Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurogenic differentiation factor 2

Gene

NEUROD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 2
Short name:
NeuroD2
Alternative name(s):
Class A basic helix-loop-helix protein 1
Short name:
bHLHa1
NeuroD-related factor
Short name:
NDRF
Gene namesi
Name:NEUROD2
Synonyms:BHLHA1, NDRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171532.4
HGNCiHGNC:7763 NEUROD2
MIMi601725 gene
neXtProtiNX_Q15784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4761
OpenTargetsiENSG00000171532
PharmGKBiPA31565

Polymorphism and mutation databases

BioMutaiNEUROD2
DMDMi6226655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273871 – 382Neurogenic differentiation factor 2Add BLAST382

Proteomic databases

PaxDbiQ15784
PeptideAtlasiQ15784
PRIDEiQ15784
ProteomicsDBi60759

PTM databases

iPTMnetiQ15784
PhosphoSitePlusiQ15784

Expressioni

Gene expression databases

BgeeiENSG00000171532 Expressed in 58 organ(s), highest expression level in cerebral cortex
CleanExiHS_NEUROD2
GenevisibleiQ15784 HS

Interactioni

Subunit structurei

Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110834, 2 interactors
IntActiQ15784, 1 interactor
MINTiQ15784
STRINGi9606.ENSP00000306754

Structurei

3D structure databases

ProteinModelPortaliQ15784
SMRiQ15784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 173bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 113Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 46Poly-Pro10
Compositional biasi82 – 91Poly-Glu10
Compositional biasi282 – 285Poly-Gly4

Domaini

The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.By similarity

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiQ15784
KOiK09078
OMAiSGSPEYN
OrthoDBiEOG091G15AI
PhylomeDBiQ15784
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032649 Neurod2
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF83 PTHR19290:SF83, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q15784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG
60 70 80 90 100
PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER
110 120 130 140 150
PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC
160 170 180 190 200
YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT
210 220 230 240 250
TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ
260 270 280 290 300
CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS
310 320 330 340 350
PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR
360 370 380
GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN
Length:382
Mass (Da):41,361
Last modified:May 30, 2000 - v2
Checksum:iE33AA5C0BE371B47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104R → G in AAH22481 (PubMed:15489334).Curated1
Sequence conflicti337 – 338PT → H in BAA77569 (PubMed:10209266).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA Translation: AAC26058.1
AB021742 mRNA Translation: BAA77569.1
BC022481 mRNA Translation: AAH22481.1
CCDSiCCDS11338.1
PIRiG02668
RefSeqiNP_006151.3, NM_006160.3
UniGeneiHs.322431

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532
GeneIDi4761
KEGGihsa:4761
UCSCiuc002hry.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58681 Genomic DNA Translation: AAC26058.1
AB021742 mRNA Translation: BAA77569.1
BC022481 mRNA Translation: AAH22481.1
CCDSiCCDS11338.1
PIRiG02668
RefSeqiNP_006151.3, NM_006160.3
UniGeneiHs.322431

3D structure databases

ProteinModelPortaliQ15784
SMRiQ15784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110834, 2 interactors
IntActiQ15784, 1 interactor
MINTiQ15784
STRINGi9606.ENSP00000306754

PTM databases

iPTMnetiQ15784
PhosphoSitePlusiQ15784

Polymorphism and mutation databases

BioMutaiNEUROD2
DMDMi6226655

Proteomic databases

PaxDbiQ15784
PeptideAtlasiQ15784
PRIDEiQ15784
ProteomicsDBi60759

Protocols and materials databases

DNASUi4761
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302584; ENSP00000306754; ENSG00000171532
GeneIDi4761
KEGGihsa:4761
UCSCiuc002hry.4 human

Organism-specific databases

CTDi4761
DisGeNETi4761
EuPathDBiHostDB:ENSG00000171532.4
GeneCardsiNEUROD2
HGNCiHGNC:7763 NEUROD2
MIMi601725 gene
neXtProtiNX_Q15784
OpenTargetsiENSG00000171532
PharmGKBiPA31565
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiQ15784
KOiK09078
OMAiSGSPEYN
OrthoDBiEOG091G15AI
PhylomeDBiQ15784
TreeFamiTF315153

Miscellaneous databases

ChiTaRSiNEUROD2 human
GeneWikiiNEUROD2
GenomeRNAii4761
PROiPR:Q15784
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171532 Expressed in 58 organ(s), highest expression level in cerebral cortex
CleanExiHS_NEUROD2
GenevisibleiQ15784 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032649 Neurod2
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF83 PTHR19290:SF83, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDF2_HUMAN
AccessioniPrimary (citable) accession number: Q15784
Secondary accession number(s): Q8TBI7, Q9UQC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again