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Protein

Ras-related protein Rab-30

Gene

RAB30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTP8
Nucleotide bindingi64 – 68GTP5
Nucleotide bindingi122 – 125GTP4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi organization Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • Rab protein signal transduction Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-30
Gene namesi
Name:RAB30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137502.9
HGNCiHGNC:9770 RAB30
MIMi605693 gene
neXtProtiNX_Q15771

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27314
OpenTargetsiENSG00000137502
PharmGKBiPA34121

Polymorphism and mutation databases

DMDMi38258937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212301 – 200Ras-related protein Rab-30Add BLAST200
PropeptideiPRO_0000370826201 – 203Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi199S-geranylgeranyl cysteineBy similarity1
Modified residuei200Cysteine methyl esterSequence analysis1
Lipidationi200S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ15771
MaxQBiQ15771
PaxDbiQ15771
PeptideAtlasiQ15771
PRIDEiQ15771
ProteomicsDBi60750

PTM databases

iPTMnetiQ15771
PhosphoSitePlusiQ15771

Expressioni

Gene expression databases

BgeeiENSG00000137502 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_RAB30
ExpressionAtlasiQ15771 baseline and differential
GenevisibleiQ15771 HS

Organism-specific databases

HPAiHPA054514
HPA060565

Interactioni

Protein-protein interaction databases

BioGridi118132, 28 interactors
DIPiDIP-60519N
IntActiQ15771, 3 interactors
STRINGi9606.ENSP00000260056

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15771
SMRiQ15771
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15771

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0095 Eukaryota
ENOG410XRPC LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ15771
KOiK07917
OMAiQPSFDCL
OrthoDBiEOG091G0HS5
PhylomeDBiQ15771
TreeFamiTF300097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT
60 70 80 90 100
VEINGEKVKL QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL
110 120 130 140 150
PEWLREIEQY ASNKVITVLV GNKIDLAERR EVSQQRAEEF SEAQDMYYLE
160 170 180 190 200
TSAKESDNVE KLFLDLACRL ISEARQNTLV NNVSSPLPGE GKSISYLTCC

NFN
Length:203
Mass (Da):23,058
Last modified:October 31, 2003 - v2
Checksum:i935E56DBD48DD7C2
GO
Isoform 2 (identifier: Q15771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-164: VGNKIDLAER...ESDNVEKLFL → ATRLTWLKGE...LIMWRNSSLT
     165-203: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,994
Checksum:i17BE813BEC1CD455
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDK7H0YDK7_HUMAN
Ras-related protein Rab-30
RAB30
167Annotation score:
E9PI18E9PI18_HUMAN
Ras-related protein Rab-30
RAB30
75Annotation score:
E9PNB9E9PNB9_HUMAN
Ras-related protein Rab-30
RAB30
122Annotation score:
E9PS06E9PS06_HUMAN
Ras-related protein Rab-30
RAB30
139Annotation score:
E9PMJ1E9PMJ1_HUMAN
Ras-related protein Rab-30
RAB30
168Annotation score:
E9PLM3E9PLM3_HUMAN
Ras-related protein Rab-30
RAB30
94Annotation score:
E9PRF7E9PRF7_HUMAN
Ras-related protein Rab-30
RAB30
114Annotation score:
E9PJQ5E9PJQ5_HUMAN
Ras-related protein Rab-30
RAB30
100Annotation score:
E9PRX0E9PRX0_HUMAN
Ras-related protein Rab-30
RAB30
55Annotation score:
E9PPW9E9PPW9_HUMAN
Ras-related protein Rab-30
RAB30
37Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45D → G in AAC50774 (PubMed:8863739).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055833120 – 164VGNKI…EKLFL → ATRLTWLKGERFPSSELKNS QKLRTCIIWRPQPRNLIMWR NSSLT in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_055834165 – 203Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57092 mRNA Translation: AAC50774.1
AF498956 mRNA Translation: AAM21104.1
CR542106 mRNA Translation: CAG46903.1
BX641138 mRNA Translation: CAE46061.1
AP000893 Genomic DNA No translation available.
AP001767 Genomic DNA No translation available.
BC014213 mRNA Translation: AAH14213.1
CCDSiCCDS8264.1 [Q15771-1]
PIRiJC4962
RefSeqiNP_001272988.1, NM_001286059.1 [Q15771-1]
NP_001272989.1, NM_001286060.1 [Q15771-1]
NP_001272990.1, NM_001286061.1 [Q15771-1]
NP_055303.2, NM_014488.4 [Q15771-1]
UniGeneiHs.40758
Hs.594773

