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Entry version 192 (18 Sep 2019)
Sequence version 2 (20 Jun 2002)
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Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).4 Publications
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.2 Publications
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.1 Publication
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi382Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi384Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi386Sodium 1By similarity1
Metal bindingi471Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi475Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAmino-acid transport, Host-virus interaction, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.23.3.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10943 SLC1A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109190 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51CytoplasmicCuratedAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 81Helical; Name=11 PublicationAdd BLAST30
Topological domaini82 – 94ExtracellularCuratedAdd BLAST13
Transmembranei95 – 116Helical; Name=21 PublicationAdd BLAST22
Topological domaini117 – 130CytoplasmicCuratedAdd BLAST14
Transmembranei131 – 153Helical; Name=31 PublicationAdd BLAST23
Topological domaini154 – 224ExtracellularCuratedAdd BLAST71
Transmembranei225 – 248Helical; Name=41 PublicationAdd BLAST24
Topological domaini249 – 257CytoplasmicCurated9
Transmembranei258 – 285Helical; Name=51 PublicationAdd BLAST28
Topological domaini286 – 306ExtracellularCuratedAdd BLAST21
Transmembranei307 – 328Helical; Name=61 PublicationAdd BLAST22
Topological domaini329 – 333CytoplasmicCurated5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei334 – 364Discontinuously helical1 PublicationAdd BLAST31
Topological domaini365 – 373CytoplasmicCurated9
Transmembranei374 – 400Helical; Name=71 PublicationAdd BLAST27
Topological domaini401 – 413ExtracellularCuratedAdd BLAST13
Intramembranei414 – 447Discontinuously helical1 PublicationAdd BLAST34
Topological domaini448 – 460ExtracellularCuratedAdd BLAST13
Transmembranei461 – 482Helical; Name=81 PublicationAdd BLAST22
Topological domaini483 – 541CytoplasmicCuratedAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6510

Open Targets

More...
OpenTargetsi
ENSG00000105281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35830

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3562162

Drug and drug target database

More...
DrugBanki
DB00174 Asparagine
DB13146 Fluciclovine (18F)
DB00130 L-Glutamine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
874

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC1A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21542389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020821 – 541Neutral amino acid transporter B(0)Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei493PhosphoserineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15758

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15758

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15758

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15758

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15758

PeptideAtlas

More...
PeptideAtlasi
Q15758

PRoteomics IDEntifications database

More...
PRIDEi
Q15758

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19331
5376
60744 [Q15758-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1562

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15758

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15758

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15758

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105281 Expressed in 220 organ(s), highest expression level in urinary bladder

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15758 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15758 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035239
HPA035240

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (Probable) (PubMed:29872227).

Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).

1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RNF5Q999424EBI-356576,EBI-348482

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112401, 88 interactors

Protein interaction database and analysis system

More...
IntActi
Q15758, 73 interactors

Molecular INTeraction database

More...
MINTi
Q15758

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000444408

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15758

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15758

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3787 Eukaryota
COG1301 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000208776

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15758

KEGG Orthology (KO)

More...
KOi
K05616

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPYTFLW

Database of Orthologous Groups

More...
OrthoDBi
1340284at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15758

TreeFam database of animal gene trees

More...
TreeFami
TF315206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3860.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00375 SDF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118215 SSF118215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
60 70 80 90 100
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
110 120 130 140 150
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
160 170 180 190 200
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
210 220 230 240 250
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
260 270 280 290 300
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
310 320 330 340 350
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
360 370 380 390 400
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
410 420 430 440 450
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
460 470 480 490 500
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
510 520 530 540
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
Length:541
Mass (Da):56,598
Last modified:June 20, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD61C789CCFFE934
GO
Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,636
Checksum:iCFF2D2673EDD4FC9
GO
Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):33,710
Checksum:iA2CF681DC2A2F24E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXM4M0QXM4_HUMAN
Amino acid transporter
SLC1A5
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX44M0QX44_HUMAN
Amino acid transporter
SLC1A5
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R144M0R144_HUMAN
Neutral amino acid transporter B(0)
SLC1A5
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18 – 24TANGGLA → PPTGAWQ in AAC50629 (PubMed:8702519).Curated7
Sequence conflicti44Q → L in AAC50629 (PubMed:8702519).Curated1
Sequence conflicti84 – 87ERLS → GALE in AAC50629 (PubMed:8702519).Curated4
Sequence conflicti341V → A in BAH14917 (PubMed:14702039).Curated1
Sequence conflicti453I → V in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti460D → G in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti463V → A in AAD09812 (PubMed:10051606).Curated1
Sequence conflicti508D → G in AAD09812 (PubMed:10051606).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02043917P → A. Corresponds to variant dbSNP:rs3027956Ensembl.1
Natural variantiVAR_013517512V → LCombined sources1 PublicationCorresponds to variant dbSNP:rs3027961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468511 – 228Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0463541 – 203MVADP…AAFRS → M in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U53347 mRNA Translation: AAC50629.1
AF102826 mRNA Translation: AAD09812.1
AF105423 mRNA Translation: AAD27806.1
GQ919058 mRNA Translation: ACX53626.1
AK292690 mRNA Translation: BAF85379.1
AK299137 mRNA Translation: BAG61189.1
AK301661 mRNA Translation: BAG63136.1
AK316546 mRNA Translation: BAH14917.1
AC008622 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57446.1
BC000062 mRNA Translation: AAH00062.1
AF334818 mRNA Translation: AAK77026.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12692.1 [Q15758-1]
CCDS46125.1 [Q15758-2]
CCDS46126.1 [Q15758-3]

