UniProtKB - Q15761 (NPY5R_HUMAN)
Protein
Neuropeptide Y receptor type 5
Gene
NPY5R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
GO - Molecular functioni
- neuropeptide Y receptor activity Source: ProtInc
- pancreatic polypeptide receptor activity Source: GO_Central
- peptide YY receptor activity Source: GO_Central
GO - Biological processi
- aging Source: Ensembl
- cardiac left ventricle morphogenesis Source: BHF-UCL
- chemical synaptic transmission Source: GO_Central
- eating behavior Source: Ensembl
- generation of ovulation cycle rhythm Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of glutamate secretion Source: Ensembl
- negative regulation of synaptic transmission, GABAergic Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- positive regulation of acute inflammatory response Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events |
SIGNORi | Q15761 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide Y receptor type 5Short name: NPY5-R Alternative name(s): NPY-Y5 receptor Short name: NPYY5-R Short name: Y5 receptor |
Gene namesi | Name:NPY5R Synonyms:NPYR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164129.11 |
HGNCi | HGNC:7958 NPY5R |
MIMi | 602001 gene |
neXtProti | NX_Q15761 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: Ensembl
- membrane Source: GO_Central
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 77 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 117 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 118 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 156 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 208 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 209 – 229 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 369 | CytoplasmicSequence analysisAdd BLAST | 140 | |
Transmembranei | 370 – 390 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 407 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 408 – 428 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 429 – 445 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4889 |
OpenTargetsi | ENSG00000164129 |
PharmGKBi | PA31742 |
Chemistry databases
ChEMBLi | CHEMBL4561 |
DrugBanki | DB05004 AC162352 |
GuidetoPHARMACOLOGYi | 308 |
Polymorphism and mutation databases
BioMutai | NPY5R |
DMDMi | 215274093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069939 | 1 – 445 | Neuropeptide Y receptor type 5Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 198 | PROSITE-ProRule annotation | ||
Lipidationi | 442 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q15761 |
PRIDEi | Q15761 |
ProteomicsDBi | 60747 |
PTM databases
iPTMneti | Q15761 |
PhosphoSitePlusi | Q15761 |
Expressioni
Tissue specificityi
Brain; hypothalamus.
Gene expression databases
Bgeei | ENSG00000164129 Expressed in 97 organ(s), highest expression level in caudate nucleus |
Genevisiblei | Q15761 HS |
Interactioni
Protein-protein interaction databases
BioGridi | 110949, 2 interactors |
IntActi | Q15761, 3 interactors |
STRINGi | 9606.ENSP00000339377 |
Chemistry databases
BindingDBi | Q15761 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HE6 | model | - | @ | 1-445 | [»] | |
ProteinModelPortali | Q15761 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161766 |
HOGENOMi | HOG000294210 |
HOVERGENi | HBG052662 |
InParanoidi | Q15761 |
KOi | K04207 |
OMAi | IKADLMS |
OrthoDBi | 609835at2759 |
PhylomeDBi | Q15761 |
TreeFami | TF315303 |
Family and domain databases
CDDi | cd15398 7tmA_NPY5R, 1 hit |
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000393 NPY5_rcpt IPR000611 NPY_rcpt |
PANTHERi | PTHR45422 PTHR45422, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01016 NRPEPTIDEY5R PR01012 NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q15761-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE
260 270 280 290 300
ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
310 320 330 340 350
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL
360 370 380 390 400
RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN
410 420 430 440
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM
Sequence cautioni
The sequence AAC50623 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66275 mRNA Translation: AAC50741.1 U56079 mRNA Translation: AAC50623.1 Different initiation. U94320 mRNA Translation: AAC51295.1 AY322538 Genomic DNA Translation: AAP84351.1 AC079238 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04839.1 BC042416 mRNA Translation: AAH42416.1 |
CCDSi | CCDS3804.1 |
RefSeqi | NP_001304020.1, NM_001317091.1 NP_001304021.1, NM_001317092.1 NP_006165.1, NM_006174.3 XP_005263095.1, XM_005263038.3 XP_011530319.1, XM_011532017.2 |
UniGenei | Hs.519058 Hs.598503 |
Genome annotation databases
Ensembli | ENST00000338566; ENSP00000339377; ENSG00000164129 ENST00000506953; ENSP00000423474; ENSG00000164129 ENST00000515560; ENSP00000423917; ENSG00000164129 |
GeneIDi | 4889 |
KEGGi | hsa:4889 |
UCSCi | uc003iqn.3 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66275 mRNA Translation: AAC50741.1 U56079 mRNA Translation: AAC50623.1 Different initiation. U94320 mRNA Translation: AAC51295.1 AY322538 Genomic DNA Translation: AAP84351.1 AC079238 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04839.1 BC042416 mRNA Translation: AAH42416.1 |
CCDSi | CCDS3804.1 |
RefSeqi | NP_001304020.1, NM_001317091.1 NP_001304021.1, NM_001317092.1 NP_006165.1, NM_006174.3 XP_005263095.1, XM_005263038.3 XP_011530319.1, XM_011532017.2 |
UniGenei | Hs.519058 Hs.598503 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HE6 | model | - | @ | 1-445 | [»] | |
ProteinModelPortali | Q15761 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 110949, 2 interactors |
IntActi | Q15761, 3 interactors |
STRINGi | 9606.ENSP00000339377 |
Chemistry databases
BindingDBi | Q15761 |
ChEMBLi | CHEMBL4561 |
DrugBanki | DB05004 AC162352 |
GuidetoPHARMACOLOGYi | 308 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q15761 |
PhosphoSitePlusi | Q15761 |
Polymorphism and mutation databases
BioMutai | NPY5R |
DMDMi | 215274093 |
Proteomic databases
PaxDbi | Q15761 |
PRIDEi | Q15761 |
ProteomicsDBi | 60747 |
Protocols and materials databases
DNASUi | 4889 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000338566; ENSP00000339377; ENSG00000164129 ENST00000506953; ENSP00000423474; ENSG00000164129 ENST00000515560; ENSP00000423917; ENSG00000164129 |
GeneIDi | 4889 |
KEGGi | hsa:4889 |
UCSCi | uc003iqn.3 human |
Organism-specific databases
CTDi | 4889 |
DisGeNETi | 4889 |
EuPathDBi | HostDB:ENSG00000164129.11 |
GeneCardsi | NPY5R |
HGNCi | HGNC:7958 NPY5R |
MIMi | 602001 gene |
neXtProti | NX_Q15761 |
OpenTargetsi | ENSG00000164129 |
PharmGKBi | PA31742 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161766 |
HOGENOMi | HOG000294210 |
HOVERGENi | HBG052662 |
InParanoidi | Q15761 |
KOi | K04207 |
OMAi | IKADLMS |
OrthoDBi | 609835at2759 |
PhylomeDBi | Q15761 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events |
SIGNORi | Q15761 |
Miscellaneous databases
GeneWikii | Neuropeptide_Y_receptor_Y5 |
GenomeRNAii | 4889 |
PROi | PR:Q15761 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164129 Expressed in 97 organ(s), highest expression level in caudate nucleus |
Genevisiblei | Q15761 HS |
Family and domain databases
CDDi | cd15398 7tmA_NPY5R, 1 hit |
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000393 NPY5_rcpt IPR000611 NPY_rcpt |
PANTHERi | PTHR45422 PTHR45422, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01016 NRPEPTIDEY5R PR01012 NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | NPY5R_HUMAN | |
Accessioni | Q15761Primary (citable) accession number: Q15761 Secondary accession number(s): Q6GTR7, Q92916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 13, 2019 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries