UniProtKB - Q15768 (EFNB3_HUMAN)
Ephrin-B3
EFNB3
Functioni
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
By similarity(Microbial infection) Acts as a receptor for nipah virus and hendra virus.
2 PublicationsGO - Molecular functioni
- ephrin receptor binding Source: MGI
- transmembrane-ephrin receptor activity Source: ProtInc
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- adult walking behavior Source: Ensembl
- axon choice point recognition Source: Ensembl
- axon guidance Source: GO_Central
- cell-cell signaling Source: ProtInc
- ephrin receptor signaling pathway Source: MGI
- negative regulation of axonogenesis Source: ARUK-UCL
- nervous system development Source: ProtInc
- T cell costimulation Source: Ensembl
- trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Host cell receptor for virus entry, Receptor |
Biological process | Differentiation, Host-virus interaction, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q15768 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928664, Ephrin signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | Q15768 |
SIGNORi | Q15768 |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin-B3Alternative name(s): EPH-related receptor transmembrane ligand ELK-L3 EPH-related receptor tyrosine kinase ligand 8 Short name: LERK-8 |
Gene namesi | Name:EFNB3 Synonyms:EPLG8, LERK8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3228, EFNB3 |
MIMi | 602297, gene |
neXtProti | NX_Q15768 |
VEuPathDBi | HostDB:ENSG00000108947 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- integral component of postsynaptic density membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: CAFA
Other locations
- glutamatergic synapse Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 226 | ExtracellularSequence analysisAdd BLAST | 199 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 340 | CytoplasmicSequence analysisAdd BLAST | 93 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 124 – 125 | LW → YM: Complete loss of Nipah protein G binding. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 1949 |
OpenTargetsi | ENSG00000108947 |
PharmGKBi | PA27663 |
Miscellaneous databases
Pharosi | Q15768, Tbio |
Genetic variation databases
BioMutai | EFNB3 |
DMDMi | 2494367 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000008395 | 28 – 340 | Ephrin-B3Add BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 62 ↔ 104 | PROSITE-ProRule annotation | ||
Disulfide bondi | 92 ↔ 156 | PROSITE-ProRule annotation | ||
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 271 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 274 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Methylation, PhosphoproteinProteomic databases
EPDi | Q15768 |
MassIVEi | Q15768 |
PaxDbi | Q15768 |
PeptideAtlasi | Q15768 |
PRIDEi | Q15768 |
ProteomicsDBi | 60749 |
PTM databases
GlyGeni | Q15768, 1 site |
iPTMneti | Q15768 |
PhosphoSitePlusi | Q15768 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000108947, Expressed in spinal cord and 173 other tissues |
Genevisiblei | Q15768, HS |
Organism-specific databases
HPAi | ENSG00000108947, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with GRIP1 and GRIP2.
1 PublicationBinary interactionsi
Q15768
With | #Exp. | IntAct |
---|---|---|
EPHA4 [P54764] | 2 | EBI-3908475,EBI-5773557 |
GO - Molecular functioni
- ephrin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 108269, 54 interactors |
DIPi | DIP-59196N |
IntActi | Q15768, 37 interactors |
MINTi | Q15768 |
STRINGi | 9606.ENSP00000226091 |
Miscellaneous databases
RNActi | Q15768, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 167 | Ephrin RBDPROSITE-ProRule annotationAdd BLAST | 140 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 168 – 225 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 254 – 298 | DisorderedSequence analysisAdd BLAST | 45 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 338 – 340 | PDZ-bindingSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 182 – 196 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000160323 |
HOGENOMi | CLU_072080_0_0_1 |
InParanoidi | Q15768 |
OMAi | KESMPGD |
OrthoDBi | 903831at2759 |
PhylomeDBi | Q15768 |
Family and domain databases
