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UniProtKB - Q15772 (SPEG_HUMAN)

Entry version 191 (23 Feb 2022)
Sequence version 4 (16 Dec 2008)
Previous versions | rss
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Protein

Striated muscle preferentially expressed protein kinase

Gene

SPEG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1630ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1719Proton acceptorBy similarity1
Binding sitei2995ATPPROSITE-ProRule annotation1
Active sitei3085Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1607 – 1615ATPPROSITE-ProRule annotation9
Nucleotide bindingi2972 – 2980ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15772

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15772

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Striated muscle preferentially expressed protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPEG
Synonyms:APEG1, KIAA1297
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16901, SPEG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615950, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15772

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072195

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, centronuclear, 5 (CNM5)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of centronuclear myopathy, a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. CNM5 features include severe neonatal hypotonia with respiratory insufficiency, difficulty feeding, and delayed motor development. Some patients die in infancy, and some develop dilated cardiomyopathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0718082757G → V in CNM5. 1 PublicationCorresponds to variant dbSNP:rs587777676EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		10290

MalaCards human disease database

More...MalaCardsi		SPEG
MIMi615959, phenotype

Open Targets

More...OpenTargetsi		ENSG00000072195

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169186, Autosomal recessive centronuclear myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15772, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPEG

Domain mapping of disease mutations (DMDM)

More...DMDMi		218512143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726661 – 3267Striated muscle preferentially expressed protein kinaseAdd BLAST3267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei139PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei375PhosphothreonineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei449PhosphothreonineBy similarity1
Modified residuei453PhosphoserineBy similarity1
Modified residuei488PhosphoserineCombined sources1
Modified residuei506PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei549PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi989 ↔ 1041PROSITE-ProRule annotation
Modified residuei1128PhosphoserineBy similarity1
Modified residuei1172PhosphoserineBy similarity1
Modified residuei1988PhosphoserineBy similarity1
Modified residuei2014PhosphoserineBy similarity1
Modified residuei2015PhosphoserineBy similarity1
Modified residuei2037PhosphoserineBy similarity1
Modified residuei2055Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei2055Omega-N-methylarginine; alternateBy similarity1
Modified residuei2109PhosphoserineBy similarity1
Modified residuei2130PhosphoserineBy similarity1
Modified residuei2139Omega-N-methylarginineBy similarity1
Modified residuei2177PhosphoserineBy similarity1
Modified residuei2376PhosphoserineBy similarity1
Modified residuei2380PhosphothreonineBy similarity1
Modified residuei2410PhosphoserineBy similarity1
Modified residuei2414PhosphoserineBy similarity1
Modified residuei2438PhosphoserineBy similarity1
Modified residuei2439PhosphoserineBy similarity1
Modified residuei2444PhosphoserineBy similarity1
Modified residuei2448PhosphoserineBy similarity1
Modified residuei2521PhosphoserineBy similarity1
Modified residuei2524PhosphoserineBy similarity1
Modified residuei2559PhosphoserineBy similarity1
Disulfide bondi2605 ↔ 2657PROSITE-ProRule annotation
Modified residuei2771PhosphothreonineBy similarity1
Modified residuei2774PhosphoserineBy similarity1
Modified residuei2949PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autophosphorylated.

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15772

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15772

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15772

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15772

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15772

PeptideAtlas

More...PeptideAtlasi		Q15772

PRoteomics IDEntifications database

More...PRIDEi		Q15772

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60751 [Q15772-5]
60752 [Q15772-1]
60753 [Q15772-3]
60754 [Q15772-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15772, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15772

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15772

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072195, Expressed in esophagus and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15772, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15772, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072195, Tissue enhanced (intestine, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTM1. Isoform 3 is found as a monomer or homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115579, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q15772, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311684

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15772, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15772

