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Entry version 181 (18 Sep 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Zinc finger protein with KRAB and SCAN domains 8

Gene

ZKSCAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 8
Alternative name(s):
LD5-1
Zinc finger protein 192
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZKSCAN8
Synonyms:ZNF192
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12983 ZKSCAN8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602240 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15776

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7745

Open Targets

More...
OpenTargetsi
ENSG00000198315

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37563

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZKSCAN8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242856

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474451 – 578Zinc finger protein with KRAB and SCAN domains 8Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei201PhosphoserineBy similarity1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki272Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15776

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15776

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15776

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15776

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15776

PeptideAtlas

More...
PeptideAtlasi
Q15776

PRoteomics IDEntifications database

More...
PRIDEi
Q15776

ProteomicsDB human proteome resource

More...
ProteomicsDBi
5520
60756 [Q15776-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q15776-1 [Q15776-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15776

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15776

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198315 Expressed in 187 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15776 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15776 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003483

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF444Q8N0Y2-23EBI-2602314,EBI-12010736

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113529, 91 interactors

Protein interaction database and analysis system

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IntActi
Q15776, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15776

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini220 – 316KRABPROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri322 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161576

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234619

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15776

KEGG Orthology (KO)

More...
KOi
K09229

Identification of Orthologs from Complete Genome Data

More...
OMAi
AARCNGD

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15776

TreeFam database of animal gene trees

More...
TreeFami
TF338146

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q15776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF
60 70 80 90 100
RLRFRQLRYQ ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL
110 120 130 140 150
TILPEELQTL VKEHQLENGE EVVTLLEDLE RQIDILGRPV SARVHGHRVL
160 170 180 190 200
WEEVVHSASA PEPPNTQLQS EATQHKSPVP QESQERAMST SQSPTRSQKG
210 220 230 240 250
SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ KDLCRDNRPE
260 270 280 290 300
NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE
310 320 330 340 350
EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY
360 370 380 390 400
QCNVCGKAFS YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH
410 420 430 440 450
TGEKPYQCNQ CGKAFSQSAG LILHQRIHSG ERPYECNECG KAFSHSSHLI
460 470 480 490 500
GHQRIHTGEK PYECDECGKT FRRSSHLIGH QRSHTGEKPY KCNECGRAFS
510 520 530 540 550
QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH TGEKPYQCNE
560 570
CGKAFIQRSS LIRHQRIHSG EKSESISV
Length:578
Mass (Da):65,816
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A4FCA610DFF31F2
GO
Isoform 2 (identifier: Q15776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: ARVHGHRVLWEEVVHSA → RRRSQLAYMDIGYSGRR
     159-578: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,490
Checksum:iFAA536A9FE01EAFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34D → A in AAB02260 (PubMed:9244436).Curated1
Sequence conflicti34D → A in AAC51656 (PubMed:9244436).Curated1
Sequence conflicti113E → D in AAB02260 (PubMed:9244436).Curated1
Sequence conflicti113E → D in AAC51656 (PubMed:9244436).Curated1
Sequence conflicti152E → G in AAH96283 (PubMed:15489334).Curated1
Sequence conflicti407Q → R in AAH96284 (PubMed:15489334).Curated1
Sequence conflicti477L → F in AAH96283 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009877163P → L1 PublicationCorresponds to variant dbSNP:rs62620225Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056437142 – 158ARVHG…VVHSA → RRRSQLAYMDIGYSGRR in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056438159 – 578Missing in isoform 2. 1 PublicationAdd BLAST420

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U57796 mRNA Translation: AAB02260.1
U88080, U88079 Genomic DNA Translation: AAC51656.1
AK302402 mRNA Translation: BAG63713.1
AL358933 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03135.1
BC096282 mRNA Translation: AAH96282.1
BC096283 mRNA Translation: AAH96283.1
BC096284 mRNA Translation: AAH96284.1
BC113961 mRNA Translation: AAI13962.1
BC130032 mRNA Translation: AAI30033.1
BC152378 mRNA Translation: AAI52379.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4645.1 [Q15776-1]

