UniProtKB - Q15772 (SPEG_HUMAN)

BLAST

>sp|Q15772|SPEG_HUMAN Striated muscle preferentially expressed protein kinase OS=Homo sapiens OX=9606 GN=SPEG PE=1 SV=4
MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGGGAPVAVAGAPVFLRPLKNAAVCAGSDV
RLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERGRASCE
AVLTVLEVGDSETAEDDISDVQGTQRLELRDDGAFSTPTGGSDTLVGTSLDTPPTSVTGT
SEEQVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVG
ASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSVPQSGLRREEPDLQPQLASEAPRRPAQ
PPPSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKRGKKSKS
SGPSLAGTAESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSP
PAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLDER
TRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPS
TPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTR
SRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWATPGLEGAAVPQTLEKN
RAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLE
APVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLL
LREARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEP
GETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVV
SWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVR
AHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFD
GRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRA
ARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVN
THGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVG
LAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKS
VIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTY
TVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLL
EHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELS
QPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGE
TARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQ
NLAGEVSCKAELAVHSAQTAMEVEGVGEDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVE
RSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEE
LLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRIC
DFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGE
NDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTQAKG
AEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVTMPRRPPPSGGLSS
SSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPETGAATPMDWQEQGRAP
SQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELGRGLHKAASVEL
PQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRAR
DPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARR
LQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKAPEPRP
EPVRASKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFA
RVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSLSSSIENLESEAVFEAKFKRS
RESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAV
GEPGLVRRLSLSLSQRLRRTPPAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFT
LERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQAGATTP
SAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQEELGHQYVRSES
DFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQ
LLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKP
GDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANRAGQGPFS
NSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVS
PSSPPTPPSQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTG
TPIPASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVS
SPGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPYA
AEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSED
DVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGH
RTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDA
FQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKE
FLGEQRRRRAEAATRHKVLLRSYPGGP

Align

Format
Add to basket Added to basket
History
Entry version 172 (07 Nov 2018)
Sequence version 4 (16 Dec 2008)
Previous versions | rss
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Protein

Striated muscle preferentially expressed protein kinase

Gene

SPEG

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	1630	ATPPROSITE-ProRule annotation	1
Active siteⁱ	1719	Proton acceptorBy similarity	1
Binding siteⁱ	2995	ATPPROSITE-ProRule annotation	1
Active siteⁱ	3085	Proton acceptorBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	1607 – 1615	ATPPROSITE-ProRule annotation		9
Nucleotide bindingⁱ	2972 – 2980	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiovascular system development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 8663449
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8663449

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Differentiation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q15772

SignaLinkⁱ

Q15772

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Striated muscle preferentially expressed protein kinase (EC:2.7.11.1) Alternative name(s): Aortic preferentially expressed protein 1 Short name: APEG-1
Gene namesⁱ	Name:SPEG Synonyms:APEG1, KIAA1297
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072195.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16901 SPEG
MIMⁱ	615950 gene
neXtProtⁱ	NX_Q15772

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Myopathy, centronuclear, 5 (CNM5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of centronuclear myopathy, a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. CNM5 features include severe neonatal hypotonia with respiratory insufficiency, difficulty feeding, and delayed motor development. Some patients die in infancy, and some develop dilated cardiomyopathy.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071808	2757	G → V in CNM5. 1 PublicationCorresponds to variant dbSNP:rs587777676EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10290
MalaCards human disease database More...MalaCardsⁱ	SPEG
MIMⁱ	615959 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000072195
Orphanetⁱ	169186 Autosomal recessive centronuclear myopathy
PharmGKBⁱ	PA142672598

Polymorphism and mutation databases

BioMutaⁱ	SPEG
DMDMⁱ	218512143

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072666	1 – 3267	Striated muscle preferentially expressed protein kinaseAdd BLAST		3267

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	139	PhosphoserineBy similarity	1
Modified residueⁱ	364	PhosphoserineBy similarity	1
Modified residueⁱ	371	PhosphoserineBy similarity	1
Modified residueⁱ	375	PhosphothreonineBy similarity	1
Modified residueⁱ	378	PhosphoserineBy similarity	1
Modified residueⁱ	381	PhosphoserineBy similarity	1
Modified residueⁱ	419	PhosphoserineBy similarity	1
Modified residueⁱ	449	PhosphothreonineBy similarity	1
Modified residueⁱ	453	PhosphoserineBy similarity	1
Modified residueⁱ	488	PhosphoserineCombined sources	1
Modified residueⁱ	506	PhosphoserineBy similarity	1
Modified residueⁱ	526	PhosphoserineBy similarity	1
Modified residueⁱ	549	PhosphoserineBy similarity	1
Disulfide bondⁱ	989 ↔ 1041	PROSITE-ProRule annotation
Modified residueⁱ	1128	PhosphoserineBy similarity	1
Modified residueⁱ	1172	PhosphoserineBy similarity	1
Modified residueⁱ	1988	PhosphoserineBy similarity	1
Modified residueⁱ	2014	PhosphoserineBy similarity	1
Modified residueⁱ	2015	PhosphoserineBy similarity	1
Modified residueⁱ	2037	PhosphoserineBy similarity	1
Modified residueⁱ	2055	Asymmetric dimethylarginine; alternateBy similarity	1
Modified residueⁱ	2055	Omega-N-methylarginine; alternateBy similarity	1
Modified residueⁱ	2109	PhosphoserineBy similarity	1
Modified residueⁱ	2130	PhosphoserineBy similarity	1
Modified residueⁱ	2139	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	2177	PhosphoserineBy similarity	1
Modified residueⁱ	2376	PhosphoserineBy similarity	1
Modified residueⁱ	2380	PhosphothreonineBy similarity	1
Modified residueⁱ	2410	PhosphoserineBy similarity	1
Modified residueⁱ	2414	PhosphoserineBy similarity	1
Modified residueⁱ	2438	PhosphoserineBy similarity	1
Modified residueⁱ	2439	PhosphoserineBy similarity	1
Modified residueⁱ	2444	PhosphoserineBy similarity	1
Modified residueⁱ	2448	PhosphoserineBy similarity	1
Modified residueⁱ	2521	PhosphoserineBy similarity	1
Modified residueⁱ	2524	PhosphoserineBy similarity	1
Modified residueⁱ	2559	PhosphoserineBy similarity	1
Disulfide bondⁱ	2605 ↔ 2657	PROSITE-ProRule annotation
Modified residueⁱ	2771	PhosphothreonineBy similarity	1
Modified residueⁱ	2774	PhosphoserineBy similarity	1
Modified residueⁱ	2949	PhosphoserineBy similarity	1