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15772

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 124Ig-like 1Add BLAST82
Domaini722 – 810Ig-like 2Add BLAST89
Domaini869 – 958Ig-like 3Add BLAST90
Domaini963 – 1057Ig-like 4Add BLAST95
Domaini1064 – 1152Ig-like 5Add BLAST89
Domaini1188 – 1278Ig-like 6Add BLAST91
Domaini1285 – 1382Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini1384 – 1480Ig-like 7Add BLAST97
Domaini1485 – 1573Ig-like 8Add BLAST89
Domaini1601 – 1854Protein kinase 1PROSITE-ProRule annotationAdd BLAST254
Domaini2583 – 2673Ig-like 9Add BLAST91
Domaini2680 – 2774Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini2966 – 3218Protein kinase 2PROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni132 – 227DisorderedSequence analysisAdd BLAST96
Regioni276 – 714DisorderedSequence analysisAdd BLAST439
Regioni812 – 872DisorderedSequence analysisAdd BLAST61
Regioni1157 – 1180DisorderedSequence analysisAdd BLAST24
Regioni1906 – 2060DisorderedSequence analysisAdd BLAST155
Regioni2074 – 2239DisorderedSequence analysisAdd BLAST166
Regioni2253 – 2325DisorderedSequence analysisAdd BLAST73
Regioni2339 – 2399DisorderedSequence analysisAdd BLAST61
Regioni2411 – 2452DisorderedSequence analysisAdd BLAST42
Regioni2466 – 2564DisorderedSequence analysisAdd BLAST99
Regioni2771 – 2896DisorderedSequence analysisAdd BLAST126
Regioni2909 – 2966DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 199Polar residuesSequence analysisAdd BLAST43
Compositional biasi295 – 331Pro residuesSequence analysisAdd BLAST37
Compositional biasi340 – 359Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi361 – 381Polar residuesSequence analysisAdd BLAST21
Compositional biasi402 – 418Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi471 – 487Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi495 – 516Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi538 – 556Polar residuesSequence analysisAdd BLAST19
Compositional biasi585 – 599Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi661 – 683Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi812 – 828Polar residuesSequence analysisAdd BLAST17
Compositional biasi848 – 868Polar residuesSequence analysisAdd BLAST21
Compositional biasi2164 – 2178Polar residuesSequence analysisAdd BLAST15
Compositional biasi2199 – 2237Pro residuesSequence analysisAdd BLAST39
Compositional biasi2353 – 2371Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2466 – 2481Polar residuesSequence analysisAdd BLAST16
Compositional biasi2512 – 2540Polar residuesSequence analysisAdd BLAST29
Compositional biasi2798 – 2828Pro residuesSequence analysisAdd BLAST31
Compositional biasi2882 – 2896Polar residuesSequence analysisAdd BLAST15
Compositional biasi2909 – 2927Pro residuesSequence analysisAdd BLAST19
Compositional biasi2928 – 2962Polar residuesSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0032, Eukaryota
KOG0613, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000381_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15772

Database of Orthologous Groups

More...OrthoDBi		7796at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15772