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR019765, Ephrin_CS IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS01299, EPHRIN_RBD_1, 1 hit PS51551, EPHRIN_RBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL
60 70 80 90 100
YPQIGDRLDL LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL
110 120 130 140 150
LLTCDRPDLD LRFTIKFQEY SPNLWGHEFR SHHDYYIIAT SDGTREGLES
160 170 180 190 200
LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP VSEMPMERDR GAAHSLEPGK
210 220 230 240 250
ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL GVAGAGGAMC
260 270 280 290 300
WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG
310 320 330 340
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002356 | 166 | R → Q. Corresponds to variant dbSNP:rs1165640333Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57001 mRNA Translation: AAB05170.1 U66406 mRNA Translation: AAC51203.1 U62775 mRNA Translation: AAC50707.1 AK314841 mRNA Translation: BAG37359.1 CH471108 Genomic DNA Translation: EAW90133.1 CH471108 Genomic DNA Translation: EAW90135.1 BC022499 mRNA Translation: AAH22499.1 BC042944 mRNA Translation: AAH42944.1 |
CCDSi | CCDS11120.1 |
RefSeqi | NP_001397.1, NM_001406.3 |
Genome annotation databases
Ensembli | ENST00000226091; ENSP00000226091; ENSG00000108947 |
GeneIDi | 1949 |
KEGGi | hsa:1949 |
MANE-Selecti | ENST00000226091.3; ENSP00000226091.2; NM_001406.4; NP_001397.1 |
UCSCi | uc002gis.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57001 mRNA Translation: AAB05170.1 U66406 mRNA Translation: AAC51203.1 U62775 mRNA Translation: AAC50707.1 AK314841 mRNA Translation: BAG37359.1 CH471108 Genomic DNA Translation: EAW90133.1 CH471108 Genomic DNA Translation: EAW90135.1 BC022499 mRNA Translation: AAH22499.1 BC042944 mRNA Translation: AAH42944.1 |
CCDSi | CCDS11120.1 |
RefSeqi | NP_001397.1, NM_001406.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BKF | X-ray | 4.65 | C/D | 27-169 | [»] | |
SMRi | Q15768 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108269, 54 interactors |
DIPi | DIP-59196N |
IntActi | Q15768, 37 interactors |
MINTi | Q15768 |
STRINGi | 9606.ENSP00000226091 |
PTM databases
GlyGeni | Q15768, 1 site |
iPTMneti | Q15768 |
PhosphoSitePlusi | Q15768 |
Genetic variation databases
BioMutai | EFNB3 |
DMDMi | 2494367 |
Proteomic databases
EPDi | Q15768 |
MassIVEi | Q15768 |
PaxDbi | Q15768 |
PeptideAtlasi | Q15768 |
PRIDEi | Q15768 |
ProteomicsDBi | 60749 |
Protocols and materials databases
Antibodypediai | 644, 299 antibodies from 30 providers |
DNASUi | 1949 |
Genome annotation databases
Ensembli | ENST00000226091; ENSP00000226091; ENSG00000108947 |
GeneIDi | 1949 |
KEGGi | hsa:1949 |
MANE-Selecti | ENST00000226091.3; ENSP00000226091.2; NM_001406.4; NP_001397.1 |
UCSCi | uc002gis.4, human |
Organism-specific databases
CTDi | 1949 |
DisGeNETi | 1949 |
GeneCardsi | EFNB3 |
HGNCi | HGNC:3228, EFNB3 |
HPAi | ENSG00000108947, Tissue enhanced (brain) |
MIMi | 602297, gene |
neXtProti | NX_Q15768 |
OpenTargetsi | ENSG00000108947 |
PharmGKBi | PA27663 |
VEuPathDBi | HostDB:ENSG00000108947 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000160323 |
HOGENOMi | CLU_072080_0_0_1 |
InParanoidi | Q15768 |
OMAi | KESMPGD |
OrthoDBi | 903831at2759 |
PhylomeDBi | Q15768 |
Enzyme and pathway databases
PathwayCommonsi | Q15768 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928664, Ephrin signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | Q15768 |
SIGNORi | Q15768 |
Miscellaneous databases
BioGRID-ORCSi | 1949, 9 hits in 1033 CRISPR screens |
ChiTaRSi | EFNB3, human |
GeneWikii | EFNB3 |
GenomeRNAii | 1949 |
Pharosi | Q15768, Tbio |
PROi | PR:Q15768 |
RNActi | Q15768, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108947, Expressed in spinal cord and 173 other tissues |
Genevisiblei | Q15768, HS |
Family and domain databases
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR019765, Ephrin_CS IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS01299, EPHRIN_RBD_1, 1 hit PS51551, EPHRIN_RBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EFNB3_HUMAN | |
Accessioni | Q15768Primary (citable) accession number: Q15768 Secondary accession number(s): B2RBW2 Q92875 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families