Post-translational modificationⁱ

May be autophosphorylated.

Keywords - PTMⁱ

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15772
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15772
PaxDbⁱ	Q15772
PeptideAtlas More...PeptideAtlasⁱ	Q15772
PRIDEⁱ	Q15772
ProteomicsDBⁱ	60751 60752 [Q15772-1] 60753 [Q15772-3] 60754 [Q15772-4]

PTM databases

iPTMnetⁱ	Q15772
PhosphoSitePlusⁱ	Q15772

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.2 Publications

Inductionⁱ

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000072195 Expressed in 199 organ(s), highest expression level in esophagus
CleanExⁱ	HS_SPEG
ExpressionAtlasⁱ	Q15772 baseline and differential
Genevisibleⁱ	Q15772 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018904

HPAⁱ

HPA018904

Interactionⁱ

Subunit structureⁱ

Interacts with MTM1. Isoform 3 is found as a monomer or homodimer.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRMT1	Q99873	3	EBI-1384196,EBI-78738

With

Entry

#Exp.

IntAct

Notes

PRMT1

Q99873

EBI-1384196,EBI-78738

Protein-protein interaction databases

BioGridⁱ	115579, 5 interactors
IntActⁱ	Q15772, 6 interactors
STRINGⁱ	9606.ENSP00000311684

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	867 – 873	Combined sources	7
Beta strandⁱ	878 – 881	Combined sources	4
Beta strandⁱ	886 – 896	Combined sources	11
Beta strandⁱ	899 – 904	Combined sources	6
Beta strandⁱ	915 – 919	Combined sources	5
Helixⁱ	921 – 923	Combined sources	3
Beta strandⁱ	924 – 931	Combined sources	8
Helixⁱ	934 – 936	Combined sources	3
Beta strandⁱ	938 – 946	Combined sources	9
Beta strandⁱ	949 – 960	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15772
SMRⁱ	Q15772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15772

EvolutionaryTraceⁱ

Q15772

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	43 – 124	Ig-like 1Add BLAST	82
Domainⁱ	722 – 810	Ig-like 2Add BLAST	89
Domainⁱ	869 – 958	Ig-like 3Add BLAST	90
Domainⁱ	963 – 1057	Ig-like 4Add BLAST	95
Domainⁱ	1064 – 1152	Ig-like 5Add BLAST	89
Domainⁱ	1188 – 1278	Ig-like 6Add BLAST	91
Domainⁱ	1285 – 1382	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	1384 – 1480	Ig-like 7Add BLAST	97
Domainⁱ	1485 – 1573	Ig-like 8Add BLAST	89
Domainⁱ	1601 – 1854	Protein kinase 1PROSITE-ProRule annotationAdd BLAST	254
Domainⁱ	2583 – 2673	Ig-like 9Add BLAST	91
Domainⁱ	2680 – 2774	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	2966 – 3218	Protein kinase 2PROSITE-ProRule annotationAdd BLAST	253

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	284 – 345	Pro-richAdd BLAST	62
Compositional biasⁱ	525 – 634	Pro-richAdd BLAST	110
Compositional biasⁱ	1919 – 1924	Poly-Ser	6
Compositional biasⁱ	1925 – 1931	Poly-Glu	7
Compositional biasⁱ	2175 – 2316	Pro-richAdd BLAST	142
Compositional biasⁱ	2339 – 2503	Arg-richAdd BLAST	165
Compositional biasⁱ	2786 – 2965	Pro-richAdd BLAST	180

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota KOG0613 Eukaryota ENOG410XQFD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150888
HOVERGENⁱ	HBG083339
InParanoidⁱ	Q15772
KEGG Orthology (KO) More...KOⁱ	K08809
OMAⁱ	STPLYMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G002S
PhylomeDBⁱ	Q15772
TreeFamⁱ	TF331962

