UniProtKB - Q15761 (NPY5R_HUMAN)
Protein
Neuropeptide Y receptor type 5
Gene
NPY5R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
GO - Molecular functioni
- neuropeptide Y receptor activity Source: ProtInc
- pancreatic polypeptide receptor activity Source: GO_Central
- peptide YY receptor activity Source: GO_Central
GO - Biological processi
- aging Source: Ensembl
- cardiac left ventricle morphogenesis Source: BHF-UCL
- chemical synaptic transmission Source: GO_Central
- eating behavior Source: Ensembl
- generation of ovulation cycle rhythm Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of glutamate secretion Source: Ensembl
- negative regulation of synaptic transmission, GABAergic Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- positive regulation of acute inflammatory response Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q15761 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q15761 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide Y receptor type 5Short name: NPY5-R Alternative name(s): NPY-Y5 receptor Short name: NPYY5-R Short name: Y5 receptor |
Gene namesi | Name:NPY5R Synonyms:NPYR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7958, NPY5R |
MIMi | 602001, gene |
neXtProti | NX_Q15761 |
VEuPathDBi | HostDB:ENSG00000164129.11 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: Ensembl
- membrane Source: GO_Central
- neuron projection Source: GO_Central
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 77 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 117 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 118 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 156 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 208 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 209 – 229 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 369 | CytoplasmicSequence analysisAdd BLAST | 140 | |
Transmembranei | 370 – 390 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 407 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 408 – 428 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 429 – 445 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4889 |
OpenTargetsi | ENSG00000164129 |
PharmGKBi | PA31742 |
Miscellaneous databases
Pharosi | Q15761, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4561 |
DrugBanki | DB05004, Peptide YY (3-36) |
GuidetoPHARMACOLOGYi | 308 |
Genetic variation databases
BioMutai | NPY5R |
DMDMi | 215274093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069939 | 1 – 445 | Neuropeptide Y receptor type 5Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 198 | PROSITE-ProRule annotation | ||
Lipidationi | 442 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q15761 |
PeptideAtlasi | Q15761 |
PRIDEi | Q15761 |
ProteomicsDBi | 60747 |
PTM databases
GlyGeni | Q15761, 2 sites |
iPTMneti | Q15761 |
PhosphoSitePlusi | Q15761 |
Expressioni
Tissue specificityi
Brain; hypothalamus.
Gene expression databases
Bgeei | ENSG00000164129, Expressed in caudate nucleus and 120 other tissues |
Genevisiblei | Q15761, HS |
Organism-specific databases
HPAi | ENSG00000164129, Tissue enhanced (brain, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 110949, 2 interactors |
IntActi | Q15761, 3 interactors |
STRINGi | 9606.ENSP00000423917 |
Chemistry databases
BindingDBi | Q15761 |
Miscellaneous databases
RNActi | Q15761, protein |
Structurei
3D structure databases
BMRBi | Q15761 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161766 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | Q15761 |
OMAi | CHVMPFL |
OrthoDBi | 609835at2759 |
PhylomeDBi | Q15761 |
TreeFami | TF315303 |
Family and domain databases
CDDi | cd15398, 7tmA_NPY5R, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000393, NPY5_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01016, NRPEPTIDEY5R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q15761-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE
260 270 280 290 300
ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
310 320 330 340 350
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL
360 370 380 390 400
RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN
410 420 430 440
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM
Sequence cautioni
The sequence AAC50623 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66275 mRNA Translation: AAC50741.1 U56079 mRNA Translation: AAC50623.1 Different initiation. U94320 mRNA Translation: AAC51295.1 AY322538 Genomic DNA Translation: AAP84351.1 AC079238 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04839.1 BC042416 mRNA Translation: AAH42416.1 |
CCDSi | CCDS3804.1 |
RefSeqi | NP_001304020.1, NM_001317091.1 NP_001304021.1, NM_001317092.1 NP_006165.1, NM_006174.3 XP_005263095.1, XM_005263038.3 XP_011530319.1, XM_011532017.2 |
Genome annotation databases
Ensembli | ENST00000338566; ENSP00000339377; ENSG00000164129 ENST00000506953; ENSP00000423474; ENSG00000164129 ENST00000515560; ENSP00000423917; ENSG00000164129 |
GeneIDi | 4889 |
KEGGi | hsa:4889 |
UCSCi | uc003iqn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66275 mRNA Translation: AAC50741.1 U56079 mRNA Translation: AAC50623.1 Different initiation. U94320 mRNA Translation: AAC51295.1 AY322538 Genomic DNA Translation: AAP84351.1 AC079238 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04839.1 BC042416 mRNA Translation: AAH42416.1 |
CCDSi | CCDS3804.1 |
RefSeqi | NP_001304020.1, NM_001317091.1 NP_001304021.1, NM_001317092.1 NP_006165.1, NM_006174.3 XP_005263095.1, XM_005263038.3 XP_011530319.1, XM_011532017.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HE6 | model | - | @ | 1-445 | [»] | |
BMRBi | Q15761 | |||||
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110949, 2 interactors |
IntActi | Q15761, 3 interactors |
STRINGi | 9606.ENSP00000423917 |
Chemistry databases
BindingDBi | Q15761 |
ChEMBLi | CHEMBL4561 |
DrugBanki | DB05004, Peptide YY (3-36) |
GuidetoPHARMACOLOGYi | 308 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q15761, 2 sites |
iPTMneti | Q15761 |
PhosphoSitePlusi | Q15761 |
Genetic variation databases
BioMutai | NPY5R |
DMDMi | 215274093 |
Proteomic databases
PaxDbi | Q15761 |
PeptideAtlasi | Q15761 |
PRIDEi | Q15761 |
ProteomicsDBi | 60747 |
Protocols and materials databases
Antibodypediai | 2946, 264 antibodies |
DNASUi | 4889 |
Genome annotation databases
Ensembli | ENST00000338566; ENSP00000339377; ENSG00000164129 ENST00000506953; ENSP00000423474; ENSG00000164129 ENST00000515560; ENSP00000423917; ENSG00000164129 |
GeneIDi | 4889 |
KEGGi | hsa:4889 |
UCSCi | uc003iqn.3, human |
Organism-specific databases
CTDi | 4889 |
DisGeNETi | 4889 |
GeneCardsi | NPY5R |
HGNCi | HGNC:7958, NPY5R |
HPAi | ENSG00000164129, Tissue enhanced (brain, lymphoid tissue) |
MIMi | 602001, gene |
neXtProti | NX_Q15761 |
OpenTargetsi | ENSG00000164129 |
PharmGKBi | PA31742 |
VEuPathDBi | HostDB:ENSG00000164129.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161766 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | Q15761 |
OMAi | CHVMPFL |
OrthoDBi | 609835at2759 |
PhylomeDBi | Q15761 |
TreeFami | TF315303 |
Enzyme and pathway databases
PathwayCommonsi | Q15761 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q15761 |
Miscellaneous databases
BioGRID-ORCSi | 4889, 6 hits in 870 CRISPR screens |
GeneWikii | Neuropeptide_Y_receptor_Y5 |
GenomeRNAii | 4889 |
Pharosi | Q15761, Tchem |
PROi | PR:Q15761 |
RNActi | Q15761, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164129, Expressed in caudate nucleus and 120 other tissues |
Genevisiblei | Q15761, HS |
Family and domain databases
CDDi | cd15398, 7tmA_NPY5R, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000393, NPY5_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01016, NRPEPTIDEY5R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPY5R_HUMAN | |
Accessioni | Q15761Primary (citable) accession number: Q15761 Secondary accession number(s): Q6GTR7, Q92916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families