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Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).4 Publications
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.2 Publications
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.1 Publication
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi382Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi384Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi386Sodium 1By similarity1
Metal bindingi471Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi475Sodium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAmino-acid transport, Host-virus interaction, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.23.3.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105281.12
HGNCiHGNC:10943 SLC1A5
MIMi109190 gene
neXtProtiNX_Q15758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicCuratedAdd BLAST51
Transmembranei52 – 81Helical; Name=11 PublicationAdd BLAST30
Topological domaini82 – 94ExtracellularCuratedAdd BLAST13
Transmembranei95 – 116Helical; Name=21 PublicationAdd BLAST22
Topological domaini117 – 130CytoplasmicCuratedAdd BLAST14
Transmembranei131 – 153Helical; Name=31 PublicationAdd BLAST23
Topological domaini154 – 224ExtracellularCuratedAdd BLAST71
Transmembranei225 – 248Helical; Name=41 PublicationAdd BLAST24
Topological domaini249 – 257CytoplasmicCurated9
Transmembranei258 – 285Helical; Name=51 PublicationAdd BLAST28
Topological domaini286 – 306ExtracellularCuratedAdd BLAST21
Transmembranei307 – 328Helical; Name=61 PublicationAdd BLAST22
Topological domaini329 – 333CytoplasmicCurated5
Intramembranei334 – 364Discontinuously helical1 PublicationAdd BLAST31
Topological domaini365 – 373CytoplasmicCurated9
Transmembranei374 – 400Helical; Name=71 PublicationAdd BLAST27
Topological domaini401 – 413ExtracellularCuratedAdd BLAST13
Intramembranei414 – 447Discontinuously helical1 PublicationAdd BLAST34
Topological domaini448 – 460ExtracellularCuratedAdd BLAST13
Transmembranei461 – 482Helical; Name=81 PublicationAdd BLAST22
Topological domaini483 – 541CytoplasmicCuratedAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6510
OpenTargetsiENSG00000105281
PharmGKBiPA35830

Chemistry databases

ChEMBLiCHEMBL3562162
DrugBankiDB00174 L-Asparagine
DB00130 L-Glutamine
GuidetoPHARMACOLOGYi874

Polymorphism and mutation databases

BioMutaiSLC1A5
DMDMi21542389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020821 – 541Neutral amino acid transporter B(0)Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei493PhosphoserineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15758
MaxQBiQ15758
PaxDbiQ15758
PeptideAtlasiQ15758
PRIDEiQ15758
ProteomicsDBi60744

PTM databases

GlyConnecti1562
iPTMnetiQ15758
PhosphoSitePlusiQ15758
SwissPalmiQ15758

Expressioni

Tissue specificityi

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Gene expression databases

BgeeiENSG00000105281 Expressed in 220 organ(s), highest expression level in urinary bladder
CleanExiHS_SLC1A5
ExpressionAtlasiQ15758 baseline and differential
GenevisibleiQ15758 HS

Organism-specific databases

HPAiHPA035239
HPA035240

Interactioni

Subunit structurei

Homotrimer (Probable) (PubMed:29872227). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF5Q999424EBI-356576,EBI-348482

Protein-protein interaction databases

BioGridi112401, 69 interactors
IntActiQ15758, 49 interactors
MINTiQ15758
STRINGi9606.ENSP00000444408

Chemistry databases

BindingDBiQ15758

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15758
SMRiQ15758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiQ15758
KOiK05616
OMAiNPYTFLW
OrthoDBiEOG091G0UCE
PhylomeDBiQ15758
TreeFamiTF315206