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 11 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR015726 Ser/Thr_kin_striated-sp IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR45065 PTHR45065, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 9 hits PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 2 hits SM00409 IG, 9 hits SM00408 IGc2, 9 hits SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 9 hits SSF49265 SSF49265, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS50835 IG_LIKE, 8 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 4 (identifier: Q15772-5) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGGGAPVAVA GAPVFLRPLK 
        60         70         80         90        100
NAAVCAGSDV RLRVVVSGTP QPSLRWFRDG QLLPAPAPEP SCLWLRRCGA 
       110        120        130        140        150
QDAGVYSCMA QNERGRASCE AVLTVLEVGD SETAEDDISD VQGTQRLELR 
       160        170        180        190        200
DDGAFSTPTG GSDTLVGTSL DTPPTSVTGT SEEQVSWWGS GQTVLEQEAG 
       210        220        230        240        250
SGGGTRRLPG SPRQAQATGA GPRHLGVEPL VRASRANLVG ASWGSEDSLS 
       260        270        280        290        300
VASDLYGSAF SLYRGRALSI HVSVPQSGLR REEPDLQPQL ASEAPRRPAQ 
       310        320        330        340        350
PPPSKSALLP PPSPRVGKRS PPGPPAQPAA TPTSPHRRTQ EPVLPEDTTT 
       360        370        380        390        400
EEKRGKKSKS SGPSLAGTAE SRPQTPLSEA SGRLSALGRS PRLVRAGSRI 
       410        420        430        440        450
LDKLQFFEER RRSLERSDSP PAPLRPWVPL RKARSLEQPK SERGAPWGTP 
       460        470        480        490        500
GASQEELRAP GSVAERRRLF QQKAASLDER TRQRSPASDL ELRFAQELGR 
       510        520        530        540        550
IRRSTSREEL VRSHESLRAT LQRAPSPREP GEPPLFSRPS TPKTSRAVSP 
       560        570        580        590        600
AAAQPPSPSS AEKPGDEPGR PRSRGPAGRT EPGEGPQQEV RRRDQFPLTR 
       610        620        630        640        650
SRAIQECRSP VPPPAADPPE ARTKAPPGRK REPPAQAVRF LPWATPGLEG 
       660        670        680        690        700
AAVPQTLEKN RAGPEAEKRL RRGPEEDGPW GPWDRRGARS QGKGRRARPT 
       710        720        730        740        750
SPELESSDDS YVSAGEEPLE APVFEIPLQN VVVAPGADVL LKCIITANPP 
       760        770        780        790        800
PQVSWHKDGS ALRSEGRLLL RAEGERHTLL LREARAADAG SYMATATNEL 
       810        820        830        840        850
GQATCAASLT VRPGGSTSPF SSPITSDEEY LSPPEEFPEP GETWPRTPTM 
       860        870        880        890        900
KPSPSQNRRS SDTGSKAPPT FKVSLMDQSV REGQDVIMSI RVQGEPKPVV 
       910        920        930        940        950
SWLRNRQPVR PDQRRFAEEA EGGLCRLRIL AAERGDAGFY TCKAVNEYGA 
       960        970        980        990       1000
RQCEARLEVR AHPESRSLAV LAPLQDVDVG AGEMALFECL VAGPTDVEVD 
      1010       1020       1030       1040       1050
WLCRGRLLQP ALLKCKMHFD GRKCKLLLTS VHEDDSGVYT CKLSTAKDEL 
      1060       1070       1080       1090       1100
TCSARLTVRP SLAPLFTRLL EDVEVLEGRA ARFDCKISGT PPPVVTWTHF 
      1110       1120       1130       1140       1150
GCPMEESENL RLRQDGGLHS LHIAHVGSED EGLYAVSAVN THGQAHCSAQ 
      1160       1170       1180       1190       1200
LYVEEPRTAA SGPSSKLEKM PSIPEEPEQG ELERLSIPDF LRPLQDLEVG 
      1210       1220       1230       1240       1250
LAKEAMLECQ VTGLPYPTIS WFHNGHRIQS SDDRRMTQYR DVHRLVFPAV 
      1260       1270       1280       1290       1300
GPQHAGVYKS VIANKLGKAA CYAHLYVTDV VPGPPDGAPQ VVAVTGRMVT 
      1310       1320       1330       1340       1350
LTWNPPRSLD MAIDPDSLTY TVQHQVLGSD QWTALVTGLR EPGWAATGLR 
      1360       1370       1380       1390       1400
KGVQHIFRVL STTVKSSSKP SPPSEPVQLL EHGPTLEEAP AMLDKPDIVY 
      1410       1420       1430       1440       1450
VVEGQPASVT VTFNHVEAQV VWRSCRGALL EARAGVYELS QPDDDQYCLR 
      1460       1470       1480       1490       1500
ICRVSRRDMG ALTCTARNRH GTQTCSVTLE LAEAPRFESI MEDVEVGAGE 
      1510       1520       1530       1540       1550