NCBI Reference Sequences

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RefSeqi
NP_001138616.1, NM_001145144.1 [Q15758-3]
NP_001138617.1, NM_001145145.1 [Q15758-2]
NP_005619.1, NM_005628.2 [Q15758-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000412532; ENSP00000397924; ENSG00000105281 [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281 [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281 [Q15758-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6510

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6510

UCSC genome browser

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UCSCi
uc002pfr.4 human [Q15758-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA Translation: AAC50629.1
AF102826 mRNA Translation: AAD09812.1
AF105423 mRNA Translation: AAD27806.1
GQ919058 mRNA Translation: ACX53626.1
AK292690 mRNA Translation: BAF85379.1
AK299137 mRNA Translation: BAG61189.1
AK301661 mRNA Translation: BAG63136.1
AK316546 mRNA Translation: BAH14917.1
AC008622 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57446.1
BC000062 mRNA Translation: AAH00062.1
AF334818 mRNA Translation: AAK77026.1
CCDSiCCDS12692.1 [Q15758-1]
CCDS46125.1 [Q15758-2]
CCDS46126.1 [Q15758-3]
RefSeqiNP_001138616.1, NM_001145144.1 [Q15758-3]
NP_001138617.1, NM_001145145.1 [Q15758-2]
NP_005619.1, NM_005628.2 [Q15758-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LLMX-ray3.25A158-230[»]
5LLUX-ray3.32A158-230[»]
5LM4X-ray3.10A158-230[»]
5MJUX-ray3.71A158-230[»]
6GCTelectron microscopy3.85A/B/C1-541[»]
SMRiQ15758
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112401, 88 interactors
IntActiQ15758, 73 interactors
MINTiQ15758
STRINGi9606.ENSP00000444408

Chemistry databases

BindingDBiQ15758
ChEMBLiCHEMBL3562162
DrugBankiDB00174 Asparagine
DB13146 Fluciclovine (18F)
DB00130 L-Glutamine
GuidetoPHARMACOLOGYi874

Protein family/group databases

TCDBi2.A.23.3.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

GlyConnecti1562
iPTMnetiQ15758
PhosphoSitePlusiQ15758
SwissPalmiQ15758

Polymorphism and mutation databases

BioMutaiSLC1A5
DMDMi21542389

Proteomic databases

EPDiQ15758
jPOSTiQ15758
MassIVEiQ15758
MaxQBiQ15758
PaxDbiQ15758
PeptideAtlasiQ15758
PRIDEiQ15758
ProteomicsDBi19331
5376
60744 [Q15758-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q15758

The DNASU plasmid repository

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DNASUi
6510
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281 [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281 [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281 [Q15758-1]
GeneIDi6510
KEGGihsa:6510
UCSCiuc002pfr.4 human [Q15758-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6510
DisGeNETi6510

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC1A5
HGNCiHGNC:10943 SLC1A5
HPAiHPA035239
HPA035240
MIMi109190 gene
neXtProtiNX_Q15758
OpenTargetsiENSG00000105281
PharmGKBiPA35830

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00940000159485
HOGENOMiHOG000208776
InParanoidiQ15758
KOiK05616
OMAiNPYTFLW
OrthoDBi1340284at2759
PhylomeDBiQ15758
TreeFamiTF315206

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC1A5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC1A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6510

Pharos

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Pharosi
Q15758

Protein Ontology

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PROi
PR:Q15758

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105281 Expressed in 220 organ(s), highest expression level in urinary bladder
ExpressionAtlasiQ15758 baseline and differential
GenevisibleiQ15758 HS

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAAT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5
, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: September 18, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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