UniProtKB - Q15773 (MLF2_HUMAN)
Protein
Myeloid leukemia factor 2
Gene
MLF2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q15773 |
Protein family/group databases
MoonDBi | Q15773, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid leukemia factor 2Alternative name(s): Myelodysplasia-myeloid leukemia factor 2 |
Gene namesi | Name:MLF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7126, MLF2 |
MIMi | 601401, gene |
neXtProti | NX_Q15773 |
VEuPathDBi | HostDB:ENSG00000089693.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8079 |
OpenTargetsi | ENSG00000089693 |
PharmGKBi | PA30844 |
Miscellaneous databases
Pharosi | Q15773, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295830 |
Genetic variation databases
BioMutai | MLF2 |
DMDMi | 17368482 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220754 | 1 – 248 | Myeloid leukemia factor 2Add BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | PhosphoserineCombined sources | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15773 |
jPOSTi | Q15773 |
MassIVEi | Q15773 |
PaxDbi | Q15773 |
PeptideAtlasi | Q15773 |
PRIDEi | Q15773 |
ProteomicsDBi | 60755 |
PTM databases
iPTMneti | Q15773 |
PhosphoSitePlusi | Q15773 |
Expressioni
Tissue specificityi
Ubiquitously expressed.
Gene expression databases
Bgeei | ENSG00000089693, Expressed in anterior cingulate cortex and 244 other tissues |
ExpressionAtlasi | Q15773, baseline and differential |
Genevisiblei | Q15773, HS |
Organism-specific databases
HPAi | ENSG00000089693, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ15773
Protein-protein interaction databases
BioGRIDi | 113752, 76 interactors |
IntActi | Q15773, 122 interactors |
MINTi | Q15773 |
STRINGi | 9606.ENSP00000203630 |
Miscellaneous databases
RNActi | Q15773, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MLF family.Curated
Phylogenomic databases
eggNOGi | KOG4049, Eukaryota |
GeneTreei | ENSGT00390000005023 |
HOGENOMi | CLU_063313_3_0_1 |
InParanoidi | Q15773 |
OMAi | PFMMDPF |
OrthoDBi | 1471165at2759 |
PhylomeDBi | Q15773 |
TreeFami | TF317561 |
Family and domain databases
InterProi | View protein in InterPro IPR019376, Myeloid_leukemia_factor |
PANTHERi | PTHR13105, PTHR13105, 1 hit |
Pfami | View protein in Pfam PF10248, Mlf1IP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q15773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG
60 70 80 90 100
TRPASRRMQQ AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ
110 120 130 140 150
TFSSSTVISY SNTGDGAPKV YQETSEMRSA PGGIRETRRT VRDSDSGLEQ
160 170 180 190 200
MSIGHHIRDR AHILQRSRNH RTGDQEERQD YINLDESEAA AFDDEWRRET
210 220 230 240
SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS RQSRRYDW
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H0Y3 | F5H0Y3_HUMAN | Myeloid leukemia factor 2 | MLF2 | 230 | Annotation score: | ||
F5H800 | F5H800_HUMAN | Myeloid leukemia factor 2 | MLF2 | 121 | Annotation score: | ||
F5H7L5 | F5H7L5_HUMAN | Myeloid leukemia factor 2 | MLF2 | 79 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036429 | 80 | F → C in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57342 mRNA Translation: AAB08988.1 AF070539 mRNA Translation: AAC28632.1 BC000898 mRNA Translation: AAH00898.1 BC002340 mRNA Translation: AAH02340.1 |
CCDSi | CCDS8559.1 |
RefSeqi | NP_005430.1, NM_005439.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57342 mRNA Translation: AAB08988.1 AF070539 mRNA Translation: AAC28632.1 BC000898 mRNA Translation: AAH00898.1 BC002340 mRNA Translation: AAH02340.1 |
CCDSi | CCDS8559.1 |
RefSeqi | NP_005430.1, NM_005439.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113752, 76 interactors |
IntActi | Q15773, 122 interactors |
MINTi | Q15773 |
STRINGi | 9606.ENSP00000203630 |
Chemistry databases
ChEMBLi | CHEMBL4295830 |
Protein family/group databases
MoonDBi | Q15773, Predicted |
PTM databases
iPTMneti | Q15773 |
PhosphoSitePlusi | Q15773 |
Genetic variation databases
BioMutai | MLF2 |
DMDMi | 17368482 |
Proteomic databases
EPDi | Q15773 |
jPOSTi | Q15773 |
MassIVEi | Q15773 |
PaxDbi | Q15773 |
PeptideAtlasi | Q15773 |
PRIDEi | Q15773 |
ProteomicsDBi | 60755 |
Protocols and materials databases
Antibodypediai | 2268, 230 antibodies |
DNASUi | 8079 |
Genome annotation databases
Organism-specific databases
CTDi | 8079 |
DisGeNETi | 8079 |
GeneCardsi | MLF2 |
HGNCi | HGNC:7126, MLF2 |
HPAi | ENSG00000089693, Low tissue specificity |
MIMi | 601401, gene |
neXtProti | NX_Q15773 |
OpenTargetsi | ENSG00000089693 |
PharmGKBi | PA30844 |
VEuPathDBi | HostDB:ENSG00000089693.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4049, Eukaryota |
GeneTreei | ENSGT00390000005023 |
HOGENOMi | CLU_063313_3_0_1 |
InParanoidi | Q15773 |
OMAi | PFMMDPF |
OrthoDBi | 1471165at2759 |
PhylomeDBi | Q15773 |
TreeFami | TF317561 |
Enzyme and pathway databases
PathwayCommonsi | Q15773 |
Miscellaneous databases
BioGRID-ORCSi | 8079, 7 hits in 864 CRISPR screens |
ChiTaRSi | MLF2, human |
GenomeRNAii | 8079 |
Pharosi | Q15773, Tbio |
PROi | PR:Q15773 |
RNActi | Q15773, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089693, Expressed in anterior cingulate cortex and 244 other tissues |
ExpressionAtlasi | Q15773, baseline and differential |
Genevisiblei | Q15773, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019376, Myeloid_leukemia_factor |
PANTHERi | PTHR13105, PTHR13105, 1 hit |
Pfami | View protein in Pfam PF10248, Mlf1IP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MLF2_HUMAN | |
Accessioni | Q15773Primary (citable) accession number: Q15773 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families