TARFAVVVEG KPLPDIMWYK DEVLLTESSH VSFVYEENEC SLVVLSTGAQ 
      1560       1570       1580       1590       1600
DGGVYTCTAQ NLAGEVSCKA ELAVHSAQTA MEVEGVGEDE DHRGRRLSDF 
      1610       1620       1630       1640       1650
YDIHQEIGRG AFSYLRRIVE RSSGLEFAAK FIPSQAKPKA SARREARLLA 
      1660       1670       1680       1690       1700
RLQHDCVLYF HEAFERRRGL VIVTELCTEE LLERIARKPT VCESEIRAYM 
      1710       1720       1730       1740       1750
RQVLEGIHYL HQSHVLHLDV KPENLLVWDG AAGEQQVRIC DFGNAQELTP 
      1760       1770       1780       1790       1800
GEPQYCQYGT PEFVAPEIVN QSPVSGVTDI WPVGVVAFLC LTGISPFVGE 
      1810       1820       1830       1840       1850
NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVQDR LRPTAEETLE 
      1860       1870       1880       1890       1900
HPWFKTQAKG AEVSTDHLKL FLSRRRWQRS QISYKCHLVL RPIPELLRAP 
      1910       1920       1930       1940       1950
PERVWVTMPR RPPPSGGLSS SSDSEEEELE ELPSVPRPLQ PEFSGSRVSL 
      1960       1970       1980       1990       2000
TDIPTEDEAL GTPETGAATP MDWQEQGRAP SQDQEAPSPE ALPSPGQEPA 
      2010       2020       2030       2040       2050
AGASPRRGEL RRGSSAESAL PRAGPRELGR GLHKAASVEL PQRRSPSPGA 
      2060       2070       2080       2090       2100
TRLARGGLGE GEYAQRLQAL RQRLLRGGPE DGKVSGLRGP LLESLGGRAR 
      2110       2120       2130       2140       2150
DPRMARAASS EAAPHHQPPL ENRGLQKSSS FSQGEAEPRG RHRRAGAPLE 
      2160       2170       2180       2190       2200
IPVARLGARR LQESPSLSAL SEAQPSSPAR PSAPKPSTPK SAEPSATTPS 
      2210       2220       2230       2240       2250
DAPQPPAPQP AQDKAPEPRP EPVRASKPAP PPQALQTLAL PLTPYAQIIQ 
      2260       2270       2280       2290       2300
SLQLSGHAQG PSQGPAAPPS EPKPHAAVFA RVASPPPGAP EKRVPSAGGP 
      2310       2320       2330       2340       2350
PVLAEKARVP TVPPRPGSSL SSSIENLESE AVFEAKFKRS RESPLSLGLR 
      2360       2370       2380       2390       2400
LLSRSRSEER GPFRGAEEED GIYRPSPAGT PLELVRRPER SRSVQDLRAV 
      2410       2420       2430       2440       2450
GEPGLVRRLS LSLSQRLRRT PPAQRHPAWE ARGGDGESSE GGSSARGSPV 
      2460       2470       2480       2490       2500
LAMRRRLSFT LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES 
      2510       2520       2530       2540       2550
LRRLGLPHNQ LAAQAGATTP SAESLGSEAS ATSGSSAPGE SRSRLRWGFS 
      2560       2570       2580       2590       2600
RPRKDKGLSP PNLSASVQEE LGHQYVRSES DFPPVFHIKL KDQVLLEGEA 
      2610       2620       2630       2640       2650
ATLLCLPAAC PAPHISWMKD KKSLRSEPSV IIVSCKDGRQ LLSIPRAGKR 
      2660       2670       2680       2690       2700
HAGLYECSAT NVLGSITSSC TVAVARVPGK LAPPEVPQTY QDTALVLWKP 
      2710       2720       2730       2740       2750
GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTHLPV GVTVRFRVAC 
      2760       2770       2780       2790       2800
ANRAGQGPFS NSSEKVFVRG TQDSSAVPSA AHQEAPVTSR PARARPPDSP 
      2810       2820       2830       2840       2850
TSLAPPLAPA APTPPSVTVS PSSPPTPPSQ ALSSLKAVGP PPQTPPRRHR 
      2860       2870       2880       2890       2900
GLQAARPAEP TLPSTHVTPS EPKPFVLDTG TPIPASTPQG VKPVSSSTPV 
      2910       2920       2930       2940       2950
YVVTSFVSAP PAPEPPAPEP PPEPTKVTVQ SLSPAKEVVS SPGSSPRSSP 
      2960       2970       2980       2990       3000
RPEGTTLRQG PPQKPYTFLE EKARGRFGVV RACRENATGR TFVAKIVPYA 
      3010       3020       3030       3040       3050
AEGKRRVLQE YEVLRTLHHE RIMSLHEAYI TPRYLVLIAE SCGNRELLCG 
      3060       3070       3080       3090       3100
LSDRFRYSED DVATYMVQLL QGLDYLHGHH VLHLDIKPDN LLLAPDNALK 
      3110       3120       3130       3140       3150
IVDFGSAQPY NPQALRPLGH RTGTLEFMAP EMVKGEPIGS ATDIWGAGVL 
      3160       3170       3180       3190       3200
TYIMLSGRSP FYEPDPQETE ARIVGGRFDA FQLYPNTSQS ATLFLRKVLS 
      3210       3220       3230       3240       3250
VHPWSRPSLQ DCLAHPWLQD AYLMKLRRQT LTFTTNRLKE FLGEQRRRRA 
      3260 
EAATRHKVLL RSYPGGP

