV QVFADVQCTV 
      1410       1420       1430       1440 
NLVGGDPYLN QPGPLGTQKP TSGPQTPQAQ QKSLLQQLLT E
Length:1,441
Mass (Da):156,757
Last modified:September 11, 2007 - v3
Checksum:i25EF6F389489121E
GO
Isoform 2 (identifier: Q15788-2) [UniParc]FASTAAdd to basket
Also known as: SRC-1E, SRC1e

The sequence of this isoform differs from the canonical sequence as follows:
     1386-1441: QVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE → DKKTEEFFSVVTTD

Note: Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation.
Show »
Length:1,399
Mass (Da):152,385
Checksum:iDACE967B31AC6B69
GO
Isoform 3 (identifier: Q15788-3) [UniParc]FASTAAdd to basket
Also known as: SRC-1 (-Q)

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1385: Missing.

Show »
Length:1,440
Mass (Da):156,628
Checksum:i4E3FFED7088CDBF8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCN7B5MCN7_HUMAN
Nuclear receptor coactivator 1
NCOA1
1,248Annotation score:

Sequence cautioni

The sequence AAA64187 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC50305 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1035Missing in AAT47737 (PubMed:15313887).Curated1
Sequence conflicti1370Q → H in AAA64187 (PubMed:11831720).Curated1
Sequence conflicti1382D → G in AAT47737 (PubMed:15313887).Curated1
Sequence conflicti1435L → R in AAB50242 (PubMed:9575154).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019768457Q → K3 PublicationsCorresponds to variant dbSNP:rs1049015Ensembl.1
Natural variantiVAR_019769466N → K3 PublicationsCorresponds to variant dbSNP:rs1049016Ensembl.1
Natural variantiVAR_019770474S → P3 PublicationsCorresponds to variant dbSNP:rs1049018Ensembl.1
Natural variantiVAR_019771591I → T3 PublicationsCorresponds to variant dbSNP:rs1049020Ensembl.1
Natural variantiVAR_019772685E → A3 PublicationsCorresponds to variant dbSNP:rs1049021Ensembl.1
Natural variantiVAR_019773794P → A1 PublicationCorresponds to variant dbSNP:rs1049025Ensembl.1
Natural variantiVAR_019774999S → F3 PublicationsCorresponds to variant dbSNP:rs1049032Ensembl.1
Natural variantiVAR_0197751154M → T3 PublicationsCorresponds to variant dbSNP:rs1049038Ensembl.1
Natural variantiVAR_0388321238V → I1 PublicationCorresponds to variant dbSNP:rs56099330Ensembl.1
Natural variantiVAR_0348821272P → S1 PublicationCorresponds to variant dbSNP:rs1804645Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0117381385Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_0117391386 – 1441QVQQV…QLLTE → DKKTEEFFSVVTTD in isoform 2. 4 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59302 mRNA Translation: AAC50631.1
AJ000881 mRNA Translation: CAA04371.1
AJ000882 mRNA Translation: CAA04372.1
U90661 mRNA Translation: AAB50242.1
EF660499 Genomic DNA Translation: ABS29266.1
AC013459 Genomic DNA Translation: AAX93184.1
AC093798 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00746.1
BC111533 mRNA Translation: AAI11534.1
BC111534 mRNA Translation: AAI11535.1
U40396 mRNA Translation: AAC50305.1 Different initiation.
U19179 mRNA Translation: AAA64187.1 Different initiation.
AY633656 mRNA Translation: AAT47737.1
CCDSiCCDS1712.1 [Q15788-1]
CCDS1713.1 [Q15788-2]
CCDS42660.1 [Q15788-3]
PIRiA57620
PC4363
PC4364
RefSeqiNP_003734.3, NM_003743.4 [Q15788-1]
NP_671756.1, NM_147223.2 [Q15788-2]
NP_671766.1, NM_147233.2 [Q15788-3]
XP_005264682.1, XM_005264625.1 [Q15788-1]
XP_005264683.1, XM_005264626.1 [Q15788-3]
XP_005264685.1, XM_005264628.1
XP_016860657.1, XM_017005168.1
XP_016860658.1, XM_017005169.1
UniGeneiHs.596314