TreeFam database of animal gene trees

More...TreeFami		TF331962

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR015726, Ser/Thr_kin_striated-sp
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR47633:SF3, PTHR47633:SF3, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679, I-set, 9 hits
PF00069, Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 9 hits
SM00408, IGc2, 9 hits
SM00220, S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 8 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q15772-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGGGAPVAVA GAPVFLRPLK 
        60         70         80         90        100
NAAVCAGSDV RLRVVVSGTP QPSLRWFRDG QLLPAPAPEP SCLWLRRCGA 
       110        120        130        140        150
QDAGVYSCMA QNERGRASCE AVLTVLEVGD SETAEDDISD VQGTQRLELR 
       160        170        180        190        200
DDGAFSTPTG GSDTLVGTSL DTPPTSVTGT SEEQVSWWGS GQTVLEQEAG 
       210        220        230        240        250
SGGGTRRLPG SPRQAQATGA GPRHLGVEPL VRASRANLVG ASWGSEDSLS 
       260        270        280        290        300
VASDLYGSAF SLYRGRALSI HVSVPQSGLR REEPDLQPQL ASEAPRRPAQ 
       310        320        330        340        350
PPPSKSALLP PPSPRVGKRS PPGPPAQPAA TPTSPHRRTQ EPVLPEDTTT 
       360        370        380        390        400
EEKRGKKSKS SGPSLAGTAE SRPQTPLSEA SGRLSALGRS PRLVRAGSRI 
       410        420        430        440        450
LDKLQFFEER RRSLERSDSP PAPLRPWVPL RKARSLEQPK SERGAPWGTP 
       460        470        480        490        500
GASQEELRAP GSVAERRRLF QQKAASLDER TRQRSPASDL ELRFAQELGR 
       510        520        530        540        550
IRRSTSREEL VRSHESLRAT LQRAPSPREP GEPPLFSRPS TPKTSRAVSP 
       560        570        580        590        600
AAAQPPSPSS AEKPGDEPGR PRSRGPAGRT EPGEGPQQEV RRRDQFPLTR 
       610        620        630        640        650
SRAIQECRSP VPPPAADPPE ARTKAPPGRK REPPAQAVRF LPWATPGLEG 
       660        670        680        690        700
AAVPQTLEKN RAGPEAEKRL RRGPEEDGPW GPWDRRGARS QGKGRRARPT 
       710        720        730        740        750
SPELESSDDS YVSAGEEPLE APVFEIPLQN VVVAPGADVL LKCIITANPP 
       760        770        780        790        800
PQVSWHKDGS ALRSEGRLLL RAEGERHTLL LREARAADAG SYMATATNEL 
       810        820        830        840        850
GQATCAASLT VRPGGSTSPF SSPITSDEEY LSPPEEFPEP GETWPRTPTM 
       860        870        880        890        900
KPSPSQNRRS SDTGSKAPPT FKVSLMDQSV REGQDVIMSI RVQGEPKPVV 
       910        920        930        940        950
SWLRNRQPVR PDQRRFAEEA EGGLCRLRIL AAERGDAGFY TCKAVNEYGA 
       960        970        980        990       1000
RQCEARLEVR AHPESRSLAV LAPLQDVDVG AGEMALFECL VAGPTDVEVD 