Note: No experimental confirmation available.

Length:3,267

Mass (Da):354,289

Last modified:December 16, 2008 - v4

Checksum:ⁱE67BEB5624144233

Isoform 2 (identifier: Q15772-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-792: Missing.
     961-962: AH → GE
     963-3267: Missing.

« Hide

        10         20         30         40         50
MATATNELGQ ATCAASLTVR PGGSTSPFSS PITSDEEYLS PPEEFPEPGE 
        60         70         80         90        100
TWPRTPTMKP SPSQNRRSSD TGSKAPPTFK VSLMDQSVRE GQDVIMSIRV 
       110        120        130        140        150
QGEPKPVVSW LRNRQPVRPD QRRFAEEAEG GLCRLRILAA ERGDAGFYTC 
       160        170
KAVNEYGARQ CEARLEVRGE

Note: No experimental confirmation available.

Show »

Length:170

Mass (Da):18,673

Checksum:ⁱ275949922564F798

Isoform 3 (identifier: Q15772-4) [UniParc]FASTA Add to basket

Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-849: Missing.
     961-962: AH → GE
     963-3267: Missing.

« Hide

        10         20         30         40         50
MKPSPSQNRR SSDTGSKAPP TFKVSLMDQS VREGQDVIMS IRVQGEPKPV 
        60         70         80         90        100
VSWLRNRQPV RPDQRRFAEE AEGGLCRLRI LAAERGDAGF YTCKAVNEYG 
       110 
ARQCEARLEV RGE

Note: Produced by alternative promoter usage.