Genome annotation databases

EnsembliENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2]
ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1]
ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3]
ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2]
ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1]
GeneIDi8648
KEGGihsa:8648
UCSCiuc002rfj.4 human [Q15788-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59302 mRNA Translation: AAC50631.1
AJ000881 mRNA Translation: CAA04371.1
AJ000882 mRNA Translation: CAA04372.1
U90661 mRNA Translation: AAB50242.1
EF660499 Genomic DNA Translation: ABS29266.1
AC013459 Genomic DNA Translation: AAX93184.1
AC093798 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00746.1
BC111533 mRNA Translation: AAI11534.1
BC111534 mRNA Translation: AAI11535.1
U40396 mRNA Translation: AAC50305.1 Different initiation.
U19179 mRNA Translation: AAA64187.1 Different initiation.
AY633656 mRNA Translation: AAT47737.1
CCDSiCCDS1712.1 [Q15788-1]
CCDS1713.1 [Q15788-2]
CCDS42660.1 [Q15788-3]
PIRiA57620
PC4363
PC4364
RefSeqiNP_003734.3, NM_003743.4 [Q15788-1]
NP_671756.1, NM_147223.2 [Q15788-2]
NP_671766.1, NM_147233.2 [Q15788-3]
XP_005264682.1, XM_005264625.1 [Q15788-1]
XP_005264683.1, XM_005264626.1 [Q15788-3]
XP_005264685.1, XM_005264628.1
XP_016860657.1, XM_017005168.1
XP_016860658.1, XM_017005169.1
UniGeneiHs.596314