      1010       1020       1030       1040       1050
WLCRGRLLQP ALLKCKMHFD GRKCKLLLTS VHEDDSGVYT CKLSTAKDEL 
      1060       1070       1080       1090       1100
TCSARLTVRP SLAPLFTRLL EDVEVLEGRA ARFDCKISGT PPPVVTWTHF 
      1110       1120       1130       1140       1150
GCPMEESENL RLRQDGGLHS LHIAHVGSED EGLYAVSAVN THGQAHCSAQ 
      1160       1170       1180       1190       1200
LYVEEPRTAA SGPSSKLEKM PSIPEEPEQG ELERLSIPDF LRPLQDLEVG 
      1210       1220       1230       1240       1250
LAKEAMLECQ VTGLPYPTIS WFHNGHRIQS SDDRRMTQYR DVHRLVFPAV 
      1260       1270       1280       1290       1300
GPQHAGVYKS VIANKLGKAA CYAHLYVTDV VPGPPDGAPQ VVAVTGRMVT 
      1310       1320       1330       1340       1350
LTWNPPRSLD MAIDPDSLTY TVQHQVLGSD QWTALVTGLR EPGWAATGLR 
      1360       1370       1380       1390       1400
KGVQHIFRVL STTVKSSSKP SPPSEPVQLL EHGPTLEEAP AMLDKPDIVY 
      1410       1420       1430       1440       1450
VVEGQPASVT VTFNHVEAQV VWRSCRGALL EARAGVYELS QPDDDQYCLR 
      1460       1470       1480       1490       1500
ICRVSRRDMG ALTCTARNRH GTQTCSVTLE LAEAPRFESI MEDVEVGAGE 
      1510       1520       1530       1540       1550
TARFAVVVEG KPLPDIMWYK DEVLLTESSH VSFVYEENEC SLVVLSTGAQ 
      1560       1570       1580       1590       1600
DGGVYTCTAQ NLAGEVSCKA ELAVHSAQTA MEVEGVGEDE DHRGRRLSDF 
      1610       1620       1630       1640       1650
YDIHQEIGRG AFSYLRRIVE RSSGLEFAAK FIPSQAKPKA SARREARLLA 
      1660       1670       1680       1690       1700
RLQHDCVLYF HEAFERRRGL VIVTELCTEE LLERIARKPT VCESEIRAYM 
      1710       1720       1730       1740       1750
RQVLEGIHYL HQSHVLHLDV KPENLLVWDG AAGEQQVRIC DFGNAQELTP 
      1760       1770       1780       1790       1800
GEPQYCQYGT PEFVAPEIVN QSPVSGVTDI WPVGVVAFLC LTGISPFVGE 
      1810       1820       1830       1840       1850
NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVQDR LRPTAEETLE 
      1860       1870       1880       1890       1900
HPWFKTQAKG AEVSTDHLKL FLSRRRWQRS QISYKCHLVL RPIPELLRAP 
      1910       1920       1930       1940       1950
PERVWVTMPR RPPPSGGLSS SSDSEEEELE ELPSVPRPLQ PEFSGSRVSL 
      1960       1970       1980       1990       2000
TDIPTEDEAL GTPETGAATP MDWQEQGRAP SQDQEAPSPE ALPSPGQEPA 
      2010       2020       2030       2040       2050
AGASPRRGEL RRGSSAESAL PRAGPRELGR GLHKAASVEL PQRRSPSPGA 
      2060       2070       2080       2090       2100
TRLARGGLGE GEYAQRLQAL RQRLLRGGPE DGKVSGLRGP LLESLGGRAR 
      2110       2120       2130       2140       2150
DPRMARAASS EAAPHHQPPL ENRGLQKSSS FSQGEAEPRG RHRRAGAPLE 
      2160       2170       2180       2190       2200
IPVARLGARR LQESPSLSAL SEAQPSSPAR PSAPKPSTPK SAEPSATTPS 
