UniProtKB - Q15773 (MLF2_HUMAN)

BLAST

>sp|Q15773|MLF2_HUMAN Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1
MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQ
AGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKV
YQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQD
YINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAEGPPRLAIQGPEDSPS
RQSRRYDW

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Myeloid leukemia factor 2

Gene

MLF2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8661158
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein family/group databases

MoonDBⁱ	Q15773 Predicted

MoonDBⁱ

Q15773 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myeloid leukemia factor 2 Alternative name(s): Myelodysplasia-myeloid leukemia factor 2
Gene namesⁱ	Name:MLF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089693.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7126 MLF2
MIMⁱ	601401 gene
neXtProtⁱ	NX_Q15773

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8079
Open Targets More...OpenTargetsⁱ	ENSG00000089693
PharmGKBⁱ	PA30844

Polymorphism and mutation databases

BioMutaⁱ	MLF2
DMDMⁱ	17368482

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220754	1 – 248	Myeloid leukemia factor 2Add BLAST		248

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	217	PhosphoserineCombined sources	1
Modified residueⁱ	238	PhosphoserineCombined sources	1
Modified residueⁱ	240	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15773
PaxDbⁱ	Q15773
PeptideAtlas More...PeptideAtlasⁱ	Q15773
PRIDEⁱ	Q15773
ProteomicsDBⁱ	60755

PTM databases

iPTMnetⁱ	Q15773
PhosphoSitePlusⁱ	Q15773

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000089693 Expressed in 231 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_MLF2
ExpressionAtlasⁱ	Q15773 baseline and differential
Genevisibleⁱ	Q15773 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010811 HPA010859

HPAⁱ

HPA010811
HPA010859

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DNAJB6	O75190	3	EBI-1051875,EBI-1053164

With

Entry

#Exp.

IntAct

Notes

DNAJB6

O75190

EBI-1051875,EBI-1053164

Protein-protein interaction databases

BioGridⁱ	113752, 47 interactors
IntActⁱ	Q15773, 39 interactors
Molecular INTeraction database More...MINTⁱ	Q15773
STRINGⁱ	9606.ENSP00000203630

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MLF family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4049 Eukaryota ENOG4111J7M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005023
HOGENOMⁱ	HOG000045671
HOVERGENⁱ	HBG019060
InParanoidⁱ	Q15773
OMAⁱ	MERMSGS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JFX
PhylomeDBⁱ	Q15773
TreeFamⁱ	TF317561

Family and domain databases

InterProⁱ	View protein in InterPro IPR019376 Myeloid_leukemia_factor
PANTHERⁱ	PTHR13105 PTHR13105, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10248 Mlf1IP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q15773-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG 
        60         70         80         90        100
TRPASRRMQQ AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ 
       110        120        130        140        150
TFSSSTVISY SNTGDGAPKV YQETSEMRSA PGGIRETRRT VRDSDSGLEQ 
       160        170        180        190        200
MSIGHHIRDR AHILQRSRNH RTGDQEERQD YINLDESEAA AFDDEWRRET 
       210        220        230        240 
SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS RQSRRYDW

Length:248

Mass (Da):28,147

Last modified:November 1, 1996 - v1

Checksum:ⁱEB1DC52AD1767715

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H800	F5H800_HUMAN	Myeloid leukemia factor 2 Myeloid leukemia factor 2	MLF2	121	Annotation score:
F5H0Y3	F5H0Y3_HUMAN	Myeloid leukemia factor 2 Myeloid leukemia factor 2	MLF2	230	Annotation score:
F5H7L5	F5H7L5_HUMAN	Myeloid leukemia factor 2 Myeloid leukemia factor 2	MLF2	79	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036429	80	F → C in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57342 mRNA Translation: AAB08988.1 AF070539 mRNA Translation: AAC28632.1 BC000898 mRNA Translation: AAH00898.1 BC002340 mRNA Translation: AAH02340.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8559.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005430.1, NM_005439.2
UniGeneⁱ	Hs.524214

Genome annotation databases

Ensemblⁱ	ENST00000203630; ENSP00000203630; ENSG00000089693 ENST00000435120; ENSP00000403941; ENSG00000089693 ENST00000539187; ENSP00000446317; ENSG00000089693 ENST00000542154; ENSP00000438671; ENSG00000089693
GeneIDⁱ	8079
KEGGⁱ	hsa:8079