Show »

Length:113

Mass (Da):12,692

Checksum:ⁱ04F367263A1397C5

Isoform 1 (identifier: Q15772-1) [UniParc]FASTA Add to basket

Also known as: SPEG

The sequence of this isoform differs from the canonical sequence as follows:
3209-3267: LQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGGP → SCLSVCHKEIKMASS

« Hide

        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGGGAPVAVA GAPVFLRPLK 
        60         70         80         90        100
NAAVCAGSDV RLRVVVSGTP QPSLRWFRDG QLLPAPAPEP SCLWLRRCGA 
       110        120        130        140        150
QDAGVYSCMA QNERGRASCE AVLTVLEVGD SETAEDDISD VQGTQRLELR 
       160        170        180        190        200
DDGAFSTPTG GSDTLVGTSL DTPPTSVTGT SEEQVSWWGS GQTVLEQEAG 
       210        220        230        240        250
SGGGTRRLPG SPRQAQATGA GPRHLGVEPL VRASRANLVG ASWGSEDSLS 
       260        270        280        290        300
VASDLYGSAF SLYRGRALSI HVSVPQSGLR REEPDLQPQL ASEAPRRPAQ 
       310        320        330        340        350
PPPSKSALLP PPSPRVGKRS PPGPPAQPAA TPTSPHRRTQ EPVLPEDTTT 
       360        370        380        390        400
EEKRGKKSKS SGPSLAGTAE SRPQTPLSEA SGRLSALGRS PRLVRAGSRI 
       410        420        430        440        450
LDKLQFFEER RRSLERSDSP PAPLRPWVPL RKARSLEQPK SERGAPWGTP 
       460        470        480        490        500
GASQEELRAP GSVAERRRLF QQKAASLDER TRQRSPASDL ELRFAQELGR 
       510        520        530        540        550
IRRSTSREEL VRSHESLRAT LQRAPSPREP GEPPLFSRPS TPKTSRAVSP 
       560        570        580        590        600
AAAQPPSPSS AEKPGDEPGR PRSRGPAGRT EPGEGPQQEV RRRDQFPLTR 
       610        620        630        640        650
SRAIQECRSP VPPPAADPPE ARTKAPPGRK REPPAQAVRF LPWATPGLEG 
       660        670        680        690        700
AAVPQTLEKN RAGPEAEKRL RRGPEEDGPW GPWDRRGARS QGKGRRARPT 
       710        720        730        740        750
SPELESSDDS YVSAGEEPLE APVFEIPLQN VVVAPGADVL LKCIITANPP 
       760        770        780        790        800
PQVSWHKDGS ALRSEGRLLL RAEGERHTLL LREARAADAG SYMATATNEL 
       810        820        830        840        850
GQATCAASLT VRPGGSTSPF SSPITSDEEY LSPPEEFPEP GETWPRTPTM 
       860        870        880        890        900
KPSPSQNRRS SDTGSKAPPT FKVSLMDQSV REGQDVIMSI RVQGEPKPVV 
       910        920        930        940        950
SWLRNRQPVR PDQRRFAEEA EGGLCRLRIL AAERGDAGFY TCKAVNEYGA 
       960        970        980        990       1000
RQCEARLEVR AHPESRSLAV LAPLQDVDVG AGEMALFECL VAGPTDVEVD 
      1010       1020       1030       1040       1050
WLCRGRLLQP ALLKCKMHFD GRKCKLLLTS VHEDDSGVYT CKLSTAKDEL 
      1060       1070       1080       1090       1100
TCSARLTVRP SLAPLFTRLL EDVEVLEGRA ARFDCKISGT PPPVVTWTHF 
      1110       1120       1130       1140       1150
GCPMEESENL RLRQDGGLHS LHIAHVGSED EGLYAVSAVN THGQAHCSAQ 
      1160       1170       1180       1190       1200
LYVEEPRTAA SGPSSKLEKM PSIPEEPEQG ELERLSIPDF LRPLQDLEVG 
      1210       1220       1230       1240       1250
LAKEAMLECQ VTGLPYPTIS WFHNGHRIQS SDDRRMTQYR DVHRLVFPAV 
      1260       1270       1280       1290       1300
GPQHAGVYKS VIANKLGKAA CYAHLYVTDV VPGPPDGAPQ VVAVTGRMVT 
      1310       1320       1330       1340       1350
LTWNPPRSLD MAIDPDSLTY TVQHQVLGSD QWTALVTGLR EPGWAATGLR 
      1360       1370       1380       1390       1400
KGVQHIFRVL STTVKSSSKP SPPSEPVQLL EHGPTLEEAP AMLDKPDIVY 
      1410       1420       1430       1440       1450
VVEGQPASVT VTFNHVEAQV VWRSCRGALL EARAGVYELS QPDDDQYCLR 
      1460       1470       1480       1490       1500
ICRVSRRDMG ALTCTARNRH GTQTCSVTLE LAEAPRFESI MEDVEVGAGE 
      1510       1520       1530       1540       1550
TARFAVVVEG KPLPDIMWYK DEVLLTESSH VSFVYEENEC SLVVLSTGAQ 
      1560       1570       1580       1590       1600
DGGVYTCTAQ NLAGEVSCKA ELAVHSAQTA MEVEGVGEDE DHRGRRLSDF 
      1610       1620       1630       1640       1650
YDIHQEIGRG AFSYLRRIVE RSSGLEFAAK FIPSQAKPKA SARREARLLA 
      1660       1670       1680       1690       1700
RLQHDCVLYF HEAFERRRGL VIVTELCTEE LLERIARKPT VCESEIRAYM 
      1710       1720       1730       1740       1750
RQVLEGIHYL HQSHVLHLDV KPENLLVWDG AAGEQQVRIC DFGNAQELTP 
      1760       1770       1780       1790       1800
GEPQYCQYGT PEFVAPEIVN QSPVSGVTDI WPVGVVAFLC LTGISPFVGE 
      1810       1820       1830       1840       1850
NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVQDR LRPTAEETLE 
      1860       1870       1880       1890       1900
HPWFKTQAKG AEVSTDHLKL FLSRRRWQRS QISYKCHLVL RPIPELLRAP 
      1910       1920       1930       1940       1950
PERVWVTMPR RPPPSGGLSS SSDSEEEELE ELPSVPRPLQ PEFSGSRVSL 
      1960       1970       1980       1990       2000
TDIPTEDEAL GTPETGAATP MDWQEQGRAP SQDQEAPSPE ALPSPGQEPA 
      2010       2020       2030       2040       2050
AGASPRRGEL RRGSSAESAL PRAGPRELGR GLHKAASVEL PQRRSPSPGA 
      2060       2070       2080       2090       2100
TRLARGGLGE GEYAQRLQAL RQRLLRGGPE DGKVSGLRGP LLESLGGRAR 
      2110       2120       2130       2140       2150
DPRMARAASS EAAPHHQPPL ENRGLQKSSS FSQGEAEPRG RHRRAGAPLE 
      2160       2170       2180       2190       2200
IPVARLGARR LQESPSLSAL SEAQPSSPAR PSAPKPSTPK SAEPSATTPS 
      2210       2220       2230       2240       2250
DAPQPPAPQP AQDKAPEPRP EPVRASKPAP PPQALQTLAL PLTPYAQIIQ 
      2260       2270       2280       2290       2300
SLQLSGHAQG PSQGPAAPPS EPKPHAAVFA RVASPPPGAP EKRVPSAGGP 
      2310       2320       2330       2340       2350
PVLAEKARVP TVPPRPGSSL SSSIENLESE AVFEAKFKRS RESPLSLGLR 
      2360       2370       2380       2390       2400
LLSRSRSEER GPFRGAEEED GIYRPSPAGT PLELVRRPER SRSVQDLRAV 
      2410       2420       2430       2440       2450
GEPGLVRRLS LSLSQRLRRT PPAQRHPAWE ARGGDGESSE GGSSARGSPV 
      2460       2470       2480       2490       2500
LAMRRRLSFT LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES 
      2510       2520       2530       2540       2550
LRRLGLPHNQ LAAQAGATTP SAESLGSEAS ATSGSSAPGE SRSRLRWGFS 
      2560       2570       2580       2590       2600
RPRKDKGLSP PNLSASVQEE LGHQYVRSES DFPPVFHIKL KDQVLLEGEA 
      2610       2620       2630       2640       2650
ATLLCLPAAC PAPHISWMKD KKSLRSEPSV IIVSCKDGRQ LLSIPRAGKR 
      2660       2670       2680       2690       2700
HAGLYECSAT NVLGSITSSC TVAVARVPGK LAPPEVPQTY QDTALVLWKP 
      2710       2720       2730       2740       2750
GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTHLPV GVTVRFRVAC 
      2760       2770       2780       2790       2800
ANRAGQGPFS NSSEKVFVRG TQDSSAVPSA AHQEAPVTSR PARARPPDSP 
      2810       2820       2830       2840       2850
TSLAPPLAPA APTPPSVTVS PSSPPTPPSQ ALSSLKAVGP PPQTPPRRHR 
      2860       2870       2880       2890       2900
GLQAARPAEP TLPSTHVTPS EPKPFVLDTG TPIPASTPQG VKPVSSSTPV 
      2910       2920       2930       2940       2950
YVVTSFVSAP PAPEPPAPEP PPEPTKVTVQ SLSPAKEVVS SPGSSPRSSP 
      2960       2970       2980       2990       3000
RPEGTTLRQG PPQKPYTFLE EKARGRFGVV RACRENATGR TFVAKIVPYA 
      3010       3020       3030       3040       3050
AEGKRRVLQE YEVLRTLHHE RIMSLHEAYI TPRYLVLIAE SCGNRELLCG 
      3060       3070       3080       3090       3100
LSDRFRYSED DVATYMVQLL QGLDYLHGHH VLHLDIKPDN LLLAPDNALK 
      3110       3120       3130       3140       3150
IVDFGSAQPY NPQALRPLGH RTGTLEFMAP EMVKGEPIGS ATDIWGAGVL 
      3160       3170       3180       3190       3200
TYIMLSGRSP FYEPDPQETE ARIVGGRFDA FQLYPNTSQS ATLFLRKVLS 
      3210       3220 
VHPWSRPSSC LSVCHKEIKM ASS

