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Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).3 Publications
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.2 Publications
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.1 Publication
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: Reactome
  • L-glutamine transmembrane transporter activity Source: BHF-UCL
  • L-serine transmembrane transporter activity Source: Ensembl
  • neutral amino acid transmembrane transporter activity Source: ProtInc
  • signaling receptor activity Source: ProtInc
  • symporter activity Source: UniProtKB-KW
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  • amino acid transport Source: Reactome
  • glutamine secretion Source: Ensembl
  • glutamine transport Source: BHF-UCL
  • L-glutamine import across plasma membrane Source: Ensembl
  • neutral amino acid transport Source: ProtInc

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAmino-acid transport, Host-virus interaction, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.23.3.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105281.12
HGNCiHGNC:10943 SLC1A5
MIMi109190 gene
neXtProtiNX_Q15758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 224ExtracellularSequence analysisAdd BLAST71
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6510
OpenTargetsiENSG00000105281
PharmGKBiPA35830

Chemistry databases

ChEMBLiCHEMBL3562162
DrugBankiDB00174 L-Asparagine
DB00130 L-Glutamine
GuidetoPHARMACOLOGYi874

Polymorphism and mutation databases

BioMutaiSLC1A5
DMDMi21542389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020821 – 541Neutral amino acid transporter B(0)Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei493PhosphoserineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15758
MaxQBiQ15758
PaxDbiQ15758
PeptideAtlasiQ15758
PRIDEiQ15758
ProteomicsDBi60744

PTM databases

iPTMnetiQ15758
PhosphoSitePlusiQ15758
SwissPalmiQ15758

Expressioni

Tissue specificityi

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Gene expression databases

BgeeiENSG00000105281
CleanExiHS_SLC1A5
ExpressionAtlasiQ15758 baseline and differential
GenevisibleiQ15758 HS

Organism-specific databases

HPAiHPA035239
HPA035240

Interactioni

Subunit structurei

Homotrimer (Probable). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF5Q999424EBI-356576,EBI-348482

Protein-protein interaction databases

BioGridi112401, 69 interactors
IntActiQ15758, 53 interactors
MINTiQ15758
STRINGi9606.ENSP00000444408

Chemistry databases

BindingDBiQ15758

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 62Combined sources9
Helixi66 – 69Combined sources4
Helixi104 – 107Combined sources4
Helixi180 – 191Combined sources12
Helixi196 – 199Combined sources4
Beta strandi202 – 204Combined sources3
Beta strandi225 – 228Combined sources4
Helixi231 – 237Combined sources7
Helixi239 – 245Combined sources7
Helixi254 – 261Combined sources8
Helixi266 – 270Combined sources5
Helixi324 – 329Combined sources6
Helixi476 – 480Combined sources5

3D structure databases

ProteinModelPortaliQ15758
SMRiQ15758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiQ15758
KOiK05616
OMAiLVRNIFP
OrthoDBiEOG091G0UCE
PhylomeDBiQ15758
TreeFamiTF315206

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication
Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
60 70 80 90 100
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
110 120 130 140 150
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
160 170 180 190 200
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
210 220 230 240 250
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
260 270 280 290 300
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
310 320 330 340 350
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
360 370 380 390 400
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
410 420 430 440 450
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
460 470 480 490 500
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
510 520 530 540
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
Length:541
Mass (Da):56,598
Last modified:June 20, 2002 - v2
Checksum:iAD61C789CCFFE934
GO
Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,636
Checksum:iCFF2D2673EDD4FC9
GO
Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):33,710
Checksum:iA2CF681DC2A2F24E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 24TANGGLA → PPTGAWQ in AAC50629 (PubMed:8702519).Curated7
Sequence conflicti44Q → L in AAC50629 (PubMed:8702519).Curated1
Sequence conflicti84 – 87ERLS → GALE in AAC50629 (PubMed:8702519).Curated4
Sequence conflicti341V → A in BAH14917 (PubMed:14702039).Curated1
Sequence conflicti453I → V in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti460D → G in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti463V → A in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti508D → G in AAD09812 (PubMed:10051606).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02043917P → A. Corresponds to variant dbSNP:rs3027956Ensembl.1
Natural variantiVAR_013517512V → LCombined sources1 PublicationCorresponds to variant dbSNP:rs3027961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468511 – 228Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0463541 – 203MVADP…AAFRS → M in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA Translation: AAC50629.1
AF102826 mRNA Translation: AAD09812.1
AF105423 mRNA Translation: AAD27806.1
GQ919058 mRNA Translation: ACX53626.1
AK292690 mRNA Translation: BAF85379.1
AK299137 mRNA Translation: BAG61189.1
AK301661 mRNA Translation: BAG63136.1
AK316546 mRNA Translation: BAH14917.1
AC008622 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57446.1
BC000062 mRNA Translation: AAH00062.1
AF334818 mRNA Translation: AAK77026.1
CCDSiCCDS12692.1 [Q15758-1]
CCDS46125.1 [Q15758-2]
CCDS46126.1 [Q15758-3]
RefSeqiNP_001138616.1, NM_001145144.1 [Q15758-3]
NP_001138617.1, NM_001145145.1 [Q15758-2]
NP_005619.1, NM_005628.2 [Q15758-1]
UniGeneiHs.631582

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281 [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281 [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281 [Q15758-1]
GeneIDi6510
KEGGihsa:6510
UCSCiuc002pfr.4 human [Q15758-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAAAT_HUMAN
AccessioniPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5
, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: July 18, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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