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Protein

CD226 antigen

Gene

CD226

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
DNAX accessory molecule 1
Short name:
DNAM-1
CD_antigen: CD226
Gene namesi
Name:CD226
Synonyms:DNAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000150637.8
HGNCiHGNC:16961 CD226
MIMi605397 gene
neXtProtiNX_Q15762

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 254ExtracellularSequence analysisAdd BLAST236
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 336CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10666
OpenTargetsiENSG00000150637
PharmGKBiPA134911130

Polymorphism and mutation databases

BioMutaiCD226
DMDMi317373338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001466519 – 336CD226 antigenAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 222PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei322PhosphotyrosineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15762
PeptideAtlasiQ15762
PRIDEiQ15762
ProteomicsDBi60748

PTM databases

iPTMnetiQ15762
PhosphoSitePlusiQ15762

Expressioni

Tissue specificityi

Expressed by peripheral blood T-lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000150637 Expressed in 108 organ(s), highest expression level in leukocyte
CleanExiHS_CD226
ExpressionAtlasiQ15762 baseline and differential
GenevisibleiQ15762 HS

Organism-specific databases

HPAiHPA015715
HPA050348

Interactioni

Subunit structurei

Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115908, 58 interactors
IntActiQ15762, 3 interactors
STRINGi9606.ENSP00000280200

Structurei

3D structure databases

ProteinModelPortaliQ15762
SMRiQ15762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 126Ig-like C2-type 1Add BLAST108
Domaini135 – 239Ig-like C2-type 2Add BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 284Poly-Arg8

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXC Eukaryota
ENOG41129MS LUCA
GeneTreeiENSGT00500000044993
HOGENOMiHOG000059567
HOVERGENiHBG050849
InParanoidiQ15762
KOiK06567
OMAiNDMTLSF
OrthoDBiEOG091G0823
PhylomeDBiQ15762
TreeFamiTF336260

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q15762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW
60 70 80 90 100
FKIGTQQDSI AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE
110 120 130 140 150
DDVGYYSCSL YTYPQGTWQK VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL
160 170 180 190 200
TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN LVHGRNFTSK FPRQIVSNCS
210 220 230 240 250
HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV AEGKTDNQYT
260 270 280 290 300
LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY
310 320 330
RSPISTSQPT NQSMDDTRED IYVNYPTFSR RPKTRV
Length:336
Mass (Da):38,614
Last modified:January 11, 2011 - v2
Checksum:i5379182CC4695097
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQW1J3QQW1_HUMAN
CD226 antigen
CD226
276Annotation score:
J3QR77J3QR77_HUMAN
CD226 antigen
CD226
181Annotation score:
J3QL19J3QL19_HUMAN
CD226 antigen
CD226
127Annotation score:
J3QRQ4J3QRQ4_HUMAN
CD226 antigen
CD226
132Annotation score:
J3QKM7J3QKM7_HUMAN
CD226 antigen
CD226
37Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018632307S → GCombined sources3 PublicationsCorresponds to variant dbSNP:rs763361Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56102 mRNA Translation: AAC50560.1
AJ537553 mRNA Translation: CAD61184.1
AK313199 mRNA Translation: BAG36015.1
AC011930 Genomic DNA No translation available.
AC090231 Genomic DNA No translation available.
AC091137 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66515.1
BC074787 mRNA Translation: AAH74787.1
CCDSiCCDS11997.1
RefSeqiNP_001290547.1, NM_001303618.1
NP_006557.2, NM_006566.3
XP_005266699.1, XM_005266642.3
UniGeneiHs.660130

Genome annotation databases

EnsembliENST00000280200; ENSP00000280200; ENSG00000150637
ENST00000582621; ENSP00000461947; ENSG00000150637
GeneIDi10666
KEGGihsa:10666
UCSCiuc002lkm.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56102 mRNA Translation: AAC50560.1
AJ537553 mRNA Translation: CAD61184.1
AK313199 mRNA Translation: BAG36015.1
AC011930 Genomic DNA No translation available.
AC090231 Genomic DNA No translation available.
AC091137 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66515.1
BC074787 mRNA Translation: AAH74787.1
CCDSiCCDS11997.1
RefSeqiNP_001290547.1, NM_001303618.1
NP_006557.2, NM_006566.3
XP_005266699.1, XM_005266642.3
UniGeneiHs.660130

3D structure databases

ProteinModelPortaliQ15762
SMRiQ15762
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115908, 58 interactors
IntActiQ15762, 3 interactors
STRINGi9606.ENSP00000280200

PTM databases

iPTMnetiQ15762
PhosphoSitePlusiQ15762

Polymorphism and mutation databases

BioMutaiCD226
DMDMi317373338

Proteomic databases

PaxDbiQ15762
PeptideAtlasiQ15762
PRIDEiQ15762
ProteomicsDBi60748

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280200; ENSP00000280200; ENSG00000150637
ENST00000582621; ENSP00000461947; ENSG00000150637
GeneIDi10666
KEGGihsa:10666
UCSCiuc002lkm.6 human

Organism-specific databases

CTDi10666
DisGeNETi10666
EuPathDBiHostDB:ENSG00000150637.8
GeneCardsiCD226
H-InvDBiHIX0039717
HGNCiHGNC:16961 CD226
HPAiHPA015715
HPA050348
MIMi605397 gene
neXtProtiNX_Q15762
OpenTargetsiENSG00000150637
PharmGKBiPA134911130
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXC Eukaryota
ENOG41129MS LUCA
GeneTreeiENSGT00500000044993
HOGENOMiHOG000059567
HOVERGENiHBG050849
InParanoidiQ15762
KOiK06567
OMAiNDMTLSF
OrthoDBiEOG091G0823
PhylomeDBiQ15762
TreeFamiTF336260

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiCD226 human
GeneWikiiCD226
GenomeRNAii10666
PROiPR:Q15762
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150637 Expressed in 108 organ(s), highest expression level in leukocyte
CleanExiHS_CD226
ExpressionAtlasiQ15762 baseline and differential
GenevisibleiQ15762 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCD226_HUMAN
AccessioniPrimary (citable) accession number: Q15762
Secondary accession number(s): B2R818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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