Note: Produced by alternative splicing.

Show »

Length:3,223

Mass (Da):348,903

Checksum:ⁱFBF1188F9F1B883A

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B9ZVR7	B9ZVR7_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	858	Annotation score:
H7BZM6	H7BZM6_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	343	Annotation score:
C9J8D8	C9J8D8_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	299	Annotation score:
H7C3Y5	H7C3Y5_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	184	Annotation score:
C9JWU5	C9JWU5_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	187	Annotation score:
H0Y3W0	H0Y3W0_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	43	Annotation score:
G5E9J7	G5E9J7_HUMAN	Aortic preferentially expressed gen... Aortic preferentially expressed gene 1, isoform CRA_i (Striated muscle preferentially-expressed protein kinase)	SPEG APEG1, hCG_2012857	53	Annotation score:
A0A087WV53	A0A087WV53_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	238	Annotation score:
F8WCA7	F8WCA7_HUMAN	Striated muscle preferentially-expr... Striated muscle preferentially-expressed protein kinase	SPEG	84	Annotation score:

Sequence cautionⁱ

The sequence AAY15052 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence ABD61734 differs from that shown. Reason: Frameshift at positions 31 and 35.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	71	Q → H in ABD61734 (PubMed:16545539).Curated	1
Sequence conflictⁱ	73	S → I in ABD61734 (PubMed:16545539).Curated	1
Sequence conflictⁱ	2047	S → G in AAT80901 (PubMed:15185077).Curated	1
Sequence conflictⁱ	2047	S → G in BAA92535 (PubMed:10718198).Curated	1
Sequence conflictⁱ	3005	R → P in AAT80901 (PubMed:15185077).Curated	1
Sequence conflictⁱ	3005	R → P in BAA92535 (PubMed:10718198).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041101	206	R → H1 PublicationCorresponds to variant dbSNP:rs55821435Ensembl.	1
Natural variantⁱVAR_041102	934	R → C1 PublicationCorresponds to variant dbSNP:rs34398769Ensembl.	1
Natural variantⁱVAR_041103	966	R → Q1 PublicationCorresponds to variant dbSNP:rs34861443Ensembl.	1
Natural variantⁱVAR_041104	1103	P → L1 PublicationCorresponds to variant dbSNP:rs56334571Ensembl.	1
Natural variantⁱVAR_041105	1135	A → V1 PublicationCorresponds to variant dbSNP:rs55670811Ensembl.	1
Natural variantⁱVAR_041106	1178	E → D in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757589345Ensembl.	1
Natural variantⁱVAR_041107	1234	R → W1 PublicationCorresponds to variant dbSNP:rs55916864Ensembl.	1
Natural variantⁱVAR_041108	1340	R → Q1 PublicationCorresponds to variant dbSNP:rs34994343Ensembl.	1
Natural variantⁱVAR_041109	1621	R → C1 PublicationCorresponds to variant dbSNP:rs55646900Ensembl.	1
Natural variantⁱVAR_041110	1903	R → W in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs762000831Ensembl.	1
Natural variantⁱVAR_059769	2189	P → L. Corresponds to variant dbSNP:rs10755037EnsemblClinVar.	1
Natural variantⁱVAR_041111	2687	P → T3 PublicationsCorresponds to variant dbSNP:rs13026308Ensembl.	1
Natural variantⁱVAR_041112	2742	V → M in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs566841339Ensembl.	1
Natural variantⁱVAR_071808	2757	G → V in CNM5. 1 PublicationCorresponds to variant dbSNP:rs587777676EnsemblClinVar.	1
Natural variantⁱVAR_041113	3079	H → R1 PublicationCorresponds to variant dbSNP:rs12464085EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018258	1 – 849	Missing in isoform 3. 3 PublicationsAdd BLAST	849
Alternative sequenceⁱVSP_018259	1 – 792	Missing in isoform 2. 1 PublicationAdd BLAST	792
Alternative sequenceⁱVSP_018261	961 – 962	AH → GE in isoform 2 and isoform 3. 4 Publications	2
Alternative sequenceⁱVSP_018262	963 – 3267	Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST	2305
Alternative sequenceⁱVSP_036071	3209 – 3267	LQDCL…YPGGP → SCLSVCHKEIKMASS in isoform 1. 3 PublicationsAdd BLAST	59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57099 mRNA Translation: AAC50599.1 AK126500 mRNA Translation: BAC86568.1 AK289531 mRNA Translation: BAF82220.1 CR542201 mRNA Translation: CAG46998.1 AC053503 Genomic DNA Translation: AAY15052.1 Sequence problems. CH471063 Genomic DNA Translation: EAW70747.1 BC006346 mRNA Translation: AAH06346.1 DQ395348 mRNA Translation: ABD61734.1 Frameshift. AY603755 mRNA Translation: AAT80901.1 AB037718 mRNA Translation: BAA92535.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42824.1 [Q15772-5] CCDS54432.1 [Q15772-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001166947.1, NM_001173476.1 [Q15772-4] NP_005867.3, NM_005876.4 [Q15772-5] XP_016858651.1, XM_017003162.1 [Q15772-3]
UniGeneⁱ	Hs.21639

Genome annotation databases

Ensemblⁱ	ENST00000312358; ENSP00000311684; ENSG00000072195 [Q15772-5] ENST00000396686; ENSP00000379917; ENSG00000072195 [Q15772-4] ENST00000396688; ENSP00000379919; ENSG00000072195 [Q15772-4] ENST00000396689; ENSP00000379920; ENSG00000072195 [Q15772-4]
GeneIDⁱ	10290
KEGGⁱ	hsa:10290
UCSC genome browser More...UCSCⁱ	uc002vlq.4 human [Q15772-5]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15772	Uncharacterized protein		AOTNA		3273	UniRef90_Q15772
Uncharacterized protein		Cebus capucinus imitator		3272
Uncharacterized protein		CALJA		3271
Uncharacterized protein		PROCO		3270
SPEG isoform 5		PANTR		3267
+147
Q15772-3	Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		MOUSE		861	UniRef90_Q62407-2
SPEG isoform 14		PANTR		113
SPEG isoform 18		PONAB		113
Uncharacterized protein		PANPA		113
Uncharacterized protein		NOMLE		113
+23
Q15772-4	Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		MOUSE		861	UniRef90_Q62407-2
SPEG isoform 14		PANTR		113
Isoform 2 of Striated muscle preferentially expressed protein kinase		HUMAN		170
SPEG isoform 18		PONAB		113
Uncharacterized protein		PANPA		113
+23