NCBI Reference Sequences

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RefSeqi
NP_001265048.1, NM_001278119.1 [Q15776-1]
NP_001265050.1, NM_001278121.1
NP_006289.2, NM_006298.3 [Q15776-1]
XP_011513172.1, XM_011514870.2 [Q15776-1]
XP_016866755.1, XM_017011266.1 [Q15776-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330236; ENSP00000332750; ENSG00000198315 [Q15776-1]
ENST00000457389; ENSP00000402948; ENSG00000198315 [Q15776-1]
ENST00000536028; ENSP00000439117; ENSG00000198315 [Q15776-2]
ENST00000606198; ENSP00000475589; ENSG00000198315 [Q15776-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7745

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7745

UCSC genome browser

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UCSCi
uc003nkn.3 human [Q15776-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57796 mRNA Translation: AAB02260.1
U88080, U88079 Genomic DNA Translation: AAC51656.1
AK302402 mRNA Translation: BAG63713.1
AL358933 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03135.1
BC096282 mRNA Translation: AAH96282.1
BC096283 mRNA Translation: AAH96283.1
BC096284 mRNA Translation: AAH96284.1
BC113961 mRNA Translation: AAI13962.1
BC130032 mRNA Translation: AAI30033.1
BC152378 mRNA Translation: AAI52379.1
CCDSiCCDS4645.1 [Q15776-1]
RefSeqiNP_001265048.1, NM_001278119.1 [Q15776-1]
NP_001265050.1, NM_001278121.1
NP_006289.2, NM_006298.3 [Q15776-1]
XP_011513172.1, XM_011514870.2 [Q15776-1]
XP_016866755.1, XM_017011266.1 [Q15776-1]

3D structure databases

SMRiQ15776
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113529, 91 interactors
IntActiQ15776, 26 interactors
STRINGi9606.ENSP00000332750

PTM databases

iPTMnetiQ15776
PhosphoSitePlusiQ15776

Polymorphism and mutation databases

BioMutaiZKSCAN8
DMDMi116242856

Proteomic databases

EPDiQ15776
jPOSTiQ15776
MassIVEiQ15776
MaxQBiQ15776
PaxDbiQ15776
PeptideAtlasiQ15776
PRIDEiQ15776
ProteomicsDBi5520
60756 [Q15776-1]
TopDownProteomicsiQ15776-1 [Q15776-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q15776
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330236; ENSP00000332750; ENSG00000198315 [Q15776-1]
ENST00000457389; ENSP00000402948; ENSG00000198315 [Q15776-1]
ENST00000536028; ENSP00000439117; ENSG00000198315 [Q15776-2]
ENST00000606198; ENSP00000475589; ENSG00000198315 [Q15776-2]
GeneIDi7745
KEGGihsa:7745
UCSCiuc003nkn.3 human [Q15776-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7745
DisGeNETi7745

GeneCards: human genes, protein and diseases

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GeneCardsi
ZKSCAN8
HGNCiHGNC:12983 ZKSCAN8
HPAiHPA003483
MIMi602240 gene
neXtProtiNX_Q15776
OpenTargetsiENSG00000198315
PharmGKBiPA37563

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161576
HOGENOMiHOG000234619
InParanoidiQ15776
KOiK09229
OMAiAARCNGD
OrthoDBi1318335at2759
PhylomeDBiQ15776
TreeFamiTF338146

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZKSCAN8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7745

Pharos

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Pharosi
Q15776

Protein Ontology

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PROi
PR:Q15776

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198315 Expressed in 187 organ(s), highest expression level in prostate gland
ExpressionAtlasiQ15776 baseline and differential
GenevisibleiQ15776 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZKSC8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15776
Secondary accession number(s): A1L3D4
, B4DYF1, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: September 18, 2019
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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