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM6X-ray2.10B/E/V/Y676-700[»]
1FM9X-ray2.10B/E676-700[»]
1K4WX-ray1.90B686-700[»]
1K74X-ray2.30B/E676-700[»]
1K7LX-ray2.50B/D/F/H680-700[»]
1KV6X-ray2.70C/D686-700[»]
1N4HX-ray2.10B686-700[»]
1NQ7X-ray1.50B687-696[»]
1NRLX-ray2.00C/D676-700[»]
1P8DX-ray2.80C/D676-700[»]
1PZLX-ray2.10B687-700[»]
1RDTX-ray2.40B676-700[»]
1TFCX-ray2.40C/D686-700[»]
1U3RX-ray2.21C/D630-640[»]
1U3SX-ray2.50C/D630-640[»]
1X76X-ray2.20C/D630-640[»]
1X78X-ray2.30C/D630-640[»]
1X7BX-ray2.30C/D630-640[»]
1X7JX-ray2.30C/D630-640[»]
1XIUX-ray2.50E/F686-700[»]
1XV9X-ray2.70E/F/G/H685-697[»]
1XVPX-ray2.60E/F/G/H685-697[»]
1YY4X-ray2.70C/D630-640[»]
1YYEX-ray2.03C/D630-640[»]
1ZAFX-ray2.20C/D630-640[»]
2A3IX-ray1.95B1430-1441[»]
2C52NMR-B920-970[»]
2FVJX-ray1.99B628-640[»]
2GTKX-ray2.10B631-640[»]
2HBHX-ray2.65B686-700[»]
2HC4X-ray2.20B686-700[»]
2HCDX-ray2.60B686-700[»]
2HFPX-ray2.00B680-700[»]
2NPAX-ray2.30B/D683-697[»]
2NV7X-ray2.10C/D631-640[»]
2P54X-ray1.79B686-696[»]
2PRGX-ray2.30C623-710[»]
3BEJX-ray1.90E/F676-700[»]
3BQDX-ray2.50B1429-1441[»]
3CTBX-ray2.00A/B678-700[»]
3CWDX-ray2.40C/D685-700[»]
3DCTX-ray2.50B741-761[»]
3DCUX-ray2.95B741-761[»]
3DR1X-ray2.70B686-700[»]
3ET1X-ray2.50P/Q681-696[»]
3ET3X-ray1.95P680-695[»]
3FEIX-ray2.40Z744-756[»]
3FEJX-ray2.01B628-640[»]
3FURX-ray2.30H629-640[»]
3FXVX-ray2.26B744-756[»]
3G8IX-ray2.20Z744-756[»]
3G9EX-ray2.30B628-640[»]
3GYTX-ray2.40B1429-1441[»]
3GYUX-ray2.40B1429-1441[»]
3H0AX-ray2.10B/E629-640[»]
3HC5X-ray2.60B741-761[»]
3HC6X-ray3.20B741-761[»]
3HVLX-ray2.10A/B678-700[»]
3IPQX-ray2.00B676-700[»]
3IPSX-ray2.26C/D676-700[»]
3IPUX-ray2.40C/D676-700[»]
3KMRX-ray1.80C686-698[»]
3LMPX-ray1.90C686-700[»]
3OKHX-ray2.50B744-757[»]
3OKIX-ray2.00B/D744-757[»]
3OLFX-ray1.90B/D744-757[»]
3OLLX-ray1.50C/D683-701[»]
3OLSX-ray2.20C/D683-701[»]
3OMKX-ray1.90B/D744-757[»]
3OMMX-ray2.10B/D744-757[»]
3OMOX-ray2.21C/D683-701[»]
3OMPX-ray2.05C/D683-701[»]
3OMQX-ray1.97C/D683-701[»]
3OOFX-ray2.29B/D744-757[»]
3OOKX-ray2.29B/D744-757[»]
3P88X-ray2.95B745-755[»]
3P89X-ray2.30B745-755[»]
3QT0X-ray2.50C685-700[»]
3RUTX-ray3.00B745-755[»]
3RUUX-ray2.50B745-755[»]
3RVFX-ray3.10B741-761[»]
3S9SX-ray2.55B685-697[»]
3T03X-ray2.10C/D683-700[»]
3UU7X-ray2.20F/G686-698[»]
3UUAX-ray2.05F/G686-698[»]
3UUDX-ray1.60C/D686-698[»]
3V9YX-ray2.10B686-700[»]
3VN2X-ray2.18C685-700[»]
4DK7X-ray2.45B/D745-756[»]
4DK8X-ray2.75B/D745-756[»]
4DM6X-ray1.90E/F676-700[»]
4DM8X-ray2.30C/D676-700[»]
4DQMX-ray2.75B/D1432-1441[»]
4F9MX-ray1.90C686-700[»]
4FGYX-ray2.84B686-696[»]
4G1DX-ray2.90B686-700[»]
4G1YX-ray2.85B686-700[»]
4G1ZX-ray2.50B686-700[»]
4G20X-ray2.90B686-700[»]
4G21X-ray2.90B686-700[»]
4G2HX-ray2.50B686-700[»]
4HEEX-ray2.50Y676-700[»]
4J5XX-ray2.80A/B/C/D678-700[»]
4JYGX-ray2.35F/G686-698[»]
4JYHX-ray2.60C/G686-698[»]
4JYIX-ray1.90F/G686-698[»]
4MG5X-ray2.05C/D686-698[»]
4MG6X-ray2.10C/D686-698[»]
4MG7X-ray2.15C/D686-698[»]
4MG8X-ray1.85C/D686-698[»]
4MG9X-ray2.00F/G686-698[»]
4MGAX-ray1.80C/D686-698[»]
4MGBX-ray1.85C/D686-698[»]
4MGCX-ray2.15F/G686-698[»]
4MGDX-ray1.90F/G686-698[»]
4RUJX-ray2.35B686-700[»]
4RUPX-ray2.75B686-700[»]
4TUZX-ray1.90F/G686-698[»]
4TV1X-ray1.85C/D686-698[»]
4UDAX-ray2.03B1427-1441[»]
4UDBX-ray2.36B1427-1441[»]
4Y29X-ray1.98B1432-1441[»]
5A86X-ray2.25C/D682-698[»]
5AVIX-ray2.70B/D676-700[»]
5AVLX-ray2.80B676-700[»]
5AZTX-ray3.45C683-697[»]
5DSHX-ray2.95B685-700[»]
5DV3X-ray2.75B685-700[»]
5DV6X-ray2.80B685-700[»]
5DV8X-ray2.75B685-700[»]
5DVCX-ray2.30B685-700[»]
5DWLX-ray2.20B685-700[»]
5E7VX-ray2.40B686-700[»]
5GTNX-ray1.85B685-700[»]
5GTOX-ray2.10B685-700[»]
5GTPX-ray2.35B685-700[»]
5HJSX-ray1.72C/D676-700[»]
5JI0X-ray1.98E/F676-700[»]
5JMMX-ray2.10F/G686-698[»]
5L7EX-ray1.86B1432-1441[»]
5L7GX-ray2.01B1432-1441[»]
5L7HX-ray1.84B1432-1441[»]
5MWPX-ray1.82B1427-1441[»]
5MWYX-ray1.75B1427-1441[»]
5MX7X-ray1.98B1686-700[»]
5NKYX-ray2.10B686-700[»]
5NMAX-ray2.80B686-700[»]
5NMBX-ray2.50B2686-700[»]
5NWMNMR-A257-385[»]
5OW7X-ray2.10B686-700[»]
5OW9X-ray2.40B686-700[»]
5OWDX-ray2.15B686-700[»]
5Q0JX-ray2.00B/D744-757[»]
5Q0KX-ray1.80B744-757[»]
5Q0LX-ray2.50B/D744-757[»]
5Q0MX-ray2.20B744-757[»]
5Q0NX-ray2.40B/D744-757[»]
5Q0OX-ray1.90B/D744-757[»]
5Q0PX-ray1.80B/D744-757[»]
5Q0QX-ray2.60B/D744-757[»]
5Q0RX-ray1.91B744-757[»]
5Q0SX-ray2.50B/D744-757[»]
5Q0TX-ray2.14B744-757[»]
5Q0UX-ray1.90B/D744-757[»]
5Q0VX-ray1.87B/D744-757[»]
5Q0WX-ray1.90B744-757[»]
5Q0XX-ray2.26B744-757[»]
5Q0YX-ray2.20B/D744-757[»]
5Q0ZX-ray2.26B/D744-757[»]
5Q10X-ray2.20B744-757[»]
5Q11X-ray2.20B744-757[»]
5Q12X-ray2.00B744-757[»]
5Q13X-ray1.90B/D744-757[»]
5Q14X-ray1.85B/D744-757[»]
5Q15X-ray1.90B/D744-757[»]
5Q16X-ray2.00B/D744-757[»]
5Q18X-ray1.90B/D744-757[»]
5Q19X-ray1.98B/D744-757[»]
5Q1AX-ray2.00B/D744-757[»]
5Q1BX-ray2.30B/D744-757[»]
5Q1CX-ray2.30B/D744-757[»]
5Q1DX-ray1.89B/D744-757[»]
5Q1EX-ray1.85B744-757[»]
5Q1FX-ray2.30B/D744-757[»]
5Q1GX-ray2.00B744-757[»]
5Q1HX-ray2.20B/D/F/H744-757[»]
5Q1IX-ray1.95B744-757[»]
5X0RX-ray2.67C/D676-700[»]
5X8UX-ray2.00B686-700[»]
5X8WX-ray2.30B686-700[»]
5YCNX-ray2.15B685-700[»]
5YCPX-ray2.00B685-700[»]
5YP6X-ray2.20B688-695[»]
6BNSX-ray2.56A/B678-710[»]
6FO7X-ray2.59B686-700[»]
6FO8X-ray2.30B686-700[»]
6FO9X-ray2.70B686-700[»]
6FOBX-ray2.75B686-700[»]
6FODX-ray2.50B686-700[»]
ProteinModelPortaliQ15788
SMRiQ15788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114200, 114 interactors
ComplexPortaliCPX-711 PPARgamma-NCOA1 activated nuclear receptor complex
CORUMiQ15788
DIPiDIP-30877N
IntActiQ15788, 36 interactors
MINTiQ15788
STRINGi9606.ENSP00000320940