Protein	Similar proteins		Species	Score	Length	Source
Q15772	Striated muscle-specific serine/threonine-protein kinase		MOUSE		3262	UniRef50_Q15772
Striated muscle-specific serine/threonine-protein kinase		RAT		3259
Uncharacterized protein		AOTNA		3273
Uncharacterized protein		Cebus capucinus imitator		3272
Uncharacterized protein		CALJA		3271
+349
Q15772-3	Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		MOUSE		861	UniRef50_Q62407-2
Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		RAT		113
Uncharacterized protein		MACMU		113
Uncharacterized protein		MACFA		113
SPEG isoform 14		PANTR		113
+81
Q15772-4	Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		MOUSE		861	UniRef50_Q62407-2
Isoform 2 of Striated muscle-specific serine/threonine-protein kinase		RAT		113
Uncharacterized protein		MACMU		113
Uncharacterized protein		MACFA		113
SPEG isoform 14		PANTR		113
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57099 mRNA Translation: AAC50599.1 AK126500 mRNA Translation: BAC86568.1 AK289531 mRNA Translation: BAF82220.1 CR542201 mRNA Translation: CAG46998.1 AC053503 Genomic DNA Translation: AAY15052.1 Sequence problems. CH471063 Genomic DNA Translation: EAW70747.1 BC006346 mRNA Translation: AAH06346.1 DQ395348 mRNA Translation: ABD61734.1 Frameshift. AY603755 mRNA Translation: AAT80901.1 AB037718 mRNA Translation: BAA92535.1
CCDSⁱ	CCDS42824.1 [Q15772-5] CCDS54432.1 [Q15772-4]
RefSeqⁱ	NP_001166947.1, NM_001173476.1 [Q15772-4] NP_005867.3, NM_005876.4 [Q15772-5] XP_016858651.1, XM_017003162.1 [Q15772-3]
UniGeneⁱ	Hs.21639

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1U2H	X-ray	0.96	A	864-960	[»]
ProteinModelPortalⁱ	Q15772
SMRⁱ	Q15772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115579, 5 interactors
IntActⁱ	Q15772, 6 interactors
STRINGⁱ	9606.ENSP00000311684

PTM databases

iPTMnetⁱ	Q15772
PhosphoSitePlusⁱ	Q15772

Polymorphism and mutation databases

BioMutaⁱ	SPEG
DMDMⁱ	218512143

Proteomic databases

EPDⁱ	Q15772
MaxQBⁱ	Q15772
PaxDbⁱ	Q15772
PeptideAtlasⁱ	Q15772
PRIDEⁱ	Q15772
ProteomicsDBⁱ	60751 60752 [Q15772-1] 60753 [Q15772-3] 60754 [Q15772-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10290
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312358; ENSP00000311684; ENSG00000072195 [Q15772-5] ENST00000396686; ENSP00000379917; ENSG00000072195 [Q15772-4] ENST00000396688; ENSP00000379919; ENSG00000072195 [Q15772-4] ENST00000396689; ENSP00000379920; ENSG00000072195 [Q15772-4]
GeneIDⁱ	10290
KEGGⁱ	hsa:10290
UCSCⁱ	uc002vlq.4 human [Q15772-5]

Organism-specific databases

CTDⁱ	10290
DisGeNETⁱ	10290
EuPathDBⁱ	HostDB:ENSG00000072195.14
GeneCardsⁱ	SPEG
H-InvDBⁱ	HIX0002864
HGNCⁱ	HGNC:16901 SPEG
HPAⁱ	HPA018904
MalaCardsⁱ	SPEG
MIMⁱ	615950 gene 615959 phenotype
neXtProtⁱ	NX_Q15772
OpenTargetsⁱ	ENSG00000072195
Orphanetⁱ	169186 Autosomal recessive centronuclear myopathy
PharmGKBⁱ	PA142672598
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota KOG0613 Eukaryota ENOG410XQFD LUCA
GeneTreeⁱ	ENSGT00930000150888
HOVERGENⁱ	HBG083339
InParanoidⁱ	Q15772
KOⁱ	K08809
OMAⁱ	STPLYMV
OrthoDBⁱ	EOG091G002S
PhylomeDBⁱ	Q15772
TreeFamⁱ	TF331962

Enzyme and pathway databases

SignaLinkⁱ	Q15772

SignaLinkⁱ

Q15772

Miscellaneous databases

ChiTaRSⁱ	SPEG human
EvolutionaryTraceⁱ	Q15772
GeneWikiⁱ	SPEG
GenomeRNAiⁱ	10290
Protein Ontology More...PROⁱ	PR:Q15772
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072195 Expressed in 199 organ(s), highest expression level in esophagus
CleanExⁱ	HS_SPEG
ExpressionAtlasⁱ	Q15772 baseline and differential
Genevisibleⁱ	Q15772 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 11 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR015726 Ser/Thr_kin_striated-sp IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR45065 PTHR45065, 1 hit
Pfamⁱ	View protein in Pfam PF07679 I-set, 9 hits PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 2 hits SM00409 IG, 9 hits SM00408 IGc2, 9 hits SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 9 hits SSF49265 SSF49265, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS50835 IG_LIKE, 8 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPEG_HUMAN
Accessionⁱ	Q15772Primary (citable) accession number: Q15772 Secondary accession number(s): A8K0G6 Q9P2P9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	December 16, 2008
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q15772 (SPEG_HUMAN)

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Striated muscle preferentially expressed protein kinase

SPEG

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