Genome annotation databases

EnsembliENST00000260056; ENSP00000260056; ENSG00000137502 [Q15771-1]
ENST00000527633; ENSP00000435089; ENSG00000137502 [Q15771-1]
ENST00000533486; ENSP00000435189; ENSG00000137502 [Q15771-1]
ENST00000534141; ENSP00000434974; ENSG00000137502 [Q15771-2]
ENST00000612684; ENSP00000478702; ENSG00000137502 [Q15771-1]
GeneIDi27314
KEGGihsa:27314
UCSCiuc001ozu.5 human [Q15771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57092 mRNA Translation: AAC50774.1
AF498956 mRNA Translation: AAM21104.1
CR542106 mRNA Translation: CAG46903.1
BX641138 mRNA Translation: CAE46061.1
AP000893 Genomic DNA No translation available.
AP001767 Genomic DNA No translation available.
BC014213 mRNA Translation: AAH14213.1
CCDSiCCDS8264.1 [Q15771-1]
PIRiJC4962
RefSeqiNP_001272988.1, NM_001286059.1 [Q15771-1]
NP_001272989.1, NM_001286060.1 [Q15771-1]
NP_001272990.1, NM_001286061.1 [Q15771-1]
NP_055303.2, NM_014488.4 [Q15771-1]
UniGeneiHs.40758
Hs.594773

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EW1X-ray2.00A2-184[»]
ProteinModelPortaliQ15771
SMRiQ15771
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118132, 28 interactors
DIPiDIP-60519N
IntActiQ15771, 3 interactors
STRINGi9606.ENSP00000260056

PTM databases

iPTMnetiQ15771
PhosphoSitePlusiQ15771

Polymorphism and mutation databases

DMDMi38258937

Proteomic databases

EPDiQ15771
MaxQBiQ15771
PaxDbiQ15771
PeptideAtlasiQ15771
PRIDEiQ15771
ProteomicsDBi60750

Protocols and materials databases

DNASUi27314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260056; ENSP00000260056; ENSG00000137502 [Q15771-1]
ENST00000527633; ENSP00000435089; ENSG00000137502 [Q15771-1]
ENST00000533486; ENSP00000435189; ENSG00000137502 [Q15771-1]
ENST00000534141; ENSP00000434974; ENSG00000137502 [Q15771-2]
ENST00000612684; ENSP00000478702; ENSG00000137502 [Q15771-1]
GeneIDi27314
KEGGihsa:27314
UCSCiuc001ozu.5 human [Q15771-1]

Organism-specific databases

CTDi27314
DisGeNETi27314
EuPathDBiHostDB:ENSG00000137502.9
GeneCardsiRAB30
HGNCiHGNC:9770 RAB30
HPAiHPA054514
HPA060565
MIMi605693 gene
neXtProtiNX_Q15771
OpenTargetsiENSG00000137502
PharmGKBiPA34121
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0095 Eukaryota
ENOG410XRPC LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ15771
KOiK07917
OMAiQPSFDCL
OrthoDBiEOG091G0HS5
PhylomeDBiQ15771
TreeFamiTF300097

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB30 human
EvolutionaryTraceiQ15771
GenomeRNAii27314
PROiPR:Q15771
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137502 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_RAB30
ExpressionAtlasiQ15771 baseline and differential
GenevisibleiQ15771 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB30_HUMAN
AccessioniPrimary (citable) accession number: Q15771
Secondary accession number(s): Q6FGK1, Q6MZH2, Q96CI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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