Chemistry databases

BindingDBiQ15788
ChEMBLiCHEMBL1615387
DrugBankiDB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
DB06875 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
DB08915 Aleglitazar
DB01645 Genistein
DB08231 MYRISTIC ACID
GuidetoPHARMACOLOGYi2693

PTM databases

iPTMnetiQ15788
PhosphoSitePlusiQ15788

Polymorphism and mutation databases

BioMutaiNCOA1
DMDMi158518533

Proteomic databases

EPDiQ15788
MaxQBiQ15788
PaxDbiQ15788
PeptideAtlasiQ15788
PRIDEiQ15788
ProteomicsDBi60761
60762 [Q15788-2]
60763 [Q15788-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288599; ENSP00000288599; ENSG00000084676 [Q15788-2]
ENST00000348332; ENSP00000320940; ENSG00000084676 [Q15788-1]
ENST00000395856; ENSP00000379197; ENSG00000084676 [Q15788-3]
ENST00000405141; ENSP00000385097; ENSG00000084676 [Q15788-2]
ENST00000406961; ENSP00000385216; ENSG00000084676 [Q15788-1]
GeneIDi8648
KEGGihsa:8648
UCSCiuc002rfj.4 human [Q15788-1]

Organism-specific databases

CTDi8648
DisGeNETi8648
EuPathDBiHostDB:ENSG00000084676.15
GeneCardsiNCOA1
HGNCiHGNC:7668 NCOA1
HPAiCAB019402
HPA070213
HPA070520
MIMi602691 gene
neXtProtiNX_Q15788
OpenTargetsiENSG00000084676
PharmGKBiPA31470
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
HOVERGENiHBG052583
InParanoidiQ15788
KOiK09101
OMAiQSMNEGP
OrthoDBiEOG091G00US
PhylomeDBiQ15788
TreeFamiTF332652

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-159418 Recycling of bile acids and salts
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781 PPARA activates gene expression
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214847 HATs acetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ15788
SIGNORiQ15788

Miscellaneous databases

ChiTaRSiNCOA1 human
EvolutionaryTraceiQ15788
GeneWikiiNuclear_receptor_coactivator_1
GenomeRNAii8648
PROiPR:Q15788
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084676 Expressed in 240 organ(s), highest expression level in forebrain
ExpressionAtlasiQ15788 baseline and differential
GenevisibleiQ15788 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR036638 HLH_DNA-bd_sf
IPR028819 NCOA1
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF1 PTHR10684:SF1, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 2 hits
PF00010 HLH, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 2 hits
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA1_HUMAN
AccessioniPrimary (citable) accession number: Q15788
Secondary accession number(s): O00150
, O43792, O43793, Q13071, Q13420, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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