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15773	MLF2 protein		HUMAN		248	UniRef100_Q15773
MLF2 isoform 1		PANTR		248
Myelodysplasia-myeloid leukemia factor 2		MACMU		248
Myeloid leukemia factor 2		MACNE		248
Uncharacterized protein		CERAT		248
+7

Protein	Similar proteins		Species	Score	Length	Source
Q15773	MLF2 protein		HUMAN		248	UniRef90_Q15773
MLF2 isoform 1		PANTR		248
Myelodysplasia-myeloid leukemia factor 2		MACMU		248
Myeloid leukemia factor 2		MACNE		248
Uncharacterized protein		CERAT		248
+25

Protein	Similar proteins		Species	Score	Length	Source
Q15773	Myeloid leukemia factor 2		MOUSE		247	UniRef50_Q15773
MLF2 protein		HUMAN		248
MLF2 isoform 1		PANTR		248
Myelodysplasia-myeloid leukemia factor 2		MACMU		248
Myeloid leukemia factor 2		MACNE		248
+312

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57342 mRNA Translation: AAB08988.1 AF070539 mRNA Translation: AAC28632.1 BC000898 mRNA Translation: AAH00898.1 BC002340 mRNA Translation: AAH02340.1
CCDSⁱ	CCDS8559.1
RefSeqⁱ	NP_005430.1, NM_005439.2
UniGeneⁱ	Hs.524214

3D structure databases

ProteinModelPortalⁱ	Q15773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113752, 47 interactors
IntActⁱ	Q15773, 39 interactors
MINTⁱ	Q15773
STRINGⁱ	9606.ENSP00000203630

Protein family/group databases

MoonDBⁱ	Q15773 Predicted

MoonDBⁱ

Q15773 Predicted

PTM databases

iPTMnetⁱ	Q15773
PhosphoSitePlusⁱ	Q15773

Polymorphism and mutation databases

BioMutaⁱ	MLF2
DMDMⁱ	17368482

Proteomic databases

EPDⁱ	Q15773
PaxDbⁱ	Q15773
PeptideAtlasⁱ	Q15773
PRIDEⁱ	Q15773
ProteomicsDBⁱ	60755

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8079
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000203630; ENSP00000203630; ENSG00000089693 ENST00000435120; ENSP00000403941; ENSG00000089693 ENST00000539187; ENSP00000446317; ENSG00000089693 ENST00000542154; ENSP00000438671; ENSG00000089693
GeneIDⁱ	8079
KEGGⁱ	hsa:8079

Organism-specific databases

CTDⁱ	8079
DisGeNETⁱ	8079
EuPathDBⁱ	HostDB:ENSG00000089693.10
GeneCardsⁱ	MLF2
HGNCⁱ	HGNC:7126 MLF2
HPAⁱ	HPA010811 HPA010859
MIMⁱ	601401 gene
neXtProtⁱ	NX_Q15773
OpenTargetsⁱ	ENSG00000089693
PharmGKBⁱ	PA30844
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4049 Eukaryota ENOG4111J7M LUCA
GeneTreeⁱ	ENSGT00390000005023
HOGENOMⁱ	HOG000045671
HOVERGENⁱ	HBG019060
InParanoidⁱ	Q15773
OMAⁱ	MERMSGS
OrthoDBⁱ	EOG091G0JFX
PhylomeDBⁱ	Q15773
TreeFamⁱ	TF317561

Miscellaneous databases

ChiTaRSⁱ	MLF2 human
GenomeRNAiⁱ	8079
Protein Ontology More...PROⁱ	PR:Q15773
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089693 Expressed in 231 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_MLF2
ExpressionAtlasⁱ	Q15773 baseline and differential
Genevisibleⁱ	Q15773 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019376 Myeloid_leukemia_factor
PANTHERⁱ	PTHR13105 PTHR13105, 1 hit
Pfamⁱ	View protein in Pfam PF10248 Mlf1IP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MLF2_HUMAN
Accessionⁱ	Q15773Primary (citable) accession number: Q15773
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q15773 (MLF2_HUMAN)

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Myeloid leukemia factor 2

MLF2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