      2210       2220       2230       2240       2250
DAPQPPAPQP AQDKAPEPRP EPVRASKPAP PPQALQTLAL PLTPYAQIIQ 
      2260       2270       2280       2290       2300
SLQLSGHAQG PSQGPAAPPS EPKPHAAVFA RVASPPPGAP EKRVPSAGGP 
      2310       2320       2330       2340       2350
PVLAEKARVP TVPPRPGSSL SSSIENLESE AVFEAKFKRS RESPLSLGLR 
      2360       2370       2380       2390       2400
LLSRSRSEER GPFRGAEEED GIYRPSPAGT PLELVRRPER SRSVQDLRAV 
      2410       2420       2430       2440       2450
GEPGLVRRLS LSLSQRLRRT PPAQRHPAWE ARGGDGESSE GGSSARGSPV 
      2460       2470       2480       2490       2500
LAMRRRLSFT LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES 
      2510       2520       2530       2540       2550
LRRLGLPHNQ LAAQAGATTP SAESLGSEAS ATSGSSAPGE SRSRLRWGFS 
      2560       2570       2580       2590       2600
RPRKDKGLSP PNLSASVQEE LGHQYVRSES DFPPVFHIKL KDQVLLEGEA 
      2610       2620       2630       2640       2650
ATLLCLPAAC PAPHISWMKD KKSLRSEPSV IIVSCKDGRQ LLSIPRAGKR 
      2660       2670       2680       2690       2700
HAGLYECSAT NVLGSITSSC TVAVARVPGK LAPPEVPQTY QDTALVLWKP 
      2710       2720       2730       2740       2750
GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTHLPV GVTVRFRVAC 
      2760       2770       2780       2790       2800
ANRAGQGPFS NSSEKVFVRG TQDSSAVPSA AHQEAPVTSR PARARPPDSP 
      2810       2820       2830       2840       2850
TSLAPPLAPA APTPPSVTVS PSSPPTPPSQ ALSSLKAVGP PPQTPPRRHR 
      2860       2870       2880       2890       2900
GLQAARPAEP TLPSTHVTPS EPKPFVLDTG TPIPASTPQG VKPVSSSTPV 
      2910       2920       2930       2940       2950
YVVTSFVSAP PAPEPPAPEP PPEPTKVTVQ SLSPAKEVVS SPGSSPRSSP 
      2960       2970       2980       2990       3000
RPEGTTLRQG PPQKPYTFLE EKARGRFGVV RACRENATGR TFVAKIVPYA 
      3010       3020       3030       3040       3050
AEGKRRVLQE YEVLRTLHHE RIMSLHEAYI TPRYLVLIAE SCGNRELLCG 
      3060       3070       3080       3090       3100
LSDRFRYSED DVATYMVQLL QGLDYLHGHH VLHLDIKPDN LLLAPDNALK 
      3110       3120       3130       3140       3150
IVDFGSAQPY NPQALRPLGH RTGTLEFMAP EMVKGEPIGS ATDIWGAGVL 
      3160       3170       3180       3190       3200
TYIMLSGRSP FYEPDPQETE ARIVGGRFDA FQLYPNTSQS ATLFLRKVLS 
      3210       3220       3230       3240       3250
VHPWSRPSLQ DCLAHPWLQD AYLMKLRRQT LTFTTNRLKE FLGEQRRRRA 
      3260 
EAATRHKVLL RSYPGGP
Length:3,267
Mass (Da):354,289
Last modified:December 16, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE67BEB5624144233
GO
Isoform 2 (identifier: Q15772-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-792: Missing.
     961-962: AH → GE
     963-3267: Missing.