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
60 70 80 90 100
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
110 120 130 140 150
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
160 170 180 190 200
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
210 220 230 240 250
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
260 270 280 290 300
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
310 320 330 340 350
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
360 370 380 390 400
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
410 420 430 440 450
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
460 470 480 490 500
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
510 520 530 540
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
Length:541
Mass (Da):56,598
Last modified:June 20, 2002 - v2
Checksum:iAD61C789CCFFE934
GO
Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,636
Checksum:iCFF2D2673EDD4FC9
GO
Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):33,710
Checksum:iA2CF681DC2A2F24E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXM4M0QXM4_HUMAN
Amino acid transporter
SLC1A5
365Annotation score:
M0QX44M0QX44_HUMAN
Amino acid transporter
SLC1A5
258Annotation score:
M0R144M0R144_HUMAN
Neutral amino acid transporter B(0)
SLC1A5
29Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 24TANGGLA → PPTGAWQ in AAC50629 (PubMed:8702519).Curated7
Sequence conflicti44Q → L in AAC50629 (PubMed:8702519).Curated1
Sequence conflicti84 – 87ERLS → GALE in AAC50629 (PubMed:8702519).Curated4
Sequence conflicti341V → A in BAH14917 (PubMed:14702039).Curated1
Sequence conflicti453I → V in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti460D → G in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti463V → A in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti508D → G in AAD09812 (PubMed:10051606).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02043917P → A. Corresponds to variant dbSNP:rs3027956Ensembl.1
Natural variantiVAR_013517512V → LCombined sources1 PublicationCorresponds to variant dbSNP:rs3027961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468511 – 228Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0463541 – 203MVADP…AAFRS → M in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA Translation: AAC50629.1
AF102826 mRNA Translation: AAD09812.1
AF105423 mRNA Translation: AAD27806.1
GQ919058 mRNA Translation: ACX53626.1
AK292690 mRNA Translation: BAF85379.1
AK299137 mRNA Translation: BAG61189.1
AK301661 mRNA Translation: BAG63136.1
AK316546 mRNA Translation: BAH14917.1
AC008622 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57446.1
BC000062 mRNA Translation: AAH00062.1
AF334818 mRNA Translation: AAK77026.1
CCDSiCCDS12692.1 [Q15758-1]
CCDS46125.1 [Q15758-2]
CCDS46126.1 [Q15758-3]
RefSeqiNP_001138616.1, NM_001145144.1 [Q15758-3]
NP_001138617.1, NM_001145145.1 [Q15758-2]
NP_005619.1, NM_005628.2 [Q15758-1]
UniGeneiHs.631582

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281 [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281 [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281 [Q15758-1]
GeneIDi6510
KEGGihsa:6510
UCSCiuc002pfr.4 human [Q15758-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA Translation: AAC50629.1
AF102826 mRNA Translation: AAD09812.1
AF105423 mRNA Translation: AAD27806.1
GQ919058 mRNA Translation: ACX53626.1
AK292690 mRNA Translation: BAF85379.1
AK299137 mRNA Translation: BAG61189.1
AK301661 mRNA Translation: BAG63136.1
AK316546 mRNA Translation: BAH14917.1
AC008622 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57446.1
BC000062 mRNA Translation: AAH00062.1
AF334818 mRNA Translation: AAK77026.1
CCDSiCCDS12692.1 [Q15758-1]
CCDS46125.1 [Q15758-2]
CCDS46126.1 [Q15758-3]
RefSeqiNP_001138616.1, NM_001145144.1 [Q15758-3]
NP_001138617.1, NM_001145145.1 [Q15758-2]
NP_005619.1, NM_005628.2 [Q15758-1]
UniGeneiHs.631582

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LLMX-ray3.25A158-230[»]
5LLUX-ray3.32A158-230[»]
5LM4X-ray3.10A158-230[»]
5MJUX-ray3.71A158-230[»]
6GCTelectron microscopy3.85A/B/C1-541[»]
ProteinModelPortaliQ15758
SMRiQ15758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112401, 69 interactors
IntActiQ15758, 49 interactors
MINTiQ15758
STRINGi9606.ENSP00000444408

Chemistry databases

BindingDBiQ15758
ChEMBLiCHEMBL3562162
DrugBankiDB00174 L-Asparagine
DB00130 L-Glutamine
GuidetoPHARMACOLOGYi874

Protein family/group databases

TCDBi2.A.23.3.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

GlyConnecti1562
iPTMnetiQ15758
PhosphoSitePlusiQ15758
SwissPalmiQ15758

Polymorphism and mutation databases

BioMutaiSLC1A5
DMDMi21542389

Proteomic databases

EPDiQ15758
MaxQBiQ15758
PaxDbiQ15758
PeptideAtlasiQ15758
PRIDEiQ15758
ProteomicsDBi60744

Protocols and materials databases

DNASUi6510
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281 [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281 [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281 [Q15758-1]
GeneIDi6510
KEGGihsa:6510
UCSCiuc002pfr.4 human [Q15758-1]

Organism-specific databases

CTDi6510
DisGeNETi6510
EuPathDBiHostDB:ENSG00000105281.12
GeneCardsiSLC1A5
H-InvDBiHIX0015262
HGNCiHGNC:10943 SLC1A5
HPAiHPA035239
HPA035240
MIMi109190 gene
neXtProtiNX_Q15758
OpenTargetsiENSG00000105281
PharmGKBiPA35830
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiQ15758
KOiK05616
OMAiNPYTFLW
OrthoDBiEOG091G0UCE
PhylomeDBiQ15758
TreeFamiTF315206

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRSiSLC1A5 human
GeneWikiiSLC1A5
GenomeRNAii6510
PROiPR:Q15758
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105281 Expressed in 220 organ(s), highest expression level in urinary bladder
CleanExiHS_SLC1A5
ExpressionAtlasiQ15758 baseline and differential
GenevisibleiQ15758 HS

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAAAT_HUMAN
AccessioniPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5
, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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