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Protein

Neuropeptide Y receptor type 5

Gene

NPY5R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: ProtInc
  • pancreatic polypeptide receptor activity Source: GO_Central
  • peptide YY receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ15761

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:NPY5R
Synonyms:NPYR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164129.11
HGNCiHGNC:7958 NPY5R
MIMi602001 gene
neXtProtiNX_Q15761

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 117ExtracellularSequence analysisAdd BLAST19
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 156CytoplasmicSequence analysisAdd BLAST18
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 208ExtracellularSequence analysisAdd BLAST31
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 369CytoplasmicSequence analysisAdd BLAST140
Transmembranei370 – 390Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini391 – 407ExtracellularSequence analysisAdd BLAST17
Transmembranei408 – 428Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini429 – 445CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4889
OpenTargetsiENSG00000164129
PharmGKBiPA31742

Chemistry databases

ChEMBLiCHEMBL4561
DrugBankiDB05004 AC162352
GuidetoPHARMACOLOGYi308

Polymorphism and mutation databases

BioMutaiNPY5R
DMDMi215274093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699391 – 445Neuropeptide Y receptor type 5Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 198PROSITE-ProRule annotation
Lipidationi442S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ15761
PRIDEiQ15761
ProteomicsDBi60747

PTM databases

iPTMnetiQ15761
PhosphoSitePlusiQ15761

Expressioni

Tissue specificityi

Brain; hypothalamus.

Gene expression databases

BgeeiENSG00000164129 Expressed in 97 organ(s), highest expression level in caudate nucleus
CleanExiHS_NPY5R
GenevisibleiQ15761 HS

Interactioni

Protein-protein interaction databases

BioGridi110949, 2 interactors
IntActiQ15761, 3 interactors
STRINGi9606.ENSP00000339377

Chemistry databases

BindingDBiQ15761

Structurei

3D structure databases

ProteinModelPortaliQ15761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000294210
HOVERGENiHBG052662
InParanoidiQ15761
KOiK04207
OMAiIKADLMS
OrthoDBiEOG091G0ZDG
PhylomeDBiQ15761
TreeFamiTF315303

Family and domain databases

CDDicd15398 7tmA_NPY5R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000393 NPY5_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR45422 PTHR45422, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01016 NRPEPTIDEY5R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q15761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE
260 270 280 290 300
ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
310 320 330 340 350
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL
360 370 380 390 400
RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN
410 420 430 440
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM
Length:445
Mass (Da):50,727
Last modified:November 25, 2008 - v2
Checksum:iA2B0F3169DBA66BE
GO

Sequence cautioni

The sequence AAC50623 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66275 mRNA Translation: AAC50741.1
U56079 mRNA Translation: AAC50623.1 Different initiation.
U94320 mRNA Translation: AAC51295.1
AY322538 Genomic DNA Translation: AAP84351.1
AC079238 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04839.1
BC042416 mRNA Translation: AAH42416.1
CCDSiCCDS3804.1
RefSeqiNP_001304020.1, NM_001317091.1
NP_001304021.1, NM_001317092.1
NP_006165.1, NM_006174.3
XP_005263095.1, XM_005263038.3
XP_011530319.1, XM_011532017.2
UniGeneiHs.519058
Hs.598503

Genome annotation databases

EnsembliENST00000338566; ENSP00000339377; ENSG00000164129
ENST00000506953; ENSP00000423474; ENSG00000164129
ENST00000515560; ENSP00000423917; ENSG00000164129
GeneIDi4889
KEGGihsa:4889
UCSCiuc003iqn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66275 mRNA Translation: AAC50741.1
U56079 mRNA Translation: AAC50623.1 Different initiation.
U94320 mRNA Translation: AAC51295.1
AY322538 Genomic DNA Translation: AAP84351.1
AC079238 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04839.1
BC042416 mRNA Translation: AAH42416.1
CCDSiCCDS3804.1
RefSeqiNP_001304020.1, NM_001317091.1
NP_001304021.1, NM_001317092.1
NP_006165.1, NM_006174.3
XP_005263095.1, XM_005263038.3
XP_011530319.1, XM_011532017.2
UniGeneiHs.519058
Hs.598503

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE6model-@1-445[»]
ProteinModelPortaliQ15761
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110949, 2 interactors
IntActiQ15761, 3 interactors
STRINGi9606.ENSP00000339377

Chemistry databases

BindingDBiQ15761
ChEMBLiCHEMBL4561
DrugBankiDB05004 AC162352
GuidetoPHARMACOLOGYi308

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15761
PhosphoSitePlusiQ15761

Polymorphism and mutation databases

BioMutaiNPY5R
DMDMi215274093

Proteomic databases

PaxDbiQ15761
PRIDEiQ15761
ProteomicsDBi60747

Protocols and materials databases

DNASUi4889
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338566; ENSP00000339377; ENSG00000164129
ENST00000506953; ENSP00000423474; ENSG00000164129
ENST00000515560; ENSP00000423917; ENSG00000164129
GeneIDi4889
KEGGihsa:4889
UCSCiuc003iqn.3 human

Organism-specific databases

CTDi4889
DisGeNETi4889
EuPathDBiHostDB:ENSG00000164129.11
GeneCardsiNPY5R
HGNCiHGNC:7958 NPY5R
MIMi602001 gene
neXtProtiNX_Q15761
OpenTargetsiENSG00000164129
PharmGKBiPA31742
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000294210
HOVERGENiHBG052662
InParanoidiQ15761
KOiK04207
OMAiIKADLMS
OrthoDBiEOG091G0ZDG
PhylomeDBiQ15761
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ15761

Miscellaneous databases

GeneWikiiNeuropeptide_Y_receptor_Y5
GenomeRNAii4889
PROiPR:Q15761
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164129 Expressed in 97 organ(s), highest expression level in caudate nucleus
CleanExiHS_NPY5R
GenevisibleiQ15761 HS

Family and domain databases

CDDicd15398 7tmA_NPY5R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000393 NPY5_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR45422 PTHR45422, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01016 NRPEPTIDEY5R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPY5R_HUMAN
AccessioniPrimary (citable) accession number: Q15761
Secondary accession number(s): Q6GTR7, Q92916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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