Show »
Length:170
Mass (Da):18,673
Checksum:i275949922564F798
GO
Isoform 3 (identifier: Q15772-4) [UniParc]FASTAAdd to basket
Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-849: Missing.
     961-962: AH → GE
     963-3267: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:113
Mass (Da):12,692
Checksum:i04F367263A1397C5
GO
Isoform 1 (identifier: Q15772-1) [UniParc]FASTAAdd to basket
Also known as: SPEG

The sequence of this isoform differs from the canonical sequence as follows:
     3209-3267: LQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGGP → SCLSVCHKEIKMASS

Note: Produced by alternative splicing.Curated
Show »
Length:3,223
Mass (Da):348,903
Checksum:iFBF1188F9F1B883A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9ZVR7B9ZVR7_HUMAN
Striated muscle preferentially-expr...
SPEG
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8D8C9J8D8_HUMAN
Striated muscle preferentially-expr...
SPEG
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWU5C9JWU5_HUMAN
Striated muscle preferentially-expr...
SPEG
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3Y5H7C3Y5_HUMAN
Striated muscle preferentially-expr...
SPEG
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9J7G5E9J7_HUMAN
Aortic preferentially expressed gen...
SPEG APEG1, hCG_2012857
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCA7F8WCA7_HUMAN
Striated muscle preferentially-expr...
SPEG
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3W0H0Y3W0_HUMAN
Striated muscle preferentially-expr...
SPEG
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY15052 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABD61734 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71Q → H in ABD61734 (PubMed:16545539).Curated1
Sequence conflicti73S → I in ABD61734 (PubMed:16545539).Curated1
Sequence conflicti2047S → G in AAT80901 (PubMed:15185077).Curated1
Sequence conflicti2047S → G in BAA92535 (PubMed:10718198).Curated1
Sequence conflicti3005R → P in AAT80901 (PubMed:15185077).Curated1
Sequence conflicti3005R → P in BAA92535 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041101206R → H1 PublicationCorresponds to variant dbSNP:rs55821435Ensembl.1
Natural variantiVAR_041102934R → C1 PublicationCorresponds to variant dbSNP:rs34398769Ensembl.1
Natural variantiVAR_041103966R → Q1 PublicationCorresponds to variant dbSNP:rs34861443Ensembl.1
Natural variantiVAR_0411041103P → L1 PublicationCorresponds to variant dbSNP:rs56334571EnsemblClinVar.1
Natural variantiVAR_0411051135A → V1 PublicationCorresponds to variant dbSNP:rs55670811Ensembl.1
Natural variantiVAR_0411061178E → D in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757589345Ensembl.1
Natural variantiVAR_0411071234R → W1 PublicationCorresponds to variant dbSNP:rs55916864EnsemblClinVar.1
Natural variantiVAR_0411081340R → Q1 PublicationCorresponds to variant dbSNP:rs34994343EnsemblClinVar.1
Natural variantiVAR_0411091621R → C1 PublicationCorresponds to variant dbSNP:rs55646900Ensembl.1
Natural variantiVAR_0411101903R → W in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs762000831Ensembl.1
Natural variantiVAR_0597692189P → L. Corresponds to variant dbSNP:rs10755037EnsemblClinVar.1
Natural variantiVAR_0411112687P → T3 PublicationsCorresponds to variant dbSNP:rs13026308Ensembl.1
Natural variantiVAR_0411122742V → M in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs566841339Ensembl.1
Natural variantiVAR_0718082757G → V in CNM5. 1 PublicationCorresponds to variant dbSNP:rs587777676EnsemblClinVar.1
Natural variantiVAR_0411133079H → R1 PublicationCorresponds to variant dbSNP:rs12464085EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0182581 – 849Missing in isoform 3. 3 PublicationsAdd BLAST849
Alternative sequenceiVSP_0182591 – 792Missing in isoform 2. 1 PublicationAdd BLAST792
Alternative sequenceiVSP_018261961 – 962AH → GE in isoform 2 and isoform 3. 4 Publications2
Alternative sequenceiVSP_018262963 – 3267Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST2305
Alternative sequenceiVSP_0360713209 – 3267LQDCL…YPGGP → SCLSVCHKEIKMASS in isoform 1. 3 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U57099 mRNA Translation: AAC50599.1
AK126500 mRNA Translation: BAC86568.1
AK289531 mRNA Translation: BAF82220.1
CR542201 mRNA Translation: CAG46998.1
AC053503 Genomic DNA Translation: AAY15052.1 Sequence problems.
CH471063 Genomic DNA Translation: EAW70747.1
BC006346 mRNA Translation: AAH06346.1
DQ395348 mRNA Translation: ABD61734.1 Frameshift.
AY603755 mRNA Translation: AAT80901.1
AB037718 mRNA Translation: BAA92535.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42824.1 [Q15772-5]
CCDS54432.1 [Q15772-4]

NCBI Reference Sequences

More...RefSeqi		NP_001166947.1, NM_001173476.1 [Q15772-4]
NP_005867.3, NM_005876.4 [Q15772-5]
XP_016858651.1, XM_017003162.1 [Q15772-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312358; ENSP00000311684; ENSG00000072195
ENST00000396686; ENSP00000379917; ENSG00000072195 [Q15772-4]
ENST00000396688; ENSP00000379919; ENSG00000072195 [Q15772-4]
ENST00000396689; ENSP00000379920; ENSG00000072195 [Q15772-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10290

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10290

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000312358.12; ENSP00000311684.7; NM_005876.5; NP_005867.3

