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Protein

Mitochondrial import receptor subunit TOM34

Gene

TOMM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.3 Publications

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

GO - Biological processi

  • protein targeting to mitochondrion Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM34
Short name:
hTom34
Alternative name(s):
Translocase of outer membrane 34 kDa subunit
Gene namesi
Name:TOMM34
Synonyms:URCC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000025772.7
HGNCiHGNC:15746 TOMM34
MIMi616049 gene
neXtProtiNX_Q15785

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10953
OpenTargetsiENSG00000025772
PharmGKBiPA38032

Polymorphism and mutation databases

BioMutaiTOMM34
DMDMi24212065

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063341 – 309Mitochondrial import receptor subunit TOM34Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15785
MaxQBiQ15785
PaxDbiQ15785
PeptideAtlasiQ15785
PRIDEiQ15785
ProteomicsDBi60760

PTM databases

iPTMnetiQ15785
PhosphoSitePlusiQ15785
SwissPalmiQ15785

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000025772 Expressed in 214 organ(s), highest expression level in right testis
CleanExiHS_TOMM34
GenevisibleiQ15785 HS

Organism-specific databases

HPAiHPA018845
HPA056875

Interactioni

Subunit structurei

Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-1054499,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116153, 46 interactors
IntActiQ15785, 11 interactors
STRINGi9606.ENSP00000361900

Structurei

3D structure databases

ProteinModelPortaliQ15785
SMRiQ15785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 42TPR 1Add BLAST34
Repeati51 – 84TPR 2Add BLAST34
Repeati86 – 118TPR 3Add BLAST33
Repeati193 – 226TPR 4Add BLAST34
Repeati227 – 260TPR 5Add BLAST34
Repeati262 – 294TPR 6Add BLAST33

Sequence similaritiesi

Belongs to the Tom34 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000070537
HOVERGENiHBG105545
InParanoidiQ15785
KOiK17766
OMAiQSFRNGQ
OrthoDBiEOG091G0FFR
PhylomeDBiQ15785
TreeFamiTF106202

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q15785-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKFPDSVE ELRAAGNESF RNGQYAEASA LYGRALRVLQ AQGSSDPEEE
60 70 80 90 100
SVLYSNRAAC HLKDGNCRDC IKDCTSALAL VPFSIKPLLR RASAYEALEK
110 120 130 140 150
YPMAYVDYKT VLQIDDNVTS AVEGINRMTR ALMDSLGPEW RLKLPSIPLV
160 170 180 190 200
PVSAQKRWNS LPSENHKEMA KSKSKETTAT KNRVPSAGDV EKARVLKEEG
210 220 230 240 250
NELVKKGNHK KAIEKYSESL LCSNLESATY SNRALCYLVL KQYTEAVKDC
260 270 280 290 300
TEALKLDGKN VKAFYRRAQA HKALKDYKSS FADISNLLQI EPRNGPAQKL

RQEVKQNLH
Length:309
Mass (Da):34,559
Last modified:October 19, 2002 - v2
Checksum:iA39D7987CC4A57E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62 – 64LKD → WKN in AAC64484 (PubMed:9324309).Curated3
Sequence conflicti126N → S in BAD96672 (Ref. 5) Curated1
Sequence conflicti147I → F in AAC64484 (PubMed:9324309).Curated1
Sequence conflicti160S → F in AAC64484 (PubMed:9324309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059860293R → K. Corresponds to variant dbSNP:rs6094061Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58970 mRNA Translation: AAC64484.1
AB085681 mRNA Translation: BAF32949.1
BT020008 mRNA Translation: AAV38811.1
BT020009 mRNA Translation: AAV38812.1
CR456765 mRNA Translation: CAG33046.1
AK222952 mRNA Translation: BAD96672.1
AL109839 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75886.1
BC007423 mRNA Translation: AAH07423.1
BC001763 mRNA Translation: AAH01763.1
BC014907 mRNA Translation: AAH14907.1
CCDSiCCDS13340.1
RefSeqiNP_006800.2, NM_006809.4
UniGeneiHs.517066

Genome annotation databases

EnsembliENST00000372813; ENSP00000361900; ENSG00000025772
GeneIDi10953
KEGGihsa:10953
UCSCiuc002xmy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58970 mRNA Translation: AAC64484.1
AB085681 mRNA Translation: BAF32949.1
BT020008 mRNA Translation: AAV38811.1
BT020009 mRNA Translation: AAV38812.1
CR456765 mRNA Translation: CAG33046.1
AK222952 mRNA Translation: BAD96672.1
AL109839 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75886.1
BC007423 mRNA Translation: AAH07423.1
BC001763 mRNA Translation: AAH01763.1
BC014907 mRNA Translation: AAH14907.1
CCDSiCCDS13340.1
RefSeqiNP_006800.2, NM_006809.4
UniGeneiHs.517066

3D structure databases

ProteinModelPortaliQ15785
SMRiQ15785
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116153, 46 interactors
IntActiQ15785, 11 interactors
STRINGi9606.ENSP00000361900

PTM databases

iPTMnetiQ15785
PhosphoSitePlusiQ15785
SwissPalmiQ15785

Polymorphism and mutation databases

BioMutaiTOMM34
DMDMi24212065

Proteomic databases

EPDiQ15785
MaxQBiQ15785
PaxDbiQ15785
PeptideAtlasiQ15785
PRIDEiQ15785
ProteomicsDBi60760

Protocols and materials databases

DNASUi10953
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372813; ENSP00000361900; ENSG00000025772
GeneIDi10953
KEGGihsa:10953
UCSCiuc002xmy.4 human

Organism-specific databases

CTDi10953
DisGeNETi10953
EuPathDBiHostDB:ENSG00000025772.7
GeneCardsiTOMM34
HGNCiHGNC:15746 TOMM34
HPAiHPA018845
HPA056875
MIMi616049 gene
neXtProtiNX_Q15785
OpenTargetsiENSG00000025772
PharmGKBiPA38032
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000070537
HOVERGENiHBG105545
InParanoidiQ15785
KOiK17766
OMAiQSFRNGQ
OrthoDBiEOG091G0FFR
PhylomeDBiQ15785
TreeFamiTF106202

Miscellaneous databases

ChiTaRSiTOMM34 human
GeneWikiiTOMM34
GenomeRNAii10953
PROiPR:Q15785
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025772 Expressed in 214 organ(s), highest expression level in right testis
CleanExiHS_TOMM34
GenevisibleiQ15785 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTOM34_HUMAN
AccessioniPrimary (citable) accession number: Q15785
Secondary accession number(s): Q53GH9, Q6IBN7, Q9NTZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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