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Protein

Myeloid leukemia factor 2

Gene

MLF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: GO_Central

GO - Biological processi

  • defense response Source: UniProtKB
  • regulation of transcription, DNA-templated Source: GO_Central

Protein family/group databases

MoonDBiQ15773 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid leukemia factor 2
Alternative name(s):
Myelodysplasia-myeloid leukemia factor 2
Gene namesi
Name:MLF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000089693.10
HGNCiHGNC:7126 MLF2
MIMi601401 gene
neXtProtiNX_Q15773

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8079
OpenTargetsiENSG00000089693
PharmGKBiPA30844

Polymorphism and mutation databases

BioMutaiMLF2
DMDMi17368482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207541 – 248Myeloid leukemia factor 2Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15773
PaxDbiQ15773
PeptideAtlasiQ15773
PRIDEiQ15773
ProteomicsDBi60755

PTM databases

iPTMnetiQ15773
PhosphoSitePlusiQ15773

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000089693 Expressed in 231 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_MLF2
ExpressionAtlasiQ15773 baseline and differential
GenevisibleiQ15773 HS

Organism-specific databases

HPAiHPA010811
HPA010859

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJB6O751903EBI-1051875,EBI-1053164

Protein-protein interaction databases

BioGridi113752, 47 interactors
IntActiQ15773, 39 interactors
MINTiQ15773
STRINGi9606.ENSP00000203630

Structurei

3D structure databases

ProteinModelPortaliQ15773
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MLF family.Curated

Phylogenomic databases

eggNOGiKOG4049 Eukaryota
ENOG4111J7M LUCA
GeneTreeiENSGT00390000005023
HOGENOMiHOG000045671
HOVERGENiHBG019060
InParanoidiQ15773
OMAiMERMSGS
OrthoDBiEOG091G0JFX
PhylomeDBiQ15773
TreeFamiTF317561

Family and domain databases

InterProiView protein in InterPro
IPR019376 Myeloid_leukemia_factor
PANTHERiPTHR13105 PTHR13105, 1 hit
PfamiView protein in Pfam
PF10248 Mlf1IP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15773-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG
60 70 80 90 100
TRPASRRMQQ AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ
110 120 130 140 150
TFSSSTVISY SNTGDGAPKV YQETSEMRSA PGGIRETRRT VRDSDSGLEQ
160 170 180 190 200
MSIGHHIRDR AHILQRSRNH RTGDQEERQD YINLDESEAA AFDDEWRRET
210 220 230 240
SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS RQSRRYDW
Length:248
Mass (Da):28,147
Last modified:November 1, 1996 - v1
Checksum:iEB1DC52AD1767715
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H800F5H800_HUMAN
Myeloid leukemia factor 2
MLF2
121Annotation score:
F5H0Y3F5H0Y3_HUMAN
Myeloid leukemia factor 2
MLF2
230Annotation score:
F5H7L5F5H7L5_HUMAN
Myeloid leukemia factor 2
MLF2
79Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03642980F → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57342 mRNA Translation: AAB08988.1
AF070539 mRNA Translation: AAC28632.1
BC000898 mRNA Translation: AAH00898.1
BC002340 mRNA Translation: AAH02340.1
CCDSiCCDS8559.1
RefSeqiNP_005430.1, NM_005439.2
UniGeneiHs.524214

Genome annotation databases

EnsembliENST00000203630; ENSP00000203630; ENSG00000089693
ENST00000435120; ENSP00000403941; ENSG00000089693
ENST00000539187; ENSP00000446317; ENSG00000089693
ENST00000542154; ENSP00000438671; ENSG00000089693
GeneIDi8079
KEGGihsa:8079

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57342 mRNA Translation: AAB08988.1
AF070539 mRNA Translation: AAC28632.1
BC000898 mRNA Translation: AAH00898.1
BC002340 mRNA Translation: AAH02340.1
CCDSiCCDS8559.1
RefSeqiNP_005430.1, NM_005439.2
UniGeneiHs.524214

3D structure databases

ProteinModelPortaliQ15773
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113752, 47 interactors
IntActiQ15773, 39 interactors
MINTiQ15773
STRINGi9606.ENSP00000203630

Protein family/group databases

MoonDBiQ15773 Predicted

PTM databases

iPTMnetiQ15773
PhosphoSitePlusiQ15773

Polymorphism and mutation databases

BioMutaiMLF2
DMDMi17368482

Proteomic databases

EPDiQ15773
PaxDbiQ15773
PeptideAtlasiQ15773
PRIDEiQ15773
ProteomicsDBi60755

Protocols and materials databases

DNASUi8079
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203630; ENSP00000203630; ENSG00000089693
ENST00000435120; ENSP00000403941; ENSG00000089693
ENST00000539187; ENSP00000446317; ENSG00000089693
ENST00000542154; ENSP00000438671; ENSG00000089693
GeneIDi8079
KEGGihsa:8079

Organism-specific databases

CTDi8079
DisGeNETi8079
EuPathDBiHostDB:ENSG00000089693.10
GeneCardsiMLF2
HGNCiHGNC:7126 MLF2
HPAiHPA010811
HPA010859
MIMi601401 gene
neXtProtiNX_Q15773
OpenTargetsiENSG00000089693
PharmGKBiPA30844
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4049 Eukaryota
ENOG4111J7M LUCA
GeneTreeiENSGT00390000005023
HOGENOMiHOG000045671
HOVERGENiHBG019060
InParanoidiQ15773
OMAiMERMSGS
OrthoDBiEOG091G0JFX
PhylomeDBiQ15773
TreeFamiTF317561

Miscellaneous databases

ChiTaRSiMLF2 human
GenomeRNAii8079
PROiPR:Q15773
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089693 Expressed in 231 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_MLF2
ExpressionAtlasiQ15773 baseline and differential
GenevisibleiQ15773 HS

Family and domain databases

InterProiView protein in InterPro
IPR019376 Myeloid_leukemia_factor
PANTHERiPTHR13105 PTHR13105, 1 hit
PfamiView protein in Pfam
PF10248 Mlf1IP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMLF2_HUMAN
AccessioniPrimary (citable) accession number: Q15773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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