UCSC genome browser

More...UCSCi		uc002vlq.4, human [Q15772-5]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57099 mRNA Translation: AAC50599.1
AK126500 mRNA Translation: BAC86568.1
AK289531 mRNA Translation: BAF82220.1
CR542201 mRNA Translation: CAG46998.1
AC053503 Genomic DNA Translation: AAY15052.1 Sequence problems.
CH471063 Genomic DNA Translation: EAW70747.1
BC006346 mRNA Translation: AAH06346.1
DQ395348 mRNA Translation: ABD61734.1 Frameshift.
AY603755 mRNA Translation: AAT80901.1
AB037718 mRNA Translation: BAA92535.1
CCDSiCCDS42824.1 [Q15772-5]
CCDS54432.1 [Q15772-4]
RefSeqiNP_001166947.1, NM_001173476.1 [Q15772-4]
NP_005867.3, NM_005876.4 [Q15772-5]
XP_016858651.1, XM_017003162.1 [Q15772-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U2HX-ray0.96A864-960[»]
SMRiQ15772
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115579, 13 interactors
IntActiQ15772, 5 interactors
STRINGi9606.ENSP00000311684

PTM databases

GlyGeniQ15772, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ15772
PhosphoSitePlusiQ15772

Genetic variation databases

BioMutaiSPEG
DMDMi218512143

Proteomic databases

EPDiQ15772
jPOSTiQ15772
MassIVEiQ15772
MaxQBiQ15772
PaxDbiQ15772
PeptideAtlasiQ15772
PRIDEiQ15772
ProteomicsDBi60751 [Q15772-5]
60752 [Q15772-1]
60753 [Q15772-3]
60754 [Q15772-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11575, 78 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		10290

Genome annotation databases

EnsembliENST00000312358; ENSP00000311684; ENSG00000072195
ENST00000396686; ENSP00000379917; ENSG00000072195 [Q15772-4]
ENST00000396688; ENSP00000379919; ENSG00000072195 [Q15772-4]
ENST00000396689; ENSP00000379920; ENSG00000072195 [Q15772-4]
GeneIDi10290
KEGGihsa:10290
MANE-SelectiENST00000312358.12; ENSP00000311684.7; NM_005876.5; NP_005867.3
UCSCiuc002vlq.4, human [Q15772-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10290
DisGeNETi10290

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPEG
HGNCiHGNC:16901, SPEG
HPAiENSG00000072195, Tissue enhanced (intestine, skeletal muscle)
MalaCardsiSPEG
MIMi615950, gene
615959, phenotype
neXtProtiNX_Q15772
OpenTargetsiENSG00000072195
Orphaneti169186, Autosomal recessive centronuclear myopathy
PharmGKBiPA142672598
VEuPathDBiHostDB:ENSG00000072195

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG0613, Eukaryota
GeneTreeiENSGT00940000161126
HOGENOMiCLU_000381_0_0_1
InParanoidiQ15772
OrthoDBi7796at2759
PhylomeDBiQ15772
TreeFamiTF331962

Enzyme and pathway databases

PathwayCommonsiQ15772
SignaLinkiQ15772

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10290, 0 hits in 1051 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPEG, human
EvolutionaryTraceiQ15772

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPEG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10290
PharosiQ15772, Tbio

Protein Ontology

More...PROi		PR:Q15772
RNActiQ15772, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072195, Expressed in esophagus and 216 other tissues
ExpressionAtlasiQ15772, baseline and differential
GenevisibleiQ15772, HS

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR015726, Ser/Thr_kin_striated-sp
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR47633:SF3, PTHR47633:SF3, 3 hits
PfamiView protein in Pfam
PF07679, I-set, 9 hits
PF00069, Pkinase, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 9 hits
SM00408, IGc2, 9 hits
SM00220, S_TKc, 2 hits
SUPFAMiSSF48726, SSF48726, 9 hits
SSF49265, SSF49265, 1 hit
SSF56112, SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 8 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15772
Secondary accession number(s): A8K0G6
, A8MRU0, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 16, 2008
Last modified: February 23, 2022
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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