UniProtKB - Q15760 (GPR19_HUMAN)
Protein
Probable G-protein coupled receptor 19
Gene
GPR19
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: ProtInc
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q15760 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 19Alternative name(s): GPR-NGA |
Gene namesi | Name:GPR19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183150.7 |
HGNCi | HGNC:4473, GPR19 |
MIMi | 602927, gene |
neXtProti | NX_Q15760 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- cilium Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 69 | ExtracellularSequence analysisAdd BLAST | 69 | |
Transmembranei | 70 – 90 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 91 – 102 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 103 – 123 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 143 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 144 – 161 | Helical; Name=3Sequence analysisAdd BLAST | 18 | |
Topological domaini | 162 – 182 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 183 – 203 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 204 – 221 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 222 – 242 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 243 – 277 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 278 – 298 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 309 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 310 – 325 | Helical; Name=7Sequence analysisAdd BLAST | 16 | |
Topological domaini | 326 – 415 | CytoplasmicSequence analysisAdd BLAST | 90 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2842 |
OpenTargetsi | ENSG00000183150 |
PharmGKBi | PA28861 |
Miscellaneous databases
Pharosi | Q15760, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 90 |
Polymorphism and mutation databases
BioMutai | GPR19 |
DMDMi | 322510031 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069538 | 1 – 415 | Probable G-protein coupled receptor 19Add BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 138 ↔ 210 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q15760 |
PeptideAtlasi | Q15760 |
PRIDEi | Q15760 |
ProteomicsDBi | 60746 |
PTM databases
GlyGeni | Q15760, 2 sites |
iPTMneti | Q15760 |
PhosphoSitePlusi | Q15760 |
Expressioni
Tissue specificityi
Abundant expression in the brain.
Gene expression databases
Bgeei | ENSG00000183150, Expressed in Brodmann (1909) area 23 and 131 other tissues |
ExpressionAtlasi | Q15760, baseline and differential |
Genevisiblei | Q15760, HS |
Organism-specific databases
HPAi | ENSG00000183150, Tissue enhanced (blood, brain, pituitary gland, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000441832 |
Miscellaneous databases
RNActi | Q15760, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160365 |
HOGENOMi | CLU_009579_20_0_1 |
InParanoidi | Q15760 |
OMAi | RETFCMS |
OrthoDBi | 1383895at2759 |
PhylomeDBi | Q15760 |
TreeFami | TF331630 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q15760-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM
60 70 80 90 100
SNQTDLHYVL KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVLLQFTTGR WTLGSATCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWVF DAGFVTPVLF
210 220 230 240 250
FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP
310 320 330 340 350
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK
410
KLAWPINSNP PNTFV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5GWU2 | F5GWU2_HUMAN | Probable G-protein-coupled receptor... | GPR19 | 59 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024256 | 189 | V → I2 PublicationsCorresponds to variant dbSNP:rs4763862Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64871 Genomic DNA Translation: AAB49751.1 U55312 Genomic DNA Translation: AAB00316.1 AC008115 Genomic DNA No translation available. |
CCDSi | CCDS8652.1 |
PIRi | S74237 |
RefSeqi | NP_006134.1, NM_006143.2 XP_011518927.1, XM_011520625.2 XP_016874705.1, XM_017019216.1 |
Genome annotation databases
Ensembli | ENST00000332427; ENSP00000333744; ENSG00000183150 ENST00000540510; ENSP00000441832; ENSG00000183150 ENST00000651487; ENSP00000498976; ENSG00000183150 |
GeneIDi | 2842 |
KEGGi | hsa:2842 |
UCSCi | uc001raq.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64871 Genomic DNA Translation: AAB49751.1 U55312 Genomic DNA Translation: AAB00316.1 AC008115 Genomic DNA No translation available. |
CCDSi | CCDS8652.1 |
PIRi | S74237 |
RefSeqi | NP_006134.1, NM_006143.2 XP_011518927.1, XM_011520625.2 XP_016874705.1, XM_017019216.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000441832 |
Chemistry databases
GuidetoPHARMACOLOGYi | 90 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q15760, 2 sites |
iPTMneti | Q15760 |
PhosphoSitePlusi | Q15760 |
Polymorphism and mutation databases
BioMutai | GPR19 |
DMDMi | 322510031 |
Proteomic databases
PaxDbi | Q15760 |
PeptideAtlasi | Q15760 |
PRIDEi | Q15760 |
ProteomicsDBi | 60746 |
Protocols and materials databases
Antibodypediai | 2961, 149 antibodies |
DNASUi | 2842 |
Genome annotation databases
Ensembli | ENST00000332427; ENSP00000333744; ENSG00000183150 ENST00000540510; ENSP00000441832; ENSG00000183150 ENST00000651487; ENSP00000498976; ENSG00000183150 |
GeneIDi | 2842 |
KEGGi | hsa:2842 |
UCSCi | uc001raq.2, human |
Organism-specific databases
CTDi | 2842 |
DisGeNETi | 2842 |
EuPathDBi | HostDB:ENSG00000183150.7 |
GeneCardsi | GPR19 |
HGNCi | HGNC:4473, GPR19 |
HPAi | ENSG00000183150, Tissue enhanced (blood, brain, pituitary gland, testis) |
MIMi | 602927, gene |
neXtProti | NX_Q15760 |
OpenTargetsi | ENSG00000183150 |
PharmGKBi | PA28861 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160365 |
HOGENOMi | CLU_009579_20_0_1 |
InParanoidi | Q15760 |
OMAi | RETFCMS |
OrthoDBi | 1383895at2759 |
PhylomeDBi | Q15760 |
TreeFami | TF331630 |
Enzyme and pathway databases
PathwayCommonsi | Q15760 |
Miscellaneous databases
BioGRID-ORCSi | 2842, 2 hits in 842 CRISPR screens |
ChiTaRSi | GPR19, human |
GeneWikii | GPR19 |
GenomeRNAii | 2842 |
Pharosi | Q15760, Tbio |
PROi | PR:Q15760 |
RNActi | Q15760, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183150, Expressed in Brodmann (1909) area 23 and 131 other tissues |
ExpressionAtlasi | Q15760, baseline and differential |
Genevisiblei | Q15760, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR19_HUMAN | |
Accessioni | Q15760Primary (citable) accession number: Q15760 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries